HRP20190199T1 - Mono- ili di-supstituirani derivati indola kao inhibitori replikacije denga virusa - Google Patents

Mono- ili di-supstituirani derivati indola kao inhibitori replikacije denga virusa

Info

Publication number: HRP20190199T1
Authority: HR; Croatia
Prior art keywords: mono; viral replication; indole derivatives; substituted indole; replication inhibitors
Prior art date: 2014-10-01

Application number

HRP20190199TT

Other languages

English (en)

Inventor

Bart Rudolf Romanie Kesteleyn

Jean-François BONFANTI

Tim Hugo Maria Jonckers

Pierre Jean-Marie Bernard Raboisson

Dorothée Alice Marie-Eve Bardiot

Arnaud Didier M Marchand

Original Assignee

Janssen Pharmaceuticals, Inc.

Katholieke Universiteit Leuven

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-10-01

Filing date

2019-01-30

Publication date

2019-04-05

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54199687&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20190199(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2019-01-30 Application filed by Janssen Pharmaceuticals, Inc., Katholieke Universiteit Leuven filed Critical Janssen Pharmaceuticals, Inc.

2019-04-05 Publication of HRP20190199T1 publication Critical patent/HRP20190199T1/hr

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Virology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

HRP20190199TT 2014-10-01 2019-01-30 Mono- ili di-supstituirani derivati indola kao inhibitori replikacije denga virusa HRP20190199T1 (hr)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
EP14187374		2014-10-01
EP15159164		2015-03-16
PCT/EP2015/072551 WO2016050841A1 (en)	2014-10-01	2015-09-30	Mono- or di-substituted indole derivatives as dengue viral replication inhibitors
EP15771136.7A EP3201176B1 (en)	2014-10-01	2015-09-30	Mono- or di-substituted indole derivatives as dengue viral replication inhibitors

Publications (1)

Publication Number	Publication Date
HRP20190199T1 true HRP20190199T1 (hr)	2019-04-05

Family

ID=54199687

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HRP20190199TT HRP20190199T1 (hr)	2014-10-01	2019-01-30	Mono- ili di-supstituirani derivati indola kao inhibitori replikacije denga virusa

Country Status (32)

