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HUP0301011A2 - Dinamikus duzzadási viselkedésű tüdőfelület-aktív készítmények - Google Patents

Dinamikus duzzadási viselkedésű tüdőfelület-aktív készítmények

Info

Publication number
HUP0301011A2
HUP0301011A2 HU0301011A HUP0301011A HUP0301011A2 HU P0301011 A2 HUP0301011 A2 HU P0301011A2 HU 0301011 A HU0301011 A HU 0301011A HU P0301011 A HUP0301011 A HU P0301011A HU P0301011 A2 HUP0301011 A2 HU P0301011A2
Authority
HU
Hungary
Prior art keywords
dispersed
lung
dynamic swelling
active
swelling
Prior art date
Application number
HU0301011A
Other languages
English (en)
Inventor
Johannes Jacobus Haitsma
Burkhard Lachmann
Kare Larsson
Marcus Larsson
Per Wollmer
Original Assignee
Johannes Jacobus Haitsma
Burkhard Lachmann
Kare Larsson
Marcus Larsson
Per Wollmer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johannes Jacobus Haitsma, Burkhard Lachmann, Kare Larsson, Marcus Larsson, Per Wollmer filed Critical Johannes Jacobus Haitsma
Publication of HUP0301011A2 publication Critical patent/HUP0301011A2/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0082—Lung surfactant, artificial mucus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

A jelen találmány tárgyát tüdőfelület-aktív készítmények képezik,amelyek képesek dinamikusan duzzadó fázis kialakítására, haelektrolitokat tartalmazó közegben vannak diszpergálva. A dinamikusduzzadási folyamat polarizált mikroszkópos vizsgálattal követhetőnyomon, és kettős törő hálózatot vagy csövecskéket hoz létre alevegő/folyadék határfelületen. A dinamikus duzzadási folyamathatására a tüdőfelület-aktív anyag nagyobb felületen terül szét, mintakkor, amikor nem dinamikus duzzadási fázisban van. A szétterülésadott időtartam alatt játszódik le azután, hogy a tüdőfelület-aktívanyagot diszpergálták, például egy fiziológiai elektrolitoldatban.Ezáltal a tüdőfelület-aktív anyag jobban szétterjedhet a léghólyagokbaa tüdőbe való bejuttatás után, ami lehetőséget ad az ilyenkészítmények vivőanyagként való alkalmazására terápiás, profilaktikusés/vagy diagnosztikus hatóanyagok tüdőbe vagy más szervekbe, vagy másolyan testrészekbe juttatására, amelyekhez nehéz hozzáférni. Atalálmány szerinti tüdőfelület-aktív készítmény tüdőfelület-aktívanyagot tartalmaz, amely - ha porként vagy szemcsék formájában vandiszpergálva 0,9 tömeg%-os nátrium-kloridban, 10 tömeg%koncentrációban, környezeti hőmérsékleten - képes a duzzadás során,kettős törő hálózat vagy csövecskék létrehozására egy levegő-folyadék-szilárd anyag határfelületen kb. 0,5-120 percen belül, amint azpolarizált mikroszkópos vizsgálattal megfigyelhető. Ó
HU0301011A 2000-09-01 2001-08-31 Dinamikus duzzadási viselkedésű tüdőfelület-aktív készítmények HUP0301011A2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200001301 2000-09-01
PCT/IB2001/001609 WO2002017878A1 (en) 2000-09-01 2001-08-31 Lung surfactant compositions with dynamic swelling behaviour

Publications (1)

Publication Number Publication Date
HUP0301011A2 true HUP0301011A2 (hu) 2003-11-28

Family

ID=8159688

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0301011A HUP0301011A2 (hu) 2000-09-01 2001-08-31 Dinamikus duzzadási viselkedésű tüdőfelület-aktív készítmények

Country Status (12)

