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HUP9801085A2 - Piperazinyl-alkyl-benzofurane derivatives, pharmaceutical compositions containing them as active ingredient and process for producing the active ingredient - Google Patents

Piperazinyl-alkyl-benzofurane derivatives, pharmaceutical compositions containing them as active ingredient and process for producing the active ingredient

Info

Publication number
HUP9801085A2
HUP9801085A2 HU9801085A HUP9801085A HUP9801085A2 HU P9801085 A2 HUP9801085 A2 HU P9801085A2 HU 9801085 A HU9801085 A HU 9801085A HU P9801085 A HUP9801085 A HU P9801085A HU P9801085 A2 HUP9801085 A2 HU P9801085A2
Authority
HU
Hungary
Prior art keywords
alkyl
optionally substituted
active ingredient
alkoxy
phenyl
Prior art date
Application number
HU9801085A
Other languages
Hungarian (hu)
Inventor
Béla Ágai
József Reiter
Gyula Simig
István Gacsályi
Endre Rivó
Gábor Szénási
Éva Schmidt
dr. Megyeri Katalin Ivanicsné
István Gyertyán
dr. Kovács Anikó Miklósné
Tamás Szabados
Katalin Pallagi
András Egyed
Szabolcs Kertész
György Lévay
Gyönös Ildikó Nagyné
Zoltán Tamás Nagy
Levente Ondi
Original Assignee
EGIS Gyógyszergyár Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EGIS Gyógyszergyár Rt. filed Critical EGIS Gyógyszergyár Rt.
Priority to HU9801085A priority Critical patent/HUP9801085A3/en
Publication of HU9801085D0 publication Critical patent/HU9801085D0/en
Priority to CA002332275A priority patent/CA2332275A1/en
Priority to AU40529/99A priority patent/AU753706B2/en
Priority to EP99923772A priority patent/EP1077973A2/en
Priority to PCT/HU1999/000038 priority patent/WO1999058527A2/en
Priority to SK1721-2000A priority patent/SK17212000A3/en
Priority to KR1020007012773A priority patent/KR20010043618A/en
Priority to JP2000548331A priority patent/JP2002514643A/en
Priority to PL99345309A priority patent/PL345309A1/en
Publication of HUP9801085A2 publication Critical patent/HUP9801085A2/en
Publication of HUP9801085A3 publication Critical patent/HUP9801085A3/en
Priority to HR20000750A priority patent/HRP20000750A2/en
Priority to US10/736,714 priority patent/US20040186170A1/en

Links

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

New benzofuran derivatives (I). Benzofuran derivatives of formula (I) are new. R1, R2 = H or 1-4C alkyl; X = O or S; Y = H or OH; Z' = H, halo, 1-4C alkyl, 1-4C alkoxy, NH2, NO2, CN, CF3, COOR3, NHCOR3 or SO2NR3R4; R3 = H or 1-4C alkyl; R4 = 1-4C alkyl; A = CH, COH, CCN, CCOOR3, COR4; or N-(CH2)n-Ar'; B = methylene group; or A + B = C=C; Ar = H; 1-4C alkyl, phenyl (1-4C alkyl), biphenylyl or naphthyl (optionally substituted by 1-4C alkoxy or 2-4C alkenyl); partially saturated 5- to 6-membered heterocyclic group (optionally substituted by 1-3 1-4C alkyl) condensed with a phenyl group and containing O atom(s); 5-6 membered heterocyclic group containing N and/or O and/or S; or phenyl substituted by R5-R7; R5-R7 = H, halo, CF3, 1-4C alkyl, methylenedioxy, phenoxy (optionally substituted by 1-4C alkoxy or halo); 2-4C alkenyl, 2-4C alkenyloxy, 1-4C alkoxy (optionally substituted by di(1-4C alkyl)amino) or 5 or 6 membered, saturated heterocyclic group containing one or two N or 1 N and 1 O, where the heterocyclic group is optionally substituted by 1-4C alkyl); Ar' = diphenylmethyl, pyrimidinyl, naphthyl (optionally substituted by 1-4C alkoxy or 2-4C alkenyloxy), partially saturated 5-6 membered heterocyclic (optionally substituted by 1-4C alkyl) condensed with a phenyl group and containing O atom(s); or phenyl substituted by R5-R7; n = 0 or 1; or NR3R4 = 5-10 membered heterocyclic group containing N, O and/or S heteroatoms. Independent claims are included for: (1) preparation of (I); (2) intermediates of formula (II) and (V). Hal = halo.
HU9801085A 1998-05-14 1998-05-14 Piperazinyl-alkyl-benzofurane derivatives, pharmaceutical compositions containing them as active ingredient and process for producing the active ingredient HUP9801085A3 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
HU9801085A HUP9801085A3 (en) 1998-05-14 1998-05-14 Piperazinyl-alkyl-benzofurane derivatives, pharmaceutical compositions containing them as active ingredient and process for producing the active ingredient
PL99345309A PL345309A1 (en) 1998-05-14 1999-05-13 Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient
PCT/HU1999/000038 WO1999058527A2 (en) 1998-05-14 1999-05-13 Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient
AU40529/99A AU753706B2 (en) 1998-05-14 1999-05-13 Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient
EP99923772A EP1077973A2 (en) 1998-05-14 1999-05-13 Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient
CA002332275A CA2332275A1 (en) 1998-05-14 1999-05-13 Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient
SK1721-2000A SK17212000A3 (en) 1998-05-14 1999-05-13 Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient
KR1020007012773A KR20010043618A (en) 1998-05-14 1999-05-13 Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient
JP2000548331A JP2002514643A (en) 1998-05-14 1999-05-13 A benzofuran derivative, a pharmaceutical composition containing the same and a method for producing the active ingredient thereof.
HR20000750A HRP20000750A2 (en) 1998-05-14 2000-11-03 Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient
US10/736,714 US20040186170A1 (en) 1998-05-14 2003-12-15 Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9801085A HUP9801085A3 (en) 1998-05-14 1998-05-14 Piperazinyl-alkyl-benzofurane derivatives, pharmaceutical compositions containing them as active ingredient and process for producing the active ingredient

Publications (3)

Publication Number Publication Date
HU9801085D0 HU9801085D0 (en) 1998-07-28
HUP9801085A2 true HUP9801085A2 (en) 2000-08-28
HUP9801085A3 HUP9801085A3 (en) 2000-09-28

Family

ID=89996540

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9801085A HUP9801085A3 (en) 1998-05-14 1998-05-14 Piperazinyl-alkyl-benzofurane derivatives, pharmaceutical compositions containing them as active ingredient and process for producing the active ingredient

Country Status (1)

Country Link
HU (1) HUP9801085A3 (en)

Also Published As

Publication number Publication date
HUP9801085A3 (en) 2000-09-28
HU9801085D0 (en) 1998-07-28

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees