HUP0204524A2 - Nucleic and proteinic acids corresponding to human gene abc1 - Google Patents
Nucleic and proteinic acids corresponding to human gene abc1Info
- Publication number
- HUP0204524A2 HUP0204524A2 HU0204524A HUP0204524A HUP0204524A2 HU P0204524 A2 HUP0204524 A2 HU P0204524A2 HU 0204524 A HU0204524 A HU 0204524A HU P0204524 A HUP0204524 A HU P0204524A HU P0204524 A2 HUP0204524 A2 HU P0204524A2
- Authority
- HU
- Hungary
- Prior art keywords
- abc1
- acids corresponding
- proteinic
- nucleic
- dysfunction
- Prior art date
Links
- 101150090313 abc1 gene Proteins 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title 1
- 150000007513 acids Chemical class 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 102100030488 HEAT repeat-containing protein 6 Human genes 0.000 abstract 2
- 101000990566 Homo sapiens HEAT repeat-containing protein 6 Proteins 0.000 abstract 2
- 101000801684 Homo sapiens Phospholipid-transporting ATPase ABCA1 Proteins 0.000 abstract 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- 230000004064 dysfunction Effects 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 108700024394 Exon Proteins 0.000 abstract 1
- 108091092195 Intron Proteins 0.000 abstract 1
- 208000001163 Tangier disease Diseases 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 230000004060 metabolic process Effects 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000004141 reverse cholesterol transport Effects 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Obesity (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Child & Adolescent Psychology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Vascular Medicine (AREA)
- Microbiology (AREA)
Abstract
A találmány tárgyát az ABC1-gén különböző exonjainak és intronjainakmegfelelő olyan nukleinsavak képezik, amelyekről kimutatták, hogykoleszterin metabolizmusának működési zavarához kapcsolódó patológiát,például olyan betegségeket indukáló gének, mint ateroszklerózis,pontosabban koleszterin reverz transzportjának működési zavara, ésörökletes HDL-elégtelenségek (FHD), például Tangier-kór. A találmánytárgyát képezik mutáns ABC1-polipeptidek is, valamint specifikusanilyen polipeptidek ellen termeltetett antitestek, amelyekdiagnosztikai reagensként alkalmazhatók ABC1-polipeptid agonistáinakvagy antagonistáinak szűrésére. Végül a találmány tárgyát képezikilyen nukleinsavakat vagy fragmentumait tartalmazó vektorok ésrekombináns gazdasejtek. ÓThe subject of the invention are nucleic acids corresponding to the various exons and introns of the ABC1 gene, which have been shown to be associated with pathology related to the dysfunction of cholesterol metabolism, for example, genes inducing diseases such as atherosclerosis, more specifically, the dysfunction of reverse cholesterol transport, and hereditary HDL insufficiency (FHD), for example Tangier disease. The subject of the invention is also mutant ABC1 polypeptides, as well as antibodies specifically produced against such polypeptides, which can be used as diagnostic reagents for the screening of ABC1 polypeptide agonists or antagonists. Finally, vectors and recombinant host cells containing nucleic acids or their fragments are the object of the invention. HE
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9907684A FR2795091B1 (en) | 1999-06-17 | 1999-06-17 | NUCLEIC ACIDS AND PROTEINS OF THE HUMAN ABC1 GENE AND THEIR APPLICATION IN THERAPY AND DIAGNOSIS |
| US14712899P | 1999-08-04 | 1999-08-04 | |
| PCT/FR2000/001595 WO2000078970A1 (en) | 1999-06-17 | 2000-06-08 | Nucleic and proteinic acids corresponding to human gene abc1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0204524A2 true HUP0204524A2 (en) | 2003-04-28 |
Family
ID=26234994
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0204524A HUP0204524A2 (en) | 1999-06-17 | 2000-06-08 | Nucleic and proteinic acids corresponding to human gene abc1 |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1190063A1 (en) |
| JP (1) | JP2003503026A (en) |
| KR (1) | KR20020012279A (en) |
| AU (1) | AU5540800A (en) |
| BR (1) | BR0011724A (en) |
| CA (1) | CA2375771A1 (en) |
| HU (1) | HUP0204524A2 (en) |
| IL (1) | IL147071A0 (en) |
| MX (1) | MXPA01013062A (en) |
| NO (1) | NO20016089L (en) |
| WO (1) | WO2000078970A1 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE364696T1 (en) | 1999-03-15 | 2007-07-15 | Univ British Columbia | ABC1 POLYPEPTIDES AND METHODS AND REAGENTS FOR MODULATING CHOLESTEROL CONTENT |
| FR2815970A1 (en) * | 2000-10-31 | 2002-05-03 | Aventis Pharma Sa | New polymorphisms in the human ABCA1 gene, useful for diagnosing predisposition to myocardial infarct and other cardiovascular diseases |
| CA2427436A1 (en) * | 2000-10-31 | 2002-05-10 | Aventis Pharma S.A. | Polymorphic sequences of the human abca1 gene, their uses, detection methods and kits |
| MXPA04006554A (en) * | 2002-01-02 | 2005-03-31 | Genentech Inc | Compositions and methods for the diagnosis and treatment of tumor. |
| CN112442114A (en) * | 2019-08-29 | 2021-03-05 | 渥太华Hdl药物研发公司 | Polypeptide and application thereof |
-
2000
- 2000-06-08 BR BR0011724-2A patent/BR0011724A/en not_active IP Right Cessation
- 2000-06-08 HU HU0204524A patent/HUP0204524A2/en unknown
- 2000-06-08 MX MXPA01013062A patent/MXPA01013062A/en unknown
- 2000-06-08 WO PCT/FR2000/001595 patent/WO2000078970A1/en not_active Application Discontinuation
- 2000-06-08 CA CA002375771A patent/CA2375771A1/en not_active Abandoned
- 2000-06-08 JP JP2001505712A patent/JP2003503026A/en not_active Withdrawn
- 2000-06-08 EP EP00940477A patent/EP1190063A1/en not_active Withdrawn
- 2000-06-08 AU AU55408/00A patent/AU5540800A/en not_active Abandoned
- 2000-06-08 IL IL14707100A patent/IL147071A0/en unknown
- 2000-06-08 KR KR1020017016224A patent/KR20020012279A/en not_active Withdrawn
-
2001
- 2001-12-13 NO NO20016089A patent/NO20016089L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20016089D0 (en) | 2001-12-13 |
| BR0011724A (en) | 2002-03-26 |
| JP2003503026A (en) | 2003-01-28 |
| MXPA01013062A (en) | 2002-06-04 |
| CA2375771A1 (en) | 2000-12-28 |
| NO20016089L (en) | 2002-02-15 |
| EP1190063A1 (en) | 2002-03-27 |
| AU5540800A (en) | 2001-01-09 |
| KR20020012279A (en) | 2002-02-15 |
| IL147071A0 (en) | 2002-08-14 |
| WO2000078970A1 (en) | 2000-12-28 |
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