HRP20140676T1 - Formulacije deoksikolne kiseline i njezinih soli - Google Patents
Formulacije deoksikolne kiseline i njezinih soli Download PDFInfo
- Publication number
- HRP20140676T1 HRP20140676T1 HRP20140676AT HRP20140676T HRP20140676T1 HR P20140676 T1 HRP20140676 T1 HR P20140676T1 HR P20140676A T HRP20140676A T HR P20140676AT HR P20140676 T HRP20140676 T HR P20140676T HR P20140676 T1 HRP20140676 T1 HR P20140676T1
- Authority
- HR
- Croatia
- Prior art keywords
- preparation
- preparation according
- vol
- deoxycholic acid
- salt
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Claims (14)
1. Taložno stabilan vodeni farmaceutski pripravak, naznačen time što se uglavnom sastoji od 0,4% tež./vol. Do 1% tež./vol. soli deoksikolne kiseline i farmaceutski prihvatljive pomoćne tvari, te što se pH navedenog pripravka održava na 8,2 do 8,5.
2. Pripravak u skladu s patentnim zahtjevom 1, naznačen time što je navedena sol deoksikolne kiseline prisutna u količini od 0,5% tež./vol. do 1% tež./vol.
3. Pripravak u skladu s patentnim zahtjevom 1 ili patentnim zahtjevom 2, naznačen time što je navedena sol deoksikolne kiseline prisutna u količini od 0,5% tež./vol.
4. Pripravak u skladu s patentnim zahtjevom 1 ili patentnim zahtjevom 2, naznačen time što je navedena sol deoksikolne kiseline prisutna u količini od 1% tež./vol.
5. Pripravak u skladu s bilo kojim od patentnih zahtjeva 1 do 4, naznačen time što je navedena pomoćna tvar otapalo, pufer, konzervans, pomoćno sredstvo za liofiliziranje, ili bilo koja kombinacija navedenog.
6. Pripravak u skladu s patentnim zahtjevom 5, naznačen time što je navedena pomoćna tvar otapalo, poput sterile water.
7. Pripravak u skladu s patentnim zahtjevom 5, naznačen time što je navedena pomoćna tvar konzervans, poput benzil-alkohola.
8. Pripravak u skladu s patentnim zahtjevom 7, naznačen time što je navedeni konzervans 0,9%-tni benzilalkohol.
9. Pripravak u skladu s patentnim zahtjevom 1, naznačen time što navedeni pripravak ima pH od 8,3.
10. Pripravak u skladu s bilo kojim od patentnih zahtjeva 1 do 9, naznačen time što je navedeni pripravak injekcijski pripravak.
11. Pripravak u skladu s patentnim zahtjevom 10, naznačen time što je navedeni pripravak pripravak za supkutanu injekciju.
12. Pripravak u skladu s bilo kojim od patentnih zahtjeva 1 do 11, naznačen time što je navedena sol sol s alkalnim metalom.
13. Pripravak u skladu s patentnim zahtjevom 12, naznačen time što je navedena sol s alkalnim metalom natrijeva sol.
14. Pripravak u skladu s bilo kojim od patentnih zahtjeva 1 do 13, naznačen time što se deoksikolnu kiselinu sintetizira prema sljedećoj shemi:
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11178538.2A EP2561876B1 (en) | 2011-08-23 | 2011-08-23 | Formulations of Deoxycholic Acid and Salts Thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20140676T1 true HRP20140676T1 (hr) | 2014-10-10 |
Family
ID=44651163
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20140676AT HRP20140676T1 (hr) | 2011-08-23 | 2014-07-15 | Formulacije deoksikolne kiseline i njezinih soli |
Country Status (11)
| Country | Link |
|---|---|
| EP (4) | EP2561876B1 (hr) |
| CY (1) | CY1115372T1 (hr) |
| DK (2) | DK2561876T3 (hr) |
| ES (3) | ES2655465T3 (hr) |
| HR (1) | HRP20140676T1 (hr) |
| HU (1) | HUE046047T2 (hr) |
| PL (2) | PL2561876T3 (hr) |
| PT (2) | PT3305298T (hr) |
| RS (1) | RS53419B (hr) |
| SI (1) | SI2561876T1 (hr) |
| SM (1) | SMT201400094B (hr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060127468A1 (en) | 2004-05-19 | 2006-06-15 | Kolodney Michael S | Methods and related compositions for reduction of fat and skin tightening |
| US8101593B2 (en) | 2009-03-03 | 2012-01-24 | Kythera Biopharmaceuticals, Inc. | Formulations of deoxycholic acid and salts thereof |
