HRP20010604A2 - 3-phenylpyridine derivatives and their use as nk-1 receptor antagonists - Google Patents

3-phenylpyridine derivatives and their use as nk-1 receptor antagonists Download PDF

Info

Publication number: HRP20010604A2
Authority: HR; Croatia
Prior art keywords: methyl; compound; formula; trifluoromethyl; phenyl
Prior art date: 1999-02-24

Application number

HR20010604A

Other languages

English (en)

Croatian (hr)

Inventor

Michael Boes

Guido Galley

Thierry Godel

Torsten Hoffmann

Walter Hunkeler

Patrick Schnider

Heinz Stadler

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-02-24

Filing date

2000-02-15

Publication date

2002-08-31

2000-02-15 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2002-08-31 Publication of HRP20010604A2 publication Critical patent/HRP20010604A2/hr

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Pulmonology (AREA)
Addiction (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Ophthalmology & Optometry (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

HR20010604A 1999-02-24 2000-02-15 3-phenylpyridine derivatives and their use as nk-1 receptor antagonists HRP20010604A2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP99103503		1999-02-24
PCT/EP2000/001223 WO2000050401A1 (en)	1999-02-24	2000-02-15	3-phenylpyridine derivatives and their use as nk-1 receptor antagonists

Publications (1)

Publication Number	Publication Date
HRP20010604A2 true HRP20010604A2 (en)	2002-08-31

Family

ID=8237624

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20010604A HRP20010604A2 (en)	1999-02-24	2000-02-15	3-phenylpyridine derivatives and their use as nk-1 receptor antagonists

Country Status (33)

Country	Link
US (1)	US6225316B1 (de)
EP (1)	EP1157005B1 (de)
JP (1)	JP4068305B2 (de)
KR (1)	KR100437587B1 (de)
CN (1)	CN1134417C (de)
AR (1)	AR029616A1 (de)
AT (1)	ATE280158T1 (de)
AU (1)	AU772446B2 (de)
BR (1)	BR0008494A (de)
CA (1)	CA2364662C (de)
CO (1)	CO5140087A1 (de)
CZ (1)	CZ20013047A3 (de)
DE (1)	DE60015089T2 (de)
DK (1)	DK1157005T3 (de)
ES (1)	ES2230070T3 (de)
GC (1)	GC0000183A (de)
HK (1)	HK1044942B (de)
HR (1)	HRP20010604A2 (de)
HU (1)	HUP0200139A3 (de)
IL (2)	IL144851A0 (de)
JO (1)	JO2254B1 (de)
MA (1)	MA26773A1 (de)
MY (1)	MY122630A (de)
NO (1)	NO320099B1 (de)
NZ (1)	NZ513370A (de)
PL (1)	PL350428A1 (de)
PT (1)	PT1157005E (de)
RU (1)	RU2236402C2 (de)
SI (1)	SI1157005T1 (de)
TR (1)	TR200102489T2 (de)
WO (1)	WO2000050401A1 (de)
YU (1)	YU59901A (de)
ZA (1)	ZA200106371B (de)

