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HUP0002905A2 - 2-{4-[-(4,5-dichloro-2-methylimidazol-1-yl)butyl]-1-piperazinyl}-5-fluoropyrimidine, its preparation and its therapeutic use - Google Patents

2-{4-[-(4,5-dichloro-2-methylimidazol-1-yl)butyl]-1-piperazinyl}-5-fluoropyrimidine, its preparation and its therapeutic use

Info

Publication number
HUP0002905A2
HUP0002905A2 HU0002905A HUP0002905A HUP0002905A2 HU P0002905 A2 HUP0002905 A2 HU P0002905A2 HU 0002905 A HU0002905 A HU 0002905A HU P0002905 A HUP0002905 A HU P0002905A HU P0002905 A2 HUP0002905 A2 HU P0002905A2
Authority
HU
Hungary
Prior art keywords
methylimidazol
fluoropyrimidine
piperazinyl
dichloro
butyl
Prior art date
Application number
HU0002905A
Other languages
Hungarian (hu)
Inventor
Jordí Frigola-Constansa
Ramon Merce-Vidal
Original Assignee
Laboratorios Del Dr. Esteve, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Del Dr. Esteve, S.A. filed Critical Laboratorios Del Dr. Esteve, S.A.
Publication of HUP0002905A2 publication Critical patent/HUP0002905A2/en
Publication of HUP0002905A3 publication Critical patent/HUP0002905A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Nutrition Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A találmány az (I) képletű új 2-{4-[4-(4,5-diklór-2-metilimidazol-1-il)-butil]-1-piperazinil}-5-fluor-pirimidinre, ennek gyógyászatilagelfogadható sóira, ilyen vegyületek előállítására, valamint ilyenvegyületeknek a humán és/vagy állatgyógyászatban hasznosítható,különösen szédülés, útibetegség (hányinger), depresszió, szorongás,túlzott gyomorsav-kiválasztás, obszesszív vagy kompulzívrendellenességek, pánikrohamok és alvás közbeni légzési zavarokkezelésére alkalmas gyógyászati készítmények előállításánál valóalkalmazására vonatkozik. ÓThe invention relates to the new 2-{4-[4-(4,5-dichloro-2-methylimidazol-1-yl)-butyl]-1-piperazinyl}-5-fluoropyrimidine of the formula (I), its pharmaceutically acceptable salts, refers to the production of such compounds, as well as to the use of such compounds in the production of medicinal preparations useful in human and/or veterinary medicine, particularly suitable for the treatment of dizziness, motion sickness (nausea), depression, anxiety, excessive gastric acid secretion, obsessive or compulsive disorders, panic attacks and breathing disorders during sleep. HE

HU0002905A 1997-06-02 1998-05-28 2-{4-[-(4,5-dichloro-2-methylimidazol-1-yl)butyl]-1-piperazinyl}-5-fluoropyrimidine, its preparation and its therapeutic use HUP0002905A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9706738A FR2763950B1 (en) 1997-06-02 1997-06-02 2- {4- [4- (4,5-DICHLORO-2-METHYLIMIDAZOL-1-YL) BUTYL] -1- PIPERAZINYL} -5-FLUOROPYRIMIDINE, ITS PREPARATION AND THERAPEUTIC USE
PCT/EP1998/003190 WO1998055476A1 (en) 1997-06-02 1998-05-28 2-{4-[4-(4,5-dichloro-2- methylimidazol-1-yl)butyl] -1-piperazinyl}-5-fluoropyrimidine, preparation and therapeutic use

Publications (2)

Publication Number Publication Date
HUP0002905A2 true HUP0002905A2 (en) 2001-06-28
HUP0002905A3 HUP0002905A3 (en) 2002-01-28

Family

ID=9507480

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0002905A HUP0002905A3 (en) 1997-06-02 1998-05-28 2-{4-[-(4,5-dichloro-2-methylimidazol-1-yl)butyl]-1-piperazinyl}-5-fluoropyrimidine, its preparation and its therapeutic use

Country Status (22)

