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HUP9801256A2 - 5'-Deoxi-citidin-származékok, ezek előállítása és alkalmazása, valamint ezeket tartalmazó gyógyászati készítmények - Google Patents

5'-Deoxi-citidin-származékok, ezek előállítása és alkalmazása, valamint ezeket tartalmazó gyógyászati készítmények

Info

Publication number
HUP9801256A2
HUP9801256A2 HU9801256A HUP9801256A HUP9801256A2 HU P9801256 A2 HUP9801256 A2 HU P9801256A2 HU 9801256 A HU9801256 A HU 9801256A HU P9801256 A HUP9801256 A HU P9801256A HU P9801256 A2 HUP9801256 A2 HU P9801256A2
Authority
HU
Hungary
Prior art keywords
deoxy
preparation
pharmaceutical compositions
cytidine derivatives
cytidine
Prior art date
Application number
HU9801256A
Other languages
English (en)
Inventor
Kazuo Hattori
Tohru Ishikawa
Hideo Ishitsuka
Yasunori Kohchi
Nobuhiro Oikawa
Nobuo Shimma
Hitomi Suda
Original Assignee
F. Hoffmann-La Roche Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche Ag. filed Critical F. Hoffmann-La Roche Ag.
Publication of HU9801256D0 publication Critical patent/HU9801256D0/hu
Publication of HUP9801256A2 publication Critical patent/HUP9801256A2/hu
Publication of HUP9801256A3 publication Critical patent/HUP9801256A3/hu
Publication of HU227852B1 publication Critical patent/HU227852B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HU9801256A 1997-06-02 1998-05-29 5'-deoxy-cytidine derivatives, preparation and use thereof and pharmaceutical compositions HU227852B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97108791 1997-06-02

Publications (4)

Publication Number Publication Date
HU9801256D0 HU9801256D0 (en) 1998-07-28
HUP9801256A2 true HUP9801256A2 (hu) 1999-05-28
HUP9801256A3 HUP9801256A3 (en) 2004-03-01
HU227852B1 HU227852B1 (en) 2012-05-02

Family

ID=8226859

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9801256A HU227852B1 (en) 1997-06-02 1998-05-29 5'-deoxy-cytidine derivatives, preparation and use thereof and pharmaceutical compositions

Country Status (33)

