HUE036009T2 - Metformin alkalmazása kombinációban egy glukokináz aktivátorral, és kompozíciók, amelyek metformint és egy glukokináz aktivátort tartalmaznak - Google Patents
Metformin alkalmazása kombinációban egy glukokináz aktivátorral, és kompozíciók, amelyek metformint és egy glukokináz aktivátort tartalmaznakInfo
- Publication number
- HUE036009T2 HUE036009T2 HUE11787250A HUE11787250A HUE036009T2 HU E036009 T2 HUE036009 T2 HU E036009T2 HU E11787250 A HUE11787250 A HU E11787250A HU E11787250 A HUE11787250 A HU E11787250A HU E036009 T2 HUE036009 T2 HU E036009T2
- Authority
- HU
- Hungary
- Prior art keywords
- metformin
- glucokinase activator
- combination
- compositions containing
- glucokinase
- Prior art date
Links
- 229940124828 glucokinase activator Drugs 0.000 title 2
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 title 2
- 229960003105 metformin Drugs 0.000 title 2
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/24—Y being a hetero atom
- C07C279/26—X and Y being nitrogen atoms, i.e. biguanides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/54—Nitrogen and either oxygen or sulfur atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34855410P | 2010-05-26 | 2010-05-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE036009T2 true HUE036009T2 (hu) | 2018-06-28 |
Family
ID=45004334
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE11787250A HUE036009T2 (hu) | 2010-05-26 | 2011-05-24 | Metformin alkalmazása kombinációban egy glukokináz aktivátorral, és kompozíciók, amelyek metformint és egy glukokináz aktivátort tartalmaznak |
Country Status (31)
| Country | Link |
|---|---|
| US (4) | US9359313B2 (hu) |
| EP (1) | EP2576524B1 (hu) |
| JP (1) | JP5902676B2 (hu) |
| KR (2) | KR101878252B1 (hu) |
| CN (1) | CN102906077B (hu) |
| AU (1) | AU2011258460B2 (hu) |
| BR (1) | BR112012029844A2 (hu) |
| CA (1) | CA2799591C (hu) |
| CO (1) | CO6640324A2 (hu) |
| CY (1) | CY1119850T1 (hu) |
| DK (1) | DK2576524T3 (hu) |
| EA (1) | EA032085B1 (hu) |
| ES (1) | ES2655396T3 (hu) |
| HK (1) | HK1181044A1 (hu) |
| HR (1) | HRP20180113T1 (hu) |
| HU (1) | HUE036009T2 (hu) |
| IL (1) | IL223137A0 (hu) |
| LT (1) | LT2576524T (hu) |
| ME (1) | ME03007B (hu) |
| MX (1) | MX347372B (hu) |
| NO (1) | NO2576524T3 (hu) |
| NZ (1) | NZ603614A (hu) |
| PE (1) | PE20130275A1 (hu) |
| PL (1) | PL2576524T3 (hu) |
| PT (1) | PT2576524T (hu) |
| RS (1) | RS56761B1 (hu) |
| SG (1) | SG185660A1 (hu) |
| SI (1) | SI2576524T1 (hu) |
| SM (1) | SMT201800140T1 (hu) |
| TW (1) | TWI508723B (hu) |
| WO (1) | WO2011149945A1 (hu) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE036009T2 (hu) * | 2010-05-26 | 2018-06-28 | Vtv Therapeutics Llc | Metformin alkalmazása kombinációban egy glukokináz aktivátorral, és kompozíciók, amelyek metformint és egy glukokináz aktivátort tartalmaznak |
| BR112014028622A2 (pt) * | 2012-05-17 | 2017-06-27 | Transtech Pharma Llc | composições de ativador de glucoquinase para o tratamento de diabetes |
| EP2964197B1 (en) * | 2013-03-04 | 2020-03-25 | vTv Therapeutics LLC | Solid compositions comprising a glucokinase activator and methods of making and using the same |
