HU194499B - Electrode-catheter for ablation of his fascicle - Google Patents
Electrode-catheter for ablation of his fascicle Download PDFInfo
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- 238000002679 ablation Methods 0.000 title claims abstract description 10
- 210000004375 bundle of his Anatomy 0.000 claims abstract description 15
- 230000007704 transition Effects 0.000 claims 1
- 230000035939 shock Effects 0.000 abstract description 7
- 206010003671 Atrioventricular Block Diseases 0.000 abstract description 4
- WABPQHHGFIMREM-UHFFFAOYSA-N lead(0) Chemical compound [Pb] WABPQHHGFIMREM-UHFFFAOYSA-N 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 230000004807 localization Effects 0.000 description 4
- 230000008901 benefit Effects 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 230000001112 coagulating effect Effects 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 238000009297 electrocoagulation Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 201000002931 third-degree atrioventricular block Diseases 0.000 description 2
- 230000001052 transient effect Effects 0.000 description 2
- 230000036982 action potential Effects 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000001066 destructive effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 210000005241 right ventricle Anatomy 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 206010047302 ventricular tachycardia Diseases 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
- A61B5/28—Bioelectric electrodes therefor specially adapted for particular uses for electrocardiography [ECG]
- A61B5/283—Invasive
- A61B5/29—Invasive for permanent or long-term implantation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B18/1492—Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
- A61B5/28—Bioelectric electrodes therefor specially adapted for particular uses for electrocardiography [ECG]
- A61B5/283—Invasive
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/00234—Surgical instruments, devices or methods for minimally invasive surgery
- A61B2017/00292—Surgical instruments, devices or methods for minimally invasive surgery mounted on or guided by flexible, e.g. catheter-like, means
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/30—Surgical pincettes, i.e. surgical tweezers without pivotal connections
- A61B2017/306—Surgical pincettes, i.e. surgical tweezers without pivotal connections holding by means of suction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/34—Trocars; Puncturing needles
- A61B2017/348—Means for supporting the trocar against the body or retaining the trocar inside the body
- A61B2017/3482—Means for supporting the trocar against the body or retaining the trocar inside the body inside
- A61B2017/3484—Anchoring means, e.g. spreading-out umbrella-like structure
- A61B2017/3488—Fixation to inner organ or inner body tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/1206—Generators therefor
- A61B2018/1266—Generators therefor with DC current output
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Abstract
Description
A találmány tárgya elektródkatéter His köteg ablatióhoz, amely katétercsövén frontális elektróddal rendelkezik, és a katétercső frontális szakaszán nyílás van kialakítva, és a frontális elektród villamos csatlakoztatását csatlakozó dugasz teszi lehetővé.BACKGROUND OF THE INVENTION The present invention relates to an electrode catheter for His bundle ablation having a frontal electrode on the catheter tube and having an opening in the frontal portion of the catheter tube and allowing a plug to be electrically connected to the frontal electrode.
A gyógyszerrezisztens paroxysmalis supraventriculáris tachicardiák újabb kezelési módja a His köteg, illetve az AV junctio elektromos roncsolása. A módszert Gallagher és munkatársai írták le 1982-ben (New Engl. J. Med. 1982; 28 pp 194-200). A módszer lényege, hogy hagyományos His elektródon keresztül DC shockot adnak le a His kötegre. Az így létrejövő elektrocoagulatio AV blockot idéz elő. A módszer hátránya, hogy a DC shock leadásakor az elektróda helyzete nem ellenőrizhető, elmozdulhat, és máshol károsíthatja a myocardiumot. Egy másik hátrány az elektród és a szív belső fala között kialakuló kontaktus esetről esetre változó értéke, amely nem ellenőrizhető. A megfelelő roncsoló hatás eléréséhez ezért nagy energiájú villamos kisülést kell létesíteni, amely nemkívánt mellékhatásokkal is járhat.Another treatment for drug-resistant paroxysmal supraventricular tachycardias is the electrical destruction of the His bundle or AV junction. The method was described by Gallagher et al., 1982 (New Engl. J. Med. 1982; 28 pp. 194-200). The essence of the method is to deliver DC shock to the His stack via a conventional His electrode. The resulting electrocoagulation produces an AV block. The disadvantage of this method is that when the DC shock is delivered, the position of the electrode cannot be controlled, displaced, and otherwise damage the myocardium. Another drawback is the value of the contact between the electrode and the inner wall of the heart, which varies from case to case and is not controllable. Therefore, in order to achieve the proper destructive effect, a high-energy electrical discharge must be provided which may have undesirable side effects.
