HU221548B1 - Skin cleaning, cosmetic composition - Google Patents

Abstract

The composition according to the invention comprises 30-60% by weight of surfactant, 0-10% by weight of preservative, 0.5 to 5% by weight of organic or inorganic salt, with an organic acid content, the pH is in the range of 2 to 5, and only by coconut as a surfactant. contains a derivative. The most common pathogenic microorganisms of the skin surface and skin are significantly inhibited and, if necessary, eliminated. ŕ

Description

EXTRACT

The composition according to the invention contains 30-601% surfactant, 0-10% preservative, 0.5-5% organic or inorganic salt, organic acid, pH in the range 2-5, only coconut fatty acid as surfactant contains a derivative.

It significantly inhibits the growth of the most common pathogenic microorganisms in the skin and vagina, and possibly eliminates it.

The scope of the description is 4 pages

HU 221 548 A1

HU 221 548 Al

BACKGROUND OF THE INVENTION The present invention relates to a skin cleanser, a skin care product, a drug which inhibits the growth of microorganisms that are most commonly found on human skin.

It is known that cleaning and sanitizing agents act by removing water-insoluble impurities (mostly fats, oils) in an aqueous medium.

This is achieved by the presence of molecules that interact with both water and water-insoluble impurities (to be removed).

In this way, the original water-insoluble contaminant can be removed by water (without being dissolved therein).

Such cleaners are referred to as surfactants, and the process is called solubilization.

The oldest members of these materials are soaps, which are sodium salts of fatty acids (for example, based on stearate, oleate, palmitate) and produced by the hydrolysis of fats (which are esters of glycerol with fatty acids) ("soap cooking").

However, traditional soaps have several disadvantages. On the one hand, they are sensitive to the water used for washing, they lose their surfactant activity as described above in hard water, and on the other hand their alkaline pH is in some cases not advantageous.

As a result, a variety of synthetic (soap-free) detergents, mainly called mineral oils, are commonly known as detergents in recent decades.

Like soaps, they contain in their molecules so-called water-soluble hydrophilic moieties and lipophilic moieties capable of binding to fats. The lipophilic moiety is non-polar, usually a long chain moiety, while the hydrophilic moiety may be nonionic (in this case hydrogen-bonding to water) or anionic or cationic. Because of their variety, the cleaning effects of detergents are far superior to those of soaps and, due to their diversity and combination, make them well suited for a particular purpose.

Paradoxically, in some cases, their very high purifying power and liposolubility may be disadvantageous: they may adversely affect the conditions required for the functioning of the human skin, especially its natural and required fatness, pH.

The skin is one of our most important organs: its surface is 1.6-1.8 square meters. Its convenient structure and function protects the body from the harmful effects of the environment. The literature calls this defense mechanism a "barrier" function and has shown that "cell membrane lipids are an essential part of the barrier; once released, barrier function ceases. The water content of the horn layer treated with detergents and organic solvents is also lower (<10%). In such cases, the stratum corneum loses its elasticity, becomes fragile and its barrier property deteriorates. ”

The skin's protective effect is also significant against the establishment of pathogenic bacteria and fungi: The pH of the skin surface is acidic in the pH range of 5-6 due to the lactic acid content of the sweat and the fat content of the dying epithelial cells.

This is called the "acid mantle" of the skin, whose protective function is based on the fact that pathogenic bacteria and fungi are usually only able to live and reproduce in alkaline media.

Since the secretion of apicrin sweat glands is neutral, the armpit, the genitofemoral tendency, is a great "tear" in the acid mantle.

Particularly important in preventing fungal infections is the even more pronounced natural acidic vaginal pH of the vagina, which is in the range of 3.5-4.

The reduction or elimination of this acidic effect and the consequent fungal infection are the cause of widespread complaints.

The strong alkalinity of soaps therefore undermines the physiological defense of the skin.

Recognizing all these conditions, so-called "acidic liquid soaps" have recently become more common, with an acidic pH of between 5 and 7, most often pH 5.5. In summary, commercially available liquid soaps fall into this category almost without exception. Although these detergents are more advantageous than conventional soaps because they are less detrimental to the skin's defenses, they are not enough to maintain or restore their natural state.

