HUP0004644A3 - Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase and pharmaceutical compositions containing them - Google Patents

Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase and pharmaceutical compositions containing them

Info

Publication number: HUP0004644A3
Authority: HU; Hungary
Prior art keywords: inhibitors; pharmaceutical compositions; compositions containing; neutrophil elastase; pyrrolopyrrolone
Prior art date: 1997-09-09

Application number

HU0004644A

Other languages

Hungarian (hu)

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-09-09

Filing date

1998-09-07

Publication date

2002-01-28

1997-09-09 Priority claimed from GBGB9719189.4A external-priority patent/GB9719189D0/en

1997-09-09 Priority claimed from GBGB9719183.7A external-priority patent/GB9719183D0/en

1997-09-10 Priority claimed from GBGB9719290.0A external-priority patent/GB9719290D0/en

1998-02-21 Priority claimed from GBGB9803611.4A external-priority patent/GB9803611D0/en

1998-09-07 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

2001-09-28 Publication of HUP0004644A2 publication Critical patent/HUP0004644A2/en

2002-01-28 Publication of HUP0004644A3 publication Critical patent/HUP0004644A3/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Hydrogenated Pyridines (AREA)

HU0004644A 1997-09-09 1998-09-07 Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase and pharmaceutical compositions containing them HUP0004644A3 (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
GBGB9719189.4A GB9719189D0 (en)	1997-09-09	1997-09-09	New therapeutic method
GBGB9719183.7A GB9719183D0 (en)	1997-09-09	1997-09-09	Compounds
GBGB9719290.0A GB9719290D0 (en)	1997-09-10	1997-09-10	Compounds
GBGB9803611.4A GB9803611D0 (en)	1998-02-21	1998-02-21	Compounds
PCT/EP1998/005609 WO1999012933A2 (en)	1997-09-09	1998-09-07	Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase

Publications (2)

Publication Number	Publication Date
HUP0004644A2 HUP0004644A2 (en)	2001-09-28
HUP0004644A3 true HUP0004644A3 (en)	2002-01-28

Family

ID=27451698

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU0004644A HUP0004644A3 (en)	1997-09-09	1998-09-07	Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase and pharmaceutical compositions containing them

Country Status (24)

Country	Link
EP (1)	EP1003748A2 (en)
JP (1)	JP2001515904A (en)
KR (1)	KR20010023766A (en)
CN (1)	CN1278820A (en)
AP (1)	AP2000001761A0 (en)
AR (1)	AR017072A1 (en)
AU (1)	AU9741298A (en)
BR (1)	BR9812062A (en)
CA (1)	CA2303176A1 (en)
CO (1)	CO4970719A1 (en)
EA (1)	EA200000204A1 (en)
EE (1)	EE200000138A (en)
HU (1)	HUP0004644A3 (en)
ID (1)	ID24452A (en)
IL (1)	IL134791A0 (en)
IS (1)	IS5391A (en)
MA (1)	MA26543A1 (en)
NO (1)	NO20001198L (en)
NZ (1)	NZ503130A (en)
PE (1)	PE107899A1 (en)
PL (1)	PL339176A1 (en)
SK (1)	SK3192000A3 (en)
TR (1)	TR200000907T2 (en)
WO (1)	WO1999012933A2 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9905418D0 (en) *	1999-03-09	1999-05-05	Glaxo Group Ltd	Process
JP2007531755A (en)	2004-03-31	2007-11-08	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	Non-imidazole heterocyclic compounds
DE102004024772A1 (en) *	2004-05-17	2005-12-22	Grünenthal GmbH	Substituted 5-aminomethyl-1H-pyrrole-2-carboxamides
TWI355380B (en)	2004-05-27	2012-01-01	Nihon Nohyaku Co Ltd	Substituted pyrazinecarboxanilide derivatives or s
JP4853759B2 (en) *	2004-05-27	2012-01-11	日本農薬株式会社	Substituted pyrazinecarboxylic acid anilide derivatives or salts thereof, intermediates thereof, agricultural and horticultural agents, and methods of use thereof
GB2418427A (en)	2004-09-02	2006-03-29	Univ Cambridge Tech	Ligands for G-protein coupled receptors
EP1819681B1 (en)	2004-11-23	2009-08-12	Warner-Lambert Company LLC	7-(2h-pyrazol-3-yl)-3,5-dihydroxy-heptanoic acid derivatives as hmg co-a reductase inhibitors for the treatment of lipidemia
DK2024367T3 (en)	2006-05-04	2011-01-03	Pulmagen Therapeutics Inflammation Ltd	Tetrahydropyrrolopyrimide indions and their use as inhibitors of human neutrophil elastase
US8198288B2 (en)	2006-05-04	2012-06-12	Pulmagen Therapeutics (Inflammation) Limited	Tetrahydropyrrolopyrimidinediones and their use in therapy
GB2452696B (en)	2007-08-02	2009-09-23	Cambridge Entpr Ltd	3-(2',2'-dimethylpropanoylamino)-tetrahydropyridin-2-one and its use in pharmaceutical compositions
US7662967B2 (en)	2007-08-02	2010-02-16	Cambridge Enterprise Limited	Anti-inflammatory compounds and compositions
WO2009060206A1 (en) *	2007-11-07	2009-05-14	Argenta Discovery Limited	3,4,6,7-tetrahydro-1h-pyrrolo[3,4-d]pyrimidine-2,5-diones and their therapeutic use
US20110212181A1 (en) *	2010-02-26	2011-09-01	The University Of Hong Kong	Compositions and methods for treating chronic respiratory inflammation
EP4031138A1 (en)	2019-09-17	2022-07-27	Mereo Biopharma 4 Limited	Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease
PL4106757T3 (en)	2020-04-16	2024-01-22	Mereo Biopharma 4 Limited	Methods involving neutrophil elastase inhibitor alvelestat for treating respiratory disease mediated by alpha-1 antitrypsin deficiency
KR20240090272A (en)	2021-10-20	2024-06-21	메레오 바이오파마 4 리미티드	Neutrophil elastase inhibitors for use in the treatment of fibrosis

