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HUT53627A - Process for producing 2-brackets open 2-brackets open 4-(4-chlorphenyl)-phenylmethyl brackets closed-1-piperazinyl brackets closed-ethosyacetic acid and salts thereof - Google Patents

Process for producing 2-brackets open 2-brackets open 4-(4-chlorphenyl)-phenylmethyl brackets closed-1-piperazinyl brackets closed-ethosyacetic acid and salts thereof

Info

Publication number
HUT53627A
HUT53627A HU896131A HU613189A HUT53627A HU T53627 A HUT53627 A HU T53627A HU 896131 A HU896131 A HU 896131A HU 613189 A HU613189 A HU 613189A HU T53627 A HUT53627 A HU T53627A
Authority
HU
Hungary
Prior art keywords
brackets
closed
open
ethosyacetic
chlorphenyl
Prior art date
Application number
HU896131A
Other languages
Hungarian (hu)
Other versions
HU896131D0 (en
HU205094B (en
Inventor
Eric Cossement
Genevieve Motte
Guy Bodson
Jean Gobert
Original Assignee
Eric Cossement
Genevieve Motte
Guy Bodson
Jean Gobert
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eric Cossement, Genevieve Motte, Guy Bodson, Jean Gobert filed Critical Eric Cossement
Publication of HU896131D0 publication Critical patent/HU896131D0/en
Publication of HUT53627A publication Critical patent/HUT53627A/en
Publication of HU205094B publication Critical patent/HU205094B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HU896131A 1988-11-23 1989-11-22 New process for producing 2-/2-/4-/(4-chlorophenyl)-phenylmethyl/-1-piperazinyl/-ethoxy/-acetic acid and its salts HU205094B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888827391A GB8827391D0 (en) 1988-11-23 1988-11-23 Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride

Publications (3)

Publication Number Publication Date
HU896131D0 HU896131D0 (en) 1990-02-28
HUT53627A true HUT53627A (en) 1990-11-28
HU205094B HU205094B (en) 1992-03-30

Family

ID=10647347

Family Applications (1)

Application Number Title Priority Date Filing Date
HU896131A HU205094B (en) 1988-11-23 1989-11-22 New process for producing 2-/2-/4-/(4-chlorophenyl)-phenylmethyl/-1-piperazinyl/-ethoxy/-acetic acid and its salts

Country Status (16)

Country Link
KR (1) KR970009728B1 (en)
AT (1) AT398971B (en)
CA (1) CA1317300C (en)
CY (1) CY1671A (en)
DK (1) DK174543B1 (en)
ES (1) ES2021907A6 (en)
FI (1) FI91862C (en)
GB (2) GB8827391D0 (en)
GR (1) GR1000553B (en)
HK (1) HK95892A (en)
HU (1) HU205094B (en)
NO (1) NO172342C (en)
PH (1) PH25982A (en)
PL (1) PL161379B1 (en)
PT (1) PT92364B (en)
SG (1) SG89492G (en)

Families Citing this family (38)