Country	Link
US (1)	US9944598B2 (hr)
EP (1)	EP3201176B1 (hr)
JP (1)	JP6732736B2 (hr)
KR (1)	KR102478311B1 (hr)
CN (1)	CN107001264B (hr)
AU (1)	AU2015326930B2 (hr)
BR (1)	BR112017006299A2 (hr)
CA (1)	CA2959573A1 (hr)
CL (1)	CL2017000782A1 (hr)
CY (1)	CY1121874T1 (hr)
DK (1)	DK3201176T3 (hr)
EA (1)	EA032546B1 (hr)
ES (1)	ES2714074T3 (hr)
HR (1)	HRP20190199T1 (hr)
HU (1)	HUE041888T2 (hr)
IL (1)	IL251396A0 (hr)
LT (1)	LT3201176T (hr)
MA (1)	MA40768B1 (hr)
ME (1)	ME03360B (hr)
MX (1)	MX2017004299A (hr)
PH (1)	PH12017500571A1 (hr)
PL (1)	PL3201176T3 (hr)
PT (1)	PT3201176T (hr)
RS (1)	RS58461B1 (hr)
SG (1)	SG11201702463YA (hr)
SI (1)	SI3201176T1 (hr)
SM (1)	SMT201900162T1 (hr)
TW (1)	TWI681951B (hr)
UA (1)	UA121119C2 (hr)
UY (1)	UY36340A (hr)
WO (1)	WO2016050841A1 (hr)
ZA (1)	ZA201702301B (hr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB201116559D0 (en)	2011-09-26	2011-11-09	Univ Leuven Kath	Novel viral replication inhibitors
GB201305376D0 (en)	2013-03-25	2013-05-08	Univ Leuven Kath	Novel viral replication inhibitors
WO2016050831A1 (en) *	2014-10-01	2016-04-07	Janssen Pharmaceuticals, Inc.	Mono- or di-substituted indoles as dengue viral replication inhibitors
CA2963203A1 (en)	2014-10-01	2016-04-07	Merck Patent Gmbh	Boronic acid derivatives
US9453018B2 (en)	2014-10-01	2016-09-27	Bristol-Myers Squibb Company	Pyrimidinones as factor XIa inhibitors
JOP20160086B1 (ar)	2015-05-08	2021-08-17	2 Katholieke Univ Leuven Ku Leuven Research And Development	مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20160198B1 (ar)	2015-09-16	2022-03-14	Janssen Pharmaceuticals Inc	مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JO3633B1 (ar)	2015-09-16	2020-08-27	Katholieke Univ Leuven Ku Leuven Research & Development	مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
ES2923771T3 (es)	2016-03-31	2022-09-30	Janssen Pharmaceuticals Inc	Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue
CA3013405A1 (en)	2016-03-31	2017-10-05	Janssen Pharmaceuticals, Inc.	Substituted indole derivatives as dengue viral replication inhibitors
MA44502A (fr) *	2016-04-01	2019-02-06	Janssen Pharmaceuticals Inc	Dérivés d'indole substitués utilisés en tant qu'inhibiteurs de réplication du virus de la dengue
JOP20170069B1 (ar)	2016-04-01	2021-08-17	1 Janssen Pharmaceuticals Inc	مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20180026A1 (ar)	2017-03-31	2019-01-30	Univ Leuven Kath	مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20180025B1 (ar)	2017-03-31	2021-08-17	Janssen Pharmaceuticals Inc	مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
US11053196B2 (en) *	2017-05-22	2021-07-06	Janssen Pharmaceuticals, Inc.	Substituted indoline derivatives as dengue viral replication inhibitors
WO2018215315A1 (en) *	2017-05-22	2018-11-29	Janssen Pharmaceuticals, Inc.	Substituted indoline derivatives as dengue viral replication inhibitors
WO2024252254A1 (en) *	2023-06-05	2024-12-12	Zydus Lifesciences Limited	Novel compounds to treat viral infections

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB201116559D0 (en) *	2011-09-26	2011-11-09	Univ Leuven Kath	Novel viral replication inhibitors

2015
- 2015-09-30 TW TW104132008A patent/TWI681951B/zh not_active IP Right Cessation
- 2015-09-30 DK DK15771136.7T patent/DK3201176T3/en active
- 2015-09-30 CN CN201580053446.3A patent/CN107001264B/zh active Active
- 2015-09-30 CA CA2959573A patent/CA2959573A1/en not_active Abandoned
- 2015-09-30 PL PL15771136T patent/PL3201176T3/pl unknown
- 2015-09-30 RS RS20190206A patent/RS58461B1/sr unknown
- 2015-09-30 MX MX2017004299A patent/MX2017004299A/es unknown
- 2015-09-30 WO PCT/EP2015/072551 patent/WO2016050841A1/en active Application Filing
- 2015-09-30 LT LTEP15771136.7T patent/LT3201176T/lt unknown
- 2015-09-30 MA MA40768A patent/MA40768B1/fr unknown
- 2015-09-30 SM SM20190162T patent/SMT201900162T1/it unknown
- 2015-09-30 BR BR112017006299-2A patent/BR112017006299A2/pt not_active Application Discontinuation
- 2015-09-30 ES ES15771136T patent/ES2714074T3/es active Active
- 2015-09-30 EP EP15771136.7A patent/EP3201176B1/en active Active
- 2015-09-30 KR KR1020177011122A patent/KR102478311B1/ko active Active
- 2015-09-30 UA UAA201704215A patent/UA121119C2/uk unknown
- 2015-09-30 AU AU2015326930A patent/AU2015326930B2/en not_active Expired - Fee Related
- 2015-09-30 SI SI201530603T patent/SI3201176T1/sl unknown
- 2015-09-30 PT PT15771136T patent/PT3201176T/pt unknown
- 2015-09-30 HU HUE15771136A patent/HUE041888T2/hu unknown
- 2015-09-30 SG SG11201702463YA patent/SG11201702463YA/en unknown
- 2015-09-30 EA EA201790758A patent/EA032546B1/ru not_active IP Right Cessation
- 2015-09-30 ME MEP-2019-62A patent/ME03360B/me unknown
- 2015-09-30 JP JP2017513061A patent/JP6732736B2/ja active Active
- 2015-09-30 US US15/515,574 patent/US9944598B2/en active Active
- 2015-10-01 UY UY0001036340A patent/UY36340A/es unknown
2017
- 2017-03-27 IL IL251396A patent/IL251396A0/en unknown
- 2017-03-27 PH PH12017500571A patent/PH12017500571A1/en unknown
- 2017-03-31 CL CL2017000782A patent/CL2017000782A1/es unknown
- 2017-03-31 ZA ZA2017/02301A patent/ZA201702301B/en unknown
2019
- 2019-01-30 HR HRP20190199TT patent/HRP20190199T1/hr unknown
- 2019-03-01 CY CY20191100257T patent/CY1121874T1/el unknown