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9211783D0 (en) *	1992-06-04	1992-07-15	Ici Plc	Amide derivatives
GB9402680D0 (en) *	1994-02-11	1994-04-06	Zeneca Ltd	Pyrrolidine derivatives
NZ331490A (en) *	1996-03-28	2000-06-23	Glaxo Group Ltd	Pyrrolopyrrolone derivatives for the treatment or prophylaxis of inflammatory disease such as chronic bronchitis, obstructive pulmonary disease and asthma

1998
- 1998-09-04 PE PE1998000828A patent/PE107899A1/en not_active Application Discontinuation
- 1998-09-07 JP JP2000510740A patent/JP2001515904A/en active Pending
- 1998-09-07 SK SK319-2000A patent/SK3192000A3/en unknown
- 1998-09-07 HU HU0004644A patent/HUP0004644A3/en unknown
- 1998-09-07 CA CA002303176A patent/CA2303176A1/en not_active Abandoned
- 1998-09-07 AU AU97412/98A patent/AU9741298A/en not_active Abandoned
- 1998-09-07 IL IL13479198A patent/IL134791A0/en unknown
- 1998-09-07 TR TR2000/00907T patent/TR200000907T2/en unknown
- 1998-09-07 AR ARP980104458A patent/AR017072A1/en unknown
- 1998-09-07 AP APAP/P/2000/001761A patent/AP2000001761A0/en unknown
- 1998-09-07 MA MA25243A patent/MA26543A1/en unknown
- 1998-09-07 KR KR1020007002422A patent/KR20010023766A/en not_active Application Discontinuation
- 1998-09-07 BR BR9812062-0A patent/BR9812062A/en not_active Application Discontinuation
- 1998-09-07 EA EA200000204A patent/EA200000204A1/en unknown
- 1998-09-07 CN CN98810954A patent/CN1278820A/en active Pending
- 1998-09-07 NZ NZ503130A patent/NZ503130A/en unknown
- 1998-09-07 WO PCT/EP1998/005609 patent/WO1999012933A2/en not_active Application Discontinuation
- 1998-09-07 EE EEP200000138A patent/EE200000138A/en unknown
- 1998-09-07 EP EP98951348A patent/EP1003748A2/en not_active Withdrawn
- 1998-09-07 PL PL98339176A patent/PL339176A1/en not_active Application Discontinuation
- 1998-09-07 ID IDW20000445A patent/ID24452A/en unknown
- 1998-09-08 CO CO98051488A patent/CO4970719A1/en unknown
2000
- 2000-02-29 IS IS5391A patent/IS5391A/en unknown
- 2000-03-08 NO NO20001198A patent/NO20001198L/en not_active Application Discontinuation

Also Published As

Publication number	Publication date
NO20001198D0 (en)	2000-03-08
NZ503130A (en)	2001-08-31
WO1999012933A2 (en)	1999-03-18
IS5391A (en)	2000-02-29
PE107899A1 (en)	1999-11-17
EP1003748A2 (en)	2000-05-31
AR017072A1 (en)	2001-08-22
BR9812062A (en)	2000-09-26
CA2303176A1 (en)	1999-03-18
NO20001198L (en)	2000-05-08
AP2000001761A0 (en)	2000-03-31
ID24452A (en)	2000-07-20
EA200000204A1 (en)	2000-10-30
CN1278820A (en)	2001-01-03
KR20010023766A (en)	2001-03-26
EE200000138A (en)	2001-02-15
HUP0004644A2 (en)	2001-09-28
CO4970719A1 (en)	2000-11-07
PL339176A1 (en)	2000-12-04
JP2001515904A (en)	2001-09-25
MA26543A1 (en)	2004-12-20
SK3192000A3 (en)	2001-03-12
WO1999012933A3 (en)	1999-05-27
IL134791A0 (en)	2001-04-30
TR200000907T2 (en)	2000-11-21
AU9741298A (en)	1999-03-29

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