Liquid soaps known in the art (HU 197 593) include, for example, alkyl and alkenyl (polyethoxy) sulfosuccinate alkaline ammonium salt, fatty alcohol sulfate salt, coconut mono- and / or diethanolamide, optionally polyhydric carboxylic acid and / or hydroxy , such as citric acid, the pH of the examples is between 6.4 and 6.5.

In another case (HU 197 594), besides the usual detergents, additives include a disinfectant additive, such as an antimicrobial component, which contains 30-60 parts by weight of 2,4,4'-trichloro-2'-hydroxydiphenyl ether, 60-30 parts by weight of o-hydroxy a mixture of 4-15 parts of a C12-C18 alkylpyridinium halide and 20-80 parts by weight of EDTA-diNa salt per 100 parts by weight of antimicrobial component.

It has been found that the acidity of so-called "acid soaps" is approximately equal to the natural pH of the skin.

However, in order to achieve the proper skin protection, regeneration effect, in particular against the pathogens important for the armpit, groin and vagina, a significantly more acidic, lower pH is required.

The sensitivity of the acidity varies from one person to another, which is in the range of pH = 2-3, so pH = 2-5 has been found to be optimal within this range.

The present invention relates to a skin cleansing cosmetic composition comprising 30-601% surfactant,

0-10% preservative,

HU 221 548 Al

Genapol CAB (Cocamid-Propyl-Betaine) Hoechst 6.000%

Genapol PGM (sodium lauryl 0.5-5% by weight of organic or inorganic salt used in the cosmetics industry,

It contains an organic acid used in the cosmetics industry to adjust the pH to between 2 and 5 and an amount of distilled water of 100% by weight.

The compositions according to the invention are preferably cationic, anionic, amphoteric and nonionic surfactants or mixtures thereof, preferably sodium lauryl sulfate, cocamidomethylamine, cocamidopropyl sulfate, glycol distearate, sodium chloride as inorganic surfactant. containing chlorhexidine gluconate as a preservative, citric acid or formic acid, preferably citric acid, as organic acid.

Our studies were carried out on the most common pathogenic microorganisms of the skin and vagina:

Candida albicans OKI 140

Eschericia coli HNCMB 35034

Streptococcus faecalis HNCMB 80171 and the following examples are provided. 20

Example 1 Effect of pH on Candida albicans test organism

The assay was performed with a starting germ number of 4.0 χ 10e5 and the effect of the following five liquid soaps of five different compositions was investigated as a function of time (short (30 s, 5 and 10 min) time for wash-off, 2.3, And 4 weeks is informative for storage stability].

The results of the tests are summarized in Table 1 below:

The composition of the liquid soaps used was as follows:

Sample 1

Genapol LRO 35 (Sodium Lauryl Sulfate) Hoechst 40,000% Sulfate + Glycol Dysterate + Cocamidomethylamine) Distilled Water Citric Acid

Chlorhexidine digluconate

Sodium chloride pH = 4

Hoechst 4,000% 45.8354%

0.166%

2.500%

1.500%

Sample 2 is the same as Sample 1 except for chlorhexidine digluconate.

Sample 3 is the same as Sample 2, but contains citric acid for pH = 2.

Sample 4 is the same as Sample 2, but contains the necessary amount of citric acid for pH 5.5.

Sample 5 is the same as Sample 2, but contains citric acid for pH = 7.

Example 2 Effect of pH on Streptococcus faecalis test organism

The assay was performed with a starting germ number of 8.0 x 10e5 over time with the liquid soaps of the composition used in Example 1.

The results of the test are given in Table 2.

EXAMPLE 3 Effect of pH on Escherichia coli Test Organ The assay was performed with 6.4 cs 10e5 starting germ number over time with liquid soaps of the composition of Example 1.

The results of the test are given in Table 3.