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GB9928222D0 (en)	1999-11-30	2000-01-26	Univ Sheffield	Chiral catalysts for asymmetric acylation and related transformations
AUPQ514600A0 (en)	2000-01-18	2000-02-10	James Cook University	Brain injury treatment
HRP20030003B1 (en) *	2000-07-14	2011-01-31	F. Hoffmann - La Roche Ag	N-oxides as nk1 receptor antagonist prodrugs of 4-phenyl-pyridine derivatives
TWI287003B (en) *	2000-07-24	2007-09-21	Hoffmann La Roche	4-phenyl-pyridine derivatives
SE0004245D0 (sv)	2000-11-20	2000-11-20	Pharmacia Ab	Novel compounds and their use
KR100846339B1 (ko) *	2000-11-20	2008-07-15	바이오비트럼 에이비(피유비엘)	세로토닌 5ｈｔ-2 수용체의 아고니스트 또는안타고니스트로서의 피페라지닐피라진 화합물
US20030083345A1 (en) *	2001-07-10	2003-05-01	Torsten Hoffmann	Method of treatment and/or prevention of brain, spinal or nerve injury
US6908935B2 (en) *	2002-05-23	2005-06-21	Amgen Inc.	Calcium receptor modulating agents
US7176322B2 (en) *	2002-05-23	2007-02-13	Amgen Inc.	Calcium receptor modulating agents
BR0314126A (pt) *	2002-09-20	2005-06-28	Pfizer Prod Inc	Ligandos de amida acìclica e sulfonamida para o receptor de estrogênio
WO2006089674A2 (en)	2005-02-25	2006-08-31	F.Hoffmann-La Roche Ag	Tablets with improved drug substance dispersibility
KR101561482B1 (ko)	2005-11-08	2015-10-20	버텍스 파마슈티칼스 인코포레이티드	Ａｔｐ 결합 카세트 수송체의 헤테로사이클릭 조정제
ATE550324T1 (de) *	2005-11-30	2012-04-15	Abbott Products Gmbh	Neue nk1- und nk2-antagonisten
US7671221B2 (en)	2005-12-28	2010-03-02	Vertex Pharmaceuticals Incorporated	Modulators of ATP-Binding Cassette transporters
US7754739B2 (en)	2007-05-09	2010-07-13	Vertex Pharmaceuticals Incorporated	Modulators of CFTR
US20080275085A1 (en) *	2007-04-24	2008-11-06	Junya Shirai	Piperidine derivative and use thereof
NZ581259A (en)	2007-05-09	2012-07-27	Vertex Pharma	Modulators of cystic fibrosis transmembrane conductance regulator
NZ585794A (en)	2007-12-07	2012-05-25	Vertex Pharma	Processes for producing cycloalkylcarboxamido-pyridine benzoic acids
HUE031913T2 (en)	2007-12-07	2017-08-28	Vertex Pharma	Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl) benzoic acid
ES2647531T3 (es)	2008-02-28	2017-12-22	Vertex Pharmaceuticals Incorporated	Derivados de heteroarilo como moduladores de CFTR
KR100943878B1 (ko) *	2008-07-11	2010-02-24	오토스테크 주식회사	디지털방식 눈부심 방지 장치 및 그 제어 방법
JP5635991B2 (ja) *	2008-10-30	2014-12-03	メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋＳｈａｒｐ＆ＤｏｈｍｅＣｏｒｐ．	イソニコチンアミドオレキシン受容体アンタゴニスト
ES2663351T3 (es)	2009-11-17	2018-04-12	Novartis Ag	Derivados de aril-piridina como inhibidores de la aldosterona sintasa
LT3150198T (lt)	2010-04-07	2021-12-10	Vertex Pharmaceuticals Incorporated	3-(6-(1-(2,2-difluorbenzo[d][1,3]dioksol-5-il) ciklopropankarboksamido)-3-metilpiridin-2-il)benzoinės rūgšties farmacinė kompozicija ir jos įvedimas
US8410107B2 (en) *	2010-10-15	2013-04-02	Hoffmann-La Roche Inc.	N-pyridin-3-yl or N-pyrazin-2-yl carboxamides
CN108066306B (zh)	2012-01-25	2021-09-07	沃泰克斯药物股份有限公司	药物制剂及其制备方法
JP5806420B1 (ja)	2013-11-08	2015-11-10	キッセイ薬品工業株式会社	カルボキシメチルピペリジン誘導体
NZ720958A (en)	2013-11-12	2022-02-25	Vertex Pharma	Process of preparing pharmaceutical compositions for the treatment of cftr mediated diseases
TWI649307B (zh)	2014-05-07	2019-02-01	日商橘生藥品工業股份有限公司	Cyclohexylpyridine derivative
PT3221692T (pt)	2014-11-18	2021-09-10	Vertex Pharma	Processo de realização de testagem de alta produtividade por cromatografia líquida de alta eficiência
EP3393519A1 (de) *	2015-12-22	2018-10-31	Takeda Pharmaceutical Company Limited	Dreiteilige modulatoren von endosomalen g-protein-gekoppelten rezeptoren
CN115915941B (zh)	2020-05-06	2025-07-15	拜耳公司	作为杀真菌化合物的吡啶（硫代）酰胺
EP4161914A1 (de)	2020-06-04	2023-04-12	Bayer Aktiengesellschaft	Heterocyclylpyridine als neue fungizide
EP4441049A1 (de)	2021-11-30	2024-10-09	Bayer Aktiengesellschaft	Bis(hetero)arylthioether-oxadiazine als fungizide verbindungen

