HN2012000437A - Nuevos agentes anticancer y la preparacion de dichos agentes - Google Patents
Nuevos agentes anticancer y la preparacion de dichos agentesInfo
- Publication number
- HN2012000437A HN2012000437A HN2012000437A HN2012000437A HN2012000437A HN 2012000437 A HN2012000437 A HN 2012000437A HN 2012000437 A HN2012000437 A HN 2012000437A HN 2012000437 A HN2012000437 A HN 2012000437A HN 2012000437 A HN2012000437 A HN 2012000437A
- Authority
- HN
- Honduras
- Prior art keywords
- agents
- preparation
- new anticancer
- anticancer agents
- new
- Prior art date
Links
- 239000002246 antineoplastic agent Substances 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 title 1
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/06—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00 containing at least one condensed beta-lactam ring system, provided for by groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00, e.g. a penem or a cepham system
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
LA INVENCION SE REFIERE A NUEVOS CONJUGADOS DE DIMEROS DE PIRROLO 1,4 BENZODIAZEPINA QUE PUEDEN SER UTILIZADOS COMO COMPUESTOS ANTICANCEROSOS.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0904043A FR2949469A1 (fr) | 2009-08-25 | 2009-08-25 | Derives anticancereux, leur preparation et leur application en therapeutique |
| FR0904368A FR2949470B1 (fr) | 2009-08-25 | 2009-09-11 | Derives anticancereux, leur preparation et leur application therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HN2012000437A true HN2012000437A (es) | 2015-03-02 |
Family
ID=41720559
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HN2012000437A HN2012000437A (es) | 2009-08-25 | 2012-02-24 | Nuevos agentes anticancer y la preparacion de dichos agentes |
Country Status (34)
| Country | Link |
|---|---|
| US (2) | US8481042B2 (es) |
| EP (1) | EP2470547B1 (es) |
| JP (1) | JP5889189B2 (es) |
| KR (1) | KR20130026405A (es) |
| CN (1) | CN102753559B (es) |
| AR (1) | AR078143A1 (es) |
| AU (1) | AU2010288382B2 (es) |
| BR (1) | BR112012004146A2 (es) |
| CA (1) | CA2772102C (es) |
| CL (2) | CL2012000489A1 (es) |
| CO (1) | CO6612210A2 (es) |
| CR (1) | CR20120085A (es) |
| DO (1) | DOP2012000038A (es) |
| EA (1) | EA026488B1 (es) |
| EC (1) | ECSP12011688A (es) |
| ES (1) | ES2484690T3 (es) |
| FR (2) | FR2949469A1 (es) |
| GT (1) | GT201200046A (es) |
| HN (1) | HN2012000437A (es) |
| IL (1) | IL218262A0 (es) |
| MA (1) | MA33600B1 (es) |
| MX (1) | MX2012002434A (es) |
| MY (1) | MY157469A (es) |
| NI (1) | NI201200031A (es) |
| NZ (1) | NZ598401A (es) |
| PE (1) | PE20120992A1 (es) |
| PH (1) | PH12012500391A1 (es) |
| SG (1) | SG178537A1 (es) |
| TN (1) | TN2012000053A1 (es) |
| TW (1) | TWI477275B (es) |
| UA (1) | UA106507C2 (es) |
| UY (1) | UY32854A (es) |
| WO (1) | WO2011023883A1 (es) |
| ZA (1) | ZA201201397B (es) |
Families Citing this family (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101772354B1 (ko) | 2010-04-15 | 2017-08-28 | 시애틀 지네틱스, 인크. | 표적화된 피롤로벤조디아제핀 접합체 |
