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HUP0004853A2 - Hepatitis C inhibitor peptidek, eljárás ezek előállítására, azokat tartalmazó gyógyszerkészítmények, alkalmazásuk és intermediereik - Google Patents

Hepatitis C inhibitor peptidek, eljárás ezek előállítására, azokat tartalmazó gyógyszerkészítmények, alkalmazásuk és intermediereik

Info

Publication number
HUP0004853A2
HUP0004853A2 HU0004853A HUP0004853A HUP0004853A2 HU P0004853 A2 HUP0004853 A2 HU P0004853A2 HU 0004853 A HU0004853 A HU 0004853A HU P0004853 A HUP0004853 A HU P0004853A HU P0004853 A2 HUP0004853 A2 HU P0004853A2
Authority
HU
Hungary
Prior art keywords
group
alkyl
substituted
hepatitis
carboxy
Prior art date
Application number
HU0004853A
Other languages
English (en)
Inventor
Montse Llinas-Brunet
Marc-André Poupart
Jean Rancourt
Bruno Simoneau
Youla Tsantrizos
Dominik Wernic
Original Assignee
Boehringer Ingelheim (Canada) Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim (Canada) Ltd. filed Critical Boehringer Ingelheim (Canada) Ltd.
Publication of HUP0004853A2 publication Critical patent/HUP0004853A2/hu
Publication of HUP0004853A3 publication Critical patent/HUP0004853A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A találmány tárgyát az általános képletű, a hepatitis Cvírus ellen hatékony vegyületek képezik, amely képletben Qmetiléncsoport, a=0, b=0, B amid-származék: vagy ha Q =N-Y általánosképletű csoport, amelyben Y hidrogénatom vagy alkilcsoport, akkor, aés b értéke 0 vagy 1, B acil-származék; R6, ha jelen van,karboxicsoporttal szubsztituált alkilcsoport; R5, ha jelen van, adottesetben karboxicsoporttal szubsztituált alkilcsoport; és ha Q vagymetiléncsoport vagy =N-Y általános képletű csoport, akkor Z oxo- vagytioxocsoport; R4 alkil-, cikloalkil- vagy alkilcikloalkil-csoport; R3karboxicsoportal szubsztitutált alkil-, cikloalkil- vagyalkilcikloalkil-csoport; W prolinszármazék; R1' hidrogénatom és R1 adott esetben merkapto-csoporttal szubsztituált alkilcsoport; vagy R1 2-6 szénatomosalkenilcsoport; és R1' és R1 együtt 3-6 tagú gyűrűt képeznek; és Ahidroxicsoport vagy ezek gyógyszerészetileg elfogadható sói vagyészterei. Ó
HU0004853A 1997-08-11 1998-08-10 Hepatitis c inhibitor peptides, process for preparation thereof, pharmaceutical compositions comprising thereof, their use and their intermediates HUP0004853A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5518697P 1997-08-11 1997-08-11
PCT/CA1998/000765 WO1999007733A2 (en) 1997-08-11 1998-08-10 Hepatitis c inhibitor peptides

Publications (2)

Publication Number Publication Date
HUP0004853A2 true HUP0004853A2 (hu) 2001-05-28
HUP0004853A3 HUP0004853A3 (en) 2001-12-28

Family

ID=21996209

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0004853A HUP0004853A3 (en) 1997-08-11 1998-08-10 Hepatitis c inhibitor peptides, process for preparation thereof, pharmaceutical compositions comprising thereof, their use and their intermediates

Country Status (13)

Country Link
EP (1) EP1003775B1 (hu)
JP (1) JP4354632B2 (hu)
AT (1) ATE291032T1 (hu)
AU (1) AU757783B2 (hu)
CA (1) CA2294049A1 (hu)
DE (1) DE69829381T2 (hu)
DK (1) DK1003775T3 (hu)
ES (1) ES2241157T3 (hu)
HU (1) HUP0004853A3 (hu)
IL (1) IL134232A0 (hu)
NZ (1) NZ503262A (hu)
PT (1) PT1003775E (hu)
WO (1) WO1999007733A2 (hu)

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