HUP0201694A3 - Polymorphs of crystalline (2-benzhydryl-1-azabicyclo[2,2,2]oct-3-yl)-(5-iso-propyl-2-methoxybenzyl)-ammoniumchloride as nk-1 receptor antagonists, process for their preparation pharmaceutical composition comprising thereof and their use - Google Patents

Polymorphs of crystalline (2-benzhydryl-1-azabicyclo[2,2,2]oct-3-yl)-(5-iso-propyl-2-methoxybenzyl)-ammoniumchloride as nk-1 receptor antagonists, process for their preparation pharmaceutical composition comprising thereof and their use

Info

Publication number: HUP0201694A3
Authority: HU; Hungary
Prior art keywords: ammoniumchloride; benzhydryl; azabicyclo; polymorphs; methoxybenzyl
Prior art date: 1999-06-22

Application number

HU0201694A

Other languages

English (en)

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-06-22

Filing date

2000-06-06

Publication date

2002-10-28

2000-06-06 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2002-09-28 Publication of HUP0201694A2 publication Critical patent/HUP0201694A2/hu

2002-10-28 Publication of HUP0201694A3 publication Critical patent/HUP0201694A3/hu

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Hospice & Palliative Care (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

HU0201694A 1999-06-22 2000-06-06 Polymorphs of crystalline (2-benzhydryl-1-azabicyclo[2,2,2]oct-3-yl)-(5-iso-propyl-2-methoxybenzyl)-ammoniumchloride as nk-1 receptor antagonists, process for their preparation pharmaceutical composition comprising thereof and their use HUP0201694A3 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US14023399P	1999-06-22	1999-06-22

Publications (2)

Publication Number	Publication Date
HUP0201694A2 HUP0201694A2 (en)	2002-09-28
HUP0201694A3 true HUP0201694A3 (en)	2002-10-28

Family

ID=22490317

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU0201694A HUP0201694A3 (en)	1999-06-22	2000-06-06	Polymorphs of crystalline (2-benzhydryl-1-azabicyclo[2,2,2]oct-3-yl)-(5-iso-propyl-2-methoxybenzyl)-ammoniumchloride as nk-1 receptor antagonists, process for their preparation pharmaceutical composition comprising thereof and their use

Country Status (35)

Country	Link
US (1)	US6262067B1 (hu)
EP (1)	EP1187834A1 (hu)
JP (1)	JP2003502425A (hu)
KR (1)	KR20020030280A (hu)
CN (1)	CN1390216A (hu)
AP (1)	AP2001002367A0 (hu)
AR (1)	AR024411A1 (hu)
AU (1)	AU767336B2 (hu)
BG (1)	BG106205A (hu)
BR (1)	BR0011835A (hu)
CA (1)	CA2375265A1 (hu)
CO (1)	CO5190663A1 (hu)
CZ (1)	CZ20014458A3 (hu)
DZ (1)	DZ3055A1 (hu)
EA (1)	EA004264B1 (hu)
EC (1)	ECSP003538A (hu)
EE (1)	EE200100698A (hu)
HR (1)	HRP20010920A2 (hu)
HU (1)	HUP0201694A3 (hu)
IL (1)	IL146410A0 (hu)
IS (1)	IS6161A (hu)
MA (1)	MA26744A1 (hu)
MX (1)	MXPA02000033A (hu)
NO (1)	NO20016187D0 (hu)
NZ (1)	NZ515348A (hu)
OA (1)	OA11952A (hu)
PA (1)	PA8496701A1 (hu)
PE (1)	PE20010322A1 (hu)
PL (1)	PL352899A1 (hu)
SK (1)	SK18672001A3 (hu)
TN (1)	TNSN00137A1 (hu)
TR (1)	TR200103688T2 (hu)
UY (1)	UY26211A1 (hu)
WO (1)	WO2000078759A1 (hu)
ZA (1)	ZA200110387B (hu)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6387925B1 (en) *	1999-06-01	2002-05-14	Pfizer Inc.	Polymorphs of a crystalline azo-bicyclo (2.2.2) oct-3-yl amine citrate and their pharmaceutical compositions
US6756379B2 (en)	2001-07-26	2004-06-29	Taro Pharmaceutical Industries Ltd.	Non-sedating barbiturate compounds as neuroprotective agents
US7683071B2 (en) *	2000-07-26	2010-03-23	Taro Pharmaceuticals Industries Ltd.	Composition and method for improved bioavailability and enhanced brain delivery of 5,5-diphenyl barbituric acid
US6939873B2 (en) *	2000-07-26	2005-09-06	Taro Pharmaceuticals Industries Limited	Non-sedating barbituric acid derivatives
EP1551846A1 (en) *	2002-10-04	2005-07-13	Merck Sharp & Dohme Ltd.	Azabicyclic spiroether derivatives as receptor antagonists
WO2004052350A2 (en) *	2002-12-11	2004-06-24	Taro Pharmaceutical Industries Limited	Method of treating movement disorders using barbituric acid derivatives
WO2006003651A2 (en) *	2004-07-02	2006-01-12	Taro Pharmaceutical Industries, Ltd	A process for preparing 1-methoxymethyl-5,5-diphenylbarbituric acid
EP2081576A4 (en) *	2006-11-14	2010-06-30	Taro Pharmaceuticals North Ame	METHOD FOR IMPROVING BIOAVAILABILITY FOR NON-EDMING BARBITURATES
UA102128C2 (en) *	2008-12-05	2013-06-10	Х. Луннбек А/С	Nalmefene hydrochloride dihydrate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1990005525A1 (en) *	1988-11-23	1990-05-31	Pfizer Inc.	Quinuclidine derivatives as substance p antagonists
CZ281403B6 (cs) *	1991-05-31	1996-09-11	Pfizer Inc.	Chinuklidinové deriváty, způsob jejich přípravy a použití.
DK0668863T3 (da) *	1992-11-12	1997-06-30	Pfizer	Quinuclidinderivat som substans P-antagonist
US5393762A (en) *	1993-06-04	1995-02-28	Pfizer Inc.	Pharmaceutical agents for treatment of emesis