Korábban javasoltam már egy tökéletesített eljárást a His köteg ablatio céljára, amelynek lényege, hogy a DC shockot létesítő elektródkatéterrel szívást kell létesíteni, és ez az elektródkatéter helyzetét rögzíti a His kötegen (P. Polgár és társai: „Closed-Chest Ablation of His Bundle: A New Technique Using Suction Electrode Catheter and DC Shock, Cardiac Pacing, pp. 883890, Dr. D. Steinkopff Verlag, Darmstadt).I have previously proposed an improved procedure for His bundle ablation, which involves suctioning with a DC shock electrode catheter that captures the position of the electrode catheter on his bundle (P. Polgár et al., Closed-Chest Ablation of His Bundle: A New Technique Using Suction Electrode Catheter and DC Shock, Cardiac Pacing, pp. 883890, Dr. D. Steinkopff Verlag, Darmstadt).
Az itt leírtak szerint a DC shockot létesítő, centrális elektróddal ellátott elektródkatéter mellett egy másik bipoláris elektródot is használtunk, amelynek feladata a His köteg megfelelő lokalizációja volt. A katéterek bevezetését röntgen képerősítő mellett végeztük és a pontos intrakardialis lokalizációt a külön bipoláris elektródról származó EKG-jelek alapján állítottuk be.As described herein, another bipolar electrode was used in addition to the electrode catheter providing the DC shock with a central electrode for proper localization of the His bundle. Catheter insertion was performed with an X-ray image intensifier and accurate intracardiac localization was performed based on ECG signals from a separate bipolar electrode.
A szívóhatást felhasználó elektródkatétereket az orvosi gyakorlatban elteijedten használják. Az egyik típust a VYGON cég (Aachen, NSZK) 1172.06 típusú bipoláris szívó elektródja képezi, amelyet monofázisú akciós potenciálok elvezetésére használnak. Ez az elektródkatéter kisméretű centrális nyílással és annak közepéből tűszerűén kiálló, rugózó centrális elektróddal rendelkezik. A másik érintkező a szigetelő anyagú elülső gyűrű mögött gyűrű alakban helyezkedik el, és koaxiálisán körülveszi a rugózó centrális tűelektródot. Ennek az elektródnak az AV block létesítésére való használata sok nehézségbe ütközik, mert a szívóhatás rögzíti ugyan az elektródkatétert a His kötegen, de a tűelektród a nagy coaguláló energia hatására felmelegszik, esetenként előbb roncsolódik, mint a célzott képlet.Suction electrode catheters are commonly used in medical practice. One type is the V72GON (Aachen, Germany) 1172.06 Bipolar Suction Electrode, which is used to discharge monophasic action potentials. This electrode catheter has a small central opening and a spring-like central electrode that protrudes from its center. The other contact is located behind the insulating front ring in the form of an annular ring and coaxially surrounds the springing central needle electrode. Using this electrode to create an AV block is a lot of trouble because the suction effect fixes the electrode catheter to the His bundle, but the needle electrode heats up due to the high coagulating energy, sometimes breaking down before the targeted formula.
Ismertek még egyéb típusú üregeselektród katéterek, amelyek elsősorban tüdő belső nyomásának mérésére használhatók. Ezek az elektródkatéterek végükön tömör frontális elektróddal, emögött mintegy 15 mm távolságben elhelyezkedő gyűrű alakú elektróddal és a két elektród közötti szigetelő csőszakasz palástján kialakított szívónyílással rendelkeznek (Vygon 1126.13 típus). Az ilyen elektródkatéterek His köteg ablatiora az idézett cikkben leírt előnyöket nem tudják biztosítani.Other types of hollow electrode catheters are also known which can be used primarily to measure intra-lung pressure. These electrode catheters have a solid frontal electrode at their ends, an annular electrode about 15 mm behind it, and a suction opening on the periphery of the insulating tube section between the two electrodes (Vygon 1126.13). His bundle ablation of such electrode catheters cannot provide the benefits described in the cited article.
A találmány feladata olyan tökéletesített elektródkatéter létrehozása, amely His köteg ablatio végzésére előnyösen használható.SUMMARY OF THE INVENTION It is an object of the present invention to provide an improved electrode catheter which is advantageously used to perform His bundle ablation.
