HUP0301900A2 - Process for producing of ointment protecting against allergenes and the product - Google Patents

Abstract

The proposed ointment may be used to prevent the development of allergies as well as alleviating or eliminating allergy symptoms already developed. As it does not affect the immune system, it may be used in conjunction with conventional medication. It is especially suitable for vulnerable persons: young children, pregnant and breast-feeding mothers, etc.

Description

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The method of the invention provides an ointment suitable for protecting the skin and mucous membrane surfaces, which form the outer covering of the body, against allergens that come into contact with them. The method provides a method by which, by using a combination of lipoid-soluble and water-soluble components, allergenic antigens can be kept away from the skin and mucous membrane surfaces, while at the same time being suitable for binding corpuscular antigens (preventing them from entering the lungs) and at the same time inhibiting the germination of pollen and fungal spores, the outflow and dissolution of allergenic components from the surface of the corpuscle or from its deeper layers.

Allergy treatment is usually based on methods that suppress the immune system in some way (immunosuppression). A generally accepted method is to move to an allergen-free area (from the lowland pollen mass to the mountains or vice versa). We can also encounter the use of refined, long-chain hydrocarbons as nasal ointments. In addition, there have been attempts to suppress allergic reactions and alleviate symptoms with a number of natural remedies, such as salt pipes, herbal extracts and teas.

In contrast to previous methods, our invention uses a solution that does not affect the immune system, spares the body from its unpleasant side effects (fatigue, drowsiness, decreased attention, etc.), but alleviates or eliminates allergic symptoms. In contrast to previously used methods, it uses both physical blocking (the corpuscle sticks), chemical neutralization (does not allow the enzymes of the irritated mucous membrane to take effect) and biological suppression (inhibits the germination of spores and pollen). The novelty of our method, in contrast to previously used methods, is that it contains both aqueous and lipoid phases, so its active ingredients can act in both directions.

According to the current state of technology, there is no effective method, not only for the risk-free prevention of allergies, but also no truly effective medicine for the risk-free treatment of allergies. Therefore, allergies can only be cured to a limited extent or are clearly considered to be incurable diseases.

It belongs to the group. The solution is offered by medicines and cosmetics that reduce or prevent the unpleasant symptoms of allergies.

According to some views, the allergic condition itself cannot be considered a disease, but merely an exaggerated manifestation of a well-functioning immune system against certain allergens. In this view, drugs that weaken the immune system themselves cause a state that is different from the physiological one. A versatile ointment that keeps allergens away seems to be a more perfect solution than medications.

Allergy treatment procedures therefore used two solutions:

1. They inhibited the manifestation of the body's defenses

2. They prevented allergens from reaching the body's skin and mucous membrane barrier.

Both solutions can be considered symptomatic treatment because they do not resolve the underlying cause of the disorder caused by the allergen. The components and conditions responsible for the increased sensitivity to allergens remain in the body. >

With our procedure, we have developed a solution that causes the allergic organism to stretch a "membrane" between the allergen receptor and the allergen, which causes little discomfort to the organism (it needs to be lubricated!), yet keeps allergens away.

The essence of this is that the surface of the skin or mucous membrane must be lubricated. On the surface coated with the ointment, the allergen particles, whether metal, dust, pollen or spores, cannot come into direct contact with the receptors in the outer covering that are attacked by the allergen.

Lubrication can reduce, prevent, or eliminate the adverse effects of substances that differ from physiological amounts and are released in the presence of antigens carried by the skin, mucous membranes, or antibodies found in the circulation, or in the form of a complex formed by an allergen (hapten) and a component of an organic substance of the body. As a result of lubrication, a situation develops at the critical point of attack (skin, nose) that affects the body as if the body had not encountered the irritating antigen. The normal level of the body's immunological response is locally restored or does not change.

None of the ingredients in the ointment are known antigens. It cannot be ruled out that in very rare cases, sensitivity to one of them may occur.

Of course, we only mention it as a possibility, despite the wide range of allergens, because in our many thousands of tests, we have not encountered such an occurrence in a single case.

Allergens can be substances that exert a wide variety of biological (spores, pollen), chemical (dust mites, feather and fur dust) and physical (metals and their alloys) effects. It is clear from this list that ragweed, the most frequently mentioned, although it is among the most dangerous, is only one of many allergens. (Horváth I.: Bioilogical Environmental Contamination Probleme in Central Europe., Sec. Intern. Symp. and Exh. on Environmental Contamination in Centr. and Eastern Europe., Budapest, 1994. 1017-1019).

The components of the ointment, which provides protection against various antigens, were composed of certain components of cosmetics, minerals from natural sources, and extracts of plants consumed or used for medicinal purposes. The ointment was “cooked” into a spreadable mass with a consistency on the border between cream and ointment, adjusted to the temperature of the nasal mucosa, while ensuring the appropriate amount of lipoid and water. To check the absorption of the ointment, we performed preliminary experiments on the skin of dehaired rabbits. The absorption test was tried on the skin of entrepreneurs and then on the mucous membranes of allergic entrepreneurs with excellent results.

Disadvantages of currently known and used methods to reduce or eliminate allergy symptoms:

1. Immunosuppressive drugs suppress not only the defense against the allergen, but also the body's defenses as a whole. This increases the risk of infection.

