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HUP0100597A2 - Hidroxámsav- és karbonsavszármazékok - Google Patents

Hidroxámsav- és karbonsavszármazékok

Info

Publication number
HUP0100597A2
HUP0100597A2 HU0100597A HUP0100597A HUP0100597A2 HU P0100597 A2 HUP0100597 A2 HU P0100597A2 HU 0100597 A HU0100597 A HU 0100597A HU P0100597 A HUP0100597 A HU P0100597A HU P0100597 A2 HUP0100597 A2 HU P0100597A2
Authority
HU
Hungary
Prior art keywords
alkyl
group
heteroaryl
aryl
heterocycloalkyl
Prior art date
Application number
HU0100597A
Other languages
English (en)
Inventor
Andrew Douglas Baxter
John Gary Montana
David Alan Owen
Original Assignee
Darwin Discovery Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9802073.8A external-priority patent/GB9802073D0/en
Priority claimed from GBGB9819574.6A external-priority patent/GB9819574D0/en
Application filed by Darwin Discovery Ltd. filed Critical Darwin Discovery Ltd.
Publication of HUP0100597A2 publication Critical patent/HUP0100597A2/hu
Publication of HUP0100597A3 publication Critical patent/HUP0100597A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/46—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A találmány mátrix metalloproteinázok és/vagy TNFa-mediált betegségek,köztük degeneratív betegségek és bizonyos rákok inhibitoraikéntalkalmazható (I) általános képletű vegyületekre B-X- (CH2)m (CR1R2)n-W-COY (I) - amelyek képletében m 0, 1 vagy 2; n 1 vagy 2, azzal amegkötéssel, hogy ha m 0, akkor n 2; X S(O)0-2 csoport; Y hidrogénatom, hidroxi- vagy hidroxi-amino-csoport; W karbonil- vagy hidroxi-metilén-csoport, vagy ha Yhidrogénatom, W N-OR8 csoportot is jelenthet; R1 hidrogénatom, adottesetben R7 csoporttal szubsztituált alkil-, alkenil-, aril-, aril-(alkil)-, heteroaril-, heteroaril-(alkil)-, heterocikloalkil-,heterocikloalkil-(alkil)-, cikloalkil- vagy cikloalkil-(alkil)-csoport; és R2 hidrogénatom vagy alkilcsoport, azzal a megkötéssel,hogy a -(CR1R2)n- csoport -(CH2)n- csoporttól eltérő; vagy CR1R2 adottesetben szubsztituált cikloalkilcsoport vagy heterocikloalkilcsoport;B adott esetben szubsztituált aril-(alkil)-, alkil-, cikloalkil-,cikloalkil-(alkil)-, cikloalkenil-, heterocikloalkenil-, heteroaril-(alkil)-, heterocikloalkil-, heterocikloalkil-(alkil)-, aril- vagyheteroarilcsoport; R3 alkilcsoport, halogénatom, ciano-, nitrocsoport,-N(R4)2, -OR4, -COR4, -C(=NOR6)R4, -CO2R8, -CON(R4)2, -NR4R5, -S(O)0-2R6 vagy -SO2N(R4)2 csoport; R4 hidrogénatom, adott esetbenszubsztituált alkil-, aril-, aril--(alkil)-, heteroaril-, heteroaril-(alkil)-, cikloalkil-, cikloalkil-(alkil)-, heterocikloalkil- vagyhetrocikloalkil-(alkil)-csoport; R5 -COR4, -CON(R4)2, -C02R6 vagy -SO2R6 csoport; R6 alkil-, aril-,aril-(alkil)-, heteroaril- vagy heteroaril-(alkil)--csoport; R7 -OR4, -COR4, -CO2R8, -CON(R4)2, -NR4R5, -S(O)0-2R6, -SO2N(R4)2csoport, halogénatom, cianocsoport vagy adott esetben R8 csoporttalszubsztituált cikloimidilcsoport; és R8 hidrogénatom vagy alkilcsoport- valamint sóikra, szolvátjaikra, hidrátjaikra, N-oxidjaikra, védettamino-, védett karboxi- és védett hidroxi-amino-származékaikravonatkozik. Ó
HU0100597A 1998-01-30 1999-01-29 Hydroxamic and carboxylic acid derivatives HUP0100597A3 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9802073.8A GB9802073D0 (en) 1998-01-30 1998-01-30 Hydroxamic and carboxylic acid derivatives having mmp and tnf inhibitory activity
GBGB9819574.6A GB9819574D0 (en) 1998-09-08 1998-09-08 Hydroxamic and carboxylic acid derivatives having mmp and tnf inhibitory activity
PCT/GB1999/000313 WO1999038843A1 (en) 1998-01-30 1999-01-29 Hydroxamic and carboxylic acid derivatives
US09/239,603 US6100266A (en) 1998-01-30 1999-01-29 Hydroxamic and carboxylic acid derivatives

Publications (2)

Publication Number Publication Date
HUP0100597A2 true HUP0100597A2 (hu) 2001-08-28
HUP0100597A3 HUP0100597A3 (en) 2001-12-28

Family

ID=27269200

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0100597A HUP0100597A3 (en) 1998-01-30 1999-01-29 Hydroxamic and carboxylic acid derivatives

Country Status (18)

