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HUE061331T2 - Mutáns IDH-1 gátlása - Google Patents

Mutáns IDH-1 gátlása

Info

Publication number
HUE061331T2
HUE061331T2 HUE19728271A HUE19728271A HUE061331T2 HU E061331 T2 HUE061331 T2 HU E061331T2 HU E19728271 A HUE19728271 A HU E19728271A HU E19728271 A HUE19728271 A HU E19728271A HU E061331 T2 HUE061331 T2 HU E061331T2
Authority
HU
Hungary
Prior art keywords
mutant idh
inhibiting mutant
inhibiting
idh
mutant
Prior art date
Application number
HUE19728271A
Other languages
English (en)
Inventor
Patrick F Kelly
Original Assignee
Forma Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forma Therapeutics Inc filed Critical Forma Therapeutics Inc
Publication of HUE061331T2 publication Critical patent/HUE061331T2/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A61K9/4825—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HUE19728271A 2018-05-16 2019-05-16 Mutáns IDH-1 gátlása HUE061331T2 (hu)

Applications Claiming Priority (18)

Application Number Priority Date Filing Date Title
US201862672462P 2018-05-16 2018-05-16
US201862672461P 2018-05-16 2018-05-16
US201862680562P 2018-06-04 2018-06-04
US201862680560P 2018-06-04 2018-06-04
US201862680571P 2018-06-04 2018-06-04
US201862680566P 2018-06-04 2018-06-04
US201862692605P 2018-06-29 2018-06-29
US201862692598P 2018-06-29 2018-06-29
US201862692591P 2018-06-29 2018-06-29
US201862692601P 2018-06-29 2018-06-29
US201862692604P 2018-06-29 2018-06-29
US201862773562P 2018-11-30 2018-11-30
US201962798677P 2019-01-30 2019-01-30
US201962798681P 2019-01-30 2019-01-30
US201962798684P 2019-01-30 2019-01-30
US201962798690P 2019-01-30 2019-01-30
US201962798687P 2019-01-30 2019-01-30
US201962812367P 2019-03-01 2019-03-01

Publications (1)

Publication Number Publication Date
HUE061331T2 true HUE061331T2 (hu) 2023-06-28

Family

ID=66691055

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE19728271A HUE061331T2 (hu) 2018-05-16 2019-05-16 Mutáns IDH-1 gátlása

Country Status (5)

Country Link
US (3) US20210196701A1 (hu)
EP (1) EP3720442B1 (hu)
HU (1) HUE061331T2 (hu)
PT (1) PT3720442T (hu)
WO (1) WO2019222553A1 (hu)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020232381A1 (en) * 2019-05-16 2020-11-19 Forma Therapeutics, Inc. INHIBITING MUTANT ISOCITRATE DEHYDROGENASE 1 (mIDH-1)
US10532047B2 (en) 2018-05-16 2020-01-14 Forma Therapeutics, Inc. Solid forms of ((S)-5-((1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)amino)-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile
US11013733B2 (en) 2018-05-16 2021-05-25 Forma Therapeutics, Inc. Inhibiting mutant isocitrate dehydrogenase 1 (mlDH-1)
US11013734B2 (en) 2018-05-16 2021-05-25 Forma Therapeutics, Inc. Treating patients harboring an isocitrate dehydrogenase-1 (IDH-1) mutation
US11311527B2 (en) 2018-05-16 2022-04-26 Forma Therapeutics, Inc. Inhibiting mutant isocitrate dehydrogenase 1 (mIDH-1)
US20210196701A1 (en) 2018-05-16 2021-07-01 Forma Therapeutics, Inc. Inhibiting mutant idh-1
US12014835B2 (en) 2020-02-19 2024-06-18 Vanderbilt University Methods for evaluating therapeutic benefit of combination therapies
IL296092A (en) 2020-03-23 2022-11-01 Lilly Co Eli Combination therapy with a mutant idh inhibitor
CA3186786A1 (en) * 2020-07-20 2022-01-27 David Michael HYMAN Combination therapy with a mutant idh1 inhibitor, a deoxyadenosine analog, and a platinum agent
WO2023141087A1 (en) * 2022-01-19 2023-07-27 Eli Lilly And Company Combination therapy with a mutant idh inhibitor

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Also Published As

Publication number Publication date
US20200108060A1 (en) 2020-04-09
US11376246B2 (en) 2022-07-05
US11576906B2 (en) 2023-02-14
EP3720442B1 (en) 2022-12-28
EP3720442A1 (en) 2020-10-14
WO2019222553A1 (en) 2019-11-21
US20210196701A1 (en) 2021-07-01
US20190350919A1 (en) 2019-11-21
PT3720442T (pt) 2023-03-13

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