Also Published As

Publication number	Publication date
EA201790758A1 (ru)	2017-07-31
ME03360B (me)	2019-10-20
ZA201702301B (en)	2018-12-19
DK3201176T3 (en)	2019-03-25
RS58461B1 (sr)	2019-04-30
CL2017000782A1 (es)	2017-11-03
SG11201702463YA (en)	2017-04-27
PT3201176T (pt)	2019-03-04
MX2017004299A (es)	2017-07-19
UA121119C2 (uk)	2020-04-10
BR112017006299A2 (pt)	2018-01-16
US9944598B2 (en)	2018-04-17
EA032546B1 (ru)	2019-06-28
UY36340A (es)	2016-04-01
PH12017500571A1 (en)	2017-08-30
ES2714074T3 (es)	2019-05-27
LT3201176T (lt)	2019-03-25
JP6732736B2 (ja)	2020-07-29
AU2015326930A1 (en)	2017-03-16
CY1121874T1 (el)	2020-10-14
HUE041888T2 (hu)	2019-06-28
WO2016050841A9 (en)	2016-06-02
MA40768A (fr)	2017-09-08
IL251396A0 (en)	2017-05-29
SI3201176T1 (sl)	2019-05-31
WO2016050841A1 (en)	2016-04-07
EP3201176B1 (en)	2018-12-12
JP2017531619A (ja)	2017-10-26
TWI681951B (zh)	2020-01-11
CA2959573A1 (en)	2016-04-07
PL3201176T3 (pl)	2019-06-28
SMT201900162T1 (it)	2019-05-10
AU2015326930B2 (en)	2020-03-26
US20170298017A1 (en)	2017-10-19
MA40768B1 (fr)	2019-03-29
CN107001264B (zh)	2021-06-15
TW201630879A (zh)	2016-09-01
EP3201176A1 (en)	2017-08-09
KR102478311B1 (ko)	2022-12-15
CN107001264A (zh)	2017-08-01
KR20170063802A (ko)	2017-06-08

Publication	Publication Date	Title
ZA202002435B (en)	2023-03-29	Mono- or di-substituted indole derivatives as dengue viral replication inhibitors
HRP20190199T1 (hr)	2019-04-05	Mono- ili di-supstituirani derivati indola kao inhibitori replikacije denga virusa
HK1258320A1 (zh)	2019-11-08	作為登革熱病毒複製抑制劑的單取代或二取代吲哚衍生物
HRP20190139T1 (hr)	2019-03-22	Mono- ili di-supstituirani indoli kao inhibitori replikacije denga virusa
HK1257842A1 (zh)	2019-11-01	作為登革熱病毒複製抑制劑的單取代的或二取代的吲哚衍生物
HK1247611A1 (zh)	2018-09-28	作為登革熱病毒複製抑制劑的吲哚衍生物
PT3294738T (pt)	2021-06-30	Derivados mono ou di-substituídos de indol como inibidores da replicação viral da dengue