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HUP9904011A2 - Novel salts of dipeptid derivatives and use of them for producing pharmaceutical compositions - Google Patents

Novel salts of dipeptid derivatives and use of them for producing pharmaceutical compositions

Info

Publication number
HUP9904011A2
HUP9904011A2 HU9904011A HUP9904011A HUP9904011A2 HU P9904011 A2 HUP9904011 A2 HU P9904011A2 HU 9904011 A HU9904011 A HU 9904011A HU P9904011 A HUP9904011 A HU P9904011A HU P9904011 A2 HUP9904011 A2 HU P9904011A2
Authority
HU
Hungary
Prior art keywords
dipeptid
derivatives
pharmaceutical compositions
salts
producing pharmaceutical
Prior art date
Application number
HU9904011A
Other languages
Hungarian (hu)
Inventor
János Fischer
Béla Stefkó
Attila Bódis
Müller Györgyi Czirfuszné
Tamás Fodor
Sándor Lévai
Gábor Toma
Original Assignee
Richter Gedeon Vegyészeti Gyár Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyészeti Gyár Rt. filed Critical Richter Gedeon Vegyészeti Gyár Rt.
Priority to HU9904011A priority Critical patent/HU226950B1/en
Publication of HU9904011D0 publication Critical patent/HU9904011D0/en
Priority to AU12918/01A priority patent/AU1291801A/en
Priority to PCT/HU2000/000115 priority patent/WO2001032689A1/en
Publication of HUP9904011A2 publication Critical patent/HUP9904011A2/en
Publication of HUP9904011A3 publication Critical patent/HUP9904011A3/en
Publication of HU226950B1 publication Critical patent/HU226950B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

A találmány tárgya új (1S)-N-(1-etoxikarbonil-3-fenilpropil)-L-alanil-L-prolin (nemzetközi szabad nevén: enalapril) (I) általános képletűalkáli- és alkáli földfém-sók - ahol a képletben X jelentése kálium-,kálcium- vagy magnézium-atom - valamint ezen sók szolvátjai. Atalálmány a fenti új sók keringési betegségek gyógyítására szolgálógyógyszerkészítményekben való alkalmazására is vonatkozik. ÓThe subject of the invention is new (1S)-N-(1-ethoxycarbonyl-3-phenylpropyl)-L-alanyl-L-proline (international free name: enalapril) alkali and alkaline earth metal salts of general formula (I) - where X in the formula means a potassium, calcium or magnesium atom - as well as solvates of these salts. The invention also applies to the use of the above new salts in medicinal preparations for the treatment of circulatory diseases. HE

HU9904011A 1999-11-03 1999-11-03 The magnesium salt of enalapril and antihypertensive pharmaceutical composition containing it HU226950B1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
HU9904011A HU226950B1 (en) 1999-11-03 1999-11-03 The magnesium salt of enalapril and antihypertensive pharmaceutical composition containing it
AU12918/01A AU1291801A (en) 1999-11-03 2000-11-02 Salts of enalapril
PCT/HU2000/000115 WO2001032689A1 (en) 1999-11-03 2000-11-02 Salts of enalapril

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9904011A HU226950B1 (en) 1999-11-03 1999-11-03 The magnesium salt of enalapril and antihypertensive pharmaceutical composition containing it

Publications (4)

Publication Number Publication Date
HU9904011D0 HU9904011D0 (en) 2000-01-28
HUP9904011A2 true HUP9904011A2 (en) 2001-10-28
HUP9904011A3 HUP9904011A3 (en) 2003-01-28
HU226950B1 HU226950B1 (en) 2010-03-29

Family

ID=89999904

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9904011A HU226950B1 (en) 1999-11-03 1999-11-03 The magnesium salt of enalapril and antihypertensive pharmaceutical composition containing it

Country Status (3)

Country Link
AU (1) AU1291801A (en)
HU (1) HU226950B1 (en)
WO (1) WO2001032689A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0624082D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril metal salts
ES2364011B1 (en) 2009-11-20 2013-01-24 Gp Pharm, S.A. CAPSULES OF PHARMACEUTICAL ACTIVE AND ESTERS OF POLYINSATURATED FATTY ACIDS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI9111842A (en) * 1991-11-25 1998-04-30 Krka Stable formulation of enalapryl salt, process for its preparation and its use
ES2125198B1 (en) * 1997-05-13 1999-11-16 Vita Invest Sa FIXED-DOSE ASSOCIATION OF AN ANGIOTENSIN CONVERTING ENZYME INHIBITOR AND AN ANTAGONIST OF THE CALCIUM CHANNELS, PROCEDURE FOR ITS PREPARATION AND USE FOR THE TREATMENT OF CARDIOVASCULAR DISEASES.

Also Published As

Publication number Publication date
AU1291801A (en) 2001-05-14
HUP9904011A3 (en) 2003-01-28
HU9904011D0 (en) 2000-01-28
WO2001032689A1 (en) 2001-05-10
HU226950B1 (en) 2010-03-29

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Legal Events

Date Code Title Description
HC9A Change of name, address

Owner name: RICHTER GEDEON NYRT., HU

Free format text: FORMER OWNER(S): RICHTER GEDEON VEGYESZETI GYAR RT., HU