A kitűzött feladatot olyan elektródkatéterrel oldottam meg, amelynek frontális elektródja persely alakban van kiképezve, amelynek központos belső nyílása a katétercsővel közlekedik és ez képezi a szívónyílást, a frontális elektród a katétercsővel egytengelyű és azzal azonos vagy közel azonos külső átmérőjű.I have solved this problem with an electrode catheter having a frontal electrode in the form of a sleeve, the central inner opening of which is in communication with the catheter tube, which forms the suction opening, the frontal electrode is coaxial with the catheter tube and has the same or nearly same external diameter.
Az így kiképzett elektródkatéter frontális elektródja gyűrű alakú frontális felülettel rendelkezik, amelynek a tűelektródnál lényegesen nagyobb kontaktusfelülete van.The electrode catheter thus formed has a frontal electrode having a ring-shaped frontal surface which has a substantially larger contact area than the needle electrode.
A találmány szerinti elektródkatéter egy előnyös kiviteli alakjánál a frontális elektród mögött, attól 5-15 mm közötti távolságban persely alakú hátsó elektróddal van ellátva, a katétercső frontális vége a hátsó elektród egy koncentrikus vállrészéhez csatlakozik, a hátsó elektród egy másik koncentrikus vállrésze pedig a katétercsőhöz hasonló csőből készített összekötő csőszakaszon keresztül van a frontális elektróddal összekötve, és mindkét elektródnak szigetelten a katétercső belsejében vezetett kivezető huzala van, amelyek egy-egy csatlakozó dugaszhoz kapcsolódnak.In a preferred embodiment of the present invention, the catheter tube is provided with a sleeve-shaped rear electrode at a distance of 5 to 15 mm behind the frontal electrode, the front end of the catheter tube being connected to a concentric shoulder portion of the rear electrode. is connected to the frontal electrode via a tubular connecting tube portion, and each of the electrodes is insulated with a lead wire inside the catheter tube that is connected to a connector plug.
Az így kialakított bipoláris elektród a lokalizációhoz korábban használt kísérő bipoláris elektródkatéter használatát szükségtelenné teszi és önmagában alkalmas a lokalizációhoz szükséges bipoláris jelek szolgáltatására.The bipolar electrode thus formed eliminates the need to use the accompanying bipolar electrode catheter previously used for localization and in itself is capable of providing the bipolar signals required for localization.
A találmány szerinti elektródkatéter használatát segíti, ha a katétercső hátsó végéhez zárócsap csatlakozik, amelynek a katétercső belsejével közlekedő, szívóberendezéshez csatlakoztatható csonkja, továbbá az elektródok kivezető huzaljait a csatlakozódugaszokkal összekötő elektródkivezetése van.The use of an electrode catheter according to the invention is facilitated by attaching a stopcock at the rear end of the catheter tube, which has a socket for connection to a suction device which is connected to the inside of the catheter tube and an electrode outlet connecting the electrode outlet wires to the plugs.
A frontális elektród kialakítása szempontjából előnyös, ha ívelt átmenetben keskenyedő és az elektród átlagos vastagságánál keskenyebb gyűrű alakú élben végződő homlokfelülettel rendelkezik.It is advantageous for the frontal electrode to have a tapered end face that has an annular edge that ends at an annular edge that is narrower than the average thickness of the electrode.
A találmány szerinti elektródkatéterrel a His köteg ablatio előnyösen, mellékhatásoktól mentesen végezhető.Advantageously, His bundle ablation with the electrode catheter of the invention can be performed without side effects.
A találmányt a továbbiakban egy kiviteli példa kapcsán, a rajz alapján ismertetem részletesebben.The invention will now be described in more detail with reference to an embodiment, based on the drawing.
A rajzon az:The drawing shows:
1. ábra a találmány szerinti elektródkatéter felhasználását szemléltető vázlat, és aFigure 1 is a schematic diagram illustrating the use of the electrode catheter of the present invention;
2. ábra az elektródkatéter frontális szakaszának nagyított képe félnézet-félmetszeti ábrázolásban.Fig. 2 is an enlarged view of a front view of an electrode catheter in a semi-perspective, semi-sectional view.