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US4174209A (en) *	1978-06-19	1979-11-13	Eli Lilly And Company	Herbicidal 1-alkyl-3-phenylpyridinium salts
US4745123A (en) *	1986-02-18	1988-05-17	Warner-Lambert Company	Substituted tetrahydro-3-pyridine-carboxylic acid, ester, and amide cholinergic agents
PL168236B1 (pl) *	1990-05-31	1996-01-31	Pfizer	Sposób wytwarzania podstawionych piperydyn PL PL PL
IL111960A (en)	1993-12-17	1999-12-22	Merck & Co Inc	Morpholines and thiomorpholines their preparation and pharmaceutical compositions containing them
CN1067683C (zh)	1993-12-29	2001-06-27	默克·夏普-道姆公司	取代的吗啉衍生物及其作为治疗剂的用途
TW385308B (en)	1994-03-04	2000-03-21	Merck & Co Inc	Prodrugs of morpholine tachykinin receptor antagonists
DE69628484T2 (de) *	1995-03-24	2004-05-19	Takeda Chemical Industries, Ltd.	Zyklische Verbindungen, ihre Herstellung und ihre Verwendung als Tachykininrezeptorantagonisten
US5972938A (en)	1997-12-01	1999-10-26	Merck & Co., Inc.	Method for treating or preventing psychoimmunological disorders

2000
- 2000-02-15 TR TR2001/02489T patent/TR200102489T2/xx unknown
- 2000-02-15 DK DK00909174T patent/DK1157005T3/da active
- 2000-02-15 BR BR0008494-8A patent/BR0008494A/pt not_active Application Discontinuation
- 2000-02-15 SI SI200030546T patent/SI1157005T1/xx unknown
- 2000-02-15 JP JP2000600984A patent/JP4068305B2/ja not_active Expired - Fee Related
- 2000-02-15 AU AU31549/00A patent/AU772446B2/en not_active Ceased
- 2000-02-15 PL PL00350428A patent/PL350428A1/xx not_active Application Discontinuation
- 2000-02-15 NZ NZ513370A patent/NZ513370A/xx unknown
- 2000-02-15 HK HK02106317.1A patent/HK1044942B/zh not_active IP Right Cessation
- 2000-02-15 WO PCT/EP2000/001223 patent/WO2000050401A1/en not_active Ceased
- 2000-02-15 YU YU59901A patent/YU59901A/sh unknown
- 2000-02-15 EP EP00909174A patent/EP1157005B1/de not_active Expired - Lifetime
- 2000-02-15 CA CA002364662A patent/CA2364662C/en not_active Expired - Fee Related
- 2000-02-15 AT AT00909174T patent/ATE280158T1/de not_active IP Right Cessation
- 2000-02-15 RU RU2001125893/04A patent/RU2236402C2/ru not_active IP Right Cessation
- 2000-02-15 HU HU0200139A patent/HUP0200139A3/hu unknown
- 2000-02-15 DE DE60015089T patent/DE60015089T2/de not_active Expired - Lifetime
- 2000-02-15 IL IL14485100A patent/IL144851A0/xx active IP Right Grant
- 2000-02-15 PT PT00909174T patent/PT1157005E/pt unknown
- 2000-02-15 KR KR10-2001-7010731A patent/KR100437587B1/ko not_active Expired - Fee Related
- 2000-02-15 CZ CZ20013047A patent/CZ20013047A3/cs unknown
- 2000-02-15 HR HR20010604A patent/HRP20010604A2/hr not_active Application Discontinuation
- 2000-02-15 ES ES00909174T patent/ES2230070T3/es not_active Expired - Lifetime
- 2000-02-15 CN CNB008042322A patent/CN1134417C/zh not_active Expired - Fee Related
- 2000-02-16 US US09/505,359 patent/US6225316B1/en not_active Expired - Fee Related
- 2000-02-22 MY MYPI20000647A patent/MY122630A/en unknown
- 2000-02-22 CO CO00012321A patent/CO5140087A1/es unknown
- 2000-02-22 JO JO200015A patent/JO2254B1/en active
- 2000-02-23 AR ARP000100756A patent/AR029616A1/es not_active Application Discontinuation
- 2000-02-23 GC GCP2000535 patent/GC0000183A/en active
2001
- 2001-08-02 ZA ZA200106371A patent/ZA200106371B/en unknown
- 2001-08-09 IL IL144851A patent/IL144851A/en not_active IP Right Cessation
- 2001-08-23 NO NO20014098A patent/NO320099B1/no unknown
- 2001-08-23 MA MA26301A patent/MA26773A1/fr unknown

