HRP20201459T1 - Liječenje nepodnošenja glutena i s tim povezanih stanja - Google Patents
Liječenje nepodnošenja glutena i s tim povezanih stanja Download PDFInfo
- Publication number
- HRP20201459T1 HRP20201459T1 HRP20201459TT HRP20201459T HRP20201459T1 HR P20201459 T1 HRP20201459 T1 HR P20201459T1 HR P20201459T T HRP20201459T T HR P20201459TT HR P20201459 T HRP20201459 T HR P20201459T HR P20201459 T1 HRP20201459 T1 HR P20201459T1
- Authority
- HR
- Croatia
- Prior art keywords
- recombinant
- preparation
- accordance
- gluten
- nepentesine
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/06—Enzymes
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/488—Aspartic endopeptidases (3.4.23), e.g. pepsin, chymosin, renin, cathepsin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/63—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from plants
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/23—Aspartic endopeptidases (3.4.23)
- C12Y304/23012—Nepenthesin (3.4.23.12)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nutrition Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Botany (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Claims (11)
1. Pripravak namijenjen upotrebi u liječenju ili inhibiranju nepodnošenja glutena, naznačen time što navedeni pripravak sadrži rekombinantni nepentezin kojeg se bira između rekombinantnog nepentezina I, rekombinantnog nepentezina II, njihovih soli, ili bilo kojih njihovih kombinacija.
2. Pripravak namijenjen upotrebi u skladu s patentnim zahtjevom 1, naznačen time što se navedeni rekombinantni nepentezin primjenjuje u dozama od 0,001 do 1000 mg/kg tjelesne težine dnevno.
3. Pripravak namijenjen upotrebi u skladu s patentnim zahtjevom 1 ili patentnim zahtjevom 2, naznačen time što se navedeni rekombinantni nepentezin primjenjuje u dozama od 0,001, 0,01, 0,1, 1, 5, 10, 50, 100, 500, ili 1000 mg/kg tjelesne težine dnevno.
4. Pripravak namijenjen upotrebi u skladu s bilo kojim od patentnih zahtjeva 1 do 3, naznačen time što ga se primjenjuje uz drugo sredstvo kojeg se bira između: inhibitora tkivne transglutaminaze, protuupalnog sredstva, antagonista leukotrienskog receptora, inhibitora COX-2, inhibitora p38 MAP kinaze, sredstva za stabiliziranje mastocita, antiulkusnog sredstva, antialergijskog sredstva, inhibitora transglutaminaze 2 (TG2), sredstva protiv TNF-α i antibiotika.
5. Pripravak namijenjen upotrebi u skladu s bilo kojim od patentnih zahtjeva 1 do 3, naznačen time što ga se primjenjuje uz drugi enzim, kojeg se bira između želučane proteaze, aspartilne proteaze, te prolilne endopeptidaze, dipeptidilni peptidaze IV (DPP IV), dipeptidilne karboksipeptidaze (DCP) i cisteinske proteinaze B.
6. Pripravak namijenjen upotrebi u skladu s bilo kojim od patentnih zahtjeva 1 do 5, naznačen time što navedeno nepodnošenje glutena uzrokuje celijakiju, alergiju na pšenicu, osjetljivost na gluten i/ili herpetiformni dermatitis.
7. Pripravak namijenjen upotrebi u skladu s bilo kojim od patentnih zahtjeva 1 do 6, naznačen time što je rekombinantni nepentezin smjesa rekombinantnih nepentezina I i nepentezina II.
8. Pripravak namijenjen upotrebi u skladu s bilo kojim od patentnih zahtjeva 1 do 6, naznačen time što je rekombinantni nepentezin rekombinantni nepentezin I.
9. Pripravak namijenjen upotrebi u skladu s bilo kojim od patentnih zahtjeva 1 do 6, naznačen time što je rekombinantni nepentezin rekombinantni nepentezin II.
10. Pripravak namijenjen upotrebi u skladu s bilo kojim od patentnih zahtjeva 1 do 9, naznačen time što se primjenu navedenog pripravka vrši oralnom primjenom.
