HRP20191486T1 - Heterobiciklički spojevi i njihova uporaba za liječenje tuberkuloze - Google Patents
Heterobiciklički spojevi i njihova uporaba za liječenje tuberkulozeInfo
- Publication number
- HRP20191486T1 HRP20191486T1 HRP20191486T HRP20191486T1 HR P20191486 T1 HRP20191486 T1 HR P20191486T1 HR P20191486 T HRP20191486 T HR P20191486T HR P20191486 T1 HRP20191486 T1 HR P20191486T1
- Authority
- HR
- Croatia
- Prior art keywords
- tuberculosis
- treatment
- heterobicyclic compounds
- heterobicyclic
- compounds
- Prior art date
Links
- 125000002618 bicyclic heterocycle group Chemical group 0.000 title 1
- 201000008827 tuberculosis Diseases 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2014174528 | 2014-08-28 | ||
PCT/JP2015/004371 WO2016031255A1 (en) | 2014-08-28 | 2015-08-28 | Heterobicyclic compounds and their use for the treatment of tuberculosis |
EP15763096.3A EP3186240B9 (en) | 2014-08-28 | 2015-08-28 | Heterobicyclic compounds and their use for the treatment of tuberculosis |
Publications (2)
Publication Number | Publication Date |
---|---|
HRP20191486T1 true HRP20191486T1 (hr) | 2019-11-15 |
HRP20191486T2 HRP20191486T2 (hr) | 2021-09-17 |
Family
ID=54105947
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20191486TT HRP20191486T2 (hr) | 2014-08-28 | 2019-08-16 | Heterobiciklički spojevi i njihova uporaba za liječenje tuberkuloze |
Country Status (29)
Country | Link |
---|---|
US (2) | US10053446B2 (hr) |
EP (1) | EP3186240B9 (hr) |
JP (1) | JP6625612B2 (hr) |
KR (1) | KR102418413B1 (hr) |
CN (1) | CN106795117B (hr) |
AP (1) | AP2017009788A0 (hr) |
AR (1) | AR101704A1 (hr) |
AU (1) | AU2015307873B2 (hr) |
BR (1) | BR112017003231B1 (hr) |
CA (1) | CA2959478C (hr) |
CY (1) | CY1122286T1 (hr) |
DK (1) | DK3186240T3 (hr) |
EA (1) | EA038414B1 (hr) |
ES (1) | ES2743788T3 (hr) |
HR (1) | HRP20191486T2 (hr) |
HU (1) | HUE045025T2 (hr) |
IL (1) | IL250484B (hr) |
LT (1) | LT3186240T (hr) |
MX (1) | MX2017002312A (hr) |
MY (1) | MY189098A (hr) |
NZ (1) | NZ729064A (hr) |
PH (1) | PH12017500290B1 (hr) |
PL (1) | PL3186240T3 (hr) |
PT (1) | PT3186240T (hr) |
SG (1) | SG11201700882XA (hr) |
SI (1) | SI3186240T1 (hr) |
TW (1) | TWI687409B (hr) |
WO (1) | WO2016031255A1 (hr) |
ZA (1) | ZA201700916B (hr) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR101704A1 (es) * | 2014-08-28 | 2017-01-04 | Otsuka Pharma Co Ltd | Compuestos heterocíclicos fusionados |
CN108884044B (zh) * | 2016-02-26 | 2023-01-31 | 大塚制药株式会社 | 哌啶衍生物 |
WO2019239382A1 (en) | 2018-06-15 | 2019-12-19 | Cadila Healthcare Limited | Condensed azaheteroaryl compounds having antibacterial activity against tuberculosis bacteria |
JP2023085582A (ja) * | 2020-05-11 | 2023-06-21 | 大塚製薬株式会社 | ジヒドロキノリノン化合物の共結晶 |
KR20220022877A (ko) * | 2020-08-19 | 2022-02-28 | 주식회사 미토이뮨테라퓨틱스 | Mabc-R 감염에 의한 병적 염증 치료제로서의 미토콘드리아 표적 항산화제 |
CN116102537B (zh) * | 2021-11-10 | 2024-10-01 | 四川大学 | 一种喹啉酮类衍生物及其制备方法和用途 |
CN116589448A (zh) * | 2023-04-24 | 2023-08-15 | 西南交通大学 | 一种3,4-二氢喹啉酮衍生物及其应用 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2608788B2 (ja) * | 1988-10-31 | 1997-05-14 | 大塚製薬 株式会社 | 精神分裂病治療剤 |
US5668127A (en) | 1995-06-26 | 1997-09-16 | Pathogenesis Corporation | Nitroimidazole antibacterial compounds and methods of use thereof |
AR041198A1 (es) | 2002-10-11 | 2005-05-04 | Otsuka Pharma Co Ltd | Compuesto 2,3-dihidro-6-nitroimidazo[2,1-b] oxaxol, y composiciones farmaceuticas que lo contienen |
