HU193289B - Cosmetical composition for treating hair and nail containing blood plasma concentrate as active agent - Google Patents

Abstract

Preparation for hair and nail care, particularly in the form of shampoos, hair rinsers, hair conditioners and hair lotions, respectively in the form of nail polish, and production method thereof. The preparation contains a quantity varying between at least 0.3 and at the most 6% by weight of blood plasma extract obtained preferably by ultrafiltration from slaughter blood and having a low salt contents. For the production of the different forms of the preparation according to the present invention, the blood plasma extract is soaked in water or an aqueous emulsion before it is mixed in the soaked state with other ingredients.

Description

FIELD OF THE INVENTION The present invention relates to a composition containing a blood plasma solution as an active ingredient for the care of hair and nails, in particular for use in the form of hair shampoo, hair rinse, hair conditioner or hair lotion or nail polish.

Hair care products can be divided into several groups according to their use and intended use. Major shampoos include hair shampoos, hair rinses, hair conditioners and various hair lotions. Depending on the nature of the hair to be treated, all these products are made for dry, normal, oily and dandruff hair.

The primary function of hair shampoos is to clean the hair 15 and the scalp. For this purpose they contain surfactants, in particular surfactants. Surfactants have a drying effect on the hair and skin. In addition to surfactants, hair shampoos contain various active ingredients, including grease and skin nourishing agents, to compensate for the drying effect and to care for the hair and scalp. In addition to these substances, hair shampoos (and the other 25 hair care products) contain fragrances, colorants and preservatives as needed. The active ingredients are usually protein and amino acid-containing substances, such as plant extracts, cola- ^{3 (3} genes, etc.). The use of shampoo ³⁵ before rinsing helps to diffuse the active ingredient into the skin.

Unlike hair shampoo, hair rinses are no longer washed with water. Due to the lasting presence of the concentration of active material ⁴⁰ hajleöblítő agents is generally less than that of the hair shampoos. The primary purpose of hair rinses is to counteract the skin and hair effects of shampooing and to improve the texture of the hair and scalp. This is especially the case for hair conditioners, which also stay on the hair permanently or more permanently. Instead of surfactants, hair conditioners contain the active ingredient in some form of an emulsion which, in accordance with the description described above, contains predominantly natural proteins. In addition to the alcohol content of the hair alcohol, there is also a natural extract. This active ingredient is usually a plant extract or animal ⁵⁵ derivative. For each of these main applications of hair care products, it is true that the active ingredient to be applied has a number of beneficial effects. On the one hand, they must ensure that the hair is degreased ⁶⁰ , has the appropriate physical properties (elasticity, combability, light, etc.), and on the other hand it protects the scalp from dehydration and delivers the hair-forming substances into the 65 2. Protein based active ingredients are used in the application of nail polish to protect, preserve or ensure the consistency of the nail. One of the most disadvantageous properties when applying nail polish is the tendency of the lacquer to crack. Due to the tendency of the lacquer to crack or crack, the lacquer already applied must be removed more frequently than its actual wear. It is also known that, from the known natural-based active ingredients, the protein and amino acid composition in the blood contains all the ingredients that would allow to fulfill these purposes. In its natural form, the use of blood for cosmetic purposes is hindered by many circumstances. These include the tendency to sleep, deterioration, color, etc.

The industrial use of slaughterhouse blood is already widely known. After treatment with an anticoagulant, the slaughterhouse blood is separated into a thickener and blood plasma with a separator, and the blood plasma is mainly used for food purposes. The major groups of proteins in the plasma are globular and lipoprotein type proteins and fibrinogen. Plasma, in its natural state, is unsuitable for use as an active ingredient due to its high water content and its tendency to deteriorate. By drying from plasma, plasma concentrates can be prepared. Plasma concentrates have a relatively high salt content. During drying, the salt concentration increases as the liquid exits. The following describes the composition of the blood plasma, followed by the dried blood plasma, and the essential amino acid content of the blood plasma (Grant, R.A .: Applied protein chemistry, Applied Sci. Publishers, Ltd. London, 1980).

