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HUE036755T2 - Antimicrobial compounds and their preparation and use - Google Patents

Antimicrobial compounds and their preparation and use

Info

Publication number
HUE036755T2
HUE036755T2 HUE12799934A HUE12799934A HUE036755T2 HU E036755 T2 HUE036755 T2 HU E036755T2 HU E12799934 A HUE12799934 A HU E12799934A HU E12799934 A HUE12799934 A HU E12799934A HU E036755 T2 HUE036755 T2 HU E036755T2
Authority
HU
Hungary
Prior art keywords
preparation
antimicrobial compounds
antimicrobial
compounds
Prior art date
Application number
HUE12799934A
Other languages
Hungarian (hu)
Inventor
Erin Duffy
Ashoke Bhattacharjee
Shili Chen
Matthew Scheideman
Zoltan Kanyo
Yuanqing Tang
Original Assignee
Melinta Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Melinta Therapeutics Inc filed Critical Melinta Therapeutics Inc
Publication of HUE036755T2 publication Critical patent/HUE036755T2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Materials For Medical Uses (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
HUE12799934A 2011-04-15 2012-04-11 Antimicrobial compounds and their preparation and use HUE036755T2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161476138P 2011-04-15 2011-04-15
US201161535118P 2011-09-15 2011-09-15
US201261610363P 2012-03-13 2012-03-13

Publications (1)

Publication Number Publication Date
HUE036755T2 true HUE036755T2 (en) 2018-07-30

Family

ID=47357660

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE12799934A HUE036755T2 (en) 2011-04-15 2012-04-11 Antimicrobial compounds and their preparation and use

Country Status (21)

Country Link
US (2) US9221827B2 (en)
EP (2) EP3404028A1 (en)
JP (2) JP6317669B2 (en)
KR (1) KR20140065378A (en)
CN (2) CN109053695A (en)
AR (1) AR088781A1 (en)
AU (3) AU2012271228B2 (en)
BR (1) BR112013026410A2 (en)
CA (1) CA2833169A1 (en)
DK (1) DK2697229T3 (en)
EA (1) EA201391536A1 (en)
ES (1) ES2665988T3 (en)
HU (1) HUE036755T2 (en)
IL (1) IL228845A0 (en)
MX (1) MX357903B (en)
MY (1) MY173518A (en)
PH (1) PH12013502135A1 (en)
PT (1) PT2697229T (en)
SG (2) SG194489A1 (en)
TW (2) TW201843154A (en)
WO (1) WO2012173689A2 (en)

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NZ599289A (en) 2009-10-16 2014-11-28 Melinta Therapeutics Inc Antimicrobial compounds and methods of making and using the same
PH12013502135A1 (en) 2011-04-15 2022-10-26 Melinta Therapeutics Inc Antimicrobial compounds and methods of making and using the same
US9346802B2 (en) 2013-03-15 2016-05-24 Epizyme, Inc. CARM1 inhibitors and uses thereof
SG11201507070XA (en) 2013-03-15 2015-10-29 Epizyme Inc Carm1 inhibitors and uses thereof
US9718816B2 (en) 2013-03-15 2017-08-01 Epizyme, Inc. 1-phenoxy-3-(alkylamino)-propan-2-ol derivatives as CARM1 inhibitors and uses thereof
CA2923179A1 (en) * 2013-09-09 2015-03-12 Melinta Therapeutics, Inc. Antimicrobial compounds and methods of making and using the same
SG11201601654TA (en) * 2013-09-09 2016-04-28 Melinta Therapeutics Inc Antimicrobial compunds and methods of making and using the same
WO2016094307A1 (en) 2014-12-08 2016-06-16 The Research Foundation For The State University Of New York Anti-fungals targeting the synthesis of fungal shingolipids
CN107922418A (en) * 2015-03-11 2018-04-17 梅琳塔治疗公司 Antimicrobial compounds and methods of making and using the same
CN105669519B (en) * 2016-01-04 2018-01-05 北方民族大学 Benzazole compounds, preparation method and its application as drug-resistance bacteria medicine
US10934295B2 (en) * 2016-05-06 2021-03-02 BioVersys AG Antimicrobials and methods of making and using same
US11098047B2 (en) * 2016-05-06 2021-08-24 BioVersys AG Antimicrobials and methods of making and using same
US10815237B2 (en) 2016-05-06 2020-10-27 BioVersys AG Antimicrobials and methods of making and using same
EP3638649A4 (en) 2017-06-16 2021-03-17 The Research Foundation for The State University of New York ANTI-FUNGAL COMPOUNDS TARGETING THE SYNTHESIS OF FUNGAL SHINGOLIPIDS
WO2018236692A1 (en) 2017-06-19 2018-12-27 Duffy Erin M ANTIMICROBIAL AGENTS AND METHODS OF PREPARATION AND USE
WO2019164880A1 (en) * 2018-02-21 2019-08-29 Duffy Erin M Antimicrobials and methods of making and using same
US20210253589A1 (en) 2018-06-06 2021-08-19 BioVersys AG Aminomethylamidine and methylamidine antimicrobial compounds
WO2019234508A1 (en) 2018-06-06 2019-12-12 BioVersys AG Biodefense agents
US20240239800A1 (en) * 2018-12-07 2024-07-18 BioVersys AG Pyrrolo[2,3-d]pyrimidin-2-one antimicrobial compounds
CN115297930B (en) * 2019-11-13 2025-02-14 库扎环球有限责任公司 Antimicrobial compounds and methods
CN111254091B (en) * 2020-01-20 2022-04-19 浙江工业大学 A Stenotrophomonas maltophilia GYH and its application in degrading chlorinated hydrocarbon pollutants

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Also Published As

Publication number Publication date
EP2697229A4 (en) 2014-09-10
AR088781A1 (en) 2014-07-10
JP2018115206A (en) 2018-07-26
AU2017204803A1 (en) 2017-07-27
CN103958514A (en) 2014-07-30
EA201391536A1 (en) 2014-08-29
MY173518A (en) 2020-01-30
WO2012173689A3 (en) 2013-04-04
PT2697229T (en) 2018-04-13
TW201305172A (en) 2013-02-01
AU2019204745A1 (en) 2019-07-18
EP3404028A1 (en) 2018-11-21
MX2013012015A (en) 2014-10-24
MX357903B (en) 2018-07-30
PH12013502135A1 (en) 2022-10-26
AU2012271228A1 (en) 2013-11-14
SG10201603027QA (en) 2016-05-30
IL228845A0 (en) 2013-12-31
CN109053695A (en) 2018-12-21
CN103958514B (en) 2018-07-03
DK2697229T3 (en) 2018-04-23
TWI656123B (en) 2019-04-11
JP2014510788A (en) 2014-05-01
CA2833169A1 (en) 2012-12-20
BR112013026410A2 (en) 2017-06-27
EP2697229B1 (en) 2018-04-04
US9221827B2 (en) 2015-12-29
JP6317669B2 (en) 2018-04-25
US20190322668A1 (en) 2019-10-24
AU2012271228B2 (en) 2017-04-13
WO2012173689A2 (en) 2012-12-20
EP2697229A2 (en) 2014-02-19
US20140163049A1 (en) 2014-06-12
TW201843154A (en) 2018-12-16
SG194489A1 (en) 2013-12-30
ES2665988T3 (en) 2018-04-30
KR20140065378A (en) 2014-05-29

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