Country Link
US (1) US6100266A (hu)
EP (1) EP1051395B1 (hu)
JP (1) JP2002501943A (hu)
CN (1) CN100402496C (hu)
AT (1) ATE346041T1 (hu)
AU (1) AU735929B2 (hu)
BR (1) BR9908215A (hu)
CA (1) CA2317455C (hu)
CY (1) CY1106338T1 (hu)
DE (1) DE69934094T2 (hu)
DK (1) DK1051395T3 (hu)
ES (1) ES2277424T3 (hu)
HK (1) HK1029330A1 (hu)
HU (1) HUP0100597A3 (hu)
IL (1) IL137146A0 (hu)
NO (1) NO326266B1 (hu)
PL (1) PL200418B1 (hu)
WO (1) WO1999038843A1 (hu)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9919776D0 (en) 1998-08-31 1999-10-27 Zeneca Ltd Compoujnds
US20040122011A1 (en) * 1998-12-23 2004-06-24 Pharmacia Corporation Method of using a COX-2 inhibitor and a TACE inhibitors as a combination therapy
ES2281346T3 (es) 1999-06-04 2007-10-01 Astrazeneca Ab Inhibidores de metaloproteinasas.
WO2001047874A1 (en) * 1999-12-24 2001-07-05 Smithkline Beecham P.L.C. (hetero)bicyclymethanesulfonylamino-substituted hydroxamic acid derivatives
CN1247547C (zh) * 2000-02-21 2006-03-29 阿斯特拉曾尼卡有限公司 作为金属蛋白酶抑制剂的哌啶和哌嗪取代的n－羟基甲酰胺
AU2001232113A1 (en) * 2000-02-21 2001-09-03 Astrazeneca Ab Arylpiperazines and their use as metalloproteinase inhibiting agents (mmp)
EP1289980B1 (en) * 2000-05-25 2004-11-17 Smithkline Beecham Plc Bicyclyl or heterobicyclylmethanesulfonylamino-substituted n-hydroxyformamides
FR2827859B1 (fr) * 2001-07-30 2005-09-23 Lipha Derives 4-(arylthio) - ou 4-(heteroarylthio) -butyrique dans la preparation de medicaments destines au traitement du diabete
GB0119474D0 (en) * 2001-08-09 2001-10-03 Astrazeneca Ab Compounds
GB0119473D0 (en) * 2001-08-09 2001-10-03 Astrazeneca Compounds
GB0119472D0 (en) * 2001-08-09 2001-10-03 Astrazeneca Ab Compounds
JP4219270B2 (ja) 2001-09-07 2009-02-04 科研製薬株式会社 リバースヒドロキサム酸誘導体
GB0128376D0 (en) 2001-11-27 2002-01-16 Smithkline Beecham Plc Novel compounds
GB0128378D0 (en) * 2001-11-27 2002-01-16 Smithkline Beecham Plc Novel Compounds
PE20030701A1 (es) 2001-12-20 2003-08-21 Schering Corp Compuestos para el tratamiento de trastornos inflamatorios
SE0301922D0 (sv) 2003-06-27 2003-06-27 Astrazeneca Ab Novel compounds
JP5199109B2 (ja) * 2005-11-24 2013-05-15 メルク セローノ ソシエテ アノニム Ｎ−ヒドロキシアミド誘導体およびその使用
US20100226922A1 (en) * 2006-06-08 2010-09-09 Dorothea Maetzel Specific protease inhibitors and their use in cancer therapy
US8765814B2 (en) 2010-07-08 2014-07-01 Kaken Pharmaceutical Co., Ltd. N-hydroxyformamide derivative and medicament containing same

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993021942A2 (en) * 1992-05-01 1993-11-11 British Biotech Pharmaceuticals Limited Use of mmp inhibitors
ES2184861T3 (es) * 1995-05-10 2003-04-16 Darwin Discovery Ltd Compuestos peptidicos inhibidores de la liberacion de la metaloproteinasa y del tnf y su utilizacion terapeutica.
KR20000022532A (ko) * 1996-06-27 2000-04-25 오노 야꾸힝 고교 가부시키가이샤 아릴(설파이드, 설폭시드 및 설폰)유도체 및 이를 활성 성분으로 함유하는 약물
US6235928B1 (en) * 1996-09-27 2001-05-22 Pharmacia & Upjohn Company β-sulfonyl hydroxamic acids
US5962481A (en) * 1996-10-16 1999-10-05 American Cyanamid Company Preparation and use of ortho-sulfonamido heteroaryl hydroxamic acids as matrix metalloproteinase and tace inhibitors
WO1998039316A1 (en) * 1997-03-04 1998-09-11 Monsanto Company N-hydroxy 4-sulfonyl butanamide compounds
US5985900A (en) * 1997-04-01 1999-11-16 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
TR199903287T2 (xx) * 1997-07-31 2000-09-21 Abbott Laboratories Matriks metaloproteinazlar�n�n ters hidroksamat inhibit�rleri.

Also Published As

Publication number Publication date
AU2291499A (en) 1999-08-16
IL137146A0 (en) 2001-07-24
US6100266A (en) 2000-08-08
WO1999038843A1 (en) 1999-08-05
ATE346041T1 (de) 2006-12-15
NO326266B1 (no) 2008-10-27
NO20003868L (no) 2000-07-28
NO20003868D0 (no) 2000-07-28
JP2002501943A (ja) 2002-01-22
AU735929B2 (en) 2001-07-19
PL200418B1 (pl) 2009-01-30
PL342184A1 (en) 2001-05-21
ES2277424T3 (es) 2007-07-01
CN100402496C (zh) 2008-07-16
DE69934094D1 (de) 2007-01-04
CA2317455A1 (en) 1999-08-05
CY1106338T1 (el) 2011-10-12
HK1029330A1 (en) 2001-03-30
DK1051395T3 (da) 2007-04-02
EP1051395A1 (en) 2000-11-15
HUP0100597A3 (en) 2001-12-28
EP1051395B1 (en) 2006-11-22
CN1289322A (zh) 2001-03-28
BR9908215A (pt) 2000-11-28
CA2317455C (en) 2011-01-25
DE69934094T2 (de) 2007-06-06

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