HRP20130549T4 - Spojevi i njihove soli specifični za ppar receptore i egf receptore te njihova primjena u području medicine - Google Patents
Spojevi i njihove soli specifični za ppar receptore i egf receptore te njihova primjena u području medicine Download PDFInfo
- Publication number
- HRP20130549T4 HRP20130549T4 HRP20130549TT HRP20130549T HRP20130549T4 HR P20130549 T4 HRP20130549 T4 HR P20130549T4 HR P20130549T T HRP20130549T T HR P20130549TT HR P20130549 T HRP20130549 T HR P20130549T HR P20130549 T4 HRP20130549 T4 HR P20130549T4
- Authority
- HR
- Croatia
- Prior art keywords
- compound
- aminophenyl
- propionic acid
- ethoxy
- use according
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C229/60—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in meta- or para- positions
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
Claims (11)
1. Spoj i njegove soli, izabran iz grupe koja obuhvaća:
[image]
[image]
i
[image]
2. Spoj prema zahtjevu 1 u enantiomerski čistom R ili S obliku.
3. Spoj izabran iz grupe koja obuhvaća:
(+-)-2-hidroksi-3-(3’-aminofenil) propionska kiselina (spoj 20)
(+-)-2-metoksi-2-(4’-aminofenil) octena kiselina (spoj 23)
(+-)-2-etoksi-2-(3’-aminofenil) octena kiselina (spoj 32)
(+-)-2-etoksi-2-(4’-aminofenil) octena kiselina (spoj 33)
(+-)-2-metoksi-3-(4’-aminofenil) propionska kiselina (spoj 34)
(+-)-2-etoksi-3-(4’-aminofenil) propionska kiselina (spoj 39) i
(+-)-2-etoksi-3-(3’-aminofenil) propionska kiselina (spoj 40) za uporabu u medicini.
4. Spoj 2-metoksi-3-(3’-aminofenil)propionska kiselina ili (±)-2-hidroksi-3-(4’-aminofenil)propionska kiselina (spoj 21) za uporabu u medicini.
5. Spoj za uporabu prema zahtjevu 3 ili zahtjevu 4 gdje je područje medicine liječenje kronične upalne bolesti ili tumora koji eksprimira PPAR i EGF.
6. Spoj za uporabu prema zahtjevu 5 gdje se tumori izabiru iz grupe koja obuhvaća tumor jednjaka, želuca, gušterače, kolona, prostate, dojke, maternice i priraslica maternici, bubrega i pluća.
7. Spoj za uporabu prema zahtjevu 6 gdje je spoj (+-)-2-metoksi-3-(4’-aminofenil) propionska kiselina (spoj 34) ili (+-)-2-etoksi-3-(4’-aminofenil) propionska kiselina (spoj 39).
8. Spoj za uporabu prema zahtjevu 5 gdje je kronična upalna bolest Crohnova bolest ili ulcerozni rektokolitis.
9. Spoj za uporabu prema zahtjevu 8 gdje je spoj
(+-)-2-metoksi-3-(4’-aminofenil) propionska kiselina (spoj 34)
(+-)-2-etoksi-3-(4’-aminofenil) propionska kiselina (spoj 39) ili
(+-)-2-etoksi-3-(3’-aminofenil) propionska kiselina (spoj 40)
10. Spoj za uporabu prema bilo kojem od zahtjeva 3 do 9 gdje se radi o uporabi spoja u mješavini u kojoj je jedan enantiomer u suvišku u odnosu na drugi, u bilo kojem omjeru.
11. Farmaceutska smjesa koja kao djelatnu tvar sadrži jedan ili više spojeva prema zahtjevima 1 do 3 u kombinaciji s jednim ili više farmaceutski prihvatljivih pomoćnih tvari ili adjuvansa.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000389A ITRM20050389A1 (it) | 2005-07-22 | 2005-07-22 | Composti e loro sali specifici per i recettori ppar ed i recettori per l'egf e loro uso in campo medico. |
| EP06766085.2A EP1910270B3 (en) | 2005-07-22 | 2006-07-24 | Compounds and their salts specific to the ppar receptors and the egf receptors and their use in the medical field |
| PCT/IE2006/000078 WO2007010516A2 (en) | 2005-07-22 | 2006-07-24 | Compounds and their salts specific to the ppar receptors and the egf receptors and their use in the medical field |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HRP20130549T1 HRP20130549T1 (en) | 2013-07-31 |
| HRP20130549T4 true HRP20130549T4 (hr) | 2016-07-15 |
Family
ID=37579831
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20130549TT HRP20130549T4 (hr) | 2005-07-22 | 2006-07-24 | Spojevi i njihove soli specifični za ppar receptore i egf receptore te njihova primjena u području medicine |
Country Status (23)
| Country | Link |
|---|---|
| US (6) | US8153841B2 (hr) |
| EP (1) | EP1910270B3 (hr) |
| JP (1) | JP5312026B2 (hr) |
| KR (1) | KR101317519B1 (hr) |
| CN (2) | CN102020577B (hr) |
| AU (1) | AU2006271165C1 (hr) |
| CA (1) | CA2616146C (hr) |
| CY (1) | CY1114294T1 (hr) |
| DK (1) | DK1910270T6 (hr) |
| EA (2) | EA014665B3 (hr) |
| ES (1) | ES2421260T7 (hr) |
| HR (1) | HRP20130549T4 (hr) |
| IL (2) | IL188878A (hr) |
| IT (1) | ITRM20050389A1 (hr) |
| MX (1) | MX366596B (hr) |
| NO (1) | NO340680B1 (hr) |
| NZ (2) | NZ566045A (hr) |
| PL (1) | PL1910270T6 (hr) |
| PT (1) | PT1910270E (hr) |
| SI (1) | SI1910270T1 (hr) |
| UA (1) | UA100359C2 (hr) |
| WO (1) | WO2007010516A2 (hr) |
| ZA (2) | ZA200801671B (hr) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITRM20050389A1 (it) | 2005-07-22 | 2007-01-23 | Giuliani Spa | Composti e loro sali specifici per i recettori ppar ed i recettori per l'egf e loro uso in campo medico. |
| ITRM20050390A1 (it) | 2005-07-22 | 2007-01-23 | Giuliani Spa | Composti e loro sali specifici per i recettori ppar ed i recettori per l'egf e loro uso in campo medico. |
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| US9096531B2 (en) | 2010-05-24 | 2015-08-04 | Toa Eiyo Ltd. | Fused imidazole derivative |
| CN109999017A (zh) | 2012-02-09 | 2019-07-12 | 诺格拉制药有限公司 | 治疗纤维化的方法 |
| NZ631049A (en) * | 2012-04-18 | 2017-02-24 | Nogra Pharma Ltd | Methods of treating lactose intolerance |
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| WO2017093444A1 (en) * | 2015-12-01 | 2017-06-08 | Nogra Pharma Limited | Compositions for oral administration in the treatment of inflammatory bowel disease |
| US20220000818A1 (en) | 2019-01-25 | 2022-01-06 | Nogra Pharma Limited | Compositions for use in preventing acne |
| SMT202500054T1 (it) | 2019-02-08 | 2025-03-12 | Nogra Pharma Ltd | Processo per produrre acido 3-(4'-amminofenil)-2-metossipropionico, e relativi analoghi e intermedi |
| WO2025132838A1 (en) | 2023-12-20 | 2025-06-26 | Nogra Pharma Limited | Acne topical formulations |
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