HU190963B - Process for production of synergyc medical preparatives containing organic acids with oxitetracylin and antimicrobatic influence - Google Patents
Process for production of synergyc medical preparatives containing organic acids with oxitetracylin and antimicrobatic influence Download PDFInfo
- Publication number
- HU190963B HU190963B HU841682A HU168284A HU190963B HU 190963 B HU190963 B HU 190963B HU 841682 A HU841682 A HU 841682A HU 168284 A HU168284 A HU 168284A HU 190963 B HU190963 B HU 190963B
- Authority
- HU
- Hungary
- Prior art keywords
- oxytetracycline
- coli
- acid
- oxolinic
- formulated
- Prior art date
Links
- 150000007524 organic acids Chemical class 0.000 title claims abstract 3
- 238000000034 method Methods 0.000 title claims description 8
- 235000005985 organic acids Nutrition 0.000 title 1
- 239000004100 Oxytetracycline Substances 0.000 claims abstract description 22
- 229960000625 oxytetracycline Drugs 0.000 claims abstract description 22
- 235000019366 oxytetracycline Nutrition 0.000 claims abstract description 22
- IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 claims abstract description 22
- 241001465754 Metazoa Species 0.000 claims abstract description 8
- 230000002195 synergetic effect Effects 0.000 claims abstract description 8
- 239000007788 liquid Substances 0.000 claims abstract description 5
- 239000007787 solid Substances 0.000 claims abstract description 4
- IWVCMVBTMGNXQD-PXOLEDIWSA-N oxytetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-PXOLEDIWSA-N 0.000 claims abstract 5
- MHWLWQUZZRMNGJ-UHFFFAOYSA-N nalidixic acid Chemical compound C1=C(C)N=C2N(CC)C=C(C(O)=O)C(=O)C2=C1 MHWLWQUZZRMNGJ-UHFFFAOYSA-N 0.000 claims description 17
- KYGZCKSPAKDVKC-UHFFFAOYSA-N Oxolinic acid Chemical compound C1=C2N(CC)C=C(C(O)=O)C(=O)C2=CC2=C1OCO2 KYGZCKSPAKDVKC-UHFFFAOYSA-N 0.000 claims description 15
- 229960000210 nalidixic acid Drugs 0.000 claims description 13
- 239000000203 mixture Substances 0.000 claims description 12
- 229960000321 oxolinic acid Drugs 0.000 claims description 12
- 244000309466 calf Species 0.000 claims description 9
- 239000004480 active ingredient Substances 0.000 claims description 7
- 241000282887 Suidae Species 0.000 claims description 4
- 239000002775 capsule Substances 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 244000144977 poultry Species 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 238000009472 formulation Methods 0.000 claims description 2
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- -1 naphthalidine carboxylic acid derivative Chemical class 0.000 claims 2
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- DJXNJVFEFSWHLY-UHFFFAOYSA-N quinoline-3-carboxylic acid Chemical compound C1=CC=CC2=CC(C(=O)O)=CN=C21 DJXNJVFEFSWHLY-UHFFFAOYSA-N 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 abstract description 6
- 239000004098 Tetracycline Substances 0.000 abstract description 3
- 235000019364 tetracycline Nutrition 0.000 abstract description 3
- 150000003522 tetracyclines Chemical class 0.000 abstract description 3
- 239000000654 additive Substances 0.000 abstract description 2
- 229960002180 tetracycline Drugs 0.000 abstract 2
- 229930101283 tetracycline Natural products 0.000 abstract 2
- 239000004606 Fillers/Extenders Substances 0.000 abstract 1
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- 210000004392 genitalia Anatomy 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 229940124531 pharmaceutical excipient Drugs 0.000 abstract 1
- 230000000241 respiratory effect Effects 0.000 abstract 1
- 230000002485 urinary effect Effects 0.000 abstract 1
- 241000588724 Escherichia coli Species 0.000 description 32
- OWFJMIVZYSDULZ-PXOLEDIWSA-N (4s,4ar,5s,5ar,6s,12ar)-4-(dimethylamino)-1,5,6,10,11,12a-hexahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide Chemical compound C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]4(O)C(=O)C3=C(O)C2=C1O OWFJMIVZYSDULZ-PXOLEDIWSA-N 0.000 description 21
- 241000283690 Bos taurus Species 0.000 description 10
- 241000282898 Sus scrofa Species 0.000 description 10