11. Pripravak namijenjen upotrebi u skladu s patentnim zahtjevom 10, naznačen time što navedeni pripravak se primjenjuje prije unosa hrane koja sadrži gluten ili se sumnja da sadrži gluten; tijekom unosa hrane koja sadrži gluten ili se sumnja da sadrži gluten; ili nakon unosa hrane koja sadrži gluten ili se sumnja da sadrži gluten.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261729210P | 2012-11-21 | 2012-11-21 | |
| US201261797040P | 2012-11-27 | 2012-11-27 | |
| US13/843,369 US9005610B2 (en) | 2012-11-21 | 2013-03-15 | Treatment of gluten intolerance and related conditions |
| PCT/CA2014/000258 WO2014138927A1 (en) | 2012-11-21 | 2014-03-14 | Treatment of gluten intolerance and related conditions |
| EP14763905.8A EP3004340B8 (en) | 2013-03-15 | 2014-03-14 | Treatment of gluten intolerance and related conditions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20201459T1 true HRP20201459T1 (hr) | 2020-12-11 |
Family
ID=50728145
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20201459TT HRP20201459T1 (hr) | 2012-11-21 | 2020-09-14 | Liječenje nepodnošenja glutena i s tim povezanih stanja |
Country Status (15)
| Country | Link |
|---|---|
| US (7) | US9005610B2 (hr) |
| EP (1) | EP2922568A1 (hr) |
| JP (1) | JP6412876B2 (hr) |
| KR (1) | KR102296428B1 (hr) |
| CN (1) | CN105007934B (hr) |
| AU (1) | AU2013350261B2 (hr) |
| CA (1) | CA2892474C (hr) |
| DK (1) | DK3004340T3 (hr) |
| ES (1) | ES2821771T3 (hr) |
| HR (1) | HRP20201459T1 (hr) |
| HU (1) | HUE050868T2 (hr) |
| IL (2) | IL238912B (hr) |
| MX (2) | MX2015006419A (hr) |
| PT (1) | PT3004340T (hr) |
| WO (2) | WO2014078935A1 (hr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9005610B2 (en) | 2012-11-21 | 2015-04-14 | Nepetx, Llc | Treatment of gluten intolerance and related conditions |
| CN105492602B (zh) * | 2013-03-15 | 2021-01-05 | 科德克希思公司 | 对麸质不耐受以及相关病症的治疗 |
| WO2015192211A1 (en) | 2014-06-16 | 2015-12-23 | Nepetx, Llc | Compositions and methods for treating gluten intolerance and disorders arising therefrom |
| WO2017106798A2 (en) * | 2015-12-16 | 2017-06-22 | Nepetx, Llc | Compositions and methods for treating gluten intolerance and disorders arising therefrom |
| AU2018335849B2 (en) * | 2017-09-20 | 2023-04-13 | Aarhus Universitet | Nepenthesin-1 derived resistance to fungal pathogens in major crop plants |
| JP7390398B2 (ja) * | 2019-04-02 | 2023-12-01 | サミ－サビンサ グループ リミテッド | グルテン不耐性の治療管理のための方法および組成物 |
| TWI864494B (zh) * | 2022-11-17 | 2024-12-01 | 國立中興大學 | 天冬胺酸蛋白酶於水解麩質蛋白之用途、編碼該天冬胺酸蛋白酶之核酸分子、生產該天冬胺酸蛋白酶之方法及其應用 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| DK81193D0 (da) * | 1993-07-06 | 1993-07-06 | Novo Nordisk As | Enzym |
| JP3767831B2 (ja) * | 1995-06-14 | 2006-04-19 | 木村 健 | ヘリコバクター・ピロリ除菌用組成物 |
| JP3521635B2 (ja) | 1996-08-07 | 2004-04-19 | 日本電信電話株式会社 | 映像生成方法および映像生成システム |
| JPH1149697A (ja) * | 1997-08-01 | 1999-02-23 | Nisshin Flour Milling Co Ltd | ストレス抑制剤及びストレス抑制用食品 |
| US8143210B2 (en) | 2002-02-14 | 2012-03-27 | The Board Of Trustees Of The Leland Stanford Junior University | Enzyme treatment of foodstuffs for celiac sprue |
| CA2475972C (en) | 2002-02-14 | 2017-07-11 | Felix Hausch | Enzyme treatment of foodstuffs for celiac sprue |
| US7320788B2 (en) * | 2002-02-14 | 2008-01-22 | The Board Of Trustees Of The Leland Stanford Junior University | Enzyme treatment of foodstuffs for Celiac Sprue |
| JP4415244B2 (ja) * | 2003-02-21 | 2010-02-17 | グリコ栄養食品株式会社 | 小麦蛋白質にプロテアーゼを限定的に作用させて得られる食品素材 |
| US7628985B2 (en) | 2004-04-26 | 2009-12-08 | The Board Of Regents Of The Leland Stanford Junior University | Therapeutic enzyme formulations and uses thereof in celiac sprue and/or dermatitis herpetoformis |