Country Link
US (2) US6303608B1 (en)
EP (1) EP1007522B1 (en)
JP (1) JP4344890B2 (en)
KR (1) KR100556559B1 (en)
CN (1) CN1094491C (en)
AT (1) ATE228126T1 (en)
AU (1) AU732722B2 (en)
BR (1) BR9810240A (en)
CA (1) CA2292746A1 (en)
DE (1) DE69809564T2 (en)
DK (1) DK1007522T3 (en)
ES (1) ES2149691B1 (en)
FR (1) FR2763950B1 (en)
HU (1) HUP0002905A3 (en)
IL (1) IL133216A0 (en)
NO (1) NO318757B1 (en)
NZ (1) NZ501566A (en)
PL (1) PL190777B1 (en)
PT (1) PT1007522E (en)
RU (1) RU2191184C2 (en)
TR (1) TR199903001T2 (en)
WO (1) WO1998055476A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101152658B1 (en) * 2009-04-30 2012-06-18 한국과학기술연구원 Pharmaceutical compositions containing piperazine derivatives for treating as serotonin antagonist
RU2660583C1 (en) * 2017-08-15 2018-07-06 Общество С Ограниченной Ответственностью "Валента - Интеллект" Use of buspirone for the treatment of functional dizziness

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2642759B1 (en) * 1989-02-09 1991-05-17 Laboratorios Esteve Sa PYRIMIDYL-PIPERAZINYL-ALKYL AZOLES DERIVATIVES WITH ANXIOLYTIC AND / OR TRANQUILIZING ACTIVITY
FR2672052B1 (en) * 1991-01-28 1995-05-24 Esteve Labor Dr DERIVATIVES OF ARYL (OR HETEROARYL) -PIPERAZINYL-ALKYL-AZOLES, THEIR PREPARATION AND THEIR APPLICATION AS MEDICAMENTS.
FR2673628B1 (en) * 1991-03-07 1993-07-09 Esteve Labor Dr PROCESS FOR THE PREPARATION OF ARYL (OR HETEROARYL) -PIPERAZINYL-BUTYL-AZOLES DERIVATIVES.
FR2712808B1 (en) * 1993-11-25 1996-02-16 Esteve Labor Dr Use of 1- {4- [4-aryl (or heteroaryl) -1-piperazinyl] -butyl} -1-H-azole derivatives for the preparation of medicaments for the treatment of disorders of gastric secretion.
FR2742052B1 (en) * 1995-12-12 1998-04-10 Esteve Labor Dr USE OF DERIVATIVES 1- (4- (4-ARYL (OR HETEROARYL) -1-PIPER AZINYL) -BUTY) -1H-AZOLE FOR THE TREATMENT OF DEPRESSION, OBSESSIVE COMPULSIVE DISORDERS, SLEEP APNEA, SEXUAL DYSFUNCTIONS , Emese and motion sickness

Also Published As

Publication number Publication date
JP2002501539A (en) 2002-01-15
DK1007522T3 (en) 2003-03-17
EP1007522A1 (en) 2000-06-14
WO1998055476A1 (en) 1998-12-10
CN1261888A (en) 2000-08-02
FR2763950B1 (en) 2002-09-20
TR199903001T2 (en) 2000-07-21
ATE228126T1 (en) 2002-12-15
KR20010013274A (en) 2001-02-26
PL337113A1 (en) 2000-07-31
NO318757B1 (en) 2005-05-02
NO995894D0 (en) 1999-12-01
KR100556559B1 (en) 2006-03-06
AU7917098A (en) 1998-12-21
ES2149691B1 (en) 2001-05-16
DE69809564D1 (en) 2003-01-02
IL133216A0 (en) 2001-03-19
EP1007522B1 (en) 2002-11-20
JP4344890B2 (en) 2009-10-14
FR2763950A1 (en) 1998-12-04
CA2292746A1 (en) 1998-12-10
DE69809564T2 (en) 2003-07-10
CN1094491C (en) 2002-11-20
AU732722B2 (en) 2001-04-26
NO995894L (en) 2000-02-01
US6346620B1 (en) 2002-02-12
PT1007522E (en) 2003-04-30
ES2149691A1 (en) 2000-11-01
NZ501566A (en) 2001-06-29
BR9810240A (en) 2000-09-05
PL190777B1 (en) 2006-01-31
HUP0002905A3 (en) 2002-01-28
RU2191184C2 (en) 2002-10-20
US6303608B1 (en) 2001-10-16

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Legal Events

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FD9A Lapse of provisional protection due to non-payment of fees