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Publication number Priority date Publication date Assignee Title
AU4932093A (en) * 1992-09-24 1994-04-12 Sepracor, Inc. Compositions for treating allergic disorders using (-) cetirizine
DK0661975T3 (en) * 1992-09-24 1999-09-27 Sepracor Inc Transdermal treatment of hives using optically pure (+) - cetirizine
AU703690B2 (en) * 1992-09-24 1999-04-01 Sepracor, Inc. Methods for treating allergic disorders using optically pure (+)cetirizine
GB9305282D0 (en) 1993-03-15 1993-05-05 Ucb Sa Enantiomers of 1-(4-chlorophenyl)phenylmethyl)-4-(4-methylphenyl)sulphonyl)piperazine
US6469009B1 (en) 1996-04-08 2002-10-22 Ucb, S.A. Pharmaceutical compositions for the treatment of rhinitis
BE1010094A3 (en) * 1996-04-10 1997-12-02 Ucb Sa NEW [2- (1-piperazinyl) ethoxy] SUBSTITUTED.
BE1010095A3 (en) * 1996-04-10 1997-12-02 Ucb Sa METHOD OF PREPARATION OF ACID 2- [2- [4 - [(4-Chlorophenyl) phenylmethyl] -1-PIPERAZINYL] ETHOXY] acetic acid AND ITS SALTS.
JP3476475B2 (en) 1997-06-04 2003-12-10 株式会社アズウェル Method for producing piperazine sulfonamide derivative and salt thereof
EP0919550A1 (en) * 1997-11-26 1999-06-02 Ucb, S.A. Pseudopolymorphic forms of 2-2-4-bis(4-fluorophenyl)methyl-1-piperazinyl-ethoxy acetic acid dihydrochloride
IL124195A (en) * 1998-04-23 2000-08-31 Chemagis Ltd Process for the preparation of esters of 2-¬4-¬4-chlorophenyl¾phenylmethyl¾-1-piperazinyl¬ethoxy¾acetic acid
GR990100135A (en) * 1999-04-22 2000-12-29 Genepharm �.�. Method of preparation 2-(2-{4-[(4-chlorophenyl)(phenyl)methhyl]piperasine}-ethoxy)acetic acid and its bihydrochloric salt
JP2002249487A (en) 2001-02-22 2002-09-06 Sumitomo Chem Co Ltd A 4- (tert-butoxycarbonyl) piperazine derivative, an optically active acid addition salt thereof, a method for producing them, and a method for producing optically active 1-[(substituted phenyl) phenylmethyl] piperazine using the same.
US6977301B1 (en) 2001-05-29 2005-12-20 Ucb, S.A. Process for preparing (S) and (R)—2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide
US7199241B1 (en) 2001-05-29 2007-04-03 Ucb, S.A. Process for preparing (S) and (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide
WO2004065360A2 (en) * 2003-01-23 2004-08-05 Ucb Farchim Sa Piperazine derivatives and their use as synthesis intermediates
KR100503443B1 (en) 2004-02-02 2005-07-22 한림제약(주) Processes for preparing an optically active cetirizine or its salt
WO2006094648A1 (en) * 2005-03-03 2006-09-14 Ucb Farchim Sa Pyroglutamate salts and their use in the optical resolution of intermediates for the synthesis of dextrocetirizine and levocetirizine
HU227325B1 (en) * 2005-12-08 2011-03-28 Egis Gyogyszergyar Nyrt Process for the production of an intermediate of (dextro- and levo)- cetirizine
SI22489A (en) * 2007-03-12 2008-10-31 Krka, Tovarna Zdravil, D.D., Novo Mesto New procedure for preparation of levocetirizine and its intermediates
US8049011B2 (en) 2007-03-12 2011-11-01 Krka, Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of levocetirizine and intermediates thereof
US8084606B2 (en) 2007-06-15 2011-12-27 Symed Labs Limited Process for preparation of substantially optically pure levorotatory and dextrorotatory enantiomers of cetirizine using novel intermediates
WO2009062036A2 (en) * 2007-11-09 2009-05-14 Dr. Reddy's Laboratories Ltd. Processes for preparing levocetirizine and pharmaceutically acceptable salts thereof
US7989623B2 (en) 2007-11-21 2011-08-02 Synthon Bv Process for making n-(diphenylmethyl)piperazines
EP2062881B1 (en) 2007-11-21 2011-02-23 Synthon B.V. Process for making N-(diphenylmethyl)piperazines
CN102046612A (en) 2008-06-02 2011-05-04 希普拉有限公司 Processes for the synthesis of levocetirizine and intermediates for use therein
EP2297122B1 (en) * 2008-06-11 2014-05-21 KRKA, tovarna zdravil, d.d., Novo mesto New process for the preparation of levocetirizine and intermediates thereof
KR100998067B1 (en) 2008-09-08 2010-12-03 주식회사 삼오제약 Bis (1-[(4-chlorophenyl) phenylmethyl] piperazin) -2,3-dibenzoyl tartaric acid novel intermediate salt and optically pure 1-[(4-chlorophenyl) phenylmethyl] piperazin using the same How to separate
US20110172425A1 (en) 2008-09-17 2011-07-14 Calyx Chemicals And Pharmaceuticals Pvt. Ltd. Novel water based process for the preparation of substituted diphenylmethyl piperazines
WO2010107404A1 (en) 2009-03-16 2010-09-23 Mahmut Bilgic Stable pharmaceutical combinations
TR201007652A2 (en) 2010-09-20 2012-04-24 Bi̇lgi̇ç Mahmut Synergistic effect.
TR201009398A2 (en) 2010-11-11 2012-05-21 Bi̇lgi̇ç Mahmut Tablet formulations with improved physical properties
WO2012101475A1 (en) 2011-01-27 2012-08-02 Jubilant Life Sciences Limited An improved process for the preparation of antihistaminic drugs via a novel carbamate intermediate
CN103044355A (en) * 2011-10-13 2013-04-17 湖南九典制药有限公司 Key intermediate for synthesizing levocetirizine and preparation method thereof
KR101418404B1 (en) 2012-01-06 2014-07-10 한미약품 주식회사 Stable pharmaceutical formulation for oral administration comprising levocetirizine or a pharmaceutically acceptable salt thereof, and montelukast or a pharmaceutically acceptable salt thereof
KR102226833B1 (en) 2013-06-28 2021-03-12 한미약품 주식회사 Complex granule formulation having improved stability comprising levocetirizine and montelukast
CN104045607B (en) * 2014-05-21 2016-04-13 丽珠医药集团股份有限公司 A kind of purification process of cetrizine hcl
CN105924409B (en) * 2016-05-12 2019-01-08 浙江永宁药业股份有限公司 The method for splitting of one kind (R) -1- ((2- chlorphenyl)-(phenyl)-methyl)-piperazine
CN111205247B (en) * 2020-04-22 2020-08-14 湖南九典宏阳制药有限公司 Preparation method of levocetirizine

