HU219154B - Compositions for improving the digestibility of feed intended for ruminants - Google Patents

Abstract

FIELD OF THE INVENTION The present invention relates to the digestibility of ruminant feeds to repair compositions. These concentrated formulations are admixed to the ruminant feed as an additive. The additive composition of the present invention comprises from 5 to 10% by weight of a cresol derivative and / or a benzoldiol derivative. The composition further comprises a flavoring agent and an absorbent carrier. Use of the composition according to the invention reduces the number of somatic cells in the animal and increases the weight of the animals. ŕ

Description

For example, mixtures of the following compositions may be used as absorbent carriers and flavoring compositions:

(a) absorbent carrier material:

- sterilized forest pine

FIELD OF THE INVENTION The present invention relates to an additive composition, a premix and a feed that improves the digestibility of ruminant feeds, which are prepared in the form of concentrated mixtures for incorporation into feeds normally administered to ruminants.

In the case of ruminants, it is important for the digestibility of the feed that the organic matter, and more particularly proteins and starches, should not be degraded too much in the rumen. In this case, the nutrients are transported in a less degraded form to the small intestine, where enzymatic digestion takes place, which requires less energy as it allows the production of higher amounts of adenosine triphosphate (ATP). 15

It has been an object of the present invention to provide formulations which, when incorporated into ruminant feeds, significantly improve the digestibility of the feed and, consequently, the weight gain of ruminant animals fed with such feed.

In the compositions of the present invention, an active ingredient, namely an aromatic phenol derivative, more particularly a cresol derivative or a benzene diol derivative, will achieve the objectives set forth in the preceding paragraph.

Surprisingly, it has been found that an aromatic phenol derivative, more particularly a cresol derivative or a benzaldiol derivative 30, in particular resorcinol, i.e. m-benzaldiol, or a mixture of these derivatives, is able to effect digestion properly.

It has also been observed that dairy cows have the additional advantage that the use of the compositions of the present invention results in less nutrient degradation in the small intestine: a reduction in the amount of nitrogenous toxins produced by microbial degradation which cause mastitis. This inflammation is eliminated by an immune response that results in a significant increase in the number of white blood cells called 'somatic cells' in milk. In fact, these somatic cells cause difficulties in cheese production. This is the reason why if a high concentration of somatic cells are present in the milk, the farmer gets less money. 45

The aromatic phenol derivatives are suitably incorporated into the animal feed in an amount such that the animals receive from 1 to 100 mg per animal per day, depending on the weight of the animals.

Compositions of the invention intended for incorporation into conventional animal feeds may include an absorbent carrier and a flavoring composition to which the active ingredient is added. The proportion of these components in the compositions of the invention may be, for example, as follows:

- 5-10% by weight of phenol derivative,

20-30% by weight of a flavoring mixture and

50-75% by weight of absorbent carrier.

As far as phenol derivatives are concerned, cresol or resorcinol or some of these two compounds are preferred.

- stearin

- turmeric powder

- rosemary powder

- limestone

- arabic gum

- water

40-50%

8-10%

4-5 m% 4-5 m% 22-28 m% about 2 m% about 10 m%

(b) flavoring mixture:

- thymol

- Guayaquol

- eugenol

- vanilla

- salicylaldehyde

- limonene (solvent)

25-35 m% 10-15 m% 5-10 m% 10-20 m% 5-10 m% 20-35 m%

In practice, cresol and / or resorcinol is added to the liquid flavoring mixture and the resulting mixture is mixed with the absorbent carrier, for example, in a flour mixer.

The compositions of the invention will generally need to be diluted before being administered to the animals. Dilution is generally carried out in two steps: in the first step, a concentrated mixture, called a premix, containing 0.3 to 3% by weight of the composition according to the invention is prepared, and in the second step, this premix is mixed with any conventionally used feed.

For example, the composition of the concentrated mixture, i.e. the premix, may be as follows:

an additive composition according to the invention

- a mixture of vitamins (which may contain, for example, vitamin A, vitamin B,

Vitamin D, Vitamin E and Niacin)

- mineral salts (CaHPO ₄ , CaCO ₃ ,

NaCl, CuO, MnO, FeSO ₄ ,

ZnO, etc.)

- fine wheat groats and bran

For example, premixes of this composition can be incorporated into feeds to produce feeds of the following composition:

0.3 to 3.5% by weight of the premix according to the invention

- cereals and peas approximately 50% by weight

oily seed meal (soya, rapeseed, etc.) about 25% by weight

- fine wheat flour and bran 21-25 m%

When administered in an amount of 2 to 10 kg per day, these feeds containing the compositions of the present invention are administered at doses ranging from 5 to 100 mg / day for cresol derivatives and 1-50 mg / day for benzenediol derivatives.

0.3-3%

0.1-1%

25-75% 21-75%

HU 219 154 Β

Three experiments were performed independently to demonstrate the efficacy of the formulations of the invention and to determine the mechanism of action that affects the incidence of somatic cells in ruminant milk and the weight gain of ruminants.

Experiment 1

Investigation of effects on the rumen of animals

This experiment was performed using Menke's "in vitro" technique. The following materials were used for incubation:

(a) feed which:

- 30% dry silage maize,

- 25% by weight of anhydrous carbon,

- 15% barley,

Maize and

- 17.5% by weight of oily soybean meal;

(b) weed bears from three animals, taken from an empty rumen with the aid of a fistula, which was constantly present in the stomach of animals otherwise fed with (a) the feed; as well as

c) Mac Dougall's buffer.

