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HUP2100077A1 - Process for the preparation of avapritinib and intermediates for the process - Google Patents

Process for the preparation of avapritinib and intermediates for the process

Info

Publication number
HUP2100077A1
HUP2100077A1 HU2100077A HUP2100077A HUP2100077A1 HU P2100077 A1 HUP2100077 A1 HU P2100077A1 HU 2100077 A HU2100077 A HU 2100077A HU P2100077 A HUP2100077 A HU P2100077A HU P2100077 A1 HUP2100077 A1 HU P2100077A1
Authority
HU
Hungary
Prior art keywords
avapritinib
intermediates
preparation
Prior art date
Application number
HU2100077A
Other languages
Hungarian (hu)
Inventor
Porcs-Makkay Marta Dr
Bertha Ferenc Dr
Enikoe Molnar
Nemeth Gabor Dr
Simon Horvath
Ildiko Szebeledi
Beatrix Bali
Monika Teller
Fadgyas Katalin Kataine
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Priority to HUP2100077A priority Critical patent/HU231413B1/en
Priority to EP22759019.7A priority patent/EP4298100A4/en
Priority to GEAP202216357A priority patent/GEP20247686B/en
Priority to PCT/HU2022/050019 priority patent/WO2022180416A1/en
Publication of HUP2100077A1 publication Critical patent/HUP2100077A1/en
Publication of HU231413B1 publication Critical patent/HU231413B1/en

Links

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F24—HEATING; RANGES; VENTILATING
    • F24F—AIR-CONDITIONING; AIR-HUMIDIFICATION; VENTILATION; USE OF AIR CURRENTS FOR SCREENING
    • F24F5/00—Air-conditioning systems or apparatus not covered by F24F1/00 or F24F3/00, e.g. using solar heat or combined with household units such as an oven or water heater
    • F24F5/0007—Air-conditioning systems or apparatus not covered by F24F1/00 or F24F3/00, e.g. using solar heat or combined with household units such as an oven or water heater cooling apparatus specially adapted for use in air-conditioning
    • F24F5/0017—Air-conditioning systems or apparatus not covered by F24F1/00 or F24F3/00, e.g. using solar heat or combined with household units such as an oven or water heater cooling apparatus specially adapted for use in air-conditioning using cold storage bodies, e.g. ice
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F24—HEATING; RANGES; VENTILATING
    • F24F—AIR-CONDITIONING; AIR-HUMIDIFICATION; VENTILATION; USE OF AIR CURRENTS FOR SCREENING
    • F24F5/00—Air-conditioning systems or apparatus not covered by F24F1/00 or F24F3/00, e.g. using solar heat or combined with household units such as an oven or water heater
    • F24F5/0007—Air-conditioning systems or apparatus not covered by F24F1/00 or F24F3/00, e.g. using solar heat or combined with household units such as an oven or water heater cooling apparatus specially adapted for use in air-conditioning
    • F24F5/0017—Air-conditioning systems or apparatus not covered by F24F1/00 or F24F3/00, e.g. using solar heat or combined with household units such as an oven or water heater cooling apparatus specially adapted for use in air-conditioning using cold storage bodies, e.g. ice
    • F24F2005/0025—Air-conditioning systems or apparatus not covered by F24F1/00 or F24F3/00, e.g. using solar heat or combined with household units such as an oven or water heater cooling apparatus specially adapted for use in air-conditioning using cold storage bodies, e.g. ice using heat exchange fluid storage tanks
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F24—HEATING; RANGES; VENTILATING
    • F24F—AIR-CONDITIONING; AIR-HUMIDIFICATION; VENTILATION; USE OF AIR CURRENTS FOR SCREENING
    • F24F2221/00—Details or features not otherwise provided for
    • F24F2221/54—Heating and cooling, simultaneously or alternatively

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Sustainable Development (AREA)
  • Combustion & Propulsion (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
HUP2100077A 2021-02-26 2021-02-26 Process for the preparation of avapritinib and intermediates for the process HU231413B1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
HUP2100077A HU231413B1 (en) 2021-02-26 2021-02-26 Process for the preparation of avapritinib and intermediates for the process
EP22759019.7A EP4298100A4 (en) 2021-02-26 2022-02-28 PROCESS FOR THE MANUFACTURE OF AVAPIRIIB AND ITS INTERMEDIATES
GEAP202216357A GEP20247686B (en) 2021-02-26 2022-02-28 Process for obtaining avapritinib and its intermediates
PCT/HU2022/050019 WO2022180416A1 (en) 2021-02-26 2022-02-28 Process for obtaining avapritinib and its intermediates

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HUP2100077A HU231413B1 (en) 2021-02-26 2021-02-26 Process for the preparation of avapritinib and intermediates for the process

Publications (2)

Publication Number Publication Date
HUP2100077A1 true HUP2100077A1 (en) 2022-08-28
HU231413B1 HU231413B1 (en) 2023-08-28

Family

ID=89993301

Family Applications (1)

Application Number Title Priority Date Filing Date
HUP2100077A HU231413B1 (en) 2021-02-26 2021-02-26 Process for the preparation of avapritinib and intermediates for the process

Country Status (4)

Country Link
EP (1) EP4298100A4 (en)
GE (1) GEP20247686B (en)
HU (1) HU231413B1 (en)
WO (1) WO2022180416A1 (en)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112016008541B1 (en) * 2013-10-17 2022-11-22 Blueprint Medicines Corporation PHARMACEUTICALLY ACCEPTABLE COMPOUND OR SALT, THE USE THEREOF FOR TREATMENT OF MAST CYSTOSIS, GASTROINTESTINAL STROMAL TUMOR AND LEUKEMIA, AND PHARMACEUTICAL COMPOSITION
CA3136707A1 (en) * 2019-04-12 2020-10-15 Blueprint Medicines Corporation Crystalline forms of (s)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1h-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazinyl)-pyrimidin-5-yl)ethan-1-amine and methods of making
CN110950872A (en) * 2019-12-25 2020-04-03 武汉九州钰民医药科技有限公司 Method for preparing targeted anticancer drug avapritinib
CN110938077B (en) * 2019-12-25 2021-04-27 武汉九州钰民医药科技有限公司 Method for synthesizing Avapritinib

Also Published As

Publication number Publication date
GEP20247686B (en) 2024-10-28
HU231413B1 (en) 2023-08-28
EP4298100A4 (en) 2025-01-22
WO2022180416A1 (en) 2022-09-01
EP4298100A1 (en) 2024-01-03

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