| WO2014137797A2 (en) * | 2013-03-04 | 2014-09-12 | Transtech Pharma, Llc | Stable glucokinase activator compositions |
| CN110167542A (zh) * | 2016-11-09 | 2019-08-23 | 诺沃梅迪科斯有限公司 | 1,1-二甲双胍的亚硝酸盐、药物组合物和使用方法 |
| US11963947B2 (en) * | 2018-05-31 | 2024-04-23 | Hua Medicine (Shanghai) Ltd. | Pharmaceutical combination, composition and compound preparation comprising glucokinase activator and DPP-IV inhibitor, and preparation method and use thereof |
| CA3093025A1 (en) | 2018-06-12 | 2019-12-19 | Vtv Therapeutics Llc | Therapeutic uses of glucokinase activators in combination with insulin or insulin analogs |
| KR20230048502A (ko) * | 2020-06-08 | 2023-04-11 | 브이티브이 테라퓨틱스 엘엘씨 | ｛2-[3-사이클로헥실-3-(트랜스-4-프로폭시-사이클로헥실)-우레이도]-티아졸-5-일설파닐｝-아세트산의 염 또는 공결정 및 그의 용도 |
| KR20230048501A (ko) * | 2020-06-08 | 2023-04-11 | 브이티브이 테라퓨틱스 엘엘씨 | ｛2-[3-사이클로헥실-3-(트랜스-4-프로폭시-사이클로헥실)-우레이도]-티아졸-5-일설파닐｝-아세트산의 결정형 및 그의 용도 |
| CN115073331A (zh) * | 2021-03-15 | 2022-09-20 | 中国医学科学院药物研究所 | 二甲双胍肉桂酸盐一水合物及制备方法和其组合物与用途 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT323195B (de) * | 1973-03-16 | 1975-06-25 | Hurka Wilhelm | Verfahren zur herstellung neuer salze von biguaniden |
| FR2243684B1 (hu) * | 1973-09-19 | 1977-01-28 | Semb | |
| US4166452A (en) | 1976-05-03 | 1979-09-04 | Generales Constantine D J Jr | Apparatus for testing human responses to stimuli |
| US4356108A (en) | 1979-12-20 | 1982-10-26 | The Mead Corporation | Encapsulation process |
| US4265874A (en) | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
| PL215132B1 (pl) | 2002-06-27 | 2013-10-31 | Novo Nordisk As | Pochodna arylokarbonylowa jako srodek terapeutyczny, jej zastosowanie i kompozycja farmaceutyczna ja zawierajaca |
| ITRM20030053A1 (it) * | 2003-02-10 | 2004-08-11 | Sigma Tau Ind Farmaceuti | Associazione di farmaci antidiabetici. |
| WO2005023766A1 (en) | 2003-09-11 | 2005-03-17 | Biocon Limited | Salt of atorvastatin with metformin |
| ES2399052T3 (es) * | 2004-01-06 | 2013-03-25 | Novo Nordisk A/S | Heteroaril-ureas y su uso como activadores de glucocinasa |
| KR20070073879A (ko) * | 2004-10-07 | 2007-07-10 | 스템 셀 테라퓨틱스 코포레이션 | 임신 관련 화합물의 투여를 통한 다능성 줄기 세포의증식을 자극하는 방법 |
| JP2009500377A (ja) * | 2005-07-08 | 2009-01-08 | ノボ・ノルデイスク・エー／エス | ジシクロアルキルウレア型グルコキナーゼ活性化剤 |
| ATE547396T1 (de) * | 2005-07-08 | 2012-03-15 | Novo Nordisk As | Dicycloalkylcarbamoyl-harnstoffe als glucokinase- aktivatoren |
| US7884210B2 (en) * | 2005-07-14 | 2011-02-08 | Novo Nordisk A/S | Ureido-thiazole glucokinase activators |
| WO2008084043A1 (en) | 2007-01-09 | 2008-07-17 | Novo Nordisk A/S | Urea glucokinase activators |
| UY31830A (es) | 2008-05-16 | 2010-01-05 | Takeda Pharmaceutical | Activadores de glucoquinasa |
| KR101190957B1 (ko) * | 2009-08-25 | 2012-10-15 | 한올바이오파마주식회사 | 메트포르민 카페익산염, 그의 제조방법, 그를 포함하는 약학 조성물 및 그를 포함하는 복합제제 |
| HUE036009T2 (hu) * | 2010-05-26 | 2018-06-28 | Vtv Therapeutics Llc | Metformin alkalmazása kombinációban egy glukokináz aktivátorral, és kompozíciók, amelyek metformint és egy glukokináz aktivátort tartalmaznak |
