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HUP0002861A2 - Benzotiofénszármazékok és ezeket tartalmazó készítmények - Google Patents

Benzotiofénszármazékok és ezeket tartalmazó készítmények

Info

Publication number
HUP0002861A2
HUP0002861A2 HU0002861A HUP0002861A HUP0002861A2 HU P0002861 A2 HUP0002861 A2 HU P0002861A2 HU 0002861 A HU0002861 A HU 0002861A HU P0002861 A HUP0002861 A HU P0002861A HU P0002861 A2 HUP0002861 A2 HU P0002861A2
Authority
HU
Hungary
Prior art keywords
group
formula
hydrogen atom
alkyl group
alkyl
Prior art date
Application number
HU0002861A
Other languages
English (en)
Inventor
Anna Bosch Rovira
Juan Castillo Nieto
Joaquin Del Rio Zambrana
Berta Lasheras Aldaz
Antonio Monge Vega
Juan Antonio Palop Cubillo
Juan Roca Acin
Original Assignee
Vita-Invest, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vita-Invest, S.A. filed Critical Vita-Invest, S.A.
Publication of HUP0002861A2 publication Critical patent/HUP0002861A2/hu
Publication of HUP0002861A3 publication Critical patent/HUP0002861A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/28—Halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/42—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms with nitro or nitroso radicals directly attached to ring carbon atoms
    • C07D333/44—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms with nitro or nitroso radicals directly attached to ring carbon atoms attached in position 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/64—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Saccharide Compounds (AREA)
  • Cosmetics (AREA)

Abstract

A találmány szerinti vegyületek (I) általános képletében Z jelentése -CO-, -CH(OR6)- vagy -C(NOR7)- képletű csoport, R1 jelentésehidrogénatom, alkilcsoport, halogénatom vagy -OR8 képletű csoport, R2és R3 jelentése hidrogénatom, alkilcsoport, halogénatom, -OR8 képletűcsoport, nitrocsoport, cianocsoport, -NR9Rl0, -COR8, -CO2R8, -SO2NR9Rl0, -SO2R8, -SR8 vagy -CONR9Rl0 képletű csoport, R4 és R5jelentése hidrogénatom, alkilcsoport, halogénatom, halogén-alkil-csoport, -OR8 képletű csoport, nitrocsoport, -NR9Rl0, -COR8, -CO2R8, -SO2NR9R10, -SO2R8 vagy -SR8 képletű csoport, cianocsoport vagy -CONR9R10 képletű csoport, vagy R4, és R5 jelentése együtt benzolgyűrű,R6 jelentése hidrogénatom, alkilcsoport, -CO2R8 vagy -C(O)NR9R10képletű csoport, naftilcsoport vagy fenilcsoport, R7 jelentésehidrogénatom vagy alkilcsoport, R8 jelentése hidrogénatom,alkilcsoport vagy fenilcsoport, R9 és R10 jelentése hidrogénatom, alkilcsoport vagy fenilcsoport,vagy R9 és R10 jelentése együtt 5- vagy 6-tagú gyűrű. A találmánykiterjed a fenti vegyületeket tartalmazó gyógyszerkészítményekre,melyek félelmi állapotok és/vagy depresszió kezelésére alkalmasak. Ó
HU0002861A 1997-07-08 1998-07-01 Benzothiophene derivatives, and compositions containing the same HUP0002861A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES009701517A ES2128266B1 (es) 1997-07-08 1997-07-08 Compuestos derivados de tiofeno y benzotiofeno y utilizacion y composicion correspondientes.
PCT/ES1998/000191 WO1999002516A1 (es) 1997-07-08 1998-07-01 Compuestos derivados de tiofeno y benzotiofeno y utilizacion y composicion correspondientes

Publications (2)

Publication Number Publication Date
HUP0002861A2 true HUP0002861A2 (hu) 2001-08-28
HUP0002861A3 HUP0002861A3 (en) 2001-09-28

Family

ID=8299986

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0002861A HUP0002861A3 (en) 1997-07-08 1998-07-01 Benzothiophene derivatives, and compositions containing the same

Country Status (21)