Country Link
US (2) US6114520A (hu)
JP (1) JP3081185B2 (hu)
KR (1) KR100312899B1 (hu)
CN (1) CN1197871C (hu)
AR (1) AR012878A1 (hu)
AT (1) ATE440854T1 (hu)
AU (1) AU746170B2 (hu)
BR (1) BR9801744A (hu)
CA (1) CA2237368C (hu)
CO (1) CO4940436A1 (hu)
CZ (1) CZ295706B6 (hu)
DE (2) DE69841086D1 (hu)
ES (2) ES2329428T3 (hu)
FR (1) FR2763953B1 (hu)
GB (1) GB2325931B (hu)
HR (1) HRP980290A2 (hu)
HU (1) HU227852B1 (hu)
ID (1) ID19801A (hu)
IL (1) IL124661A0 (hu)
IT (1) ITMI981196A1 (hu)
MA (1) MA26503A1 (hu)
MY (1) MY128985A (hu)
NO (1) NO316609B1 (hu)
NZ (1) NZ330360A (hu)
PE (1) PE79599A1 (hu)
PL (1) PL192832B1 (hu)
RS (1) RS50010B (hu)
RU (1) RU2238278C2 (hu)
SA (1) SA98190103B1 (hu)
SG (1) SG66466A1 (hu)
TR (1) TR199800988A3 (hu)
TW (1) TW584636B (hu)
ZA (1) ZA984478B (hu)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030119724A1 (en) * 1995-11-22 2003-06-26 Ts`O Paul O.P. Ligands to enhance cellular uptake of biomolecules
EP1057831B1 (en) * 1999-05-26 2004-09-22 F. Hoffmann-La Roche Ag Process for the preparation of vinyl pyrimidine derivatives
JP2004536027A (ja) 2000-12-01 2004-12-02 ジョーンズ・ホプキンス・ユニーバーシティー グリコシル化／ガラクトシル化ペプチドの接合体、二官能性リンカー、およびヌクレオチドのモノマー／ポリマー、および関連する組成物および使用方法
EP1827443A1 (en) * 2004-12-03 2007-09-05 Adherex Technologies, Inc. Methods for administering dpd inhibitors in combination with 5-fu and 5-fu prodrugs
US20060189893A1 (en) * 2005-01-06 2006-08-24 Diamics, Inc. Systems and methods for detecting abnormal cells
US20060161076A1 (en) * 2005-01-06 2006-07-20 Diamics, Inc. Systems and methods for collection of cell clusters
WO2009042064A2 (en) 2007-09-21 2009-04-02 Nektar Therapeutics Al, Corporation Oligomer-nucleoside phosphate conjugates
WO2009082844A1 (fr) * 2007-12-28 2009-07-09 Topharman Shanghai Co., Ltd Dérivé hydroxyle de la capécitabine, ses procédés de préparation et ses utilisations pour préparer la capécitabine
CN101469008B (zh) * 2007-12-29 2013-08-07 上海特化医药科技有限公司 卡培他滨羟基衍生物、其制备方法和用于制备卡培他滨
WO2009094847A1 (fr) * 2007-12-28 2009-08-06 Topharman Shanghai Co., Ltd. Dérivé hydroxyle de capécitabine, procédés de préparation et d' utilisation de la capécitabine
WO2009082846A1 (fr) * 2007-12-28 2009-07-09 Topharman Shanghai Co., Ltd. Dérivé hydroxyle de la capécitabine, ses procédés de préparation et ses utilisations pour préparer la capécitabine
WO2009114814A2 (en) 2008-03-14 2009-09-17 Retrotope, Inc. Therapeutic substances that modulate genome methylation
EP2393472B1 (en) * 2008-12-05 2019-06-05 NanoMed Holdings Pty Ltd Amphiphile prodrugs
GB0907551D0 (en) 2009-05-01 2009-06-10 Univ Dundee Treatment or prophylaxis of proliferative conditions
CA2777546C (en) * 2009-10-14 2019-11-05 Adherex Technologies, Inc. Treating neurotoxicity associated with combinations of 5-fu or its prodrugs and dpd inhibitors
CN104926890B (zh) * 2015-06-04 2018-04-03 新乡学院 一种1,2‑o‑二乙酰基‑3,5‑o‑二苯甲酰基核糖的合成方法
JP2021512953A (ja) 2018-02-02 2021-05-20 メイベリックス オンコロジー インコーポレイテッド ゲムシタビンモノホスフェートの小分子薬物コンジュゲート
CN113321694A (zh) * 2021-06-22 2021-08-31 药康众拓(江苏)医药科技有限公司 N4-羟基胞苷衍生物及其制备方法和用途

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5726278B2 (hu) * 1973-03-13 1982-06-03
GB1561290A (en) * 1975-10-16 1980-02-20 Nyegaard & Co As Pyrimid - 2 - ones
US4071680A (en) * 1976-12-20 1978-01-31 Hoffmann-La Roche Inc. 5'-Deoxy-5-fluoropyrimidine nucleosides
CH633810A5 (en) * 1978-01-01 1982-12-31 Hoffmann La Roche Novel nucleosides and process for their preparation
US4328229A (en) * 1978-03-29 1982-05-04 Taiho Pharmaceutical Company Limited Anti-cancer composition for delivering 5-fluorouracil to cancer tissues
JPS5677226A (en) * 1979-11-27 1981-06-25 Taiho Yakuhin Kogyo Kk Antitumorigenic agent
WO1985001871A1 (en) * 1983-10-26 1985-05-09 Greer Sheldon B Method and materials for sensitizing neoplastic tissue to radiation
US5736531A (en) * 1987-10-28 1998-04-07 Pro-Neuron, Inc. Compositions of chemotherapeutic agent or antiviral agent with acylated pyrimidine nucleosides
CA1327358C (en) * 1987-11-17 1994-03-01 Morio Fujiu Fluoro cytidine derivatives
GB9020930D0 (en) * 1990-09-26 1990-11-07 Wellcome Found Pharmaceutical combinations
JP2614164B2 (ja) * 1991-05-27 1997-05-28 大鵬薬品工業株式会社 抗腫瘍効果増強のための及び腫瘍治療のための組成物
DE4123520A1 (de) * 1991-07-16 1993-01-21 Inst Molekularbiologie Ak Mittel zur regeneration des blutbildes durch foerderung der leukozytenproliferation
TW254946B (hu) * 1992-12-18 1995-08-21 Hoffmann La Roche
AU671491B2 (en) * 1992-12-18 1996-08-29 F. Hoffmann-La Roche Ag N-oxycarbonyl substituted 5'-deoxy-5-fluorcytidines
WO1994026761A1 (en) * 1993-05-14 1994-11-24 Pro-Neuron, Inc. Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
CN1042429C (zh) * 1993-09-14 1999-03-10 默里尔药物公司 用作抗肿瘤药的嘧啶二酮衍生物、药物组合物及制备方法
US5476932A (en) * 1994-08-26 1995-12-19 Hoffmann-La Roche Inc. Process for producing N4-acyl-5'-deoxy-5-fluorocytidine derivatives
TR199701435T1 (xx) * 1995-05-26 1998-03-21 F. Hoffmann-La Roche Ag İnterleukin ve pirimidin nükleositlerinin kompozisyonları