| BR112014028622A2 (pt) | 2012-05-17 | 2017-06-27 | Transtech Pharma Llc | composições de ativador de glucoquinase para o tratamento de diabetes |
| WO2014137797A2 (en) | 2013-03-04 | 2014-09-12 | Transtech Pharma, Llc | Stable glucokinase activator compositions |
| EP2964197B1 (en) | 2013-03-04 | 2020-03-25 | vTv Therapeutics LLC | Solid compositions comprising a glucokinase activator and methods of making and using the same |
-
2011
- 2011-05-24 HU HUE11787250A patent/HUE036009T2/hu unknown
- 2011-05-24 CA CA2799591A patent/CA2799591C/en active Active
- 2011-05-24 JP JP2013512164A patent/JP5902676B2/ja active Active
- 2011-05-24 MX MX2012013617A patent/MX347372B/es active IP Right Grant
- 2011-05-24 PL PL11787250T patent/PL2576524T3/pl unknown
- 2011-05-24 ES ES11787250.7T patent/ES2655396T3/es active Active
- 2011-05-24 PT PT117872507T patent/PT2576524T/pt unknown
- 2011-05-24 PE PE2012002211A patent/PE20130275A1/es not_active Application Discontinuation
- 2011-05-24 LT LTEP11787250.7T patent/LT2576524T/lt unknown
- 2011-05-24 US US13/114,964 patent/US9359313B2/en active Active
- 2011-05-24 CN CN201180025744.3A patent/CN102906077B/zh active Active
- 2011-05-24 KR KR1020187006115A patent/KR101878252B1/ko active IP Right Grant
- 2011-05-24 WO PCT/US2011/037752 patent/WO2011149945A1/en active Application Filing
- 2011-05-24 EA EA201201617A patent/EA032085B1/ru not_active IP Right Cessation
- 2011-05-24 DK DK11787250.7T patent/DK2576524T3/en active
- 2011-05-24 RS RS20180055A patent/RS56761B1/sr unknown
- 2011-05-24 NZ NZ603614A patent/NZ603614A/en not_active IP Right Cessation
- 2011-05-24 BR BR112012029844A patent/BR112012029844A2/pt not_active IP Right Cessation
- 2011-05-24 KR KR1020127033687A patent/KR101860120B1/ko active IP Right Grant
- 2011-05-24 SG SG2012085080A patent/SG185660A1/en unknown
- 2011-05-24 SI SI201131369T patent/SI2576524T1/en unknown
- 2011-05-24 SM SM20180140T patent/SMT201800140T1/it unknown
- 2011-05-24 EP EP11787250.7A patent/EP2576524B1/en active Active
- 2011-05-24 AU AU2011258460A patent/AU2011258460B2/en active Active
- 2011-05-24 ME MEP-2018-24A patent/ME03007B/me unknown
- 2011-05-24 NO NO11787250A patent/NO2576524T3/no unknown
- 2011-05-25 TW TW100118368A patent/TWI508723B/zh active
-
2012
- 2012-11-19 IL IL223137A patent/IL223137A0/en not_active IP Right Cessation
- 2012-12-21 CO CO12232453A patent/CO6640324A2/es not_active Application Discontinuation
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2013
- 2013-07-15 HK HK13108290.5A patent/HK1181044A1/xx unknown
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2016
- 2016-02-11 US US14/988,143 patent/US9855251B2/en active Active
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2017
- 2017-08-28 US US15/687,824 patent/US10064846B2/en active Active
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2018
- 2018-01-04 CY CY20181100011T patent/CY1119850T1/el unknown
- 2018-01-22 HR HRP20180113TT patent/HRP20180113T1/hr unknown
- 2018-08-08 US US16/058,512 patent/US10363244B2/en active Active
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