- 230000000844 anti-bacterial effect Effects 0.000 description 8
- 241000588779 Bordetella bronchiseptica Species 0.000 description 7
- 241000191967 Staphylococcus aureus Species 0.000 description 7
- 241000120569 Streptococcus equi subsp. zooepidemicus Species 0.000 description 7
- 239000003814 drug Substances 0.000 description 7
- 241000588747 Klebsiella pneumoniae Species 0.000 description 6
- 241000186779 Listeria monocytogenes Species 0.000 description 6
- 241000293869 Salmonella enterica subsp. enterica serovar Typhimurium Species 0.000 description 6
- 241000186064 Trueperella pyogenes Species 0.000 description 6
- 229940079593 drug Drugs 0.000 description 6
- 241000606856 Pasteurella multocida Species 0.000 description 5
- 241000588767 Proteus vulgaris Species 0.000 description 5
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 5
- 239000002246 antineoplastic agent Substances 0.000 description 5
- 229940127089 cytotoxic agent Drugs 0.000 description 5
- 229940007042 proteus vulgaris Drugs 0.000 description 5
- 241001293418 Mannheimia haemolytica Species 0.000 description 4
- 241000607142 Salmonella Species 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 229940051027 pasteurella multocida Drugs 0.000 description 4
- 241000588748 Klebsiella Species 0.000 description 3
- 241000204022 Mycoplasma gallisepticum Species 0.000 description 3
- 241000202938 Mycoplasma hyorhinis Species 0.000 description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- 241000194017 Streptococcus Species 0.000 description 3
- 208000035143 Bacterial infection Diseases 0.000 description 2
- 241000588807 Bordetella Species 0.000 description 2
- 241000606860 Pasteurella Species 0.000 description 2
- 241000588769 Proteus <enterobacteria> Species 0.000 description 2
- 241000191940 Staphylococcus Species 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 239000007900 aqueous suspension Substances 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 208000022362 bacterial infectious disease Diseases 0.000 description 2
- 239000000890 drug combination Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000002906 microbiologic effect Effects 0.000 description 2
- 235000013594 poultry meat Nutrition 0.000 description 2
- 230000002787 reinforcement Effects 0.000 description 2
- 208000004145 Endometritis Diseases 0.000 description 1
- 208000004232 Enteritis Diseases 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 208000018522 Gastrointestinal disease Diseases 0.000 description 1
- 238000012404 In vitro experiment Methods 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 229930193140 Neomycin Natural products 0.000 description 1
- 241000009328 Perro Species 0.000 description 1
- 206010062233 Uterine infection Diseases 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 235000020346 chamomile tea Nutrition 0.000 description 1
- 235000013330 chicken meat Nutrition 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 244000000058 gram-negative pathogen Species 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 230000000366 juvenile effect Effects 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 229960004927 neomycin Drugs 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- JOHZPMXAZQZXHR-UHFFFAOYSA-N pipemidic acid Chemical compound N1=C2N(CC)C=C(C(O)=O)C(=O)C2=CN=C1N1CCNCC1 JOHZPMXAZQZXHR-UHFFFAOYSA-N 0.000 description 1
- 229960004444 piromidic acid Drugs 0.000 description 1
- RCIMBBZXSXFZBV-UHFFFAOYSA-N piromidic acid Chemical compound N1=C2N(CC)C=C(C(O)=O)C(=O)C2=CN=C1N1CCCC1 RCIMBBZXSXFZBV-UHFFFAOYSA-N 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 229940040944 tetracyclines Drugs 0.000 description 1
- IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 description 1
- 229960001082 trimethoprim Drugs 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU841682A HU190963B (en) | 1984-04-28 | 1984-04-28 | Process for production of synergyc medical preparatives containing organic acids with oxitetracylin and antimicrobatic influence |
