HRP20210704T1 - Formulacija suhog praška koja sadrži antikolinergik, kortikosteroid i beta-adrenergik za davanje inhalacijom - Google Patents
Formulacija suhog praška koja sadrži antikolinergik, kortikosteroid i beta-adrenergik za davanje inhalacijom Download PDFInfo
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- HRP20210704T1 HRP20210704T1 HRP20210704TT HRP20210704T HRP20210704T1 HR P20210704 T1 HRP20210704 T1 HR P20210704T1 HR P20210704T T HRP20210704T T HR P20210704TT HR P20210704 T HRP20210704 T HR P20210704T HR P20210704 T1 HRP20210704 T1 HR P20210704T1
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- 239000000203 mixture Substances 0.000 title claims 18
- 238000009472 formulation Methods 0.000 title claims 17
- 239000000843 powder Substances 0.000 title claims 13
- 230000001078 anti-cholinergic effect Effects 0.000 title 1
- 239000003246 corticosteroid Substances 0.000 title 1
- 239000002245 particle Substances 0.000 claims 14
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 6
- 239000000546 pharmaceutical excipient Substances 0.000 claims 6
- 239000013543 active substance Substances 0.000 claims 5
- 239000010419 fine particle Substances 0.000 claims 5
- 239000011362 coarse particle Substances 0.000 claims 4
- 229940112141 dry powder inhaler Drugs 0.000 claims 3
- 235000019359 magnesium stearate Nutrition 0.000 claims 3
- 230000002757 inflammatory effect Effects 0.000 claims 2
- 230000000414 obstructive effect Effects 0.000 claims 2
- RATSWNOMCHFQGJ-TUYNVFRMSA-N (e)-but-2-enedioic acid;n-[2-hydroxy-5-[(1s)-1-hydroxy-2-[[(2s)-1-(4-methoxyphenyl)propan-2-yl]amino]ethyl]phenyl]formamide;dihydrate Chemical compound O.O.OC(=O)\C=C\C(O)=O.C1=CC(OC)=CC=C1C[C@H](C)NC[C@@H](O)C1=CC=C(O)C(NC=O)=C1.C1=CC(OC)=CC=C1C[C@H](C)NC[C@@H](O)C1=CC=C(O)C(NC=O)=C1 RATSWNOMCHFQGJ-TUYNVFRMSA-N 0.000 claims 1
- WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical compound O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 claims 1
- KUVIULQEHSCUHY-XYWKZLDCSA-N Beclometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O KUVIULQEHSCUHY-XYWKZLDCSA-N 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- VPNYRYCIDCJBOM-UHFFFAOYSA-M Glycopyrronium bromide Chemical compound [Br-].C1[N+](C)(C)CCC1OC(=O)C(O)(C=1C=CC=CC=1)C1CCCC1 VPNYRYCIDCJBOM-UHFFFAOYSA-M 0.000 claims 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 1
- 229950000210 beclometasone dipropionate Drugs 0.000 claims 1
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 229960003610 formoterol fumarate dihydrate Drugs 0.000 claims 1
- 210000003918 fraction a Anatomy 0.000 claims 1
- 229960002462 glycopyrronium bromide Drugs 0.000 claims 1
- 229960001375 lactose Drugs 0.000 claims 1
- 239000008101 lactose Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 210000002345 respiratory system Anatomy 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/02—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of powders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Otolaryngology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (12)
1. Formulacija suhog praška za upotrebu u inhalatoru za suhi prašak (DPI) za davanje inhalacijom, rečena formulacija sadrži:
a) frakciju finih čestica koje sadrže smjesu od 90 do 99.5 posto po masi mikroniziranih čestica fiziološki prihvatljivog ekscipijensa i 0.5 do 10 posto po masi magnezijeva stearata, gdje najmanje 90% svih rečenih čestica ima volumni promjer manji od 15 mikrona, i volumni medijalni promjer rečenih čestica je između 3 i 7 mikrona, te ne više od 10% rečenih čestica ima promjer manji od 1.8 mikrona;
b) frakciju grubih čestica koje sadrže fiziološki prihvatljiv ekscipijens koji ima promjer medijalne mase jednak ili veći od 100 mikrona,
pri čemu je omjer između finih čestica a) i grubih čestica b) između 1:99 i 30:70 posto po masi;
c) mikronizirane čestice glikopironijeva bromida, beklometazon-dipropionata, te formoterol-fumarat dihidrata kao aktivnih tvari; pri čemu najmanje 90% mikroniziranih čestica svake aktivne tvari ima volumni promjer jednak ili manji od 6 mikrona, i formulacija isporučuje terapijski učinkovitu dozu svih triju aktivnih tvari između 100 i 500 mikrograma;
gdje se rečena formulacija može dobiti postupkom koji obuhvaća korake i) miješanje čestica ekscipijensa i magnezijeva stearata u visokoenergijskoj aparaturi u periodu manjem od 30 minuta; te ii) miješanje frakcije finih čestica a), frakcije grubih laktoza čestica b) i svih mikroniziranih aktivnih tvari; te pri čemu, nakon isporuke iz inhalatora, formulacija isporučuje frakciju aktivnih čestica u kojima 30% ili više čestica ima veličinu čestice jednaku ili manju od 2.0 mikrona.