| US20060095096A1 (en) | 2004-09-09 | 2006-05-04 | Debenedictis Leonard C | Interchangeable tips for medical laser treatments and methods for using same |
| US8119385B2 (en) | 2005-03-04 | 2012-02-21 | Bp Corporation North America Inc. | Nucleic acids and proteins and methods for making and using them |
| WO2007054988A1 (en) * | 2005-10-11 | 2007-05-18 | Mofin S.R.L. | 'gluten-free' blu-veined dairy products intended for persons affected by celiac disease |
| US8119125B2 (en) | 2005-10-11 | 2012-02-21 | Alvine Pharmaceuticals, Inc. | Compositions and methods for enhanced gastrointestinal stability of oligopeptides and polypeptides |
| WO2008034648A1 (en) | 2006-04-05 | 2008-03-27 | Metanomics Gmbh | Process for the production of a fine chemical |
| US8148105B2 (en) | 2007-03-16 | 2012-04-03 | The Board Of Trustees Of The Leland Stanford Junior University | Scaleable manufacturing process for cysteine endoprotease B, isoform 2 |
| US20100322912A1 (en) * | 2007-12-10 | 2010-12-23 | Chaitan Khosla | Combination Enzyme Therapy for Gastric Digestion of Dietary Gluten in Celiac Sprue Patients |
| WO2010021752A1 (en) | 2008-08-21 | 2010-02-25 | Alvine Pharmaceuticals, Inc. | Formulation for oral administration of proteins |
| JP2011049697A (ja) | 2009-08-25 | 2011-03-10 | Panasonic Corp | フリッカ検出装置、撮像装置、フリッカ検出プログラム、及び、フリッカ検出方法 |
| US20110200574A1 (en) | 2010-02-02 | 2011-08-18 | Jolly James F | Use of proteases for gluten intolerance |
| JP2013523133A (ja) | 2010-03-30 | 2013-06-17 | アルヴィン ファーマシューティカルズ インコーポレーティッド | グルテンを分解するためのプロテアーゼ |
| US9023345B2 (en) * | 2011-03-01 | 2015-05-05 | Novus International, Inc. | Methods for improving gut health |
| US9005610B2 (en) | 2012-11-21 | 2015-04-14 | Nepetx, Llc | Treatment of gluten intolerance and related conditions |
-
2013
- 2013-03-15 US US13/843,369 patent/US9005610B2/en active Active
- 2013-06-06 US US13/912,077 patent/US9623092B2/en active Active
- 2013-11-20 MX MX2015006419A patent/MX2015006419A/es unknown
- 2013-11-20 CN CN201380070689.9A patent/CN105007934B/zh active Active
- 2013-11-20 EP EP13857431.4A patent/EP2922568A1/en not_active Withdrawn
- 2013-11-20 WO PCT/CA2013/000970 patent/WO2014078935A1/en active Application Filing
- 2013-11-20 KR KR1020157016524A patent/KR102296428B1/ko active Active
- 2013-11-20 AU AU2013350261A patent/AU2013350261B2/en active Active
- 2013-11-20 CA CA2892474A patent/CA2892474C/en active Active
- 2013-11-20 JP JP2015543220A patent/JP6412876B2/ja active Active
-
2014
- 2014-03-14 ES ES14763905T patent/ES2821771T3/es active Active
- 2014-03-14 HU HUE14763905A patent/HUE050868T2/hu unknown
- 2014-03-14 PT PT147639058T patent/PT3004340T/pt unknown
- 2014-03-14 DK DK14763905.8T patent/DK3004340T3/da active
- 2014-03-14 WO PCT/CA2014/000258 patent/WO2014138927A1/en active Application Filing
- 2014-03-14 MX MX2015011825A patent/MX374220B/es active IP Right Grant
- 2014-10-03 US US14/506,456 patent/US9745565B2/en active Active
-
2015
- 2015-02-11 US US14/620,066 patent/US20150290301A1/en not_active Abandoned
- 2015-05-20 IL IL238912A patent/IL238912B/en active IP Right Grant
-
2016
- 2016-07-13 US US15/209,681 patent/US10266818B2/en active Active
-
2019
- 2019-03-18 US US16/357,191 patent/US10982201B2/en active Active
-
2020
- 2020-09-14 HR HRP20201459TT patent/HRP20201459T1/hr unknown
-
2021
- 2021-03-23 US US17/209,879 patent/US11725198B2/en active Active
- 2021-05-26 IL IL283484A patent/IL283484A/en unknown
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