| EP2675460A4 (en) | 2011-02-18 | 2014-07-09 | Kythera Biopharmaceuticals Inc | TREATMENT OF FAT TISSUE UNDER CHIN |
| US8653058B2 (en) | 2011-04-05 | 2014-02-18 | Kythera Biopharmaceuticals, Inc. | Compositions comprising deoxycholic acid and salts thereof suitable for use in treating fat deposits |
| EP3370710A1 (en) * | 2015-11-04 | 2018-09-12 | Kythera Biopharmaceuticals, Inc. | Treatments of accumulated fat with deoxycholic acid and salts thereof |
| CN118005707A (zh) * | 2024-01-18 | 2024-05-10 | 山东省食品药品检验研究院 | 一种脱氧胆酸钠晶型a及其制备方法和应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2754709B1 (fr) | 1996-10-23 | 1999-03-05 | Sanofi Sa | Composition cosmetique contenant un antagoniste des recepteurs du neuropeptide gamma et alpha 2 antagonistes susceptibles d'etre incorpores dans une telle composition |
| US6417179B1 (en) * | 1998-10-13 | 2002-07-09 | Craig G. Burkhart | Ear wax solution |
| US20050048126A1 (en) * | 2000-12-22 | 2005-03-03 | Barrett Rabinow | Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug |
| HUE038247T2 (hu) | 2004-05-19 | 2018-10-29 | Los Angeles Biomedical Res Inst Harbor Ucla Medical Ct | Nátrium-deoxikolátot tartalmazó injektálható készítmény |
| US7754230B2 (en) | 2004-05-19 | 2010-07-13 | The Regents Of The University Of California | Methods and related compositions for reduction of fat |
| US20060127468A1 (en) | 2004-05-19 | 2006-06-15 | Kolodney Michael S | Methods and related compositions for reduction of fat and skin tightening |
| EP1888101B1 (en) | 2005-06-06 | 2012-03-21 | Georgetown University | Compositions and methods for lipo modeling |
| TW201011755A (en) | 2008-09-10 | 2010-03-16 | Skymedi Corp | Flash memory system and its data recovery method |
-
2011
- 2011-08-23 EP EP11178538.2A patent/EP2561876B1/en active Active
- 2011-08-23 HU HUE17188946A patent/HUE046047T2/hu unknown
- 2011-08-23 PT PT17188946T patent/PT3305298T/pt unknown
- 2011-08-23 EP EP19159371.4A patent/EP3511007A1/en not_active Withdrawn
- 2011-08-23 RS RS20140368A patent/RS53419B/en unknown
- 2011-08-23 SI SI201130212T patent/SI2561876T1/sl unknown
- 2011-08-23 EP EP14155614.2A patent/EP2735310B1/en active Active
- 2011-08-23 ES ES14155614.2T patent/ES2655465T3/es active Active
- 2011-08-23 DK DK11178538.2T patent/DK2561876T3/da active
- 2011-08-23 EP EP17188946.2A patent/EP3305298B1/en active Active
- 2011-08-23 PT PT111785382T patent/PT2561876E/pt unknown
- 2011-08-23 PL PL11178538T patent/PL2561876T3/pl unknown
- 2011-08-23 DK DK17188946.2T patent/DK3305298T3/da active
- 2011-08-23 PL PL17188946T patent/PL3305298T3/pl unknown
- 2011-08-23 ES ES17188946T patent/ES2738500T3/es active Active
- 2011-08-23 ES ES11178538.2T patent/ES2478447T3/es active Active
-
2014
- 2014-07-11 CY CY20141100522T patent/CY1115372T1/el unknown
- 2014-07-15 HR HRP20140676AT patent/HRP20140676T1/hr unknown
- 2014-07-16 SM SM201400094T patent/SMT201400094B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3305298A1 (en) | 2018-04-11 |
| SI2561876T1 (sl) | 2014-08-29 |
| RS53419B (en) | 2014-12-31 |
| EP2561876B1 (en) | 2014-04-16 |
| HUE046047T2 (hu) | 2020-01-28 |
| PL3305298T3 (pl) | 2020-02-28 |
| DK3305298T3 (da) | 2019-07-29 |
| ES2478447T3 (es) | 2014-07-22 |
| PT2561876E (pt) | 2014-07-18 |
| EP3511007A1 (en) | 2019-07-17 |
| EP2561876A1 (en) | 2013-02-27 |
| PT3305298T (pt) | 2019-07-29 |
| EP2735310B1 (en) | 2017-10-11 |
| SMT201400094B (it) | 2014-11-10 |
| ES2738500T3 (es) | 2020-01-23 |
| CY1115372T1 (el) | 2017-01-04 |
| EP2735310A1 (en) | 2014-05-28 |
| ES2655465T3 (es) | 2018-02-20 |
| EP3305298B1 (en) | 2019-05-01 |
| DK2561876T3 (da) | 2014-07-21 |
| PL2561876T3 (pl) | 2014-09-30 |
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