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HUP0001998A2 - Arginin-szilikát-inozit komplex és alkalmazása - Google Patents

Arginin-szilikát-inozit komplex és alkalmazása

Info

Publication number
HUP0001998A2
HUP0001998A2 HU0001998A HUP0001998A HUP0001998A2 HU P0001998 A2 HUP0001998 A2 HU P0001998A2 HU 0001998 A HU0001998 A HU 0001998A HU P0001998 A HUP0001998 A HU P0001998A HU P0001998 A2 HUP0001998 A2 HU P0001998A2
Authority
HU
Hungary
Prior art keywords
complex
silicate
arginine
inositol
prevention
Prior art date
Application number
HU0001998A
Other languages
English (en)
Inventor
Mark Mccarty
Jan Zielinski
Original Assignee
Nutrition 21
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nutrition 21 filed Critical Nutrition 21
Publication of HUP0001998A2 publication Critical patent/HUP0001998A2/hu
Publication of HUP0001998A3 publication Critical patent/HUP0001998A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/695—Silicon compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/04—Esters of silicic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A találmány tárgya arginin-szilikát komplex és annak alkalmazásaateroszklerózis megelőzésére és kezelésére, étrendi kiegészítőként,valamint csontok és porc szerkezeti épségének az elősegítésére.Közelebbről, a találmány szerinti arginin-szilikát-inozit komplexet akövetkező lépésekben állítják elő: (a) arginin, szilikátsó és inozitösszekeverésével szuszpenziót alakítanak ki; (b) a szuszpenziót agélképződés elősegítésére melegítik; (c) a gélt kristályosodnihagyják; (d) a (c) lépésben képződött kristályokat valamilyenalkohollal keverve a kristályosodást elősegítik; és (e) a (d) lépésbenkialakult kristályokat összegyűjtik. Szilikátsóként előnyösen kálium-szilikátot, a komplex harmadik tagjaként általában inozitotalkalmaznak. A találmány a csont ásványanyag-veszteségét megszüntető,valamint a porc lebomlását gátló olyan gyógyászati készítményekre isvonatkozik, amelyek a találmány szerinti komplex terápiásan hatásosmennyiségét egy gyógyászati szempontból elfogadható vivőanyaggal vagyhígítószerrel együtt tartalmazzák. E készítményt előnyösen orálisanvagy parenterálisan adagolják. A találmány szerinti komplex, illetvekészítmény elsősorban a csont ásványanyag-veszteségének megelőzésérevagy gátlására, valamint csontritkulás és ateroszklerózis kezelésére,illetve megelőzésére alkalmazható. Ó
HU0001998A 1997-02-12 1998-02-11 Arginine silicate inositol complex and use thereof HUP0001998A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/799,784 US5707970A (en) 1997-02-12 1997-02-12 Arginine silicate complex and use thereof
PCT/US1998/002443 WO1998034647A1 (en) 1997-02-12 1998-02-11 Arginine silicate inositol complex and use thereof

Publications (2)

Publication Number Publication Date
HUP0001998A2 true HUP0001998A2 (hu) 2000-10-28
HUP0001998A3 HUP0001998A3 (en) 2002-01-28

Family

ID=25176739

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0001998A HUP0001998A3 (en) 1997-02-12 1998-02-11 Arginine silicate inositol complex and use thereof

Country Status (16)

