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HU0001789D0 - New substituted pyridine or piperidine compounds, process for their preparation and medicaments containing the same - Google Patents

New substituted pyridine or piperidine compounds, process for their preparation and medicaments containing the same

Info

Publication number
HU0001789D0
HU0001789D0 HU0001789A HUP0001789A HU0001789D0 HU 0001789 D0 HU0001789 D0 HU 0001789D0 HU 0001789 A HU0001789 A HU 0001789A HU P0001789 A HUP0001789 A HU P0001789A HU 0001789 D0 HU0001789 D0 HU 0001789D0
Authority
HU
Hungary
Prior art keywords
group
alkoxy
pyridine
piperidine
preparation
Prior art date
Application number
HU0001789A
Other languages
English (en)
Inventor
Daniel-Henri Caignard
Marie-Cecile Lebrun
Pierre Lestage
Otto Meth-Cohn
Pierre Renard
Chu-Yi Yu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of HU0001789D0 publication Critical patent/HU0001789D0/hu
Publication of HUP0001789A2 publication Critical patent/HUP0001789A2/hu
Publication of HUP0001789A3 publication Critical patent/HUP0001789A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
HU0001789A 1999-05-05 2000-05-05 Substituted pyridine or piperidine compounds, process for their preparation and medicaments containing the same HUP0001789A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9905690A FR2793245B1 (fr) 1999-05-05 1999-05-05 Nouveaux composes pyridiniques ou piperidiniques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (3)

Publication Number Publication Date
HU0001789D0 true HU0001789D0 (en) 2000-07-28
HUP0001789A2 HUP0001789A2 (en) 2001-03-28
HUP0001789A3 HUP0001789A3 (en) 2004-04-28

Family

ID=9545222

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0001789A HUP0001789A3 (en) 1999-05-05 2000-05-05 Substituted pyridine or piperidine compounds, process for their preparation and medicaments containing the same

Country Status (22)

Country Link
US (6) US6323220B1 (hu)
EP (1) EP1050531B1 (hu)
JP (2) JP3533361B2 (hu)
KR (1) KR100472519B1 (hu)
CN (1) CN100371326C (hu)
AT (1) ATE282595T1 (hu)
AU (1) AU764388B2 (hu)
BR (1) BR0002287A (hu)
CA (1) CA2308867C (hu)
DE (1) DE60015844T2 (hu)
DK (1) DK1050531T3 (hu)
EA (1) EA003053B1 (hu)
ES (1) ES2233302T3 (hu)
FR (1) FR2793245B1 (hu)
HU (1) HUP0001789A3 (hu)
MX (1) MXPA00004343A (hu)
NO (1) NO317095B1 (hu)
NZ (1) NZ504338A (hu)
PL (1) PL197661B1 (hu)
PT (1) PT1050531E (hu)
SI (1) SI1050531T1 (hu)
ZA (1) ZA200002207B (hu)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7687513B1 (en) 2004-10-21 2010-03-30 University Of Notre Dame Du Lac Aminopyridinium ionic liquids
US7812098B2 (en) * 2006-03-31 2010-10-12 Depuy Products, Inc. Bearing material of medical implant having reduced wear rate and method for reducing wear rate
FR2905009A1 (fr) * 2006-08-18 2008-02-22 Servier Lab Methode de criblage de composes aux proprietes anti-amyloide
EP2217236A1 (en) * 2007-11-02 2010-08-18 Yaupon Therapeutics, Inc. Use of lobeline epimers in the treatment of central nervous system diseases, pathologies, and drug abuse
WO2009061906A2 (en) * 2007-11-06 2009-05-14 Mayo Foundation For Medical Education And Research Treating protein misfolding diseases
EP2186419A1 (en) * 2008-11-13 2010-05-19 Tchibo GmbH NMP-containing extract, a method of its production and uses thereof
WO2010087315A1 (ja) * 2009-01-29 2010-08-05 株式会社林原生物化学研究所 抗アルツハイマー病剤
US20120035187A1 (en) * 2009-01-29 2012-02-09 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Anti-neurodegenerative disease agent
JPWO2010087313A1 (ja) * 2009-01-29 2012-08-02 株式会社林原生物化学研究所 神経突起伸展促進剤
CA3141404A1 (en) * 2019-06-14 2020-12-17 Disarm Therapeutics, Inc. Inhibitors of sarm1