2. Formulacija praška prema patentnom zahtjevu 1, naznačeno time da ne više od 10% finih čestica a) ima promjer manji od 1.5 mikrona.
3. Formulacija praška prema patentnom zahtjevu 1 ili 2, naznačeno time da visokoenergijska aparatura jest mehano-fuzijska aparatura.
4. Formulacija praška prema bilo kojem od patentnih zahtjeva 1 do 3, naznačeno time da fiziološki prihvatljiv ekscipijens jest kristalinični šećer.
5. Formulacija praška prema patentnom zahtjevu 4, naznačeno time da se ekscipijens sastoji od alfa-laktoze monohidrata.
6. Formulacija praška prema bilo kojem od prethodnih patentnih zahtjeva, naznačeno time da magnezijev stearat oblaže površinu čestica ekscipijensa fine frakcije a) na takav način da je stupanj obloženosti površine najmanje 50%.
7. Formulacija praška prema bilo kojem od prethodnih patentnih zahtjeva, naznačeno time da najmanje 90% svih rečenih mikroniziranih čestica aktivnih tvari ima volumni promjer manji od 6.0 mikrona, a volumni medijalni promjer rečenih čestica jest između 1.2 i 2.5 mikrona.
8. Formulacija praška prema bilo kojem od prethodnih patentnih zahtjeva, naznačeno time da grube čestice frakcije b) imaju promjer medijalne mase jednak ili veći od 175 mikrona.
9. Formulacija praška prema bilo kojem od prethodnih patentnih zahtjeva, naznačeno time da omjer između finih čestica a) i grubih čestica b) jest 10:90 posto po masi.
10. Inhalator za suhi prašak punjen formulacijom suhog praška iz bilo kojeg od patentnih zahtjeva 1 do 10.
11. Formulacija suhog praška prema bilo kojem od patentnih zahtjeva 1 do 10 za upotrebu u sprječavanju i/ili liječenju upalne i/ili opstruktivne bolesti dišnih puteva.
12. Formulacija suhog praška prema patentnom zahtjevu 11, naznačeno time da upalna i/ili opstruktivna bolest dišnih puteva jest kronična opstruktivna plućna bolest (COPD).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13176114 | 2013-07-11 | ||
| EP13194763 | 2013-11-28 | ||
| EP18178893.6A EP3409270B1 (en) | 2013-07-11 | 2014-07-10 | Dry powder formulation comprising an anticholinergic, a corticosteroid and a beta-adrenergic for administration by inhalation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20210704T1 true HRP20210704T1 (hr) | 2021-06-11 |
Family
ID=51292914
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20241300TT HRP20241300T1 (hr) | 2013-07-11 | 2014-07-10 | Formulacija suhog praška koja sadrži antikolinergik, kortikosteroid i beta-adrenergik za davanje inhalacijom |
| HRP20182008TT HRP20182008T1 (hr) | 2013-07-11 | 2018-11-29 | Formulacija suhog praška koja sadrži antikolinergik, kortikosteroid i beta-adrenergik za davanje inhalacijom |
| HRP20210704TT HRP20210704T1 (hr) | 2013-07-11 | 2021-05-06 | Formulacija suhog praška koja sadrži antikolinergik, kortikosteroid i beta-adrenergik za davanje inhalacijom |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20241300TT HRP20241300T1 (hr) | 2013-07-11 | 2014-07-10 | Formulacija suhog praška koja sadrži antikolinergik, kortikosteroid i beta-adrenergik za davanje inhalacijom |
| HRP20182008TT HRP20182008T1 (hr) | 2013-07-11 | 2018-11-29 | Formulacija suhog praška koja sadrži antikolinergik, kortikosteroid i beta-adrenergik za davanje inhalacijom |
Country Status (36)
| Country | Link |