Also Published As

Publication number Publication date
US6211166B1 (en) 2001-04-03
HUP9801256A3 (en) 2004-03-01
JP3081185B2 (ja) 2000-08-28
US6114520A (en) 2000-09-05
TW584636B (en) 2004-04-21
ZA984478B (en) 1998-12-02
AR012878A1 (es) 2000-11-22
CN1197871C (zh) 2005-04-20
KR100312899B1 (ko) 2002-03-08
ATE440854T1 (de) 2009-09-15
TR199800988A2 (xx) 1998-12-21
CZ167598A3 (cs) 1998-12-16
ES2142763B1 (es) 2001-04-01
KR19990006547A (ko) 1999-01-25
CA2237368C (en) 2009-03-03
JPH10330395A (ja) 1998-12-15
MY128985A (en) 2007-03-30
RS50010B (sr) 2008-09-29
NO982473D0 (no) 1998-05-29
SG66466A1 (en) 1999-07-20
HU9801256D0 (en) 1998-07-28
NZ330360A (en) 1999-03-29
AU6798598A (en) 1998-12-03
YU22598A (sh) 2001-12-26
DE19823484A1 (de) 1998-12-03
HU227852B1 (en) 2012-05-02
PE79599A1 (es) 1999-08-25
ID19801A (id) 1998-08-06
PL192832B1 (pl) 2006-12-29
CZ295706B6 (cs) 2005-10-12
TR199800988A3 (tr) 1998-12-21
GB2325931B (en) 2001-07-25
FR2763953B1 (fr) 2005-01-07
FR2763953A1 (fr) 1998-12-04
ITMI981196A1 (it) 1999-11-29
RU2238278C2 (ru) 2004-10-20
NO982473L (no) 1998-12-03
SA98190103B1 (ar) 2006-04-18
CA2237368A1 (en) 1998-12-02
ES2329428T3 (es) 2009-11-25
ES2142763A1 (es) 2000-04-16
HRP980290A2 (en) 1999-04-30
MA26503A1 (fr) 2004-12-20
IL124661A0 (en) 1998-12-06
DE69841086D1 (de) 2009-10-08
GB9811762D0 (en) 1998-07-29
GB2325931A (en) 1998-12-09
CO4940436A1 (es) 2000-07-24
PL326604A1 (en) 1998-12-07
NO316609B1 (no) 2004-03-08
BR9801744A (pt) 2000-03-21
CN1201037A (zh) 1998-12-09
AU746170B2 (en) 2002-04-18

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Legal Events

Date Code Title Description
FH91 Appointment of a representative

Free format text: FORMER REPRESENTATIVE(S): DR. TOTH-URBAN LASZLO ES DR. JALSOVSZKY GYOERGYNE, HU

Representative=s name: DR. JALSOVSZKY GYOERGYNE ES DR. MISKOLCZI MARI, HU

FH92 Termination of representative

Representative=s name: DR. TOTH-URBAN LASZLO ES DR. JALSOVSZKY GYOERG, HU