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HU9502323D0 - Novel platinium complexes - Google Patents

Novel platinium complexes

Info

Publication number
HU9502323D0
HU9502323D0 HU9502323A HU9502323A HU9502323D0 HU 9502323 D0 HU9502323 D0 HU 9502323D0 HU 9502323 A HU9502323 A HU 9502323A HU 9502323 A HU9502323 A HU 9502323A HU 9502323 D0 HU9502323 D0 HU 9502323D0
Authority
HU
Hungary
Prior art keywords
novel
image
complexes
hydrogen atom
same
Prior art date
Application number
HU9502323A
Other languages
Hungarian (hu)
Other versions
HUT72890A (en
Inventor
Ganghyeok Kim
Dae-Kee Kim
Jongsik Gam
Yong Baik Cho
Hun Taek Kim
Key Hyup Kim
Joo Ho Tai
Original Assignee
Sunkyong Ind Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1019910019969A external-priority patent/KR940010296B1/en
Priority claimed from KR1019910024632A external-priority patent/KR940010298B1/en
Priority claimed from KR1019910024631A external-priority patent/KR940010297B1/en
Application filed by Sunkyong Ind Ltd filed Critical Sunkyong Ind Ltd
Publication of HU9502323D0 publication Critical patent/HU9502323D0/en
Publication of HUT72890A publication Critical patent/HUT72890A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Catalysts (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

Abstract

Disclosed herein are novel platinum(II) complexes having a potent anti-tumor activity which are represented by the formula (1), <IMAGE> (1) <IMAGE> (a) <IMAGE> (b) wherein R1 and R2, which may be the same or different, are a hydrogen atom or a C1-4 alkyl group, respectively, or jointly form a cycloalkane group together with the carbon atom attached thereto; two Xs jointly form a group represented by formula (a) or (b) wherein, R3 is a hydrogen atom or a methyl group; R4 and R5, which may be the same or different, are a hydrogen atom or a C1-4 alkyl group, respectively, or jointly form a cyclobutane together with the carbon thereto; and the absolute configurations at the respective chiral centers in the 4,5-bis(aminomethyl)-1,3-dioxolane moiety are (4R,5R) or (4S,5S); processes for the preparing the same; and their use for treating animal or human cancer. Further, disclosed herein are novel intermediates useful for the preparation of the platinum(II) complexes and processes for preparing said intermediates.
HU9502323A 1991-03-23 1991-12-30 Process for producing novel platinium complexes HUT72890A (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
KR910004627 1991-03-23
KR910007207 1991-05-03
KR910013205 1991-07-31
KR1019910019969A KR940010296B1 (en) 1991-05-03 1991-11-11 New pt(ñœ)complexes and process for the preparation thereof
KR1019910024632A KR940010298B1 (en) 1991-07-31 1991-12-27 New pt(ñœ) complexes and process for the preparation thereof
KR1019910024631A KR940010297B1 (en) 1991-03-23 1991-12-27 Novel Platinum (II) Complexes and Preparation Methods

Publications (2)

Publication Number Publication Date
HU9502323D0 true HU9502323D0 (en) 1995-09-28
HUT72890A HUT72890A (en) 1996-06-28

Family

ID=27555050

Family Applications (3)

Application Number Title Priority Date Filing Date
HU9302461A HUT65220A (en) 1991-03-23 1991-12-30 Process for producing new platinum(ii) complexes
HU9502323A HUT72890A (en) 1991-03-23 1991-12-30 Process for producing novel platinium complexes
HU9302461A HU220869B1 (en) 1991-03-23 1991-12-30 Platinum(ii) complexes, pharmaceutical compositions comprising thereof and processes for preparing the same

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HU9302461A HUT65220A (en) 1991-03-23 1991-12-30 Process for producing new platinum(ii) complexes

Family Applications After (1)

Application Number Title Priority Date Filing Date
HU9302461A HU220869B1 (en) 1991-03-23 1991-12-30 Platinum(ii) complexes, pharmaceutical compositions comprising thereof and processes for preparing the same

Country Status (21)