Country Link
US (1) US6262056B1 (hu)
EP (1) EP1008594B1 (hu)
JP (1) JP2002511883A (hu)
KR (1) KR20010021632A (hu)
CN (1) CN1125821C (hu)
AT (1) ATE261956T1 (hu)
AU (1) AU735637B2 (hu)
BR (1) BR9810557A (hu)
CA (1) CA2295715A1 (hu)
DE (1) DE69822478D1 (hu)
EA (1) EA002687B1 (hu)
ES (1) ES2128266B1 (hu)
HU (1) HUP0002861A3 (hu)
IL (1) IL133566A (hu)
IS (1) IS5328A (hu)
NZ (1) NZ502128A (hu)
OA (1) OA11274A (hu)
PL (1) PL337930A1 (hu)
SK (1) SK272000A3 (hu)
TR (1) TR200000058T2 (hu)
WO (1) WO1999002516A1 (hu)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001007431A2 (en) * 1999-07-21 2001-02-01 Eli Lilly And Company Benzothiophene derivatives
CA2395705C (en) * 1999-12-30 2006-10-17 H. Lundbeck A/S Substituted phenyl-piperazine derivatives, their preparation and use
DE10043659A1 (de) * 2000-09-05 2002-03-14 Merck Patent Gmbh Arylpiperazinderivate
ES2188344B1 (es) * 2000-11-29 2004-09-16 Laboratorios Vita, S.A. Compuestos derivados de benzotiofeno, su procedimiento de obtencion y utilizacion de los mismos.
AU2004204827B2 (en) 2003-01-13 2006-06-29 Dynogen Pharmaceuticals, Inc. Method of treating nausea, vomiting, retching or any combination thereof
WO2004082686A2 (en) * 2003-03-13 2004-09-30 Dynogen Pharmaceuticals, Inc. Use of compounds with combined 5-ht1a and ssri activities to treat sexual dysfunction
TWI320783B (en) 2005-04-14 2010-02-21 Otsuka Pharma Co Ltd Heterocyclic compound
RU2460731C2 (ru) * 2007-05-14 2012-09-10 Ск Байофармасьютикалз Ко., Лтд. Карбамоилоксиарилалканоиларилпиперазиновое соединение, фармацевтические композиции, содержащие его, и способ лечения боли, беспокойства и депрессии
CN101613347B (zh) * 2008-06-23 2012-07-04 中国人民解放军军事医学科学院毒物药物研究所 胺类化合物及其医药用途
CN101619056B (zh) 2008-07-02 2013-07-17 石药集团中奇制药技术（石家庄）有限公司 苯并噻吩烷醇哌嗪衍生物及其作为抗抑郁症药物的应用
WO2011106039A1 (en) * 2010-02-24 2011-09-01 Research Triangle Institute Arylpiperazone opioid receptor antagonists
EP3083589B1 (en) 2013-12-20 2019-12-18 Sunshine Lake Pharma Co., Ltd. Substituted piperazine compounds and methods of use thereof
WO2021152113A1 (en) 2020-01-31 2021-08-05 Bayer Aktiengesellschaft Substituted 2,3-benzodiazepines derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2979507A (en) * 1959-03-26 1961-04-11 Paul Adriaan J Janssen 1-(2-thenoyl) alkyl-4-arylpiperazines
US3002976A (en) * 1959-10-12 1961-10-03 Paul A J Janssen 1-(2-thienyl)-omega-(4-arylpiperazine)alkanols
GB1096341A (en) * 1965-03-09 1967-12-29 Mauvernay Roland Yves Novel derivatives of the phenyl-piperazine series and process for their preparation
US4515793A (en) * 1983-07-27 1985-05-07 Edna Mcconnell Clark Foundation Phenylpiperazines which are useful in the treatment of schistosomiasis
EP0596120A4 (en) * 1991-08-09 1994-07-06 Yoshitomi Pharmaceutical Thiophene compound.
FR2692264B1 (fr) * 1992-06-12 1994-08-05 Adir Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant.
US5632898A (en) * 1996-08-13 1997-05-27 Isis Pharmaceuticals, Inc. Method for removing unreacted electrophiles from a reaction mixture

Also Published As

Publication number Publication date
EP1008594B1 (en) 2004-03-17
BR9810557A (pt) 2000-08-08
EP1008594A1 (en) 2000-06-14
ATE261956T1 (de) 2004-04-15
AU8111398A (en) 1999-02-08
EA002687B1 (ru) 2002-08-29
HUP0002861A3 (en) 2001-09-28
US6262056B1 (en) 2001-07-17
CA2295715A1 (en) 1999-01-21
WO1999002516A1 (es) 1999-01-21
SK272000A3 (en) 2000-07-11
IS5328A (is) 1999-12-29
OA11274A (en) 2003-07-29
JP2002511883A (ja) 2002-04-16
IL133566A0 (en) 2001-04-30
EA200000101A1 (ru) 2000-08-28
ES2128266B1 (es) 2000-01-16
IL133566A (en) 2003-10-31
KR20010021632A (ko) 2001-03-15
ES2128266A1 (es) 1999-05-01
AU735637B2 (en) 2001-07-12
NZ502128A (en) 2001-09-28
CN1265106A (zh) 2000-08-30
DE69822478D1 (de) 2004-04-22
PL337930A1 (en) 2000-09-11
CN1125821C (zh) 2003-10-29
TR200000058T2 (tr) 2000-09-21

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