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HUP0003826A2 - Új triazolo [4,5-d] pirimidin-származékok, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények - Google Patents

Új triazolo [4,5-d] pirimidin-származékok, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0003826A2
HUP0003826A2 HU0003826A HUP0003826A HUP0003826A2 HU P0003826 A2 HUP0003826 A2 HU P0003826A2 HU 0003826 A HU0003826 A HU 0003826A HU P0003826 A HUP0003826 A HU P0003826A HU P0003826 A2 HUP0003826 A2 HU P0003826A2
Authority
HU
Hungary
Prior art keywords
alkyl
preparation
pharmaceutical compositions
pyrimidine derivatives
group
Prior art date
Application number
HU0003826A
Other languages
English (en)
Inventor
Roger Brown
Garry Pairaudeau
Original Assignee
Astra Pharmaceuticals Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Pharmaceuticals Ltd. filed Critical Astra Pharmaceuticals Ltd.
Publication of HUP0003826A2 publication Critical patent/HUP0003826A2/hu
Publication of HUP0003826A3 publication Critical patent/HUP0003826A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Use Of Switch Circuits For Exchanges And Methods Of Control Of Multiplex Exchanges (AREA)

Abstract

A találmány tárgyát (I) általános képletű vegyületek - ahol R1 különböző csoportokkal szubsztituált alkil- vagy fenilcsoport; R2 különböző csoportokkal szubsztituált alkil- vagy cikloalkilcsoport; R3 és R4 közül az egyik hidrogénatom, a másik hidroxicsoport; X hidroxi- vagy -NHR5 általános képletű csoport; R5 különböző csoportokkal szubsztituált alkilcsoport vagy egylaktámgyűrű; R6, R9, R12, R13, R14, R15 és R16 hidrogénatom vagy alkilcsoport; R10 és R11 hidrogénatom, alkil- vagy acilcsoport - és gyógyászatilagelfogadható sóik vagy szolvátjaik, az előállításukra szolgáló eljárás,valamint a fenti vegyületeket tartalmazó vérlemezke-aggregációt gátlóhatású gyógyszerkészítmények képezik. Ó
HU0003826A 1997-07-22 1998-07-15 Novel triazolo [4,5-b] pyrimidine derivatives, process for their preparation and pharmaceutical compositions thereof HUP0003826A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9702774A SE9702774D0 (sv) 1997-07-22 1997-07-22 Novel compounds
PCT/SE1998/001394 WO1999005144A1 (en) 1997-07-22 1998-07-15 Novel compounds

Publications (2)

Publication Number Publication Date
HUP0003826A2 true HUP0003826A2 (hu) 2001-04-28
HUP0003826A3 HUP0003826A3 (en) 2001-11-28

Family

ID=20407805

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0003826A HUP0003826A3 (en) 1997-07-22 1998-07-15 Novel triazolo [4,5-b] pyrimidine derivatives, process for their preparation and pharmaceutical compositions thereof

Country Status (21)