| BE1/011244A BE902251A (fr) | 1984-04-28 | 1985-04-22 | Nouvelles compositions pharmaceutiques ayant une activite antimicrobienne et procede pour leur preparation. |
| CH1750/85A CH666817A5 (de) | 1984-04-28 | 1985-04-24 | Antimikrobiell wirkende arzneimittelpraeparate und verfahren zu ihrer herstellung. |
| DE19853515214 DE3515214A1 (de) | 1984-04-28 | 1985-04-26 | Synergistisch wirkende kombinationsarzneimittel |
| NL8501198A NL8501198A (nl) | 1984-04-28 | 1985-04-26 | Nieuwe geneesmiddelen met antimicrobiele werking en werkwijze voor de bereiding ervan. |
| FR8506395A FR2563433B1 (fr) | 1984-04-28 | 1985-04-26 | Nouvelles compositions pharmaceutiques comprenant de l'oxytetracycline et un acide organique ayant une activite antimicrobienne et procede pour leur preparation |
| IT20514/85A IT1200460B (it) | 1984-04-28 | 1985-04-26 | Composizioni di farmaci dotae di attivita' antimicrobica e procedimento per la loro preparazione |
| SE8502039A SE467445B (sv) | 1984-04-28 | 1985-04-26 | Nya laekemedelskompositioner med antimikrobiell aktivitet och foerfarande foer deras framstaellning |
| ES542611A ES8706028A1 (es) | 1984-04-28 | 1985-04-26 | Procedimiento de preparacion de nuevas composiciones sinergeticas antimicrobianas que contienen aritetraciclina y un acido organico de acitividad antimicrobiana. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU841682A HU190963B (en) | 1984-04-28 | 1984-04-28 | Process for production of synergyc medical preparatives containing organic acids with oxitetracylin and antimicrobatic influence |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUT37349A HUT37349A (en) | 1985-12-28 |
| HU190963B true HU190963B (en) | 1986-12-28 |
Family
ID=10955662
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU841682A HU190963B (en) | 1984-04-28 | 1984-04-28 | Process for production of synergyc medical preparatives containing organic acids with oxitetracylin and antimicrobatic influence |
Country Status (9)
| Country | Link |
|---|---|
| BE (1) | BE902251A (it) |
| CH (1) | CH666817A5 (it) |
| DE (1) | DE3515214A1 (it) |
| ES (1) | ES8706028A1 (it) |
| FR (1) | FR2563433B1 (it) |
| HU (1) | HU190963B (it) |
| IT (1) | IT1200460B (it) |
| NL (1) | NL8501198A (it) |
| SE (1) | SE467445B (it) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU200917B (en) * | 1987-07-20 | 1990-09-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing pharmaceutical compositions comprising quinoline or naphthyridinecarboxylic acid and tetracycline derivatives as active ingredient |
| EP0951902A1 (en) * | 1998-03-31 | 1999-10-27 | Edmund J.H. Campion | A feed mixture |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH642850A5 (it) * | 1978-10-20 | 1984-05-15 | Ausonia Farma Srl | Composizioni farmaceutiche ad attivita antibatterica contro infezioni da germi gram-positivi e gram-negativi. |
-
1984
- 1984-04-28 HU HU841682A patent/HU190963B/hu not_active IP Right Cessation
-
1985
- 1985-04-22 BE BE1/011244A patent/BE902251A/fr not_active IP Right Cessation
- 1985-04-24 CH CH1750/85A patent/CH666817A5/de not_active IP Right Cessation
- 1985-04-26 FR FR8506395A patent/FR2563433B1/fr not_active Expired
- 1985-04-26 NL NL8501198A patent/NL8501198A/nl not_active Application Discontinuation
- 1985-04-26 ES ES542611A patent/ES8706028A1/es not_active Expired
- 1985-04-26 DE DE19853515214 patent/DE3515214A1/de not_active Withdrawn
- 1985-04-26 IT IT20514/85A patent/IT1200460B/it active
- 1985-04-26 SE SE8502039A patent/SE467445B/sv not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| BE902251A (fr) | 1985-10-22 |
| IT8520514A0 (it) | 1985-04-26 |
| HUT37349A (en) | 1985-12-28 |
| SE8502039L (sv) | 1985-10-29 |
| FR2563433B1 (fr) | 1988-12-02 |
| FR2563433A1 (fr) | 1985-10-31 |
| IT1200460B (it) | 1989-01-18 |
| SE467445B (sv) | 1992-07-20 |
| SE8502039D0 (sv) | 1985-04-26 |
| ES542611A0 (es) | 1987-06-01 |
| CH666817A5 (de) | 1988-08-31 |
| NL8501198A (nl) | 1985-11-18 |
| DE3515214A1 (de) | 1985-10-31 |
| ES8706028A1 (es) | 1987-06-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HU90 | Patent valid on 900628 | ||
| HMM4 | Cancellation of final prot. due to non-payment of fee |