Country Link
US (3) US5707970A (hu)
EP (1) EP1007096B1 (hu)
JP (1) JP2001512443A (hu)
KR (1) KR20000070977A (hu)
CN (1) CN1182873C (hu)
AT (1) ATE251914T1 (hu)
AU (1) AU722975B2 (hu)
BR (1) BR9807675A (hu)
CA (1) CA2279233A1 (hu)
DE (1) DE69819016T2 (hu)
DK (1) DK1007096T3 (hu)
ES (1) ES2209112T3 (hu)
HU (1) HUP0001998A3 (hu)
IL (1) IL130925A0 (hu)
PT (1) PT1007096E (hu)
WO (1) WO1998034647A1 (hu)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5707970A (en) 1997-02-12 1998-01-13 Nutrition 21 Arginine silicate complex and use thereof
US20020068365A1 (en) * 1998-07-28 2002-06-06 Eric H. Kuhrts Controlled release nitric oxide producing agents
WO2002008175A2 (en) * 2000-07-24 2002-01-31 Nutrition 21, Inc. Arginine saccharate and use thereof
US6552074B2 (en) * 2000-11-16 2003-04-22 Fukumi Morishige Arginine/ascorbic acid mixed powder as an oral supplement
TWI283427B (en) * 2001-07-12 2007-07-01 Semiconductor Energy Lab Display device using electron source elements and method of driving same
US7147661B2 (en) * 2001-12-20 2006-12-12 Boston Scientific Santa Rosa Corp. Radially expandable stent
CA2468951A1 (en) * 2001-12-20 2003-07-03 Trivascular, Inc. Advanced endovascular graft
US20040097467A1 (en) * 2002-08-22 2004-05-20 Vijaya Juturu Arginine silicate inositol complex and use thereof
US6803456B1 (en) * 2003-08-13 2004-10-12 Rutherford Chemicals Llc Process for the production of arginine-silicate complex
US7803178B2 (en) * 2004-01-30 2010-09-28 Trivascular, Inc. Inflatable porous implants and methods for drug delivery
JP4852033B2 (ja) * 2004-03-11 2012-01-11 トリバスキュラー インコーポレイテッド モジュール式血管内移植片
WO2006129353A1 (ja) * 2005-06-01 2006-12-07 Coral Biotech Kabushiki Kaisha 新規な血圧上昇抑制剤
ITMI20060677A1 (it) * 2006-04-06 2007-10-07 Damor Farmaceutici Profarmaci dell'arginina ad elevata attivita'terapeutica
US20100143488A1 (en) * 2006-09-21 2010-06-10 Toshiki Oguro Promoter of hard tissue regeneration
PL2134351T3 (pl) 2007-03-13 2017-10-31 Jds Therapeutics Llc Sposoby i kompozycje do przedłużonego uwalniania chromu
WO2009002867A2 (en) 2007-06-26 2008-12-31 Nutrition 21, Inc. Multiple unit dosage form having a therapeutic agents in combination with a nutritional supplement
GB0805279D0 (en) * 2008-03-20 2008-04-30 Univ Nottingham Trent Food supplement
WO2012035364A1 (en) 2010-09-15 2012-03-22 Creogen D.O.O. Stabilized solution of ortho-silicic acid, its preparation and use
JP6152346B2 (ja) 2011-03-01 2017-06-21 ジェーディーエス セラピューティックス、エルエルシーＪＤＳ Ｔｈｅｒａｐｅｕｔｉｃｓ，ＬＬＣ 糖尿病、低血糖、および関連障害の治療および予防のためのインスリンとクロムの組成物
US11191735B2 (en) 2015-03-13 2021-12-07 Nutrition 21, Llc Arginine silicate for periodontal disease
WO2017004226A1 (en) * 2015-06-30 2017-01-05 Jds Therepeutics, Llc Arginine silicate inositol for improving cognitive function
US10703608B2 (en) 2015-07-13 2020-07-07 Otis Elevator Company Deterrent device inhibition key
US20170135969A1 (en) 2015-11-12 2017-05-18 Jds Therapeutics, Llc Topical arginine-silicate-inositol for wound healing
EP3413900A1 (en) 2016-02-11 2018-12-19 Nutrition 21, LLC Chromium containing compositions for improving health and fitness
EP3506895A4 (en) 2016-09-01 2020-04-15 JDS Therapeutics, LLC MAGNESIUM BIOTINATE COMPOSITIONS AND METHODS OF USE
CA3118583C (en) 2018-11-02 2024-05-14 Nutrition 21, Llc Compositions containing inositol-stabilized arginine silicate complexes and inositol for improving cognitive function in video gamers
GB2613672A (en) 2019-12-16 2023-06-14 Nutrition 21 Llc Methods of production of aginine-silicate complexes
CA3237984A1 (en) * 2021-11-12 2023-05-19 Nutrition21, LLC Compositions and methods for treating or preventing myopathy in poultry

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3337403A (en) * 1963-09-05 1967-08-22 Hoffmann La Roche Stable and palatable pharmaceutical compositions
US4297349A (en) * 1980-04-15 1981-10-27 Sandoz, Inc. Silicon-bearing carboxylic acids and amides
US4385052A (en) * 1981-07-20 1983-05-24 International Plant Research Institute, Inc. Use of trialkylsilyl-6-aminonicotinamides for the treatment of psoriasis
FR2610522B1 (fr) * 1987-02-06 1989-08-18 Gueyne Jean Produit therapeutique a base de derives organiques du silicium
US5250569A (en) * 1991-04-22 1993-10-05 Godfrey Science & Design, Inc. Amino acid flavorings of aluminum astringent for oral use
US5622980A (en) * 1993-08-17 1997-04-22 Applied Analytical Industries, Inc. Oral compositions of H2-antagonists
FR2745498A1 (fr) * 1996-02-29 1997-09-05 Giroux Jean Marc Composition pur augmenter conjointement la tolerance biologique et l'efficacite amincissante des produits hyperproteines hypocaloriques destines au traitement de l'obesite
US5707970A (en) * 1997-02-12 1998-01-13 Nutrition 21 Arginine silicate complex and use thereof

Also Published As

Publication number Publication date
IL130925A0 (en) 2001-01-28
KR20000070977A (ko) 2000-11-25
DE69819016D1 (de) 2003-11-20
ES2209112T3 (es) 2004-06-16
AU722975B2 (en) 2000-08-17
JP2001512443A (ja) 2001-08-21
US5707970A (en) 1998-01-13
AU6273798A (en) 1998-08-26
CA2279233A1 (en) 1998-08-13
DE69819016T2 (de) 2004-04-29
EP1007096B1 (en) 2003-10-15
HUP0001998A3 (en) 2002-01-28
BR9807675A (pt) 2000-02-15
US6344444B1 (en) 2002-02-05
ATE251914T1 (de) 2003-11-15
US6156735A (en) 2000-12-05
CN1246801A (zh) 2000-03-08
PT1007096E (pt) 2004-03-31
CN1182873C (zh) 2005-01-05
WO1998034647A1 (en) 1998-08-13
EP1007096A1 (en) 2000-06-14
DK1007096T3 (da) 2003-12-01

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