Average composition of blood plasma (60% of total blood)

90.8%

Water Salt Fat

Other materials

proteins

albumin

fibrinogen

Globulin

0.8 t% 0J t% 0.4 t% 7.9 t% 3.3 t% 0.4 t% 4.2 t%

Average composition of dried blood plasma 7.0% water

Protein 71.9%

Salts 7.3% of the plasma

9.2% w / w anticoagulant Fat 1.0% w / w

Other 3,6 t%

Essential amino acid content of blood plasma (g amino acid / 100 g)

L.izin Treon Metionin Valin

phenylalanine

10.1

2.9

1.9 3.5

9.2

6.2 1.0 7.0 5.6

Leucine i-Leucine Tryptophan Histidine

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From the above composition, it can be seen that the protein content of the concentrated plasma is 71.9% compared to 7.9% in the plasma. This almost tenfold amount is due to a significant decrease in water content. However, during drying, not only the relative protein content but also the salt content increases. 16.5% salt in concentrated plasma is a barrier in most cosmetic applications. Salts derived from anticoagulants are particularly dangerous here. They contain different phosphate salts, the presence of which coagulates and precipitates proteins on the skin surface. High salt content has a dehydrating effect, dries and sometimes irritates the skin. Due to its high salt content, the plasma concentration is therefore very small for cosmetic purposes despite its very good protein and amino acid composition.

From the very extensive literature on hair and nail care compositions, reference is made to German Patent Publication No. 1 467 952, which discloses hair and nail care compositions containing conventionally prepared plasma plasma concentrates among various natural substances. However, these preparations have exactly the aforementioned disadvantages with respect to conventional plasma concentration. It is an object of the present invention to provide a hair and nail care composition which is free of said side effects. It has now been found that the above problem can be solved by using ultrafiltration plasma concentrate as a blood plasma concentrate in hair and nail care compositions. This technology, called ultrafiltration, enables Fine Filtration to separate particles of molecular weight 16,000-18,000 from the liquid phase. Precious proteins and amino acids in the plasma have molecular weights above this range and can be separated from the liquid phase by ultrafiltration. In contrast to the 16.5% salinity in the dried blood plasma, the plasma concentration of the ultrafiltrated condensed plasma is about 4.1% and the remainder of this anticoagulant is only about 2.5%. This amount of salt is already negligible.

The invention thus relates to a composition for the care of hair and nails, in particular for use in the form of a hair shampoo, hair rinse, hair conditioner or hair lotion or nail polish containing a new type of plasma plasma concentrate obtained from 0.3 to 3% by weight. in which the salt concentration is not more than 6%, the residues from these anticoagulant substances added to the slaughterhouse blood do not exceed 60% of the permitted salt content and the protein concentration is at least 60%. In addition to the amount described herein, the benefits of the protein components in plasma can even compensate for the potential disadvantages of salt content in the dried plasma, and the protein and amino acid composition of the concentrate essentially corresponds to that of the non-concentrated plasma. Significantly better results are obtained when the salt concentration in the plasma is below 4.5%. Such a concentration can therefore only be achieved by ultrafiltration from currently known technologies.

To understand the benefits of the active ingredient obtained from the plasma concentration, we refer to the composition of hair proteins. Keratin is made up of cystine and methionine to a very large extent, so the introduction of these amino acids into the scalp helps the hair structure to recover. Plasma fibrinogen amino acid composition is more favorable for biologically active compounds than collagen and elastin. Thus, the threonine content is three and six times, respectively, the leucine and isoleucine content is nearly three times that of collagen. The tyrosine content is five times that of collagen, the content of lysine is more than twice that of collagen, and sixteen times that of elastin. Arginine is present in the plasma six times as much as elastin. Tryptophan is completely free of collagen and elastin, whereas it is found in significant amounts in fibrinogen. Collagen does not contain cystine and elastin has a seventh of cystine content as fibrinogen. The other important sulfur-containing amino acid, mcthionine, is only trace and contains about a quarter relative to collagen relative to fibrinogen. These ratios are further increased when one considers that the concentration of protein and amino acids in plasma concentrates is multiplied with that of plasma. The data described herein reflect some of the benefits of the use of plasma compared to the two most preferred hair care ingredients, collagen and elastin. Ineffective, it is not yet fully proven, but it is highly likely that, in addition to the presence of higher concentrations of valuable amino acids, their binding state is more favorable for integration into the body than if the same substances were bound to a tissue foreign vehicle. In the known active substances, the latter conditions prevail. The globular proteins in the blood plasma concentrate give the skin a moisturizing effect, giving it natural elasticity. Plasma lipoprotein proteins are fat-containing, reducing the liposuction effect of surfactants. Due to their property described herein, it is excellent for skin nutrition

-3193289 proteins are adsorbed on the surface of the scalp and compensate for dehydration of the scalp, moisturize and reduce excitement. Fat-containing substances have a positive influence on the mechanical properties of the hair.

The active ingredient according to the invention is particularly suitable for use in hair care products for the reasons described herein. Due to the similarity of the structure of the hair and the nail, it can be used as an active ingredient of nail polish, which at the same time increases the elasticity of the lacquer layer.