2. Locally applied active ingredients, including ointments containing long-chain hydrocarbons, unilaterally utilize only the barrier potential inherent in the lipoid.

3. The effects of treatment methods based on psychological influence — although they should not be underestimated — do not apply in all cases.

4. Desensitization, which can have a dramatic effect, is not a risk-free procedure.

5. Interventions involving mucosal destruction are disadvantageous due to the adverse effects that manifest after exposure to an allergen-free environment.

The ointment we have developed, by mixing aqueous and lipoid phases, provides a protective option that, in addition to the separating barrier function, suppresses the allergenic effect of biological substances to a greater extent with the help of active ingredients soluble in the aqueous phase. The water-soluble substances provide the opportunity to create isotonic conditions suitable for soothing the mucous membrane.

When developing the solution according to the invention, our goal was to develop a process and an ointment created by the process, with the help of which we can reduce the effects of substances that allergenicize both the mucous membrane and the skin.

When creating the solution according to the inventions, we recognized that in addition to reducing the allergenic effect when applying the ointment, the application of the ointment also has a positive effect on the effects of redness and itching resulting from insect bites.

Formation of the lipoid fraction

By heating the water-insoluble substances in a water bath at the appropriate temperature, a water-clear melt is created. The task and purpose of the lipoid fraction is to separate the mucous membrane and skin from pollen and other corpuscular allergens. The components of the lipoid fraction are combined in the correct order after melting, while continuously stirring.

Creation of the aqueous phase.

The ointment contains a smaller proportion of water-soluble substances than the lipoid phase. The aqueous phase performs the task of hydrating the mucous membrane and skin, and partly of creating normotonic conditions on the surface of the already swollen and overproducing mucous membrane. The temperature of the water as a solvent is heated to the same temperature as the lipoid phase, in order to prepare it for combining with the lipoid phase.

Preparation of the ointment

The preparation of the ointment is achieved by combining the aqueous and lipoid phases. The lipoid substances must be combined with the aqueous phase in such a way that, after perfect mixing, they do not separate even under temperature changes that are tolerable for the living organism. They must retain their effectiveness and must not undergo significant color changes due to temperature changes. The stability of the aqueous and lipoid phases must be maintained for at least one year.

The ointment can be characterized by:

1. When applied to the skin, it forms a greasy coating.

2. When applied to the surface of the healthy nasal mucosa, it does not irritate it and forms an even coating on it.

3. It shifts the inflamed, swollen nasal mucosa towards the normotonic direction, causing a stinging sensation during this process. After a few applications, the mucosa calms down and the stinging sensation disappears.

4. The ointment applied to the nose has a slightly runny consistency.

5. In case of contact allergy on the skin, after a few minutes of application, it forms a film-like layer on the skin surface and protects it from allergenic antigens.

Example 1:

Squeeze 100-250 mg of the ointment from the tube into the palm of your hand. Place it on a cotton swab and apply it to the nasal mucosa, evenly and carefully, so as not to damage the nasal mucosa. Apply it to both nostrils and squeeze the nose sideways a few times to even out the internal lubrication.

Example 2

To eliminate or prevent an allergic skin reaction caused by the alloy of the earrings "Bissu Fem", we place 100 mg of ointment on the tip of our finger. We apply it evenly to the skin of the affected area of the ear. We make sure that in the case of pierced ears, the ointment also gets into the opening of the hole. We repeat the application twice a day. From the second day onwards, after applying it once a day, the earrings can be worn without any problems.

Claims (10)

Patent claims. 1. Process for the production of an ointment from a mixture of lipoid and water-soluble substances, which is suitable for the prevention and elimination of allergic lesions on the surface of the skin and nasal mucosa. characterized in that the ointment contains two main components, which are water-soluble and lipoid substances. The ointment is suitable for preventing the development of an allergic reaction and for reducing and eliminating an already established allergic response 2. The method according to claim 1, characterized in that in the preparation of the ointment, a stable water-lipoid ointment can be produced by mixing the lipoid and water-soluble components at a suitable temperature. 3. The method according to claim 1 or 2, characterized in that the compounds dissolved in water contain the various elements or their compounds both in high concentration and in trace element form. 4. The ointment prepared by the method according to claims 1-3, characterized in that when the aqueous and lipoid phases are brought together, the lipoids are perfectly melted and the water-soluble components are present in the form of a perfect solution, in the two main components at the same temperature. 5. The ointment according to claims 1-4, characterized in that the ingredients are substances that occur in nature or are widely used in the field of medicine and cosmetics, and are therefore also suitable for preventing allergic reactions in small children, pregnant and lactating mothers. 6. Ointment according to any one of claims 1-5, characterized in that the ratio of the aqueous and lipoid phases can be varied within wide limits, between 30-70% and 70-30%. 7. The ointment according to any one of claims 1-6, characterized in that the lipoid components can be individually replaced by compounds of similar chemical structure that are certainly non-allergenic. 8. The ointment according to any one of claims 1-7, characterized in that it is suitable for protection against any allergen that exerts its effect through the external covering (skin and mucous membrane). 9. The ointment according to any one of claims 1-8, characterized in that it can be applied to the surface exposed to allergy by smearing or in the form of a spray at a temperature above 40 Celsius. 10. The ointment according to any one of claims 1-9, characterized in that the protection against allergy resulting from its action does not affect the immune system or only to a very small extent and its effect is exerted only on the surfaces where it is present.