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HUP9802736A2 - 1,4-Dihidropiridin-származékok alkalmazása artériafal ateroszklerózisos degradálódásának megelőzésére és gyógyítására alkalmas gyógyszerkészítmény előállítására - Google Patents

1,4-Dihidropiridin-származékok alkalmazása artériafal ateroszklerózisos degradálódásának megelőzésére és gyógyítására alkalmas gyógyszerkészítmény előállítására

Info

Publication number
HUP9802736A2
HUP9802736A2 HU9802736A HUP9802736A HUP9802736A2 HU P9802736 A2 HUP9802736 A2 HU P9802736A2 HU 9802736 A HU9802736 A HU 9802736A HU P9802736 A HUP9802736 A HU P9802736A HU P9802736 A2 HUP9802736 A2 HU P9802736A2
Authority
HU
Hungary
Prior art keywords
powder
phenyl
carbon
chain
arterial walls
Prior art date
Application number
HU9802736A
Other languages
English (en)
Inventor
Amedeo Leonardi
Abraham Sartani
Rodolfo Testa
Original Assignee
Recordati S.A. Chemical And Pharmaceutical Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Recordati S.A. Chemical And Pharmaceutical Company filed Critical Recordati S.A. Chemical And Pharmaceutical Company
Publication of HUP9802736A2 publication Critical patent/HUP9802736A2/hu
Publication of HUP9802736A3 publication Critical patent/HUP9802736A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A találmány tárgya az (I) általánős képletű vegyületek - a képletben Ph jelentése fenilcsőpőrt, Ar jelentése 2-nitrő-fenil-, 3-nitrő-fenil-, 2,3-diklór-fenil- vagybenzőfűrán-4-il-csőpőrt, A jelentése 3-6 szénatőmős elágazó láncú alkiléncsőpőrt, R jelentése adőtt esetben 1-6 szénatőmős alkőxicsőpőrttalmőnőszűbsztitűált 1-6 szénatőmős egyenes vagy elágazó szénláncúalkilcsőpőrt, R1,2 jelentése hidrőgénatőm, hidrőxilcsőpőrt, vagy 1-4 szénatőmősalkilcsőpőrt, és R1,2 jelentése hidrőgénatőm vagy metilcsőpőrt - vagy sója, enantiőmerje, hidrátja vagy szőlvátja alkalmazása betegekartériafalának aterőszklerózisős degradációjának megelőzésére,megállítására, vagy visszafőrdítására alkalmas gyógyszerkészítményelőállítására. ŕ
HU9802736A 1995-07-14 1996-06-28 Use of 1,4-dihydropyridine derivatives for the preparation of medicament for the prevention and therapy of atherosclerotic degradation in the arterial walls HUP9802736A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI951513A IT1275532B (it) 1995-07-14 1995-07-14 Uso di derivati 1,4-diidropiridinici per la prevenzione e la terapia della degenerazione aterosclerotica della parete arteriosa

Publications (2)

Publication Number Publication Date
HUP9802736A2 true HUP9802736A2 (hu) 1999-03-29
HUP9802736A3 HUP9802736A3 (en) 2000-03-28

Family

ID=11371972

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9802736A HUP9802736A3 (en) 1995-07-14 1996-06-28 Use of 1,4-dihydropyridine derivatives for the preparation of medicament for the prevention and therapy of atherosclerotic degradation in the arterial walls

Country Status (19)

Country Link
EP (1) EP0839036B1 (hu)
JP (1) JPH11509214A (hu)
KR (1) KR19990028741A (hu)
CN (1) CN1190345A (hu)
AT (1) ATE183644T1 (hu)
AU (1) AU690471B2 (hu)
CA (1) CA2219501A1 (hu)
CZ (1) CZ11698A3 (hu)
DE (1) DE69603968T2 (hu)
DK (1) DK0839036T3 (hu)
ES (1) ES2138359T3 (hu)
GR (1) GR3031096T3 (hu)
HU (1) HUP9802736A3 (hu)
IL (1) IL122302A (hu)
IT (1) IT1275532B (hu)
NO (1) NO980171L (hu)
SK (1) SK4198A3 (hu)
WO (1) WO1997003669A1 (hu)
ZA (1) ZA965924B (hu)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6852737B2 (en) 2001-08-06 2005-02-08 Recordati Ireland Limited Crude and crystalline forms of lercanidipine hydrochloride
ITMI20011726A1 (it) * 2001-08-06 2003-02-06 Recordati Ind Chimica E Farma Forme polimorfe della lercanidipina cloridrato
TW200613275A (en) * 2004-08-24 2006-05-01 Recordati Ireland Ltd Lercanidipine salts
AR053023A1 (es) * 2005-02-25 2007-04-18 Recordati Ireland Ltd Base libre de lercanidipina, metodos para su preparacion y composiciones farmaceuticas que las contienen
WO2011161223A2 (en) 2010-06-23 2011-12-29 Krka, Tovarna Zdravil, D.D., Novo Mesto Pharmaceutical oral dosage forms comprising lercanidipine and enalapril and their pharmaceutically acceptable salts
US8658676B2 (en) 2010-10-12 2014-02-25 The Medicines Company Clevidipine emulsion formulations containing antimicrobial agents
DK2627173T4 (en) 2010-10-12 2018-10-22 Chiesi Farm Spa CLEVIDIPINE EMULSUM FORMULATIONS CONTAINING ANTIMICROBIANTS
EP2654729B1 (en) 2010-12-24 2016-05-04 KRKA, d.d., Novo mesto Homogenous pharmaceutical oral dosage forms comprising lercanidipine and enalapril or their pharmaceutically acceptable salts together with an organic acid

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8403866D0 (en) * 1984-02-14 1984-03-21 Recordati Chem Pharm Diphenylalkylaminoalkyl esters

Also Published As

Publication number Publication date
CZ11698A3 (cs) 1998-06-17
IL122302A0 (en) 1998-04-05
EP0839036B1 (en) 1999-08-25
NO980171D0 (no) 1998-01-14
KR19990028741A (ko) 1999-04-15
IT1275532B (it) 1997-08-07
DK0839036T3 (da) 2000-01-24
GR3031096T3 (en) 1999-12-31
IL122302A (en) 2000-08-13
CN1190345A (zh) 1998-08-12
DE69603968D1 (de) 1999-09-30
ZA965924B (en) 1997-01-30
HUP9802736A3 (en) 2000-03-28
ES2138359T3 (es) 2000-01-01
NO980171L (no) 1998-01-14
SK4198A3 (en) 1998-05-06
WO1997003669A1 (en) 1997-02-06
EP0839036A1 (en) 1998-05-06
ITMI951513A0 (it) 1995-07-14
DE69603968T2 (de) 2000-04-06
CA2219501A1 (en) 1997-02-06
AU6516496A (en) 1997-02-18
JPH11509214A (ja) 1999-08-17
ATE183644T1 (de) 1999-09-15
ITMI951513A1 (it) 1997-01-14
AU690471B2 (en) 1998-04-23

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