GB0319150D0 (en) * | 2003-08-14 | 2003-09-17 | Glaxo Group Ltd | Novel compounds |
JP4761756B2 (ja) | 2003-10-31 | 2011-08-31 | 大塚製薬株式会社 | 2,3−ジヒドロイミダゾ[2,1−b]オキサゾ−ル化合物 |
KR100851802B1 (ko) * | 2003-10-31 | 2008-08-13 | 오쓰까 세이야꾸 가부시키가이샤 | 결핵의 치료를 위한2,3-디히드로-6-니트로이미다조[2,1-b]옥사졸 화합물 |
CN100497345C (zh) * | 2003-10-31 | 2009-06-10 | 大塚制药株式会社 | 治疗结核病的2,3-二氢-6-硝基咪唑并[2,1-b]唑化合物 |
DK2502911T3 (en) * | 2004-06-24 | 2017-06-06 | Vertex Pharma | Modulators of ATP-binding cassette transporters |
US7935706B2 (en) | 2006-02-23 | 2011-05-03 | Shionogi & Co., Ltd. | Nitrogen-containing heterocycle derivatives substituted with cyclic group |
GB0812648D0 (en) * | 2008-07-10 | 2008-08-20 | Prosidion Ltd | Compounds |
WO2010045987A1 (en) * | 2008-10-23 | 2010-04-29 | Glaxo Group Limited | Substituted (aza) -1-methyl-1h-quin0lin-2-0nes as antibacterials |
AU2010278779B2 (en) | 2009-07-31 | 2014-08-14 | Global Alliance For Tb Drug Development | Nitroimidazooxazine and nitroimidazooxazole analogues and their uses |
EP2697232B1 (en) | 2011-04-15 | 2016-05-18 | Otsuka Pharmaceutical Co., Ltd. | 6,7-dihydroimidazo[2,1-b][1,3]oxazine bactericides |
AR101704A1 (es) * | 2014-08-28 | 2017-01-04 | Otsuka Pharma Co Ltd | Compuestos heterocíclicos fusionados |
CN108884044B (zh) * | 2016-02-26 | 2023-01-31 | 大塚制药株式会社 | 哌啶衍生物 |
-
2015
- 2015-08-27 AR ARP150102746A patent/AR101704A1/es active IP Right Grant
- 2015-08-27 TW TW104128109A patent/TWI687409B/zh active
- 2015-08-28 EP EP15763096.3A patent/EP3186240B9/en active Active
- 2015-08-28 BR BR112017003231-7A patent/BR112017003231B1/pt active IP Right Grant
- 2015-08-28 LT LTEP15763096.3T patent/LT3186240T/lt unknown
- 2015-08-28 PH PH1/2017/500290A patent/PH12017500290B1/en unknown
- 2015-08-28 EA EA201790464A patent/EA038414B1/ru unknown
- 2015-08-28 CA CA2959478A patent/CA2959478C/en active Active
- 2015-08-28 SI SI201530868T patent/SI3186240T1/sl unknown
- 2015-08-28 PT PT15763096T patent/PT3186240T/pt unknown
- 2015-08-28 US US15/506,887 patent/US10053446B2/en active Active
- 2015-08-28 KR KR1020177007855A patent/KR102418413B1/ko active Active
- 2015-08-28 DK DK15763096.3T patent/DK3186240T3/da active
- 2015-08-28 AU AU2015307873A patent/AU2015307873B2/en active Active
- 2015-08-28 MX MX2017002312A patent/MX2017002312A/es active IP Right Grant
- 2015-08-28 PL PL15763096T patent/PL3186240T3/pl unknown
- 2015-08-28 WO PCT/JP2015/004371 patent/WO2016031255A1/en active Application Filing
- 2015-08-28 AP AP2017009788A patent/AP2017009788A0/en unknown
- 2015-08-28 SG SG11201700882XA patent/SG11201700882XA/en unknown
- 2015-08-28 CN CN201580045974.4A patent/CN106795117B/zh active Active
- 2015-08-28 HU HUE15763096A patent/HUE045025T2/hu unknown
- 2015-08-28 NZ NZ729064A patent/NZ729064A/en unknown
- 2015-08-28 JP JP2017507903A patent/JP6625612B2/ja active Active
- 2015-08-28 ES ES15763096T patent/ES2743788T3/es active Active
- 2015-08-28 MY MYPI2017700649A patent/MY189098A/en unknown
-
2017
- 2017-02-06 ZA ZA2017/00916A patent/ZA201700916B/en unknown
- 2017-02-07 IL IL250484A patent/IL250484B/en active IP Right Grant
-
2018
- 2018-07-09 US US16/029,850 patent/US10464926B2/en active Active
-
2019
- 2019-08-16 HR HRP20191486TT patent/HRP20191486T2/hr unknown
- 2019-08-26 CY CY20191100906T patent/CY1122286T1/el unknown
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