| CN102971329B (zh) | 2010-04-15 | 2016-06-29 | 麦迪穆有限责任公司 | 用于治疗增殖性疾病的吡咯并苯并二氮杂卓 |
| CA2849039C (en) | 2011-09-20 | 2018-09-18 | Spirogen Sarl | Pyrrolobenzodiazepines as unsymmetrical dimeric pbd compounds for inclusion in targeted conjugates |
| ES2945932T3 (es) | 2011-10-14 | 2023-07-10 | Seagen Inc | Pirrolobenzodiazepinas y conjugados dirigidos |
| EA027386B1 (ru) | 2011-10-14 | 2017-07-31 | Медимьюн Лимитед | Пирролобензодиазепины |
| JP6399930B2 (ja) | 2011-10-14 | 2018-10-03 | シアトル ジェネティクス，インコーポレーテッド | ピロロベンゾジアゼピンおよび標的コンジュゲート |
| WO2013053873A1 (en) | 2011-10-14 | 2013-04-18 | Spirogen Sàrl | Pyrrolobenzodiazepines |
| EP2793947B1 (en) | 2011-12-23 | 2021-02-03 | Innate Pharma | Enzymatic conjugation of polypeptides |
| US9504756B2 (en) | 2012-05-15 | 2016-11-29 | Seattle Genetics, Inc. | Self-stabilizing linker conjugates |
| HK1207388A1 (en) | 2012-05-15 | 2016-01-29 | Seattle Genetics, Inc. | Self-stabilizing linker conjugates |
| EP2872894B1 (en) | 2012-07-13 | 2019-04-17 | Innate Pharma | Screening of conjugated antibodies |
| ES2703151T3 (es) | 2012-10-12 | 2019-03-07 | Adc Therapeutics Sa | Conjugados de anticuerpos de pirrolobenzodiazepinas |
| EP2906297B1 (en) | 2012-10-12 | 2017-12-06 | ADC Therapeutics SA | Pyrrolobenzodiazepine-antibody conjugates |
| BR112015008238A2 (pt) | 2012-10-12 | 2017-11-28 | Adc Therapeutics Sarl | conjugados de pirrolbenzodiazepina-anticorpo anti-cd22 |
| HUE052835T2 (hu) | 2012-10-12 | 2021-05-28 | Medimmune Ltd | Pirrolobenzodiazepinek és konjugátumaik |
| WO2014057114A1 (en) | 2012-10-12 | 2014-04-17 | Adc Therapeutics Sàrl | Pyrrolobenzodiazepine-anti-psma antibody conjugates |
| US10751346B2 (en) | 2012-10-12 | 2020-08-25 | Medimmune Limited | Pyrrolobenzodiazepine—anti-PSMA antibody conjugates |
| CA2885305C (en) | 2012-10-12 | 2019-11-12 | Spirogen Sarl | Synthesis and intermediates of pyrrolobenzodiazepine derivatives for conjugation |
| SI2906296T1 (en) | 2012-10-12 | 2018-06-29 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates |
| CN109134599A (zh) | 2012-10-12 | 2019-01-04 | 麦迪穆有限责任公司 | 吡咯并苯并二氮杂卓及其结合物 |
| US10036010B2 (en) | 2012-11-09 | 2018-07-31 | Innate Pharma | Recognition tags for TGase-mediated conjugation |
| PL2968494T3 (pl) | 2013-03-13 | 2019-04-30 | Seattle Genetics Inc | Filtracja z węglem aktywnym do oczyszczania benzodiazepinowych ADC |
| MX363787B (es) * | 2013-03-13 | 2019-04-03 | Medimmune Ltd | Pirrolobenzodiazepinas y conjugados de los mismos. |
| MX364330B (es) * | 2013-03-13 | 2019-04-23 | Medimmune Ltd | Pirrolobenzodiazepinas y conjugados de las mismas. |
| WO2014140300A1 (en) | 2013-03-15 | 2014-09-18 | Innate Pharma | Solid phase tgase-mediated conjugation of antibodies |
| WO2014202773A1 (en) | 2013-06-20 | 2014-12-24 | Innate Pharma | Enzymatic conjugation of polypeptides |
| CN105517577A (zh) | 2013-06-21 | 2016-04-20 | 先天制药公司 | 多肽的酶促偶联 |
| EP3054985B1 (en) | 2013-10-11 | 2018-12-26 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
