HRP20110666T1 - Uporaba 4-ciklopropilmetoksi-n-(3,5-diklor-1-oksidopiridin-4-il)-5-(metoksi)piridin-2-karboksamida u liječenju motoričkih poremećaja povezanih s parkinsonovom bolesti - Google Patents
Uporaba 4-ciklopropilmetoksi-n-(3,5-diklor-1-oksidopiridin-4-il)-5-(metoksi)piridin-2-karboksamida u liječenju motoričkih poremećaja povezanih s parkinsonovom bolesti Download PDFInfo
- Publication number
- HRP20110666T1 HRP20110666T1 HR20110666T HRP20110666T HRP20110666T1 HR P20110666 T1 HRP20110666 T1 HR P20110666T1 HR 20110666 T HR20110666 T HR 20110666T HR P20110666 T HRP20110666 T HR P20110666T HR P20110666 T1 HRP20110666 T1 HR P20110666T1
- Authority
- HR
- Croatia
- Prior art keywords
- oxidopyridin
- carboxamide
- use according
- disorders
- cyclopropylmethoxy
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
Uporaba 4-ciklopropilmetoksi-N-(3,5-dikloro-1-oksidopiridin-4-il)-5-metoksipiridin-2-karboksamida u obliku hidrata, solvata ili baze ili u obliku doli nastale dodatkom kiseline, naznačena time da je za pripravu medikamenta namijenjenom liječenju motoričkih poremećaja povezanih s Parkinsonovom bolesti. Patent sadrži još 4 patentna zahtjeva.
Claims (5)
1. Uporaba 4-ciklopropilmetoksi-N-(3,5-dikloro-1-oksidopiridin-4-il)-5-metoksipiridin-2-karboksamida u obliku hidrata, solvata ili baze ili u obliku doli nastale dodatkom kiseline, naznačena time da je za pripravu medikamenta namijenjenom liječenju motoričkih poremećaja povezanih s Parkinsonovom bolesti.
2. Uporaba prema zahtjevu 1, naznačena time da je 4-ciklopropilmetoksi-N-(3,5-dikloro-1-oksidopiridin-4-il)-5-metoksipiridin-2-karboksamid u obliku baze.
3. Uporaba prema bilo kojem od zahtjeva 1 i 2, naznačena time da su motorički poremećaji povezani s Parkinsonovom bolesti bradikinezija, akinezija, ukočenost, poremećaj posturalne ravnoteže, nestabilnost, poremećaj hodanja, tremor, poremećaji usmenog i pismenog izražavanja, disfagija, respiratorni poremećaji ili poremećaji sfinktera mjehura.
4. Uporaba prema bilo kojem od zahtjeva 1-3, naznačena time da se izbjegava emetički učinak.
5. Uporaba prema zahtjevu 4, naznačena time da se ne inducira ni nagon za povraćanjem niti povraćanje.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0702853A FR2915100B1 (fr) | 2007-04-19 | 2007-04-19 | Utilisation du 4-cyclopropylmethoxy-n-(3,5-dichloro-1-oxydo- pyridin-4-yl)-5-(methoxy)pyridine-2-carboxalide pour le traitement des desordres moteurs lies a la maladie de parkinson |
| PCT/FR2008/000534 WO2008145841A1 (fr) | 2007-04-19 | 2008-04-16 | Utilisation du 4-cyclopropylmethoxy-n-(3,5-dichloro-1 -oxydo- pyridin-4-yl)-5-(methoxy)pyridine-2-carboxamide pour le traitement des desordres moteurs lies a la maladie de parkinson |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20110666T1 true HRP20110666T1 (hr) | 2011-10-31 |
Family
ID=38712405
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20110666T HRP20110666T1 (hr) | 2007-04-19 | 2008-04-16 | Uporaba 4-ciklopropilmetoksi-n-(3,5-diklor-1-oksidopiridin-4-il)-5-(metoksi)piridin-2-karboksamida u liječenju motoričkih poremećaja povezanih s parkinsonovom bolesti |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US20100130554A1 (hr) |
| EP (1) | EP2146714B1 (hr) |
| JP (1) | JP5386478B2 (hr) |
| KR (2) | KR101503942B1 (hr) |
| CN (1) | CN101663035B (hr) |
| AR (1) | AR066108A1 (hr) |
| AT (1) | ATE513548T1 (hr) |
| AU (1) | AU2008257322B2 (hr) |
| BR (1) | BRPI0810444A2 (hr) |
| CA (1) | CA2684174C (hr) |
| CL (1) | CL2008001136A1 (hr) |
| CY (1) | CY1111840T1 (hr) |
| DK (1) | DK2146714T3 (hr) |
| EA (1) | EA019194B1 (hr) |
| ES (1) | ES2367408T3 (hr) |
| FR (1) | FR2915100B1 (hr) |
| HR (1) | HRP20110666T1 (hr) |
| IL (1) | IL201448A (hr) |
| JO (1) | JO2678B1 (hr) |
| MA (1) | MA31367B1 (hr) |
| ME (1) | ME00935B (hr) |
| MX (1) | MX2009011284A (hr) |
| MY (1) | MY148092A (hr) |
| NZ (1) | NZ580482A (hr) |
| PA (1) | PA8776801A1 (hr) |
| PL (1) | PL2146714T3 (hr) |
| PT (1) | PT2146714E (hr) |
| RS (1) | RS51869B (hr) |
| SI (1) | SI2146714T1 (hr) |
| TW (1) | TWI439269B (hr) |
| UY (1) | UY31035A1 (hr) |
| WO (1) | WO2008145841A1 (hr) |