In the preparation of the hair care composition of the present invention, the concentrated blood plasma must first be swelled in water and then the other conventional ingredients added to the resulting fluid, sometimes homogenized by mixing or maturing. The foregoing applies primarily to hair shampoo formulations and hair rinse products, but in the latter case, it is preferable to select between 0.4 and 2% by weight of the active ingredient. Another advantageous effect of blood plasma concentrate is achieved in the preparation of a hair conditioning product. Such products contain an aqueous emulsion instead of a surfactant and the effect of the lipoproteins in stabilizing water-in-oil emulsion systems is apparent. The present invention will now be described in more detail with reference to some examples. The plasma concentrate used in the Examples was prepared by the ultrasound procedure described in Hungarian Patent No. 186,957, with the characteristics given therein.

Example 1

Hair shampoo is prepared from 40% sodium lauryl ether sulfate (tradename Texapon N-25 from Henkel Düsseldorf, Germany), 10% betaine derivative (trade name Zalabetain from Caola), 2% degreasing agent (coconut fatty acid diethanolamide, marketed by Henkel under the tradename Comperlan KD), 45% distilled water, 0.5% preservative (sold by Rohm and Haas, Philadelphia, USA under the brand name Kathon CG) a mixture of 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one) and 1% by weight of a plasma concentrate with a dry matter content of 93.09%, of which protein 80.57 sodium chloride (2.05% w / w, ash content 4.44% w / w) by swelling the former in water and then adding the above components with stirring. After homogenization, it is perfumed at 30 ° C by adding 0.8% by volume of the fragrance sold by the Dutch company 1FF Hilversum under the trade name FAH 42095. The hair shampoo so prepared should be kept on the scalp for a few minutes to allow the active ingredient to diffuse into the scalp. The obtained results prove the elasticity of the hair, its proper consistency, its good combing ability and its pleasant fall.

Example 2

In the preparation of a hair rinse product, the plasma concentration of Example 1 was swollen in 0.8% water, followed by Antara 430 (a polyacrylic resin manufactured by GAF NSC) in 0.08% and citric acid in 0.3% by weight. is added. The water content is then about 99%. Application of the product has resulted in long-lasting hair.

Example 3 ¹

The following two ingredients are used in the production of hair conditioner:

A) Lanette trade name (lanolin): 12% Cetiol trade name (manufactured by Henkel; oleic ester of oleic acid)

Comperlan KD (trade name Henkel): 3% plasma concentration: 2%; glycerol 5% citric acid: 0.5%; and water 76.5%.

B) Lanette (sodium cetyl stearyl sulfate): 3.2%;

Emulgin B2 commercially available from Henkel;

0.8% by weight of cetylstearyl alcohol containing moles of ethylene oxide;

Eutanol 6 (trade name Henkel); 2%

Example 1 blood plasma concentration: 1> 5%; glycerol: 5%;

Citric acid: 0.5% and water 87%.

Here again, the plasma concentrate is swelled in water and the other ingredients are added thereto. The product has been found to be very favorable by hairdressers and beauticians.

Example 4

A preferred composition for making hair alcohol is: ethanol 85.5%, distilled water 9.5%, isopropyl myristate 3%, plasma concentration of Example 1 0.5%, fragrance (see Example 1): 1.5 % by weight. First, the plasma concentrate is swollen in water, then dissolved in alcohol for one to two weeks, filtered if necessary. The use of the hair lotion thus produced has also yielded positive results.

Example 5

Nail polish 20% nitrocellulose, 1.8% di-4193289 butyl phthalate, 9.5% (by Monsanto under the trade name Santolite), 3.27% by weight toluene, 14% by weight butyl acetate, 14% ethyl acetate and 8% isopropanol were used, the solvents were first mixed, then the plasticizer and nitrocellulose were dissolved and finally the resin. A thixotropic varnish consisting of 84% varnish, 16% bentonite gel was then prepared by adding 1% modified titanium dioxide (Timiron Super Silver from Merck, Darmstadt, NS) and 1% by weight of Example 1. plasma concentration. Nail polish protects the texture of the nail, prevents fragmentation and gives the lacquer a sufficient amount of elasticity.

The broad spectrum mechanism of action of the present invention improves the quality of hair and nail care products and is simple to apply and relatively inexpensive to produce in bulk.

Claims (3)

PATENT CLAIMS 1. Preparations for the care of the hair and nails, in particular hair shampoo, hair rinse, conditioner or hair lotion, or 5 in the form of nail polish which conventionally utilizes carriers and / or excipients, preferably distilled water as carrier, physiologically acceptable organic solvent and / or excipient It contains 10 preservatives and, in the case of nail polish, a carrier comprising thixotropic lacquer and optionally a pigment, characterized in that it contains 0.3-3% by weight, based on the weight of the composition, of a plasma concentration of not more than 6% by weight. residues from anticoagulant salts added to the slaughterhouse blood of up to 60% by weight and having a protein concentration of at least 60% by weight.