Country Link
US (1) US6770619B2 (hu)
EP (1) EP1315475A1 (hu)
JP (1) JP2004507485A (hu)
KR (1) KR20030053507A (hu)
CN (1) CN1449278A (hu)
AU (1) AU2001284332A1 (hu)
CA (1) CA2419606A1 (hu)
HU (1) HUP0301011A2 (hu)
IL (1) IL154628A0 (hu)
PL (1) PL361206A1 (hu)
RU (1) RU2003108871A (hu)
WO (1) WO2002017878A1 (hu)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0115505D0 (en) * 2001-06-25 2001-08-15 Britannia Pharmaceuticals Ltd Prevention of surgical adhesions
US6939534B2 (en) 2001-08-13 2005-09-06 Genomed, Llc Method to treat pulmonary hypoplasia in the newborn
US6998384B2 (en) * 2001-12-12 2006-02-14 The Penn State Research Foundation Surfactant prevention of lung complications from cancer chemotherapy
US20030170223A1 (en) * 2002-02-01 2003-09-11 Board Of Trustees Of Michigan State University Pulmonary vasodilator surfactant compositions and method of use
EP1785156B1 (en) * 2002-08-23 2012-06-27 Schering Corporation Metered dose inhaler containing an aerosol suspension formulation
EP1481665A1 (en) * 2003-05-30 2004-12-01 CHIESI FARMACEUTICI S.p.A. Novel lipid mixtures for synthetic surfactants
US20090011978A1 (en) * 2003-08-28 2009-01-08 Atlanta Pharma Ag Use of Surfactant Preparations for the Treatment of Surgical Adhesions
US20070037722A1 (en) * 2003-09-10 2007-02-15 National Instof Adv Industrial Science And Tech. Oxygen scavenger and method for production thereof
US20060078506A1 (en) * 2004-05-20 2006-04-13 Ralph Niven Methods, systems and devices for noninvasive pulmonary delivery
GB0426010D0 (en) * 2004-11-26 2004-12-29 Britannia Pharmaceuticals Ltd Improvements in or relating to organic materials
EP1830810A4 (en) 2004-12-30 2011-02-02 Dobeel Co Ltd SPRAY-DRYED COMPOSITION WITH PROTEINS OF THE COLLECTIN FAMILY OR VARIATIONS THEREOF AND METHOD OF PREPARATION THEREOF
KR100891595B1 (ko) * 2005-02-28 2009-04-03 주식회사 케이티앤지 혈액 단백질의 삼출을 감소시키는 조성물
US8028697B2 (en) 2005-04-28 2011-10-04 Trudell Medical International Ventilator circuit and method for the use thereof
US20070010429A1 (en) * 2005-05-03 2007-01-11 The Hospital For Sick Children Phospholipid formulations and uses thereof in lung disease detection and treatment
WO2008057248A2 (en) 2006-10-26 2008-05-15 Next Breath Llc Phospholipid-based inhalation system
EP2265309B1 (en) * 2008-03-17 2015-12-16 Discovery Laboratories, Inc. Ventilation circuit adaptor and proximal aerosol delivery system
CA2905402C (en) 2008-10-22 2017-02-28 Trudell Medical International Modular aerosol delivery system
US20180147262A1 (en) 2015-04-30 2018-05-31 University Of Bremen Novel skin medical and cosmetic care product
WO2016199146A1 (en) * 2015-06-09 2016-12-15 B. G. Negev Technologies And Applications Ltd A controlled release system for pulmonary delivery of surfactant protein d
CN112135604A (zh) * 2018-05-18 2020-12-25 韩国科学技术院 基于肺表面活性物质的抗癌药物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3073789A (en) 1988-03-31 1989-10-05 Abbott Laboratories Drug delivery using pulmonary surfactant to facilitate absorption
US5238920A (en) * 1989-08-22 1993-08-24 Abbott Laboratories Pulmonary surfactant protein fragments
GB9120005D0 (en) * 1991-09-19 1991-11-06 Wellcome Found Method of administering phospholipid dispersions
DE4202425C2 (de) 1992-01-29 1997-07-17 Leybold Ag Verfahren und Vorrichtung zum Beschichten eines Substrats, insbesondere mit elektrisch nichtleitenden Schichten
US6129934A (en) * 1995-06-07 2000-10-10 Ony, Inc. Modification of animal lung surfactant for treating respiratory disease due to lung surfactant deficiency or dysfunction
WO2001001609A1 (en) 1999-05-12 2001-01-04 Samsung Electronics Co., Ltd. Channel assignment method for a base station in a mobile communication system

Also Published As

Publication number Publication date
CN1449278A (zh) 2003-10-15
PL361206A1 (pl) 2004-09-20
US6770619B2 (en) 2004-08-03
US20020072540A1 (en) 2002-06-13
IL154628A0 (en) 2003-09-17
WO2002017878A1 (en) 2002-03-07
JP2004507485A (ja) 2004-03-11
CA2419606A1 (en) 2002-03-07
KR20030053507A (ko) 2003-06-28
AU2001284332A1 (en) 2002-03-13
WO2002017878A8 (en) 2003-12-18
RU2003108871A (ru) 2004-08-27
EP1315475A1 (en) 2003-06-04

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