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HUP0001111A2 - Arilszulfonamidok és analógjaik, valamint alkalmazásuk neurovegetatív megbetegedések kezelésére - Google Patents

Arilszulfonamidok és analógjaik, valamint alkalmazásuk neurovegetatív megbetegedések kezelésére

Info

Publication number
HUP0001111A2
HUP0001111A2 HU0001111A HUP0001111A HUP0001111A2 HU P0001111 A2 HUP0001111 A2 HU P0001111A2 HU 0001111 A HU0001111 A HU 0001111A HU P0001111 A HUP0001111 A HU P0001111A HU P0001111 A2 HUP0001111 A2 HU P0001111A2
Authority
HU
Hungary
Prior art keywords
alkyl
acyl
optionally substituted
halo
aryl
Prior art date
Application number
HU0001111A
Other languages
English (en)
Inventor
Jean-Marie-Victor De Vry
Jürgen Dressel
Jürgen Franz
Arno Friedl
Ervin Horvath
Reinhard Jork
Jörg Keldenich
Michael Matzke
Frank Mauler
Joachim Mittendorf
Klaus-Helmut Mohrs
Siegfried Raddatz
Michael-Harold Rock
Joachim Schuhmacher
Peter Spreyer
Verena Vöhringer
Original Assignee
Bayer Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19740785A external-priority patent/DE19740785A1/de
Application filed by Bayer Ag. filed Critical Bayer Ag.
Publication of HUP0001111A2 publication Critical patent/HUP0001111A2/hu
Publication of HUP0001111A3 publication Critical patent/HUP0001111A3/hu
Publication of HU228509B1 publication Critical patent/HU228509B1/hu

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    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C317/18—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
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    • C07C217/90—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to a carbon atom of a six-membered aromatic ring, e.g. amino-diphenylethers
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    • C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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    • C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
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Abstract

Atalálmány R1-A-D-E-G-L-R2 (I) általánős képletű arilszűlfőnamidőkra,analógjaikra, előállításűkra és neűrődegenerációs megbetegedésekmegelőzésére és kezelésére, különösen a gűtaütés és kőpőnya/agysérülések kezelésére való alkalmazásűkra vőnatkőzik. ŕ
HU0001111A 1997-02-21 1998-02-10 Aryl sulfonamides and analogues thereof and their use in the treatment of neurodegenerative diseases HU228509B1 (en)

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DE19706902 1997-02-21
DE19740785A DE19740785A1 (de) 1997-02-21 1997-09-17 Arylsulfonamide und Analoga
PCT/EP1998/000716 WO1998037061A1 (de) 1997-02-21 1998-02-10 Arylsulfonamide und analoga und ihre verwendung zur behandlung von neurodegenerativen erkrankungen

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HUP0001111A2 true HUP0001111A2 (hu) 2000-08-28
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