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HUT53629A - Process for producing ethanolamine derivatives - Google Patents

Process for producing ethanolamine derivatives

Info

Publication number
HUT53629A
HUT53629A HU892273A HU227389A HUT53629A HU T53629 A HUT53629 A HU T53629A HU 892273 A HU892273 A HU 892273A HU 227389 A HU227389 A HU 227389A HU T53629 A HUT53629 A HU T53629A
Authority
HU
Hungary
Prior art keywords
alkyl
halo
nr14r15
hydroxy
alkylene
Prior art date
Application number
HU892273A
Other languages
Hungarian (hu)
Other versions
HU206333B (en
Inventor
Ian Frederick Skidmore
Harry Finch
Alan Naylor
Lawrence Henry Charles Lunts
Charles Willbe
David Middlemiss
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB878729597A external-priority patent/GB8729597D0/en
Priority claimed from GB878729596A external-priority patent/GB8729596D0/en
Priority to ZA889405A priority Critical patent/ZA889405B/en
Priority to NZ227365A priority patent/NZ227365A/en
Priority to PT89239A priority patent/PT89239B/en
Priority to EP88311956A priority patent/EP0322164B1/en
Priority to US07/285,530 priority patent/US5032609A/en
Priority to DK702188A priority patent/DK702188A/en
Priority claimed from EP88311956A external-priority patent/EP0322164B1/en
Priority to AT88311956T priority patent/ATE94876T1/en
Priority to DE88311956T priority patent/DE3884363T2/en
Priority to JP63320318A priority patent/JPH01301673A/en
Priority to HU892273A priority patent/HU206333B/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Priority to SU894614274A priority patent/SU1711673A3/en
Priority to US07/521,107 priority patent/US5039697A/en
Priority to US07/521,106 priority patent/US5002966A/en
Publication of HUT53629A publication Critical patent/HUT53629A/en
Publication of HU206333B publication Critical patent/HU206333B/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Amine derivs. of formula Ar-CH(OH)-CH(R18)NHO(R1)(R2)-XCH2 OCH2 YQ (I) and their physiologically acceptable salts and solvents are new, where Ar = 3-Z-4-hydroxyphenyl; phenyl substd. by R4 and R5; 3,5-dichloro-4-aminophenyl, 3-trifluoromethyl- 4-amino-5-chlorophenyl; 5-hydroxy-6-hydroxymethyl- 2-pyridyl; 8-hydroxy-2-oxo- 1,2-dihydrpquinolin-5-yl; or 8-hydroxy-2-oxo- 1,2,3,4-tetrahydroquinolin-5-yl; Z = R3-OH, (CH2)pNHR6, NR17R16, CH2OR10, CH2SO2Me or CH2CN; R3 = 1-3C opt. branched alkylene; one of R4 and R5 = OH; the other = H, halo or OH; R6 = COR7; CONHR7, SO2NR7R8 or SO2R9; R7 and R8 = H or 1-3C alkyl; R9 = 1-3C alkyl; p = 0-1; R16 and R17 = H or 1-4C alkyl; R17 can also be 2-5C alkoxycarbonyl when R16 = H; .R10 = 1-3C alkyl; X = bond, 1-7C alkylene, 2-7C alkenylene or 2-7C alkynylene; Y = bond, 1-6C alkylene, 2-6C alkenylene or 2-6C alkynylene; provided that the total no. of C in X+Y = 2-10; R1 and R2 = H or 1-3C alkyl; provided the total no. of cin R1 and R2 is not more than 4; R18 = H or 1-4C alkyl; Q = a gp. of formula (a)-(d); Z = O or S; R11 = H, halo, 1-3C alkyl, NO2, (CH2)tR (CH2)rCOR13 or SO2NR14R15; R12 = H, or 1-3C alkyl and can also be halo when R11 = halo; R = OH 1-3C alkoxy or NR14R15; R13 = OH, 1-4C alkoxy or NR14R15; R14 and R15 = H or 1-4C alkyl; or NR14R15 = 5- to 7-membered satd. heterocyclyl opt. contg. one or more of O, S, NH or NMe; t = 1-3; r = 0-3.
HU892273A 1987-12-18 1989-05-09 Proces sfor producing ethanol-amine derivatives and pharmaceutical compositions containing them as active components HU206333B (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
ZA889405A ZA889405B (en) 1987-12-18 1988-12-15 Ethanolamine derivatives
DE88311956T DE3884363T2 (en) 1987-12-18 1988-12-16 Ethanolamine derivatives.
PT89239A PT89239B (en) 1987-12-18 1988-12-16 PROCESS FOR THE PREPARATION OF ETHANOLAMINE DRIVATES
AT88311956T ATE94876T1 (en) 1987-12-18 1988-12-16 ETHANOLAMINE DERIVATIVES.
EP88311956A EP0322164B1 (en) 1987-12-18 1988-12-16 Ethanolamine derivatives
US07/285,530 US5032609A (en) 1987-12-18 1988-12-16 Ethanolamine derivatives
DK702188A DK702188A (en) 1987-12-18 1988-12-16 ETHANOLAMINE DERIVATIVES
NZ227365A NZ227365A (en) 1987-12-18 1988-12-16 Aromatic amino ethers and pharmaceutical compositions
JP63320318A JPH01301673A (en) 1987-12-18 1988-12-19 Ethanolamine derivative
HU892273A HU206333B (en) 1987-12-18 1989-05-09 Proces sfor producing ethanol-amine derivatives and pharmaceutical compositions containing them as active components
SU894614274A SU1711673A3 (en) 1987-12-18 1989-06-15 Method for the synthesis of ethanolamine or theirs physiologically acceptable salts or solvates
US07/521,106 US5002966A (en) 1987-12-18 1990-05-09 Ethanolamine derivatives
US07/521,107 US5039697A (en) 1987-12-18 1990-05-09 Ethanolamine derivatives

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB878729597A GB8729597D0 (en) 1987-12-18 1987-12-18 Chemical compounds
GB878729596A GB8729596D0 (en) 1987-12-18 1987-12-18 Chemical compounds
EP88311956A EP0322164B1 (en) 1987-12-18 1988-12-16 Ethanolamine derivatives
HU892273A HU206333B (en) 1987-12-18 1989-05-09 Proces sfor producing ethanol-amine derivatives and pharmaceutical compositions containing them as active components

Publications (2)

Publication Number Publication Date
HUT53629A true HUT53629A (en) 1990-11-28
HU206333B HU206333B (en) 1992-10-28

Family

ID=27441583

Family Applications (1)

Application Number Title Priority Date Filing Date
HU892273A HU206333B (en) 1987-12-18 1989-05-09 Proces sfor producing ethanol-amine derivatives and pharmaceutical compositions containing them as active components

Country Status (2)

Country Link
AT (1) ATE94876T1 (en)
HU (1) HU206333B (en)

Also Published As

Publication number Publication date
ATE94876T1 (en) 1993-10-15
HU206333B (en) 1992-10-28

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Legal Events

Date Code Title Description
HMM4 Cancellation of final prot. due to non-payment of fee