|---|---|
| US (2) | US9402825B2 (hr) |
| EP (3) | EP3019153B1 (hr) |
| JP (1) | JP6426167B2 (hr) |
| KR (2) | KR20160029797A (hr) |
| CN (1) | CN105338960B (hr) |
| AR (1) | AR129501A2 (hr) |
| AU (1) | AU2014289185B2 (hr) |
| BR (1) | BR112015030914B1 (hr) |
| CA (1) | CA2917752C (hr) |
| CL (1) | CL2016000028A1 (hr) |
| CY (2) | CY1120806T1 (hr) |
| DK (3) | DK3409270T3 (hr) |
| EA (1) | EA029125B1 (hr) |
| ES (3) | ES2867552T3 (hr) |
| FI (1) | FI3569222T3 (hr) |
| GE (1) | GEP20186853B (hr) |
| HK (1) | HK1218712A1 (hr) |
| HR (3) | HRP20241300T1 (hr) |
| HU (3) | HUE053957T2 (hr) |
| IL (1) | IL243507A0 (hr) |
| LT (3) | LT3409270T (hr) |
| MX (1) | MX2016000290A (hr) |
| MY (1) | MY176176A (hr) |
| NZ (1) | NZ715797A (hr) |
| PE (2) | PE20160372A1 (hr) |
| PH (1) | PH12016500043B1 (hr) |
| PL (3) | PL3409270T3 (hr) |
| PT (1) | PT3019153T (hr) |
| RS (3) | RS65951B1 (hr) |
| SA (1) | SA516370373B1 (hr) |
| SG (1) | SG11201600110RA (hr) |
| SI (3) | SI3409270T1 (hr) |
| TN (1) | TN2016000007A1 (hr) |
| TW (1) | TWI642450B (hr) |
| UA (1) | UA116907C2 (hr) |
| WO (1) | WO2015004243A1 (hr) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5914354B2 (ja) * | 2009-12-23 | 2016-05-11 | シエシー ファルマセウティチィ ソシエタ ペル アチオニ | Ｃｏｐｄ用併用療法 |
| FI3412277T3 (fi) * | 2012-01-25 | 2023-03-23 | Chiesi Farm Spa | Kortikosteroidia ja beeta-adrenergista ainetta käsittävä kuivajauheformulaatio annettavaksi inhalaatiolla |
| SG11201600110RA (en) * | 2013-07-11 | 2016-02-26 | Chiesi Farma Spa | Dry powder formulation comprising an anticholinergic, a corticosteroid and a beta-adrenergic for administration by inhalation |
| GB201321717D0 (en) * | 2013-12-09 | 2014-01-22 | Pharmachemie Bv | Inhalable Medicaments |
| US9554992B2 (en) | 2014-06-09 | 2017-01-31 | Chiesi Farmaceutici S.P.A. | Inhalation particles comprising a combination of an anticholinergic, a corticosteroid and a beta-adrenergic |
| TR201407010A2 (tr) | 2014-06-16 | 2015-12-21 | Arven Ilac Sanayi Ve Ticaret Anonim Sirketi | Vilanterol formülasyonları. |
| JP6600961B2 (ja) * | 2015-03-30 | 2019-11-06 | ブラザー工業株式会社 | 表示制御装置、表示制御方法及び記憶媒体 |
| BR112017023351B1 (pt) * | 2015-05-01 | 2023-11-28 | Board Of Regents, The University Of Texas System | Composição farmacêutica e uso da composição farmacêutica |
| KR20180082442A (ko) | 2015-11-16 | 2018-07-18 | 키에시 파르마슈티시 엣스. 피. 에이. | 항콜린제, 코르티코스테로이드 및 베타-아드레날린성 약물을 포함하는 건조 분말 제제의 제조 방법 |
| EA037716B1 (ru) * | 2015-11-16 | 2021-05-13 | КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. | Способ получения сухой порошковой композиции, содержащей антихолинергическое средство, кортикостероид и бета-адренергическое средство, порошковая композиция, ингалятор, применение сухой порошковой композиции для профилактики и/или лечения воспалительного и/или обструктивного заболевания дыхательных путей |
| US10231903B2 (en) | 2016-11-10 | 2019-03-19 | Medisca Pharmaceutique Inc. | Pharmaceutical compounding methods and systems |
| ES2882153T3 (es) | 2017-05-11 | 2021-12-01 | Chiesi Farm Spa | Un proceso para preparar una formulación en polvo seco que comprende un anticolinérgico, un corticosteroide y un betaadrenérgico |
| ES2891346T3 (es) * | 2017-05-11 | 2022-01-27 | Chiesi Farm Spa | Un proceso para preparar una formulación en polvo seco que comprende un anticolinérgico, un corticosteroide y un beta-adrenérgico |
