HUP0100294A3 - Polycyclic alpha-amino-sigma-caprolactams and related compounds - Google Patents
Polycyclic alpha-amino-sigma-caprolactams and related compoundsInfo
- Publication number
- HUP0100294A3 HUP0100294A3 HU0100294A HUP0100294A HUP0100294A3 HU P0100294 A3 HUP0100294 A3 HU P0100294A3 HU 0100294 A HU0100294 A HU 0100294A HU P0100294 A HUP0100294 A HU P0100294A HU P0100294 A3 HUP0100294 A3 HU P0100294A3
- Authority
- HU
- Hungary
- Prior art keywords
- caprolactams
- polycyclic
- sigma
- alpha
- amino
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 125000003367 polycyclic group Chemical group 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/996,422 US6635632B1 (en) | 1996-12-23 | 1997-12-22 | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| US10272698A | 1998-06-22 | 1998-06-22 | |
| PCT/US1998/022637 WO1999032453A1 (en) | 1997-12-22 | 1998-10-29 | POLYCYCLIC α-AMINO-⊂-CAPROLACTAMS AND RELATED COMPOUNDS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0100294A2 HUP0100294A2 (hu) | 2001-09-28 |
| HUP0100294A3 true HUP0100294A3 (en) | 2003-04-28 |
Family
ID=26799672
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0100294A HUP0100294A3 (en) | 1997-12-22 | 1998-10-29 | Polycyclic alpha-amino-sigma-caprolactams and related compounds |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1042298A1 (pt) |
| JP (1) | JP2003521438A (pt) |
| KR (1) | KR20010033408A (pt) |
| AU (1) | AU1277799A (pt) |
| BR (1) | BR9812773A (pt) |
| CA (1) | CA2307221A1 (pt) |
| HU (1) | HUP0100294A3 (pt) |
| IL (1) | IL135564A0 (pt) |
| WO (1) | WO1999032453A1 (pt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP990246A2 (en) | 1998-08-07 | 2000-06-30 | Du Pont Pharm Co | Succinoylamino benzodiazepines as inhibitors of a beta protein production |
| NZ509241A (en) | 1998-08-07 | 2003-08-29 | Du Pont Pharm Co | Succinoylamino lactams as inhibitors of alpha-beta protein production |
| WO2000038618A2 (en) | 1998-12-24 | 2000-07-06 | Du Pont Pharmaceuticals Company | SUCCINOYLAMINO BENZODIAZEPINES AS INHIBITORS OF Aβ PROTEIN PRODUCTION |
| EP1226139A2 (en) | 1999-07-06 | 2002-07-31 | Vertex Pharmaceuticals Incorporated | Cyclized amide derivatives for treating or preventing neuronal damage |
| US6503902B2 (en) | 1999-09-13 | 2003-01-07 | Bristol-Myers Squibb Pharma Company | Hydroxyalkanoylaminolactams and related structures as inhibitors of a β protein production |
| US6960576B2 (en) | 1999-09-13 | 2005-11-01 | Bristol-Myers Squibb Pharma Company | Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production |
| BR0014269A (pt) * | 1999-09-13 | 2002-07-02 | Bristol Myers Squibb Pharma Co | Compostos de lactamas, seus sais e pró-drogas farmaceuticamente aceitáveis, composição farmacêutica, método de tratamento de disfunções neurológicas associadas com a produção de "beta"-amilóide, método de inibição da atividade da "alfa"-secretase e usos dos compostos |
| WO2001027091A1 (en) * | 1999-10-08 | 2001-04-19 | Du Pont Pharmaceuticals Company | AMINO LACTAM SULFONAMIDES AS INHIBITORS OF Aβ PROTEIN PRODUCTION |
| EP1261610A2 (en) | 2000-02-17 | 2002-12-04 | Bristol-Myers Squibb Pharma Company | Succinoylamino carbocycles and heterocycles as inhibitors of a-beta protein production |
| IL151576A0 (en) | 2000-04-03 | 2003-04-10 | Bristol Myers Squibb Pharma Co | Cyclic lactams as inhibitors of a-beta protein production |
| BR0110051A (pt) | 2000-04-03 | 2004-12-07 | Bristol Myers Squibb Pharma Co | Composto, uso do composto, composição farmacêutica e método de tratamento do mal de alzheimer |
| WO2001077086A1 (en) * | 2000-04-11 | 2001-10-18 | Dupont Pharmaceuticals Company | SUBSTITUTED LACTAMS AS INHIBITORS OF Aβ PROTEIN PRODUCTION |
| IL147629A0 (en) | 2000-06-01 | 2002-08-14 | Bristol Myers Squibb Pharma Co | LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF Aβ PROTEIN PRODUCTION |
| US6432944B1 (en) | 2000-07-06 | 2002-08-13 | Bristol-Myers Squibb Company | Benzodiazepinone β-amyloid inhibitors: arylacetamidoalanyl derivatives |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4666829A (en) * | 1985-05-15 | 1987-05-19 | University Of California | Polypeptide marker for Alzheimer's disease and its use for diagnosis |
| JP3553592B2 (ja) * | 1992-10-26 | 2004-08-11 | ビー． シェンク，デイル | 可溶性β−アミロイド・ペプチドの検出のための方法及び組成物 |
| ZA945719B (en) * | 1993-08-09 | 1996-02-01 | Lilly Co Eli | Identification and use of protease inhibitors |
| US5580979A (en) * | 1994-03-15 | 1996-12-03 | Trustees Of Tufts University | Phosphotyrosine peptidomimetics for inhibiting SH2 domain interactions |
| US6251928B1 (en) * | 1994-03-16 | 2001-06-26 | Eli Lilly And Company | Treatment of alzheimer's disease employing inhibitors of cathepsin D |
| CA2272305A1 (en) * | 1996-12-23 | 1998-07-02 | Elan Pharmaceuticals, Inc. | Cycloalkyl, lactam, lactone and related compounds as .beta.-amyloid peptide release inhibitors |
| AR011164A1 (es) * | 1997-02-28 | 2000-08-02 | Lilly Co Eli | Compuestos heterociclicos, composiciones farmaceuticas que los comprenden, y metodos para inhibir la liberacion del peptido beta-amiloide y/o su sintesismediante el uso de dichos compuestos |
-
1998
- 1998-10-29 WO PCT/US1998/022637 patent/WO1999032453A1/en not_active Application Discontinuation
- 1998-10-29 BR BR9812773-0A patent/BR9812773A/pt not_active IP Right Cessation
- 1998-10-29 KR KR1020007006883A patent/KR20010033408A/ko not_active Application Discontinuation
- 1998-10-29 IL IL13556498A patent/IL135564A0/xx unknown
- 1998-10-29 HU HU0100294A patent/HUP0100294A3/hu unknown
- 1998-10-29 JP JP2000525390A patent/JP2003521438A/ja not_active Withdrawn
- 1998-10-29 CA CA002307221A patent/CA2307221A1/en not_active Abandoned
- 1998-10-29 AU AU12777/99A patent/AU1277799A/en not_active Abandoned
- 1998-10-29 EP EP98956198A patent/EP1042298A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999032453A1 (en) | 1999-07-01 |
| EP1042298A1 (en) | 2000-10-11 |
| AU1277799A (en) | 1999-07-12 |
| BR9812773A (pt) | 2000-10-10 |
| IL135564A0 (en) | 2001-05-20 |
| CA2307221A1 (en) | 1999-07-01 |
| KR20010033408A (ko) | 2001-04-25 |
| JP2003521438A (ja) | 2003-07-15 |
| HUP0100294A2 (hu) | 2001-09-28 |
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