Country Link
US (1) US5395947A (en)
EP (1) EP0586378B1 (en)
JP (1) JP2801965B2 (en)
CN (2) CN1038590C (en)
AT (1) ATE171455T1 (en)
AU (2) AU654990B2 (en)
BR (1) BR9107299A (en)
CA (1) CA2106679C (en)
CZ (1) CZ285904B6 (en)
DE (1) DE69130261T2 (en)
ES (1) ES2124251T3 (en)
FI (1) FI934150A (en)
HU (3) HUT65220A (en)
IE (1) IE920687A1 (en)
IL (1) IL101167A (en)
NO (1) NO304652B1 (en)
NZ (1) NZ241824A (en)
PH (1) PH30926A (en)
PT (1) PT100272B (en)
RU (1) RU2067099C1 (en)
WO (1) WO1992016539A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1068002C (en) * 1997-04-30 2001-07-04 中国科学院大连化学物理研究所 Mesoplatinum anticarcinogen and its synthesis
EP1229934B1 (en) 1999-10-01 2014-03-05 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
CN100497359C (en) * 2006-01-06 2009-06-10 昆明贵研药业有限公司 Novel synthesis process of anti-cancer Sunpla
RU2457838C1 (en) * 2011-04-13 2012-08-10 Федеральное Государственное Бюджетное Учреждение Науки Институт Химии И Химической Технологии Сибирского Отделения Российской Академии Наук (Иххт Со Ран) Method of obtaining trans-1,2-diaminocyclohexane tetrachloroplatinum (iv)
CN103242509B (en) * 2013-04-18 2015-06-10 艾达索高新材料无锡有限公司 Degradable cyclic acetal and cyclic ketal diamine epoxy resin curing agent and application thereof
AU2015390714B2 (en) * 2015-04-10 2021-02-04 Medoncare Pharmaceutical Co., Ltd Process for the preparation of dicycloplatin

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4657927A (en) * 1978-05-04 1987-04-14 Research Corporation Malonato platinum compounds
NZ197104A (en) * 1980-05-27 1984-05-31 Bristol Myers Co Soluble ammonium and sodium salts of 2-hydroxymalonato platinum ii derivatives
DE3432320A1 (en) * 1984-09-03 1986-03-13 Behringwerke Ag, 3550 Marburg CIS-PLATINUM COMPLEXES WITH A PENTAERYTHRITE DERIVATIVE AS A LIGAND, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL AGENT CONTAINING THESE COMPOUNDS
US4665210A (en) * 1984-12-17 1987-05-12 American Cyanamid Company Platinum complexes of aliphatic tricarboxylic acids
GB8525689D0 (en) * 1985-10-18 1985-11-20 Johnson Mathey Plc Platinum coordination compounds
EP0284197A1 (en) * 1987-02-20 1988-09-28 Tanabe Seiyaku Co., Ltd. Novel organic platinum complex and process for the preparation thereof
IL85595A0 (en) * 1987-03-06 1988-08-31 Tanabe Seiyaku Co Organic platinum complex and its preparation
JPS63267794A (en) * 1987-04-23 1988-11-04 Sanwa Kagaku Kenkyusho Co Ltd Organic platinum complex and antitumor agent containing the same
US4808730A (en) * 1987-06-23 1989-02-28 American Cyanamid Company Synthesis of cisplatin analogs
US4870070A (en) * 1987-08-10 1989-09-26 American Cyanamid Company Water soluble platinum complexes of novel malonate derivatives
JPH01294683A (en) * 1988-02-04 1989-11-28 Kanebo Ltd Novel platinum complex, antitumor agent containing said complex as active ingredient and intermediate for preparing the same compound

Also Published As

Publication number Publication date
HUT65220A (en) 1994-05-02
AU654990B2 (en) 1994-12-01
AU7443994A (en) 1994-12-08
IL101167A0 (en) 1992-11-15
DE69130261T2 (en) 1999-05-20
CN1204650A (en) 1999-01-13
JP2801965B2 (en) 1998-09-21
FI934150A0 (en) 1993-09-22
AU9124791A (en) 1992-10-21
ATE171455T1 (en) 1998-10-15
IE920687A1 (en) 1992-09-23
US5395947A (en) 1995-03-07
BR9107299A (en) 1994-06-14
FI934150A (en) 1993-10-08
EP0586378A1 (en) 1994-03-16
CN1063753C (en) 2001-03-28
NO933370L (en) 1993-09-22
HU220869B1 (en) 2002-06-29
HU9302461D0 (en) 1993-11-29
CA2106679A1 (en) 1992-09-24
PT100272B (en) 1999-09-30
CN1038590C (en) 1998-06-03
ES2124251T3 (en) 1999-02-01
CZ285904B6 (en) 1999-11-17
NZ241824A (en) 1993-04-28
NO933370D0 (en) 1993-09-22
DE69130261D1 (en) 1998-10-29
PH30926A (en) 1997-12-23
CN1065274A (en) 1992-10-14
CA2106679C (en) 1996-01-09
CS87392A3 (en) 1992-10-14
RU2067099C1 (en) 1996-09-27
PT100272A (en) 1993-08-31
NO304652B1 (en) 1999-01-25
EP0586378B1 (en) 1998-09-23
WO1992016539A1 (en) 1992-10-01
JPH06510520A (en) 1994-11-24
IL101167A (en) 1996-08-04
HUT72890A (en) 1996-06-28

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Legal Events

Date Code Title Description
DFC4 Cancellation of temporary protection due to refusal