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HUP2100108A1 - Process for consecutive continuous-flow reductions in the synthesis of medicinally relevant piperazine derivatives using a new device - Google Patents

Process for consecutive continuous-flow reductions in the synthesis of medicinally relevant piperazine derivatives using a new device

Info

Publication number
HUP2100108A1
HUP2100108A1 HU2100108A HUP2100108A HUP2100108A1 HU P2100108 A1 HUP2100108 A1 HU P2100108A1 HU 2100108 A HU2100108 A HU 2100108A HU P2100108 A HUP2100108 A HU P2100108A HU P2100108 A1 HUP2100108 A1 HU P2100108A1
Authority
HU
Hungary
Prior art keywords
synthesis
new device
piperazine derivatives
flow reductions
consecutive continuous
Prior art date
Application number
HU2100108A
Other languages
Hungarian (hu)
Inventor
Peter Bana
Zsolt Fueloep
Janos Dr Eles
Original Assignee
Richter Gedeon Nyrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Nyrt filed Critical Richter Gedeon Nyrt
Priority to HU2100108A priority Critical patent/HUP2100108A1/en
Priority to PCT/IB2022/052191 priority patent/WO2022190047A1/en
Publication of HUP2100108A1 publication Critical patent/HUP2100108A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J10/00—Chemical processes in general for reacting liquid with gaseous media other than in the presence of solid particles, or apparatus specially adapted therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/24—Stationary reactors without moving elements inside
    • B01J19/2415—Tubular reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00164—Controlling or regulating processes controlling the flow

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HU2100108A 2021-03-12 2021-03-12 Process for consecutive continuous-flow reductions in the synthesis of medicinally relevant piperazine derivatives using a new device HUP2100108A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
HU2100108A HUP2100108A1 (en) 2021-03-12 2021-03-12 Process for consecutive continuous-flow reductions in the synthesis of medicinally relevant piperazine derivatives using a new device
PCT/IB2022/052191 WO2022190047A1 (en) 2021-03-12 2022-03-11 Process for consecutive continuous-flow reductions in the synthesis of medicinally relevant piperazine derivatives using a tubular reactor with alternating diameter

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU2100108A HUP2100108A1 (en) 2021-03-12 2021-03-12 Process for consecutive continuous-flow reductions in the synthesis of medicinally relevant piperazine derivatives using a new device

Publications (1)

Publication Number Publication Date
HUP2100108A1 true HUP2100108A1 (en) 2022-09-28

Family

ID=89993316

Family Applications (1)

Application Number Title Priority Date Filing Date
HU2100108A HUP2100108A1 (en) 2021-03-12 2021-03-12 Process for consecutive continuous-flow reductions in the synthesis of medicinally relevant piperazine derivatives using a new device

Country Status (2)

Country Link
HU (1) HUP2100108A1 (en)
WO (1) WO2022190047A1 (en)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU227534B1 (en) 2003-08-04 2011-08-29 Richter Gedeon Nyrt (thio)carbamoyl-cyclohexane derivatives, process for producing them and pharmaceutical compositions containing them
HU230067B1 (en) 2008-12-17 2015-06-29 Richter Gedeon Nyrt Novel piperazine salt and preparation method thereof
ITMI20131693A1 (en) 2013-10-14 2015-04-15 Chemo Res S L DERIVATIVES OF 1,4-CYCLOHEXYLAMINE AND THEIR PREPARATION
HU231173B1 (en) 2016-07-08 2021-06-28 Richter Gedeon Nyrt. Industrial procedure for production of cariprazine

Also Published As

Publication number Publication date
WO2022190047A1 (en) 2022-09-15

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