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HUP9904379A2 - Novel process for production of 6-methyl-2-(4-methyl-phenyl)-imidazo[1,2-a]pyrimidyne-3-(n,n-dimethyl-acetamide) - Google Patents

Novel process for production of 6-methyl-2-(4-methyl-phenyl)-imidazo[1,2-a]pyrimidyne-3-(n,n-dimethyl-acetamide)

Info

Publication number
HUP9904379A2
HUP9904379A2 HU9904379A HUP9904379A HUP9904379A2 HU P9904379 A2 HUP9904379 A2 HU P9904379A2 HU 9904379 A HU9904379 A HU 9904379A HU P9904379 A HUP9904379 A HU P9904379A HU P9904379 A2 HUP9904379 A2 HU P9904379A2
Authority
HU
Hungary
Prior art keywords
methyl
phenyl
imidazo
acetamide
dimethyl
Prior art date
Application number
HU9904379A
Other languages
Hungarian (hu)
Inventor
Pongo Laszlo Dr
Reiter Joszef Dr
Laszlo Koncz
Nagy Kalman Dr
Vereczkeyne Donath Gyoergyi Dr
Simig Gyula Dr
Toempe Peter Dr
Fekete Valeria Hoffmanne
Rivo Endre Dr
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Priority to HU9904379A priority Critical patent/HU227358B1/en
Publication of HU9904379D0 publication Critical patent/HU9904379D0/en
Priority to SK712-2002A priority patent/SK7122002A3/en
Priority to PL00354366A priority patent/PL354366A1/en
Priority to AU18739/01A priority patent/AU1873901A/en
Priority to ES00981505T priority patent/ES2248154T3/en
Priority to CZ20021713A priority patent/CZ300711B6/en
Priority to CNB008173044A priority patent/CN1227252C/en
Priority to DE60022684T priority patent/DE60022684T2/en
Priority to EP00981505A priority patent/EP1259509B1/en
Priority to KR1020027006461A priority patent/KR100656636B1/en
Priority to JP2001540090A priority patent/JP2003518016A/en
Priority to RU2002116672/04A priority patent/RU2254334C2/en
Priority to AT00981505T priority patent/ATE304540T1/en
Priority to DK00981505T priority patent/DK1259509T3/en
Priority to PCT/HU2000/000120 priority patent/WO2001038327A2/en
Priority to HR20020471A priority patent/HRP20020471B1/en
Publication of HUP9904379A2 publication Critical patent/HUP9904379A2/en
Publication of HU227358B1 publication Critical patent/HU227358B1/en

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  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

6-methyl-2-(4-methyl-phenyl)-imidazo(1,2- a)pyrimidine-3-(N,N-dimethyl-acetamide) (I) is prepared by reaction of an acetate ester (II) with dimethylamine in a polar aprotic solvent. Preparation of a compound of formula (I), or an acid addition salt of (I), comprises: (a) reaction of an ester compound of formula (II) with dimethylamine in a polar aprotic solvent; and optionally (b) converting the product (I) into an acid addition salt. R = lower alkyl or phenyl-lower alky.l Independent claims are included for: (i) esters (II), with the exception of (II; R = ethyl), and (ii) crystalline esters of formula (II).
HU9904379A 1999-11-22 1999-11-22 Novel process for the preparation of 6-methyl-2-(4-methyl-phenyl)-imidazo[1,2-a]pyrimidyne-3-(n,n-dimethyl-acetamide) HU227358B1 (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
HU9904379A HU227358B1 (en) 1999-11-22 1999-11-22 Novel process for the preparation of 6-methyl-2-(4-methyl-phenyl)-imidazo[1,2-a]pyrimidyne-3-(n,n-dimethyl-acetamide)
PCT/HU2000/000120 WO2001038327A2 (en) 1999-11-22 2000-11-22 Process for the preparation of 6-methyl-2-(4-methyl-phenyl)-imidazo[1,2-a]pyrimidine-3-(n,n-dimethyl-acetamide) and intermediates
EP00981505A EP1259509B1 (en) 1999-11-22 2000-11-22 Process for the preparation of 6-methyl-2-(4-methyl-phenyl)-imidazo 1,2-a]pyridine-3-(n,n-dimethyl-acetamide) and intermediates
JP2001540090A JP2003518016A (en) 1999-11-22 2000-11-22 Preparation of 6-methyl-2- (4-methyl-phenyl) -imidazo [1,2-a] pyridine-3- (N, N-dimethyl-acetamide) and intermediates
AU18739/01A AU1873901A (en) 1999-11-22 2000-11-22 Process for the preparation of 6-methyl-2-(4-methyl-phenyl)-imidazo(1,2-A)pyrimidine-3- (N,N-dimethyl-acetamide) and intermediates
ES00981505T ES2248154T3 (en) 1999-11-22 2000-11-22 PROCEDURE FOR THE PREPARATION OF 6-METHYL-2- (4-METHYL-PHENYL) -IMIDAZO (1,2-A) -PIRIDINA-3- (N, N-DIMETHYL-ACETAMIDE) AND INTERMEDIATE PRODUCTS.
CZ20021713A CZ300711B6 (en) 1999-11-22 2000-11-22 Process for preparing 6-metyl-2-(4-metyl-phenyl)-imidazo[1,2-A]pyrimidine-3-(N,N-dimetylacetamide) and intermediates
CNB008173044A CN1227252C (en) 1999-11-22 2000-11-22 Process for preparation of 6-methyl-2-(4-methyl-phenyl)-imidazo [1,2-a] pyrimidine-3-(N,N-dimethyl-acetamide) and intermediates
DE60022684T DE60022684T2 (en) 1999-11-22 2000-11-22 Process for the preparation of 6-methyl-2- (4-methyl-phenyl) -imidazo [1,2-A] pyridine-3- (N, N-dimethyl-acetamide) and intermediates
SK712-2002A SK7122002A3 (en) 1999-11-22 2000-11-22 Process for the preparation of 6-methyl-2-(4-methyl-phenyl)- imidazo[1,2-a]pyrimidine-3-(n,n-dimethyl-acetamide) and intermediates
KR1020027006461A KR100656636B1 (en) 1999-11-22 2000-11-22 Preparation of 6-methyl-2- (4-methyl-phenyl) -imidazo [1,2-a] pyridine-3- (N, N-dimethyl-acetamide) and intermediates
PL00354366A PL354366A1 (en) 1999-11-22 2000-11-22 Process for the preparation of 6-methyl-2-(4-methyl-phenyl)-imidazo[1,2-a]pyrimidine-3-(n,n-dimethyl-acetamide) and intermediates
RU2002116672/04A RU2254334C2 (en) 1999-11-22 2000-11-22 Method for preparing 6-methyl-2-(4-methylphenyl)-imidazolo[1,2-a]pyridine-3-(n,n-dimethylacetam ide), esters, crystalline esters, method for their preparing
AT00981505T ATE304540T1 (en) 1999-11-22 2000-11-22 METHOD FOR PRODUCING 6-METHYL-2-(4-METHYLPHENYL)IMIDAZO(1,2-A)PYRIDINE-3-(N,N-DIMETHYLACETAMIDE) AND INTERMEDIATE PRODUCTS
DK00981505T DK1259509T3 (en) 1999-11-22 2000-11-22 Process for the preparation of 6-methyl-2- (4-methylphenyl) imidazole [1,2-a] pyridine-3- (N, N-dimethylacetamide) and intermediates
HR20020471A HRP20020471B1 (en) 1999-11-22 2002-05-28 Process for the preparation of 6-methyl-2-(4-methyl-phenyl)-imidazo[1,2-a]pyrimidine-3-(n,n-dimethyl-acetamide) and intermediates

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9904379A HU227358B1 (en) 1999-11-22 1999-11-22 Novel process for the preparation of 6-methyl-2-(4-methyl-phenyl)-imidazo[1,2-a]pyrimidyne-3-(n,n-dimethyl-acetamide)

Publications (3)

Publication Number Publication Date
HU9904379D0 HU9904379D0 (en) 2000-02-28
HUP9904379A2 true HUP9904379A2 (en) 2002-09-28
HU227358B1 HU227358B1 (en) 2011-04-28

Family

ID=90000033

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9904379A HU227358B1 (en) 1999-11-22 1999-11-22 Novel process for the preparation of 6-methyl-2-(4-methyl-phenyl)-imidazo[1,2-a]pyrimidyne-3-(n,n-dimethyl-acetamide)

Country Status (1)

Country Link
HU (1) HU227358B1 (en)

Also Published As

Publication number Publication date
HU227358B1 (en) 2011-04-28
HU9904379D0 (en) 2000-02-28

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Legal Events

Date Code Title Description
HC9A Change of name, address

Owner name: EGIS GYOGYSZERGYAR NYILVANOSAN MUEKOEDOE RESZV, HU

Free format text: FORMER OWNER(S): EGIS GYOGYSZERGYAR RT., HU

MM4A Lapse of definitive patent protection due to non-payment of fees