Incubation was continued for 48 hours at 39 ° C. The digestibility of different metabolites in ruminants was determined at 6 and 48 hours.

The test was repeated 12 times with feed alone (control test) and feed containing the composition of the invention prepared using a premix containing 10% cresol / resorcinol in a ratio of 3: 1 by weight, 20% by weight. containing a flavoring mixture and 70% absorbent carrier material (the flavoring mixture and absorbent carrier used in the compositions previously described.) The results are shown in the following table.

Table 1

Control test Nutrition prepared with the masterbatch according to the invention 6h 48 h 6h 48 h (A) Precipitating Protein (TCA) (mg / 100 ml) 107.88 86.31 133.69 113.63 (B) Ammonia, expressed as nitrogen (mg / 100 ml) 24.19 40.32 4.83 6.75 (C) Total volatile acid (mg / 100 ml) 58.85 188.14 41.46 131.40 (D) Gas evolution (mg / 100 ml) 72 122 56 85 (E) Dry matter content (m% decomposition relative to original value) - - 54.12 41.28

(A) Higher values for feeds containing the premix of the present invention indicate that the protein in the feed is more protected.

(B) A significant reduction in the amount of ammonia in nitrogen indicates that the protein is more protected and thus less degraded in the rumen.

(C) The reduction in the amount of total volatile acid indicates that the starch has a higher degree of protection.

(D) Decreased gas evolution also indicates that the nutrient organic material is less degraded and consequently more protected. 50

Thus, the results obtained in this study clearly show that feeds containing the premix according to the invention show less degradation in the rumen and thus improve digestibility of the feed.

Experiment 2 55

Investigation of effects on somatic cells in milk

This test was first performed on farms, usually under normal conditions, on a goulash consisting of 46 dairy cows in excellent health. Half of the gully (control group) received the usual feed, while the other half of the gully (the test group) received food containing, in addition to the feed, a premix of the invention, the composition of which was previously exemplified. After six weeks, 113,000 somatic cells per ml of control and 99,900 somatic cells per ml of milk were detected.

Another study was carried out on a goulash consisting of 50 dairy cows in average health with an average of 393,000 somatic cells per ml of milk. This cell count was reduced as follows for animals fed with the feed containing the premix of the invention:

- after 1 week: 305 000 / ml of milk,

- after 3 weeks: 236 000 / ml milk,

- after 5 weeks: 219 000 / ml milk,

- after 6 weeks: 195 000 / ml of milk and milk

- after 7 weeks: 128,000 / ml milk.

These data clearly demonstrate that the compositions of the invention can significantly reduce microbial degradation.

HU 219 154 Β

Experiment 3

Study of the effect on weight gain of animals

This assay was performed under normal conditions on farms for 35 days on growing cattle. Two groups of 20-20 animals were formed for the study. The animals in one group (the control group) were fed on conventional feed, while the animals in the other group (the test group) were fed a diet which contained, in addition to the feed, an amount of about 3, 100 kg of active ingredient was administered in 3 kg of food.

The following results were obtained:

control group examined group average weight of the experiment at the beginning, kg 185.7 185.1 average weight of the experiment at completion, kg 227.9 233.0

- average daily weight gain, g 1206 1369

The average weight gain of 13.5% can be explained by the improved digestibility of the feed according to the present invention.

Claims (6)

PATENT CLAIMS CLAIMS 1. A digestibility additive composition for ruminant animals comprising at least one aromatic phenol derivative selected from the group consisting of 5-10% by weight of cresol derivatives and benzenediol derivatives, as well as a conventional carrier and optionally an absorbent carrier and flavoring composition. Composition according to claim 1, characterized in that it contains as active ingredient cresol or resorcin or a mixture of 60-90% by weight of cresol and 10-40% by weight of resorcinol. Composition according to claim 1 or 2, characterized in that it contains from 20 to 30% by weight of a flavoring composition and from 50 to 75% by weight of an absorbent carrier. 4. Composition according to any one of claims 1 to 5, characterized in that the flavoring mixture is 25-35% by weight of thymol, 10-15% by weight of guaiacol, 5-10% by weight of eugenol, 10-20% by weight of vanillin, 5-10% by weight of salicylaldehyde and 20-35% by weight. it contains% limonene and the absorbent carrier is 40-50% by weight of sawdust, Contains 8-10% by weight of stearin, 4-5% by weight of turmeric powder, 4-5% by weight of rosemary powder, 22-28% by weight of limestone, 2% by weight of gum arabic and 10% by weight of water. 5. A premix which can be incorporated into ruminant feed, characterized in that 0.3-3% by weight of 1-4%. A composition according to any one of claims 1 to 4, optionally containing 0.1-1% by weight of a vitamin mixture, 25-75% by weight of mineral salts and 21-75% by weight of a milling product. 6. Feed for ruminants, characterized in that the standard nutrient is 0.3 to 3.5% by weight of the premix as defined in claim 5 and optionally 50% by weight of cereals and peas, 25% by weight of cereals. Contains milled flour and 21-25% by weight of mill products.