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO155805C (en) * 1981-02-06 1987-06-10 Ucb Sa ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVITY 2- (4- (DIPHENYLMETHYL) -1-PIPERAZINYL) -ACDIC ACIDS AND THEIR AMIDS AND NON-TOXIC SALTS.

Also Published As

Publication number Publication date
HU896131D0 (en) 1990-02-28
DK586789A (en) 1990-05-24
SG89492G (en) 1992-12-04
CA1317300C (en) 1993-05-04
HU205094B (en) 1992-03-30
FI895564A0 (en) 1989-11-22
CY1671A (en) 1993-05-14
PL161379B1 (en) 1993-06-30
GR890100770A (en) 1990-12-31
PH25982A (en) 1992-01-13
AT398971B (en) 1995-02-27
GB2225321A (en) 1990-05-30
ES2021907A6 (en) 1991-11-16
GB2225321B (en) 1992-04-08
KR900007825A (en) 1990-06-02
NO172342C (en) 1993-07-07
DK586789D0 (en) 1989-11-22
PT92364B (en) 1995-07-18
NO894651L (en) 1990-05-25
NO894651D0 (en) 1989-11-22
GR1000553B (en) 1992-08-26
ATA266589A (en) 1994-07-15
HK95892A (en) 1992-12-11
GB8827391D0 (en) 1988-12-29
DK174543B1 (en) 2003-05-19
PT92364A (en) 1990-05-31
FI91862C (en) 1994-08-25
KR970009728B1 (en) 1997-06-17
NO172342B (en) 1993-03-29
GB8926243D0 (en) 1990-01-10
FI91862B (en) 1994-05-13

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Legal Events

Date Code Title Description
MM4A Lapse of definitive patent protection due to non-payment of fees