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HRP20040707B1 - Supstituirani piridinoni kao modulatori p38 map kinaze - Google Patents

Supstituirani piridinoni kao modulatori p38 map kinaze

Info

Publication number
HRP20040707B1
HRP20040707B1 HRP20040707AA HRP20040707A HRP20040707B1 HR P20040707 B1 HRP20040707 B1 HR P20040707B1 HR P20040707A A HRP20040707A A HR P20040707AA HR P20040707 A HRP20040707 A HR P20040707A HR P20040707 B1 HRP20040707 B1 HR P20040707B1
Authority
HR
Croatia
Prior art keywords
supstituted
pyridinones
modulators
map kinase
aryl
Prior art date
Application number
HRP20040707AA
Other languages
English (en)
Inventor
Balekudru Devadas
John Walker
Shaun R. Selness
Terri L. Boehm
Richard Durley
Rajesh Devraj
Brian S. Hickory
Paul V. Rucker
Kevin D. Jerome
Heather M. Madsen
Edgardo Alvira
Michele A. Promo
Radhika M. Blevis-Bal
Laura D. Marrufo
Jeff Hitchock
Thomas Owen
Win Naing
Li Xing
Huey S. Shieh
Aruna Sambandam
Shuang Liu
Ian L. Scott
Kevin F. Mcgee
Original Assignee
Pharmacia Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corporation filed Critical Pharmacia Corporation
Publication of HRP20040707A2 publication Critical patent/HRP20040707A2/hr
Publication of HRP20040707B1 publication Critical patent/HRP20040707B1/hr

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
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Abstract

Ar = nesupstituirani ili supstituirani aril ili heteroarilR= alkil sa 1 do 8 ugljikovih atoma, aril ili aralkilR= O, OH, CN ili halogen ia = jednostruka veza ili dvostruka veza.
HRP20040707AA 2002-02-14 2003-02-14 Supstituirani piridinoni kao modulatori p38 map kinaze HRP20040707B1 (hr)

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PCT/US2003/004634 WO2003068230A1 (en) 2002-02-14 2003-02-14 Substituted pyridinones as modulators of p38 map kinase

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