Table 1

Behavior of different composition of liquid soap samples against contact organism of Candida albicans test organism

Samples Oh (k) 30 sec 5 minutes 10 minutes 30 minutes 4 o'clock 2 weeks 3 weeks 4 weeks First 4,0xl0e5 3,8xl0e4 3,7xl0e4 5.1 χ 10e3 4,2xl0e3 4.0 χ 10e3 0 0 0 Second 4,0xl0e5 3,9xl0e4 3,8xl0e4 3,9xl0e4 3,6xl0e4 4.1 χ 10e3 0 0 0 Third 4,0xl0e5 2,8xl0e4 l 2xl0e3 0 0 0 0 0 0 4th 4,0xl0e5 3,95xl0e5 4.0 x 10e5 3,9xl0e5 3,75xl0e5 5,15xlOe5 4.78 χ 10e6 4.5 χ 10e6 1.54 χ 10e6 5th 4,0xl0e5 4.1 χ 10e5 4,0xl0e5 3,8xl0e5 3,65xl0e5 3,3xl0e5 2,35xl0e6 l 8xl0e6 l 25xl0e6

Table 2

Behavior of liquid soap samples of different compositions against Streptococcus faecalis test organism as a function of contact time

Samples Oh (k) 30 sec 5 minutes 10 minutes 30 minutes 4 o'clock 2 weeks 3 weeks 4 weeks First 8,0xl0e5 0 0 0 0 0 0 0 0 Second 8, OxlOe5 0 0 0 0 0 0 0 0 Third 8, OxlOe5 0 0 0 0 0 0 0 0

HU 221 548 Al

Table 2 (continued)

Samples Oh (k) 30 sec 5 minutes 10 minutes 30 minutes 4 o'clock 2 weeks 3 weeks 4 weeks 4th 8.0 χ 10e5 8.1 x 10e4 8,0xl0e4 7,8xl0e4 7,5xl0e4 9,6xl0e4 3.8 x 10e6 2.4 x 10e6 2,2xl0e6 1 ⁵ · 8,0xl0e5 5,5xl0e4 5.6 x 10.4e 5,4xl0e4 5,5xl0e4 5,5xl0e4 1.3 x 10e6 2.8 χ 10e6 3,12xl0e6

Table 3

Behavior of liquid soap samples of different compositions against Escherchia coli test organism as a function of contact time

1 Patterns Oh (k) 30 sec 5 minutes 10 minutes 30 minutes 4 o'clock 2 weeks 3 weeks 4 weeks First 6.4 χ 10e5 8.1 χ 10e4 5.1 χ 10e4 4,2xl0e4 9,2xl0e2 0 0 0 0 Second 6,4xl0e5 l lxl0e5 6.0 χ 10e4 7, lxl0e2 8,0xl0el 0 0 0 0 Third 6,4xl0e5 <10 0 0 0 0 0 0 0 6,4xl0e5 4,8xl0e5 4,6xl0e5 4,7xl0e5 4,65xl0e5 4,55xl0e5 5, lxl0e6 4,8xl0e6 4.9 χ 10e6 L 6,4xl0e5 4,65xl0e5 4.4 χ 10e5 4,0xl0e5 3,2xl0e5 4,3xl0e5 l lxl0e6 9,0xl0e5 9, lxl0e5

The examples presented clearly support our observation that if the pH of the formulation is below 5.5 in the commercially available acid soaps, preferably between pH 2 and pH 4.5, the pathogenic microorganisms are killed while pH = 5. At values of 5 and above, not only do they die, but they even begin to reproduce. This latter phenomenon, in addition to providing a good alternative to the skin nourishing effect, also has the disadvantage that the composition is a preservative, without additives, is degradable and unstable.

Preservatives are widely recognized by dermatologists as one of the most dangerous allergens (allergenic agents).

Claims (5)

PATENT CLAIMS A skin cleansing composition comprising 30-60% by weight of a surfactant, 0-10% by weight of a preservative, 0.5-5% by weight of organic or inorganic salts and organic acids used in the cosmetic industry, characterized in that it has an acidity of at pH 5. and the surfactants used are all coconut fatty acid derivatives. Composition according to Claim 1, characterized in that, as a surfactant, a cationic, anionic, amphoteric and nonionic surfactant or a mixture thereof, preferably sodium lauryl sulfate, cocamidomethylamine, cocamidopropyl sulfate, glycol 35 distearate. contain. 3. A composition according to claim 1 wherein the inorganic salt is sodium chloride. Composition according to claim 1, characterized in that it contains chlorhexidine gluconate as a preservative. Composition according to claim 1, characterized in that it contains, as an organic acid, citric acid or formic acid, preferably citric acid. Published by the Hungarian Patent Office, Budapest Responsible for publishing: Zsuzsanna Törőcsik Deputy Head of Department