Az 1. ábra a találmány szerinti (1) elektródkatéter felhasználási vázlatát szemlélteti. Az (1) elektródkatétert egyszer használatos eszközként célszerű kiképezni. Az (1) elektródkatéter tartalmaz (2) katétercsövet, mely a példakénti esetben a nemzetközileg elfogadott szabványos méretsor szerint F6-os nagyságú, és hossza célszerűen 100 cm; ennek elülső végén kialakított (3) frontális elektródot, a (3) frontális elektród mögött kb. 10 mm távolságban elhelyezett (4) hátsó elektródot és a (2) katétercsőnek a (3) frontális elektróddal átellenes végéhez csatlakoztatott (5) zárócsapot, amelynek szívócsőhöz csatlakoztatható (6) csonkja van, és amelyből (7) és (8) elektródkivezetések nyúlnak ki végükön szabványos (9), (10) csatlakozódugaszokkal. A 2. ábrán az (1) elektródkatéter frontális szakaszát tüntettük fel nagyított, félnézet-félmetszeti ábrázolásban. A (3) frontális elektródot elöl kissé legömbölyített szélű persely képezi, amelyhez belül vékony (11) kivezetőhuzal van forrasztással vagy egyéb stabil módonFigure 1 illustrates a schematic of the use of the electrode catheter (1) according to the invention. The electrode catheter (1) is preferably designed as a disposable device. The electrode catheter (1) comprises (2) a catheter tube which, in the exemplary case, is of the size F6 according to the internationally accepted standard size range and is preferably 100 cm long; a front electrode (3) formed at the front end thereof, and a distance of approx. A back electrode (4) disposed at a distance of 10 mm and a stopcock (5) connected to the opposite end of the catheter tube (2) having a socket (6) for connection to a suction tube, from which the electrode terminals (7) and (8) extend at their ends with standard plugs (9), (10). Fig. 2 is a front view of the electrode catheter (1) in enlarged, half-view, semi-sectional view. The front electrode (3) is formed by a sleeve with a slightly rounded edge at the front, with a thin outlet wire (11) soldered or otherwise stable inside.
194 499 rögzítve. A példakénti kiviteli alaknál a (4) hátsó elektródot elöl és hátul vállal ellátott csőszakasz képezi, amelynek elülső válla és a (3) frontális elektród között a (2) katétercsővel azonos anyagból készített (12) távtartó cső létesít kapcsolatot. A (4) hátsó elektród 5 belsejéhez a (11) kivezető huzalhoz hasonló (13) kivezető huzal csatlakozik. A (2) katétercső elülső vége a (4) hátsó elektród vállán fekszik fel, és az így létrejött (1) elektródkatéter belül folyamatos cső alakú üreggel rendelkezik. A (11) és (13) kivezető huzalok az (5) zá- 10 rócsap belsejében a (7) és (8) elektródkivezetésekkel kapcsolódnak.194,499 recorded. In the exemplary embodiment, the rear electrode (4) is formed by a tubular section with a front and a back shoulder having a spacer tube (12) made of the same material as the catheter tube (2) between the front shoulder and the front electrode (3). A lead wire (13) similar to the lead wire (11) is connected to the inside of the rear electrode (4). The front end of the catheter tube (2) rests on the shoulder of the rear electrode (4) and the resulting cathode tube (1) has a continuous tubular cavity. The lead wires (11) and (13) are connected to the electrode terminals (7) and (8) on the inside of the pin (5).
Most ismét az 1. ábrára hivatkozunk, amelyen látható, hogy az (1) elektródkatéter a véna femorális percután punctióját követő bevezetés eredményeként a jobb 15 szívfélbe nyúlik be, és a (3) frontális elektród a His kötegnek ütközik. Ezt a helyzetet az (1) elektródkatéter röntgen képerősítővel végzett ellenőrzése, továbbá a (3) frontális elektródhoz és a (4) hátsó elektródhoz csatlakoztatott (15) EKG-készülék által végzett megfi- 20 gyelés alapján lehet beállítani. A beállított helyzet elérésekor az (5) zárócsap reteszének elfordításával az (1) elektródkatétert (16) szívóberendezéshez csatlakoztatjuk, és vele -13,6 kPa szívást létesítünk. Ennek hatására a (3) frontális elektród homlokfelülete a His 25 köteghez tapad. A szívás fenntartásával a (3) frontális elektródot így a kívánt helyen és helyzetben rögzítettük.Referring now to Figure 1, it is shown that as a result of the introduction of the catheter (1) following a femoral percutaneous vein puncture, it projects into the right heart 15 and the frontal electrode (3) collides with the His bundle. This position can be adjusted based on the X-ray image intensifier check of the electrode catheter (1) and the ECG device (15) connected to the front electrode (3) and the back electrode (4). When the set position is reached, the electrode catheter (1) is connected to the suction device by turning the stopcock latch (5) and suction is applied to it at -13.6 kPa. As a result, the front surface of the front electrode (3) adheres to the His 25 stack. By maintaining suction, the frontal electrode (3) is thus secured in the desired position and position.