| CN109200034A (zh) * | 2017-06-30 | 2019-01-15 | 正大天晴药业集团股份有限公司 | 一种可吸入干粉形式的组合物及其制备方法 |
| WO2019060595A1 (en) | 2017-09-20 | 2019-03-28 | Teva Branded Pharmaceutical Products R&D, Inc. | INHALABLE DRY POWDER MEDICINAL PRODUCT COMPRISING GLYCOPYRRONIUM |
| JP2022549445A (ja) * | 2019-09-24 | 2022-11-25 | キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ | 吸入用乾燥粉末製剤のための新規担体粒子 |
| US12029709B2 (en) * | 2022-08-11 | 2024-07-09 | De Motu Cordis Pty Ltd | Inhalable epinephrine formulation |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2192866T3 (es) * | 1998-11-13 | 2003-10-16 | Jago Res Ag | Polvo seco para inhalacion. |
| US20070212422A1 (en) | 1999-11-10 | 2007-09-13 | Manfred Keller | Dry powder for inhalation |
| PE20011227A1 (es) | 2000-04-17 | 2002-01-07 | Chiesi Farma Spa | Formulaciones farmaceuticas para inhaladores de polvo seco en la forma de aglomerados duros |
| GB0015043D0 (en) | 2000-06-21 | 2000-08-09 | Glaxo Group Ltd | Medicament dispenser |
| DK1296651T3 (da) * | 2000-06-27 | 2008-02-11 | Vectura Ltd | Fremgangsmåde til fremstilling af partikler til anvendelse i et farmaceutisk præparat |
| US8048451B2 (en) * | 2000-11-30 | 2011-11-01 | Vectura Limited | Pharmaceutical compositions for inhalation |
| SI1658872T2 (sl) | 2002-07-31 | 2019-12-31 | Chiesi Farmacetuici S.P.A. | Inhalator prahu |
| JO3102B1 (ar) * | 2004-03-17 | 2017-09-20 | Chiesi Framaceutici S P A | صيغ صيدلانية لوسائل استنشاق بها مسحوق جاف تشتمل على مكون فعال بقوة منخفضة الجرعة |
| GB0425758D0 (en) * | 2004-11-23 | 2004-12-22 | Vectura Ltd | Preparation of pharmaceutical compositions |
| GB0613161D0 (en) | 2006-06-30 | 2006-08-09 | Novartis Ag | Organic Compounds |
| EP1944018A1 (en) * | 2007-01-10 | 2008-07-16 | CHIESI FARMACEUTICI S.p.A. | Micronised particles of low-dosage strength active agents for powder formulations for inhalation |
| JP5914354B2 (ja) | 2009-12-23 | 2016-05-11 | シエシー ファルマセウティチィ ソシエタ ペル アチオニ | Ｃｏｐｄ用併用療法 |
| ES2468835T3 (es) | 2009-12-23 | 2014-06-17 | Chiesi Farmaceutici S.P.A. | Terapia combinada para EPOC |
| TR201000681A2 (tr) | 2010-01-29 | 2011-08-22 | B�Lg�� Mahmut | İnhalasyon yoluyla alınan kuru toz formülasyonları. |
| WO2011120779A1 (en) * | 2010-04-01 | 2011-10-06 | Chiesi Farmaceutici S.P.A. | Process for preparing carrier particles for dry powders for inhalation |
| AU2011244384B2 (en) | 2010-04-21 | 2016-06-23 | Chiesi Farmaceutici S.P.A. | "Process for providing particles with reduced electrostatic charges" |
| NZ604983A (en) * | 2010-06-22 | 2014-07-25 | Chiesi Farma Spa | Dry powder formulation comprising an antimuscarinic drug |
| FI3412277T3 (fi) | 2012-01-25 | 2023-03-23 | Chiesi Farm Spa | Kortikosteroidia ja beeta-adrenergista ainetta käsittävä kuivajauheformulaatio annettavaksi inhalaatiolla |
| US9393202B2 (en) | 2013-04-26 | 2016-07-19 | Chiesi Farmaceutici S.P.A | Particle size reduction of an antimuscarinic compound |
| SG11201600110RA (en) * | 2013-07-11 | 2016-02-26 | Chiesi Farma Spa | Dry powder formulation comprising an anticholinergic, a corticosteroid and a beta-adrenergic for administration by inhalation |
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