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HUT45039A - Process for producing new benzhydryl-piperazine derivatives and pharmaceuticals comprising the compounds - Google Patents

Process for producing new benzhydryl-piperazine derivatives and pharmaceuticals comprising the compounds

Info

Publication number
HUT45039A
HUT45039A HU861751A HU175186A HUT45039A HU T45039 A HUT45039 A HU T45039A HU 861751 A HU861751 A HU 861751A HU 175186 A HU175186 A HU 175186A HU T45039 A HUT45039 A HU T45039A
Authority
HU
Hungary
Prior art keywords
compounds
general formula
piperazine derivatives
pharmaceuticals
producing new
Prior art date
Application number
HU861751A
Other languages
English (en)
Other versions
HU196196B (en
Inventor
Edit Toth
Jozsef Toerley
Erzsebet Lapis
Istvan Laszlovszky
Dora Groo
Laszlo Szporny
Eva Palosi
Istvan Hajdu
Bela Kiss
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Priority to HU861751A priority Critical patent/HU196196B/hu
Priority to US07/041,233 priority patent/US4868184A/en
Priority to DK212387A priority patent/DK212387A/da
Priority to EP87106034A priority patent/EP0243905B1/de
Priority to FI871876A priority patent/FI85268C/fi
Priority to JP62106156A priority patent/JPS62273970A/ja
Priority to GR870661A priority patent/GR870661B/el
Priority to CA000535729A priority patent/CA1298299C/en
Priority to DE8787106034T priority patent/DE3765451D1/de
Priority to AT87106034T priority patent/ATE57378T1/de
Priority to ES8701262A priority patent/ES2004410A6/es
Priority to IL82354A priority patent/IL82354A/xx
Priority to ZA873027A priority patent/ZA873027B/xx
Priority to AU72160/87A priority patent/AU594759B2/en
Publication of HUT45039A publication Critical patent/HUT45039A/hu
Publication of HU196196B publication Critical patent/HU196196B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HU861751A 1986-04-28 1986-04-28 Process for producing new benzhydryl-piperazine derivatives and pharmaceuticals comprising the compounds HU196196B (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
HU861751A HU196196B (en) 1986-04-28 1986-04-28 Process for producing new benzhydryl-piperazine derivatives and pharmaceuticals comprising the compounds
US07/041,233 US4868184A (en) 1986-04-28 1987-04-22 Benzhydrylpiperazines pharmaceutical compositions thereof and method of use
DK212387A DK212387A (da) 1986-04-28 1987-04-27 Benzhydrylpiperazinderivater eller farmaceutisk acceptable syreadditonssalte og kvaternaere ammoni-umsalte deraf, deres fremstilling og anvendelse
EP87106034A EP0243905B1 (de) 1986-04-28 1987-04-28 1(omega-[bis-(Phenyl)-alkoxy]-alkyl)-4-(di-(phenyl)-methyl)- Piperazine, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
FI871876A FI85268C (fi) 1986-04-28 1987-04-28 Foerfarande foer framstaellning av terapeutiskt anvaendbara benshydrylpiperazin-derivat.
JP62106156A JPS62273970A (ja) 1986-04-28 1987-04-28 ベンズヒドリルピペラジン誘導体、その製造方法、並びに前記誘導体を含む薬剤、その製造方法及び薬剤による治療方法
GR870661A GR870661B (en) 1986-04-28 1987-04-28 Process for preparing benzhydrylpiperazine derivatives
CA000535729A CA1298299C (en) 1986-04-28 1987-04-28 Benzhydrylpiperazine derivatives, pharmaceutical compositions containing them and process for preparing same
DE8787106034T DE3765451D1 (de) 1986-04-28 1987-04-28 1(omega-(bis-(phenyl)-alkoxy)-alkyl)-4-(di-(phenyl)-methyl)- piperazine, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
AT87106034T ATE57378T1 (de) 1986-04-28 1987-04-28 1(omega-(bis-(phenyl)-alkoxy>-alkyl)-4-(di(phenyl)-methyl)- piperazine, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
ES8701262A ES2004410A6 (es) 1986-04-28 1987-04-28 Porcedimiento para la preparacion e nuevos derivados benzohidrilpiperazinas
IL82354A IL82354A (en) 1986-04-28 1987-04-28 Benzhydrylpiperazine derivatives,their preparation and pharmaceutical compositions containing them
ZA873027A ZA873027B (en) 1986-04-28 1987-04-28 Benzhydryipiperazine derivatives,pharmaceutical compositions containing them and process for preparing same
AU72160/87A AU594759B2 (en) 1986-04-28 1987-04-28 Benzhydrylpiperazine derivatives, pharmaceutical compositions containing them and process for preparing same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU861751A HU196196B (en) 1986-04-28 1986-04-28 Process for producing new benzhydryl-piperazine derivatives and pharmaceuticals comprising the compounds

Publications (2)

Publication Number Publication Date
HUT45039A true HUT45039A (en) 1988-05-30
HU196196B HU196196B (en) 1988-10-28

Family

ID=10956008

Family Applications (1)

Application Number Title Priority Date Filing Date
HU861751A HU196196B (en) 1986-04-28 1986-04-28 Process for producing new benzhydryl-piperazine derivatives and pharmaceuticals comprising the compounds

Country Status (14)

