HUT45255A - Process for producing furo/3,4-b/pyridine derivatives and pharmaceutical compositions comprising these compounds - Google Patents
Process for producing furo/3,4-b/pyridine derivatives and pharmaceutical compositions comprising these compoundsInfo
- Publication number
- HUT45255A HUT45255A HU87122A HU12287A HUT45255A HU T45255 A HUT45255 A HU T45255A HU 87122 A HU87122 A HU 87122A HU 12287 A HU12287 A HU 12287A HU T45255 A HUT45255 A HU T45255A
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- opt
- substd
- furo
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Endocrinology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
Abstract
Alkyl 1,2,4-trisubstd. -7-hydroxy-5-oxo- 1,4,5,7-tetrahydrofuro (3,4-b)pyrimidine -3-carboxylates of formula (I) and their salts are new. R1 = Ph, naphthyl, thienyl, pyridyl, chromonyl, thiochromonyl or thiochromenyl, each opt. substd. by 1 or 2 F, Cl, Br, 1-6C alkyl, 1-6C alkoxy, 1-6C alkylthio, NO2, CN or fluoroalkyl or fluoroalkoxy each having up to 3C and 3F; R2 = n-, branched or cyclic alkyl having up to 12C and opt. interrupted by 1 or 2 O or S atoms and opt. substd. by F, Cl, Ph, CN, OH, NH2, mono- or di-(1-3C)alkylamino or N-benzylmethylamino; R3 = CN or 1-4C alkyl opt. interrupted by N-(1-3C alkyl) and/or O; R4 = n-, branched or cyclic alkyl having up to 6C and opt. interrupted by 1 or 2 O atoms and opt. substd. by F, Cl, OH, Ph, NH2, COOH or (1-4C) alkoxycarbonyl. In (I) pref. R1 = Ph opt. substd. by NO2, CL, 1-3C trifluoroalkyl or 1-3C alkyl; R2 = 1-4C alkyl opt. substd. by MeO or EtO; R3 = 1-3C alkyl; R4 = 1-4C alkyl.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19863601226 DE3601226A1 (en) | 1986-01-17 | 1986-01-17 | DIHYDROPYRIDINE LACTOLS, METHOD FOR THE PRODUCTION AND THEIR USE IN MEDICINAL PRODUCTS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUT45255A true HUT45255A (en) | 1988-06-28 |
| HU196804B HU196804B (en) | 1989-01-30 |
Family
ID=6292033
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU87122A HU196804B (en) | 1986-01-17 | 1987-01-16 | Process for producing furo/3,4-b/pyridine derivatives and pharmaceutical compositions containing them |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US4721719A (en) |
| EP (1) | EP0235347B1 (en) |
| JP (1) | JPH0762018B2 (en) |
| KR (1) | KR870007179A (en) |
| CN (2) | CN1061528A (en) |
| AT (1) | ATE68184T1 (en) |
| AU (1) | AU587068B2 (en) |
| CA (1) | CA1293508C (en) |
| CS (1) | CS258492B2 (en) |
| DD (1) | DD268945A5 (en) |
| DE (2) | DE3601226A1 (en) |
| DK (1) | DK161252C (en) |
| EG (1) | EG18031A (en) |
| ES (1) | ES2009209A6 (en) |
| FI (1) | FI870151A (en) |
| GR (1) | GR862107B (en) |
| HU (1) | HU196804B (en) |
| IL (1) | IL81258A (en) |
| NO (1) | NO164597C (en) |
| NZ (1) | NZ217308A (en) |
| PH (1) | PH23676A (en) |
| PL (2) | PL149184B1 (en) |
| PT (1) | PT84120B (en) |
| SU (1) | SU1440345A3 (en) |
| ZA (1) | ZA865968B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3410645A1 (en) * | 1984-03-23 | 1985-09-26 | Bayer Ag, 5090 Leverkusen | L-ALKYL-SUBSTITUTED 1,4-DIHYDROPYRIDINE LACTONE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN MEDICINAL PRODUCTS |
| JP2594809B2 (en) * | 1988-04-02 | 1997-03-26 | 日本ゼオン株式会社 | Rubber composition for tire tread |
| JP4860050B2 (en) * | 2001-04-23 | 2012-01-25 | 富士重工業株式会社 | Drilling method by fusing device and fusing device |
| EP1663227A2 (en) * | 2003-09-10 | 2006-06-07 | Synta Pharmaceuticals Corporation | Dihydropyridine compounds for treating or preventing metabolic disorders |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0080220B1 (en) * | 1981-11-17 | 1986-02-19 | FISONS plc | Dihydropyridines, methods for their production and their formulation and use as pharmaceuticals |
| EP0111455A3 (en) * | 1982-12-10 | 1984-07-25 | Ciba-Geigy Ag | Unsaturated lactones |
| DE3343658A1 (en) * | 1983-12-02 | 1985-06-13 | Bayer Ag, 5090 Leverkusen | HYDROXY-TETRAHYDROPYRIDINLACTONE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN MEDICINAL PRODUCTS |
-
1986
- 1986-01-17 DE DE19863601226 patent/DE3601226A1/en not_active Withdrawn
- 1986-08-05 DK DK372586A patent/DK161252C/en not_active IP Right Cessation
- 1986-08-06 EP EP86110896A patent/EP0235347B1/en not_active Expired - Lifetime
- 1986-08-06 DE DE8686110896T patent/DE3681913D1/en not_active Expired - Lifetime
- 1986-08-06 AT AT86110896T patent/ATE68184T1/en active
- 1986-08-08 DD DD86293531A patent/DD268945A5/en not_active IP Right Cessation
- 1986-08-08 ZA ZA865968A patent/ZA865968B/en unknown
- 1986-08-11 GR GR862107A patent/GR862107B/en unknown
- 1986-08-15 PL PL1986261050A patent/PL149184B1/en unknown
- 1986-08-15 PL PL1986271190A patent/PL149694B1/en unknown
- 1986-08-19 ES ES8601187A patent/ES2009209A6/en not_active Expired
- 1986-08-21 NZ NZ217308A patent/NZ217308A/en unknown
- 1986-08-22 JP JP61195704A patent/JPH0762018B2/en not_active Expired - Lifetime
- 1986-08-25 EG EG536/86A patent/EG18031A/en active
- 1986-08-27 US US06/900,866 patent/US4721719A/en not_active Expired - Lifetime
- 1986-08-27 SU SU864028009A patent/SU1440345A3/en active
- 1986-08-29 PH PH34199A patent/PH23676A/en unknown
- 1986-09-02 CA CA000517282A patent/CA1293508C/en not_active Expired - Lifetime
- 1986-09-16 KR KR1019860007764A patent/KR870007179A/en not_active Application Discontinuation
- 1986-09-29 AU AU63233/86A patent/AU587068B2/en not_active Ceased
- 1986-10-04 CN CN91108007A patent/CN1061528A/en active Pending
- 1986-10-04 CN CN86106735A patent/CN1019488B/en not_active Expired
- 1986-11-03 CS CS867923A patent/CS258492B2/en unknown
- 1986-12-29 NO NO865324A patent/NO164597C/en unknown
-
1987
- 1987-01-14 IL IL81258A patent/IL81258A/en unknown
- 1987-01-15 FI FI870151A patent/FI870151A/en not_active Application Discontinuation
- 1987-01-16 HU HU87122A patent/HU196804B/en not_active IP Right Cessation
- 1987-01-16 PT PT84120A patent/PT84120B/en not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HU90 | Patent valid on 900628 | ||
| HMM4 | Cancellation of final prot. due to non-payment of fee |