2000
- 2000-05-04 US US09/564,528 patent/US6262067B1/en not_active Expired - Fee Related
- 2000-06-06 CN CN00809305A patent/CN1390216A/zh active Pending
- 2000-06-06 CA CA002375265A patent/CA2375265A1/en not_active Abandoned
- 2000-06-06 TR TR2001/03688T patent/TR200103688T2/xx unknown
- 2000-06-06 WO PCT/IB2000/000756 patent/WO2000078759A1/en not_active Application Discontinuation
- 2000-06-06 EA EA200101179A patent/EA004264B1/ru not_active IP Right Cessation
- 2000-06-06 PL PL00352899A patent/PL352899A1/xx not_active Application Discontinuation
- 2000-06-06 OA OA1200100314A patent/OA11952A/en unknown
- 2000-06-06 SK SK1867-2001A patent/SK18672001A3/sk unknown
- 2000-06-06 MX MXPA02000033A patent/MXPA02000033A/es unknown
- 2000-06-06 HU HU0201694A patent/HUP0201694A3/hu unknown
- 2000-06-06 KR KR1020017016407A patent/KR20020030280A/ko not_active Application Discontinuation
- 2000-06-06 AU AU47745/00A patent/AU767336B2/en not_active Ceased
- 2000-06-06 EP EP00929745A patent/EP1187834A1/en not_active Withdrawn
- 2000-06-06 PA PA20008496701A patent/PA8496701A1/es unknown
- 2000-06-06 AP APAP/P/2001/002367A patent/AP2001002367A0/en unknown
- 2000-06-06 IL IL14641000A patent/IL146410A0/xx unknown
- 2000-06-06 NZ NZ515348A patent/NZ515348A/en unknown
- 2000-06-06 BR BR0011835-4A patent/BR0011835A/pt not_active IP Right Cessation
- 2000-06-06 JP JP2001504925A patent/JP2003502425A/ja active Pending
- 2000-06-06 CZ CZ20014458A patent/CZ20014458A3/cs unknown
- 2000-06-06 EE EEP200100698A patent/EE200100698A/xx unknown
- 2000-06-13 CO CO00043885A patent/CO5190663A1/es not_active Application Discontinuation
- 2000-06-20 PE PE2000000613A patent/PE20010322A1/es not_active Application Discontinuation
- 2000-06-20 AR ARP000103053A patent/AR024411A1/es not_active Application Discontinuation
- 2000-06-20 UY UY26211A patent/UY26211A1/es not_active Application Discontinuation
- 2000-06-21 TN TNTNSN00137A patent/TNSN00137A1/fr unknown
- 2000-06-21 MA MA26007A patent/MA26744A1/fr unknown
- 2000-06-21 DZ DZ000113A patent/DZ3055A1/xx active
- 2000-06-22 EC EC2000003538A patent/ECSP003538A/es unknown
2001
- 2001-11-13 IS IS6161A patent/IS6161A/is unknown
- 2001-12-10 BG BG106205A patent/BG106205A/bg unknown
- 2001-12-11 HR HR20010920A patent/HRP20010920A2/hr not_active Application Discontinuation
- 2001-12-18 NO NO20016187A patent/NO20016187D0/no not_active Application Discontinuation
- 2001-12-19 ZA ZA200110387A patent/ZA200110387B/en unknown

Also Published As

Publication number	Publication date
JP2003502425A (ja)	2003-01-21
AU767336B2 (en)	2003-11-06
HRP20010920A2 (en)	2003-02-28
AU4774500A (en)	2001-01-09
NZ515348A (en)	2003-07-25
AR024411A1 (es)	2002-10-02
MXPA02000033A (es)	2002-07-02
EP1187834A1 (en)	2002-03-20
PE20010322A1 (es)	2001-03-14
SK18672001A3 (sk)	2002-08-06
UY26211A1 (es)	2001-01-31
EA200101179A1 (ru)	2002-06-27
BR0011835A (pt)	2002-03-05
CZ20014458A3 (cs)	2002-03-13
ECSP003538A (es)	2002-01-25
BG106205A (bg)	2002-07-31
NO20016187L (no)	2001-12-18
OA11952A (en)	2006-04-13
EE200100698A (et)	2003-02-17
DZ3055A1 (fr)	2004-03-27
KR20020030280A (ko)	2002-04-24
NO20016187D0 (no)	2001-12-18
IL146410A0 (en)	2002-07-25
CN1390216A (zh)	2003-01-08
MA26744A1 (fr)	2004-12-20
WO2000078759A1 (en)	2000-12-28
HUP0201694A2 (en)	2002-09-28
CA2375265A1 (en)	2000-12-28
TNSN00137A1 (fr)	2002-05-30
PL352899A1 (en)	2003-09-22
PA8496701A1 (es)	2002-07-30
IS6161A (is)	2001-11-13
US6262067B1 (en)	2001-07-17
TR200103688T2 (tr)	2002-12-23
EA004264B1 (ru)	2004-02-26
CO5190663A1 (es)	2002-08-29
AP2001002367A0 (en)	2001-12-31
ZA200110387B (en)	2002-12-19

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Legal Events

Date	Code	Title	Description
2006-03-28	FD9A	Lapse of provisional protection due to non-payment of fees