Country Link
US (1) US6166022A (hu)
EP (1) EP0998475B1 (hu)
JP (1) JP2001510843A (hu)
KR (1) KR20010022084A (hu)
CN (1) CN1270591A (hu)
AT (1) ATE216390T1 (hu)
AU (1) AU8370798A (hu)
BR (1) BR9811028A (hu)
CA (1) CA2296426A1 (hu)
DE (1) DE69804966T2 (hu)
EE (1) EE200000048A (hu)
HU (1) HUP0003826A3 (hu)
ID (1) ID25856A (hu)
IL (1) IL134111A0 (hu)
IS (1) IS5352A (hu)
NO (1) NO20000313L (hu)
PL (1) PL338181A1 (hu)
SE (1) SE9702774D0 (hu)
SK (1) SK188299A3 (hu)
TR (1) TR200000152T2 (hu)
WO (1) WO1999005144A1 (hu)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9702773D0 (sv) * 1997-07-22 1997-07-22 Astra Pharma Prod Novel compounds
US6369064B1 (en) * 1998-02-17 2002-04-09 Astrazeneca Ab Triazolo(4,5-d)pyrimidine compounds
US6593489B1 (en) 1999-09-09 2003-07-15 Chirotechtechnology Limited Substituted cyclopentenes, their preparation and their use for chiral scaffolds
SE9904129D0 (sv) * 1999-11-15 1999-11-15 Astra Pharma Prod Novel compounds
US7115585B2 (en) * 2000-08-21 2006-10-03 Inspire Pharmaceuticals, Inc. Compositions for treating epithelial and retinal tissue diseases
US7452870B2 (en) * 2000-08-21 2008-11-18 Inspire Pharmaceuticals, Inc. Drug-eluting stents coated with P2Y12 receptor antagonist compound
AR039558A1 (es) * 2000-08-21 2005-02-23 Inspire Pharmaceuticals Inc Composiciones y metodo para el tratamiento de glaucoma o hipertension ocular
US7018985B1 (en) 2000-08-21 2006-03-28 Inspire Pharmaceuticals, Inc. Composition and method for inhibiting platelet aggregation
US7132408B2 (en) * 2000-08-21 2006-11-07 Inspire Pharmaceuticals, Inc. Composition and method for inhibiting platelet aggregation
US6897201B2 (en) 2000-08-21 2005-05-24 Inspire Pharmaceuticals, Inc. Compositions and methods for the treatment of glaucoma or ocular hypertension
US7435724B2 (en) * 2002-02-27 2008-10-14 Inspire Pharmaceutical, Inc. Degradation-resistant mononucleoside phosphate compounds
KR20060113699A (ko) 2003-10-03 2006-11-02 포톨라 파마슈티컬스, 인코포레이티드 치환된 이소퀴놀리논
JP2007507551A (ja) 2003-10-03 2007-03-29 ポートラ ファーマシューティカルズ， インコーポレイテッド ２，４−ジオキソ−３−キナゾリニルアリールスルホニル尿素
DE602004027409D1 (de) 2003-10-21 2010-07-08 Inspire Pharmaceuticals Inc Tetrahydrofuroä3,4-düdioxolverbindungen und zusammensetzungen und verfahren zur inhibierung der trombozytenaggregation
US7504497B2 (en) 2003-10-21 2009-03-17 Inspire Pharmaceuticals, Inc. Orally bioavailable compounds and methods for inhibiting platelet aggregation
US7749981B2 (en) 2003-10-21 2010-07-06 Inspire Pharmaceuticals, Inc. Drug-eluting stents coated with non-nucleotide P2Y12 receptor antagonist compound
US7335648B2 (en) 2003-10-21 2008-02-26 Inspire Pharmaceuticals, Inc. Non-nucleotide composition and method for inhibiting platelet aggregation
KR20070064356A (ko) 2004-09-29 2007-06-20 포톨라 파마슈티컬스, 인코포레이티드 치환된 2ｈ-1,3-벤족사진-4(3ｈ)온
US7932376B2 (en) 2005-05-05 2011-04-26 Inspire Pharmaceuticals, Inc. Pyrimidine-based non-nucleotide composition and method for inhibiting platelet aggregation
WO2007020935A1 (ja) * 2005-08-17 2007-02-22 Ono Pharmaceutical Co., Ltd. Ｐ２ｙ１２受容体および／またはｐ２ｙ１４受容体ブロッカーを含有してなる疼痛治療剤
TW200728260A (en) 2005-11-03 2007-08-01 Portola Pharm Inc Substituted-(quinazolinyl)phenyl thiophenyl-sulfonylureas, methods for making and intermediates thereof
EP2081433A2 (en) * 2006-10-31 2009-07-29 Janssen Pharmaceutica N.V. Triazolopyrimidine derivatives as adp p2y12 receptor antagonists
US9725479B2 (en) 2010-04-22 2017-08-08 Ionis Pharmaceuticals, Inc. 5′-end derivatives
IN2012CN10271A (hu) * 2010-05-27 2015-04-10 Reddy’S Lab Ltd Dr
US9458244B2 (en) 2012-12-28 2016-10-04 Abbvie Inc. Single chain multivalent binding protein compositions and methods

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4742064A (en) * 1985-09-10 1988-05-03 Regents Of The University Of Minnesota Antiviral carbocyclic analogs of xylofuranosylpurines
GB8826205D0 (en) * 1988-11-09 1988-12-14 Wellcome Found Heterocyclic compounds
JPH08506343A (ja) * 1993-02-03 1996-07-09 ジェンシア・インコーポレイテッド リキソフラノシル誘導体を含むアデノシンキナーゼ阻害物質
JP4084415B2 (ja) * 1995-07-11 2008-04-30 アストラゼネカ・アクチエボラーグ 新しい血小板凝集抑制剤

Also Published As

Publication number Publication date
IS5352A (is) 2000-01-19
CN1270591A (zh) 2000-10-18
SK188299A3 (en) 2000-08-14
JP2001510843A (ja) 2001-08-07
EP0998475B1 (en) 2002-04-17
PL338181A1 (en) 2000-10-09
CA2296426A1 (en) 1999-02-04
IL134111A0 (en) 2001-04-30
DE69804966D1 (de) 2002-05-23
WO1999005144A1 (en) 1999-02-04
NO20000313L (no) 2000-03-22
EP0998475A1 (en) 2000-05-10
NO20000313D0 (no) 2000-01-21
SE9702774D0 (sv) 1997-07-22
EE200000048A (et) 2000-10-16
ID25856A (id) 2000-11-09
KR20010022084A (ko) 2001-03-15
AU8370798A (en) 1999-02-16
ATE216390T1 (de) 2002-05-15
TR200000152T2 (tr) 2000-07-21
BR9811028A (pt) 2000-08-01
HUP0003826A3 (en) 2001-11-28
US6166022A (en) 2000-12-26
DE69804966T2 (de) 2002-11-07

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