A beteg bal lapockájához külső (17) elektródot érintkeztetünk, majd a (3) frontális elektróddal összekötött 30 (9) csatlakozódugaszt és a (17)elektródot (14) defibrillátorhoz kapcsolva megfelelő, például 50 Ws energiájú szinkron kisütéssel DC shockot létesítünk. Az így előidézett elektrocoagulatio totál AV blockot hoz létre.An external electrode (17) is contacted with the left shoulder of the patient, and a connector (30) connected to the front electrode (3) and the electrode (17) is connected to a defibrillator (14) to provide a suitable DC shock with a synchronous discharge. The resulting electrocoagulation creates a complete AV block.
Ezt követően a szívást megszüntetjük, és az (1) 35 elektródkatéteren keresztül fiziológiás nátrium-klorid infúziót vezetünk be, hogy a (3) frontális elektród leváljon a His kötegről. A beteg szívét az előzőleg a jobb kamrába vezetett átmeneti pacemaker elektróda segítségével külső pacemakerrel vezéreljük. 40The suction is then stopped and a physiological infusion of sodium chloride is introduced through the electrode catheter (1) to detach the frontal electrode (3) from the His bundle. The patient's heart is controlled by an external pacemaker using a transient pacemaker electrode previously inserted into the right ventricle. 40
Amennyiben a teljes AV block tíz napon keresztül megmarad, a betegbe végleges pacemakert implantálunk.If the complete AV block is maintained for ten days, a permanent pacemaker is implanted into the patient.
A találmány szerinti (1) elektródkatéter alkalmazásával az eddig ismert megoldásokhoz képest a legna- 45 gyobb előny a (3) frontális elektród pontos rögzítése, továbbá a lényegesen jobb és biztosabb kontaktus a koaguláló elektróda és a His köteg között. A szívóhatás és a (3) elektród homlokfelületének körgyűrű mentén történő határozott felfekvése kis átmeneti ellenállású érintkezést biztosít, és ezért az AV block létesítéséhez kisebb energia is elegendő.The greatest advantage of using the electrode catheter (1) of the present invention compared to the prior art is the precise fixation of the front electrode (3) and the significantly better and more secure contact between the coagulating electrode and His bundle. The suction effect and the firm positioning of the electrode face (3) along the annular ring provide low transient resistance and therefore less energy is required to construct the AV block.
Az itt vázolt előnyöket az eddig végzett nagyszámú kísérlet is igazolta, és a találmány szerinti (1) elektródkatéterrel végzett ablatio a hagyományos kiképzésű elektródákkal végzetthez képest biztonságosabb a beteg szempontjából. A kísérletek során komplikáció egyetlen alkalommal sem jelentkezett.The advantages outlined herein have also been confirmed by numerous experiments to date, and ablation with the electrode catheter (1) of the present invention is safer for the patient compared to conventional electrodes. No complications occurred during the experiments.
Claims (4)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU8679A HU194499B (en) | 1986-01-08 | 1986-01-08 | Electrode-catheter for ablation of his fascicle |
| PCT/HU1987/000001 WO1987004081A1 (en) | 1986-01-08 | 1987-01-08 | Electrode catheter for the ablation of the his bundle |
| EP87900679A EP0256043A1 (en) | 1986-01-08 | 1987-01-08 | Electrode catheter for the ablation of the his bundle |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU8679A HU194499B (en) | 1986-01-08 | 1986-01-08 | Electrode-catheter for ablation of his fascicle |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUT42332A HUT42332A (en) | 1987-07-28 |
| HU194499B true HU194499B (en) | 1988-02-29 |
Family
ID=10947805
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU8679A HU194499B (en) | 1986-01-08 | 1986-01-08 | Electrode-catheter for ablation of his fascicle |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP0256043A1 (en) |
| HU (1) | HU194499B (en) |
| WO (1) | WO1987004081A1 (en) |
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-
1986
- 1986-01-08 HU HU8679A patent/HU194499B/en unknown
-
1987
- 1987-01-08 WO PCT/HU1987/000001 patent/WO1987004081A1/en not_active Ceased
- 1987-01-08 EP EP87900679A patent/EP0256043A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| WO1987004081A1 (en) | 1987-07-16 |
| EP0256043A1 (en) | 1988-02-24 |
| HUT42332A (en) | 1987-07-28 |
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