| ZA (1) | ZA200907251B (hr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2621894C2 (ru) * | 2012-11-28 | 2017-06-08 | Санофи | Способ получения новых кристаллических форм-4(циклопропилметокси)-n-(3, 5-дихлор-1-оксидопиридин-4-ил)-5-метоксипиридин-2-карбоксамида и его кристаллические формы |
| US9624100B2 (en) | 2014-06-12 | 2017-04-18 | Apple Inc. | Micro pick up array pivot mount with integrated strain sensing elements |
| WO2025079694A1 (ja) * | 2023-10-12 | 2025-04-17 | 株式会社 メドレックス | 経皮吸収組成物 |
| WO2025080415A1 (en) * | 2023-10-12 | 2025-04-17 | Alto Neuroscience, Inc. | Treatment of neuropsychiatric disorders with tilivapram |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4193926A (en) * | 1974-03-20 | 1980-03-18 | Schering Aktiengesellschaft | 4-(Polyalkoxy phenyl)-2-pyrrolidones |
| AU7267094A (en) * | 1993-07-28 | 1995-02-28 | Rhone-Poulenc Rorer Limited | Compounds as pde iv and tnf inhibitors |
| US6177077B1 (en) * | 1999-02-24 | 2001-01-23 | Edward L. Tobinick | TNT inhibitors for the treatment of neurological disorders |
| EP1244649B1 (en) * | 1999-12-23 | 2005-03-02 | Icos Corporation | Cyclic amp-specific phosphodiesterase inhibitors |
| JP2005506286A (ja) * | 2001-03-02 | 2005-03-03 | ブリストル−マイヤーズ スクイブ カンパニー | サイクリック−ａｍｐ関連疾患の治療を目的としたメラノコルチン受容体アゴニストおよびホスホジエステラーゼ阻害剤の併用投与 |
| EP1519922A1 (en) * | 2002-07-02 | 2005-04-06 | Merck Frosst Canada & Co. | Di-aryl-substituted ethane pyridone pde4 inhibitors |
| MXPA05009535A (es) * | 2003-03-12 | 2005-11-16 | Celgene Corp | Compuestos de acido n - alquil - hidroxamico - isoindolilo y sus usos farmaceuticos. |
| CA2611562A1 (en) * | 2005-06-10 | 2006-12-21 | Memory Pharmaceuticals Corporation | Trisubstituted amines as phosphodiesterase 4 inhibitors |
| US20070021451A1 (en) * | 2005-07-20 | 2007-01-25 | Hamamatsu University School Of Medicine | Method for preventing or treating neurologic damage after spinal cord injury |
-
2007
- 2007-04-19 FR FR0702853A patent/FR2915100B1/fr not_active Expired - Fee Related
-
2008
- 2008-04-15 PA PA20088776801A patent/PA8776801A1/es unknown
- 2008-04-16 CA CA2684174A patent/CA2684174C/fr not_active Expired - Fee Related
- 2008-04-16 ME MEP-2009-299A patent/ME00935B/me unknown
- 2008-04-16 CN CN2008800126498A patent/CN101663035B/zh not_active Expired - Fee Related
- 2008-04-16 EP EP08787963A patent/EP2146714B1/fr active Active
- 2008-04-16 SI SI200830357T patent/SI2146714T1/sl unknown
- 2008-04-16 KR KR1020097021593A patent/KR101503942B1/ko not_active Expired - Fee Related
- 2008-04-16 PL PL08787963T patent/PL2146714T3/pl unknown
- 2008-04-16 BR BRPI0810444A patent/BRPI0810444A2/pt not_active IP Right Cessation
- 2008-04-16 PT PT08787963T patent/PT2146714E/pt unknown
- 2008-04-16 WO PCT/FR2008/000534 patent/WO2008145841A1/fr active Application Filing
- 2008-04-16 EA EA200970970A patent/EA019194B1/ru not_active IP Right Cessation
- 2008-04-16 ES ES08787963T patent/ES2367408T3/es active Active
- 2008-04-16 DK DK08787963.1T patent/DK2146714T3/da active
- 2008-04-16 NZ NZ580482A patent/NZ580482A/en not_active IP Right Cessation
- 2008-04-16 AT AT08787963T patent/ATE513548T1/de active
- 2008-04-16 AU AU2008257322A patent/AU2008257322B2/en not_active Ceased
- 2008-04-16 HR HR20110666T patent/HRP20110666T1/hr unknown
- 2008-04-16 JP JP2010503549A patent/JP5386478B2/ja not_active Expired - Fee Related
- 2008-04-16 MX MX2009011284A patent/MX2009011284A/es active IP Right Grant
- 2008-04-16 RS RS20110358A patent/RS51869B/en unknown
- 2008-04-16 KR KR1020147033000A patent/KR20150004885A/ko not_active Ceased
- 2008-04-16 MY MYPI20094343A patent/MY148092A/en unknown
- 2008-04-17 JO JO2008182A patent/JO2678B1/en active
- 2008-04-17 TW TW097113997A patent/TWI439269B/zh not_active IP Right Cessation
- 2008-04-18 UY UY31035A patent/UY31035A1/es not_active Application Discontinuation
- 2008-04-18 CL CL2008001136A patent/CL2008001136A1/es unknown
- 2008-04-18 AR ARP080101602A patent/AR066108A1/es unknown
-
2009
- 2009-10-05 US US12/573,326 patent/US20100130554A1/en not_active Abandoned
- 2009-10-11 IL IL201448A patent/IL201448A/en not_active IP Right Cessation
- 2009-10-16 ZA ZA2009/07251A patent/ZA200907251B/en unknown
- 2009-11-10 MA MA32333A patent/MA31367B1/fr unknown
-
2011
- 2011-09-15 CY CY20111100887T patent/CY1111840T1/el unknown
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