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3840523A (en) * 1973-04-25 1974-10-08 Richardson Merrell Inc Tricyclic arylalkylene lactamimides
US4082806A (en) 1975-12-18 1978-04-04 Wright State University Preparation of tetraketones
JPS5328177A (en) * 1976-08-25 1978-03-16 Teijin Ltd Optical active piperidine derivatives and their preparation
EP0336886B1 (de) * 1988-03-16 1992-08-26 Ciba-Geigy Ag Thioverbindungen
EP0346791B1 (en) * 1988-06-14 1994-04-06 G.D. Searle & Co. 1,2-diarylethylamines for treatment of neurotoxic injury
JP2522690B2 (ja) 1988-06-16 1996-08-07 富士写真フイルム株式会社 ハロゲン化銀カラ―写真感光材料
US5414005A (en) * 1993-10-28 1995-05-09 Dynagen, Inc. Methods and articles of manufacture for the treatment of nicotine withdrawal and as an aid in smoking cessation
GB9304919D0 (en) * 1993-03-10 1993-04-28 Celltech Ltd Chemical compounds
FR2756826B1 (fr) * 1996-12-05 1999-01-08 Adir Nouveaux derives tetrahydropyridiniques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US5830904A (en) * 1997-02-05 1998-11-03 University Of Kentucky Research Foundation Lobeline compounds as a treatment for psychostimulant abuse and withdrawal, and for eating disorders
US6087376A (en) * 1997-02-05 2000-07-11 University Of Kentucky Research Foundation Use of lobeline compounds in the treatment of central nervous system diseases and pathologies
WO1998034615A1 (en) * 1997-02-07 1998-08-13 Synapse Pharmaceuticals International, Inc. Pharmaceutical composition for treatment of synaptic dysfunction comprising an oxime
JPH10287634A (ja) * 1997-04-11 1998-10-27 Otsuka Pharmaceut Co Ltd ベンゼン誘導体
TW544448B (en) * 1997-07-11 2003-08-01 Novartis Ag Pyridine derivatives
ATE224366T1 (de) * 1997-10-31 2002-10-15 Hoffmann La Roche D-prolinderivate
US6015824A (en) * 1998-02-10 2000-01-18 Hoffmann-La Roche Ag Pyrrolidine and piperidine derivatives and treatment of neurodegenerative disorders

Also Published As

Publication number Publication date
AU3255200A (en) 2000-11-09
US20030139408A1 (en) 2003-07-24
DE60015844D1 (de) 2004-12-23
KR20010020808A (ko) 2001-03-15
SI1050531T1 (en) 2005-04-30
CN1277192A (zh) 2000-12-20
NO317095B1 (no) 2004-08-09
JP2002179652A (ja) 2002-06-26
NO20002351D0 (no) 2000-05-04
NZ504338A (en) 2001-06-29
HUP0001789A3 (en) 2004-04-28
FR2793245B1 (fr) 2002-10-11
CA2308867A1 (fr) 2000-11-05
EP1050531B1 (fr) 2004-11-17
DE60015844T2 (de) 2005-10-27
CN100371326C (zh) 2008-02-27
EA003053B1 (ru) 2002-12-26
JP3533361B2 (ja) 2004-05-31
PT1050531E (pt) 2005-03-31
ATE282595T1 (de) 2004-12-15
KR100472519B1 (ko) 2005-03-07
US6734196B2 (en) 2004-05-11
CA2308867C (fr) 2006-03-14
EP1050531A1 (fr) 2000-11-08
DK1050531T3 (da) 2005-03-21
US6638946B2 (en) 2003-10-28
US20020035123A1 (en) 2002-03-21
EA200000389A2 (ru) 2000-12-25
FR2793245A1 (fr) 2000-11-10
ZA200002207B (en) 2000-11-14
EA200000389A3 (ru) 2001-02-26
US20030181484A1 (en) 2003-09-25
US20020040036A1 (en) 2002-04-04
JP2000355579A (ja) 2000-12-26
PL197661B1 (pl) 2008-04-30
PL339994A1 (en) 2000-11-06
BR0002287A (pt) 2001-01-02
NO20002351L (no) 2000-11-06
HUP0001789A2 (en) 2001-03-28
US6511992B2 (en) 2003-01-28
US20050004168A1 (en) 2005-01-06
ES2233302T3 (es) 2005-06-16
MXPA00004343A (es) 2002-03-08
AU764388B2 (en) 2003-08-14
US6323220B1 (en) 2001-11-27

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Legal Events

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FD9A Lapse of provisional protection due to non-payment of fees