Country Link
US (1) US4868184A (hu)
EP (1) EP0243905B1 (hu)
JP (1) JPS62273970A (hu)
AT (1) ATE57378T1 (hu)
AU (1) AU594759B2 (hu)
CA (1) CA1298299C (hu)
DE (1) DE3765451D1 (hu)
DK (1) DK212387A (hu)
ES (1) ES2004410A6 (hu)
FI (1) FI85268C (hu)
GR (1) GR870661B (hu)
HU (1) HU196196B (hu)
IL (1) IL82354A (hu)
ZA (1) ZA873027B (hu)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU196194B (en) * 1986-04-28 1988-10-28 Richter Gedeon Vegyeszet Process for producing new 1-4 disubstituted piperazines and pharmaceuticals comprising the compounds
HU196195B (en) * 1986-04-28 1988-10-28 Richter Gedeon Vegyeszet Process for producing 1,4-disubstituted piperazine derivatives and pharmaceuticals comprising the compounds
FR2601366B1 (fr) * 1986-07-10 1988-11-25 Andre Buzas Derives de la benzhydryloxyethyl-piperazine, procedes d'obtention et de compositions pharmaceutiques les contenant.
US5028610A (en) * 1987-03-18 1991-07-02 Sankyo Company Limited N-benzhydryl-substituted heterocyclic derivatives, their preparation and their use
DK178490D0 (da) * 1990-07-26 1990-07-26 Novo Nordisk As 1,4-disubstituerede piperaziner
US5276035A (en) * 1990-07-26 1994-01-04 Novo Nordisk A/S 1,4-disubstituted piperazines
FR2673182A1 (fr) * 1991-02-22 1992-08-28 Univ Caen Piperazines n,n'-disubstituees, leur procede de preparation et leur application en therapeutique.
US5583665A (en) * 1995-02-13 1996-12-10 Eastman Kodak Company Method and apparatus for performing color transformations using a reference image combined with a color tracer
US6304277B1 (en) 1999-01-15 2001-10-16 Colorcentric.Com, Inc. Remote modification of digital images using scripts

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2899436A (en) * 1959-08-11 chjch
US2709169A (en) * 1955-05-24 X c chs
US2603435A (en) * 1948-02-06 1952-07-15 Earl G Metzler Resilient mounting for airplane wings
US2861072A (en) * 1952-07-19 1958-11-18 Abbott Lab Preparation of piperazine derivatives
DE1062248B (de) * 1956-07-10 1959-07-30 Henri Morren Verfahren zur Herstellung antiulceroes wirkender Piperazine
GB837986A (en) * 1956-07-10 1960-06-22 Henri Morren New piperazine derivatives and process for the preparation thereof
DE1470224B2 (de) * 1961-10-02 1976-09-30 G.D. Searle & Co., Chicago, Hl. (V.St.A.) In 1-stellung substituierte 4- aminopiperazinderivate
DE1795375A1 (de) * 1968-09-21 1972-01-05 Boehringer Mannheim Gmbh Basische AEther und Verfahren zur Herstellung derselben
GB1545094A (en) * 1976-12-14 1979-05-02 Gist Brocades Nv Piperazine derivatives
FR2374318A1 (en) * 1976-12-14 1978-07-13 Gist Brocades Nv 1-Benzhydryl:oxy-alkyl-4-phenylalkyl- or cinnamyl-piperazine derivs. - with dopaminergic, anticholinergic and antiparkinson activity (BE 14.6.78)
DE3600390A1 (de) * 1986-01-09 1987-07-16 Hoechst Ag Diarylalkyl-substituierte alkylamine, verfahren zu ihrer herstellung, ihre verwendung sowie sie enthaltende arzneimittel
HU196194B (en) * 1986-04-28 1988-10-28 Richter Gedeon Vegyeszet Process for producing new 1-4 disubstituted piperazines and pharmaceuticals comprising the compounds
HU196195B (en) * 1986-04-28 1988-10-28 Richter Gedeon Vegyeszet Process for producing 1,4-disubstituted piperazine derivatives and pharmaceuticals comprising the compounds

Also Published As

Publication number Publication date
DE3765451D1 (de) 1990-11-15
EP0243905A1 (de) 1987-11-04
FI871876A0 (fi) 1987-04-28
IL82354A (en) 1991-09-16
FI85268B (fi) 1991-12-13
AU594759B2 (en) 1990-03-15
CA1298299C (en) 1992-03-31
AU7216087A (en) 1987-10-29
DK212387D0 (da) 1987-04-27
US4868184A (en) 1989-09-19
ES2004410A6 (es) 1989-01-01
DK212387A (da) 1987-10-29
EP0243905B1 (de) 1990-10-10
FI871876A (fi) 1987-10-29
ATE57378T1 (de) 1990-10-15
IL82354A0 (en) 1987-10-30
JPS62273970A (ja) 1987-11-28
GR870661B (en) 1987-09-02
HU196196B (en) 1988-10-28
ZA873027B (en) 1988-03-30
FI85268C (fi) 1992-03-25

Similar Documents

Publication Publication Date Title
HUT45038A (en) Process for producing 1,4-disubstituted piperazine derivatives and pharmaceuticals comprising the compounds
AU7216187A (en) 1,4-disubstituted piperazine derivatives, pharmaceutical compositions containing them and process for preparing same
HUT45039A (en) Process for producing new benzhydryl-piperazine derivatives and pharmaceuticals comprising the compounds
ZA839615B (en) Dialkyl-amino-alkoxy derivatives,process for their preparation and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
HU90 Patent valid on 900628
HMM4 Cancellation of final prot. due to non-payment of fee