Also Published As

Publication number	Publication date
JP4068305B2 (ja)	2008-03-26
TR200102489T2 (tr)	2002-04-22
IL144851A0 (en)	2002-06-30
CN1134417C (zh)	2004-01-14
DE60015089D1 (de)	2004-11-25
CA2364662A1 (en)	2000-08-31
CZ20013047A3 (cs)	2002-02-13
MY122630A (en)	2006-04-29
NO320099B1 (no)	2005-10-24
PL350428A1 (en)	2002-12-16
PT1157005E (pt)	2005-02-28
CO5140087A1 (es)	2002-03-22
NO20014098L (no)	2001-08-23
AU772446B2 (en)	2004-04-29
AR029616A1 (es)	2003-07-10
HK1044942A1 (en)	2002-11-08
YU59901A (sh)	2005-07-19
ES2230070T3 (es)	2005-05-01
WO2000050401A1 (en)	2000-08-31
HUP0200139A2 (en)	2002-06-29
HK1044942B (zh)	2004-05-28
SI1157005T1 (en)	2005-02-28
CA2364662C (en)	2009-10-20
EP1157005B1 (de)	2004-10-20
JO2254B1 (en)	2004-10-07
KR100437587B1 (ko)	2004-06-30
DE60015089T2 (de)	2006-02-16
GC0000183A (en)	2006-03-29
ZA200106371B (en)	2002-11-04
IL144851A (en)	2006-08-20
DK1157005T3 (da)	2005-02-14
MA26773A1 (fr)	2004-12-20
US6225316B1 (en)	2001-05-01
KR20010102347A (ko)	2001-11-15
ATE280158T1 (de)	2004-11-15
HUP0200139A3 (en)	2003-01-28
EP1157005A1 (de)	2001-11-28
JP2002537382A (ja)	2002-11-05
CN1341100A (zh)	2002-03-20
RU2236402C2 (ru)	2004-09-20
AU3154900A (en)	2000-09-14
BR0008494A (pt)	2002-02-05
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NO20014098D0 (no)	2001-08-23

Publication	Publication Date	Title
HRP20010604A2 (en)	2002-08-31	3-phenylpyridine derivatives and their use as nk-1 receptor antagonists
ES2359235T3 (es)	2011-05-19	Derivados de 4-fenilpiridina y su empleo como antagonistas del receptor nk-1.
RS59901B1 (sr)	2020-03-31	Proizvodnja fosfatnih jedinjenja iz materijala koji sadrže fosfor i najmanje jedno od gvožđa i aluminijuma
DE60031513T2 (de)	2007-08-30	Phenyl- und pyridinyl-derivate verwendbar als neurokinin-1-antagonisten
CA2416874C (en)	2011-01-18	4-phenyl-pyridine derivatives as neurokinin-1 receptor antagonists
HRP20000809A2 (en)	2001-12-31	2-(3,5-bis-trifluoromethyl-phenyl)-n-methyl-n-(6-morpholin-4-yl-4-o-tolyl-pyridin-3-yl)-isobutyramide
DE60025918T2 (de)	2006-09-28	4-phenyl-pyrimidine derivate
HRP20010629A2 (en)	2002-08-31	Biphenyl derivatives as antagonists of the neurokinine-1 receptor
JP4767973B2 (ja)	2011-09-07	Ｎｋ１アンタゴニスト
MXPA01008511A (es)	2002-05-09	Derivados de 3-fenilpiridina y su uso como antagonistas del receptor de la neuroquinina (nk-1)

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