| GB201317981D0 (en) | 2013-10-11 | 2013-11-27 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
| EP3054986B1 (en) | 2013-10-11 | 2019-03-20 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
| US10010624B2 (en) | 2013-10-11 | 2018-07-03 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
| CA2921707C (en) | 2013-10-15 | 2023-03-28 | Seattle Genetics, Inc. | Pegylated drug-linkers for improved ligand-drug conjugate pharmacokinetics |
| EP4212181A3 (en) | 2013-12-19 | 2023-11-15 | Seagen Inc. | Methylene carbamate linkers for use with targeted-drug conjugates |
| KR20230088389A (ko) | 2014-02-11 | 2023-06-19 | 씨젠 인크. | 단백질의 선택적 환원 |
| WO2016008112A1 (en) | 2014-07-16 | 2016-01-21 | Medshine Discovery Inc. | Linkers and application towards adc thereof |
| GB201416112D0 (en) | 2014-09-12 | 2014-10-29 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
| SG10201809668TA (en) | 2014-09-12 | 2018-11-29 | Genentech Inc | Anti-her2 antibodies and immunoconjugates |
| BR112017004953A2 (pt) * | 2014-09-17 | 2017-12-05 | Genentech Inc | imunoconjugado, formulação farmacêutica, método de tratamento e método de inibição da proliferação de uma célula |
| US10780096B2 (en) | 2014-11-25 | 2020-09-22 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates |
| ES2747386T3 (es) | 2015-01-14 | 2020-03-10 | Bristol Myers Squibb Co | Dímeros de benzodiacepina unidos por heteroarileno, conjugados de los mismos y métodos de preparación y uso |
| BR112017014599A2 (pt) | 2015-01-14 | 2018-01-16 | Bristol-Myers Squibb Company | dímeros de benzodiazepina, conjugados dos mesmos, e métodos de preparação e uso |
| GB201506411D0 (en) | 2015-04-15 | 2015-05-27 | Bergenbio As | Humanized anti-axl antibodies |
| GB201506402D0 (en) | 2015-04-15 | 2015-05-27 | Berkel Patricius H C Van And Howard Philip W | Site-specific antibody-drug conjugates |
| KR20180019592A (ko) | 2015-06-23 | 2018-02-26 | 브리스톨-마이어스 스큅 컴퍼니 | 마크로시클릭 벤조디아제핀 이량체, 그의 접합체, 제조법 및 용도 |
| MA43345A (fr) | 2015-10-02 | 2018-08-08 | Hoffmann La Roche | Conjugués anticorps-médicaments de pyrrolobenzodiazépine et méthodes d'utilisation |
| GB201601431D0 (en) | 2016-01-26 | 2016-03-09 | Medimmune Ltd | Pyrrolobenzodiazepines |
| GB201602356D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| GB201602359D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| EP3433278A4 (en) | 2016-03-25 | 2019-11-06 | Seattle Genetics, Inc. | METHOD FOR THE PRODUCTION OF PEGYLATED ACTIVE LINKERS AND INTERMEDIATE PRODUCTS THEREOF |
| GB201607478D0 (en) | 2016-04-29 | 2016-06-15 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| US11944689B2 (en) | 2016-08-09 | 2024-04-02 | Seagen Inc. | Drug conjugates with self-stabilizing linkers having improved physiochemical properties |
| GB201617466D0 (en) | 2016-10-14 | 2016-11-30 | Medimmune Ltd | Pyrrolobenzodiazepine conjugates |
| JP7244987B2 (ja) | 2016-12-14 | 2023-03-23 | シージェン インコーポレイテッド | 多剤抗体薬物コンジュゲート |
| JP7246321B2 (ja) | 2017-01-24 | 2023-03-27 | インネイト ファーマ | ＮＫｐ４６結合物質 |
| WO2018141959A1 (en) | 2017-02-06 | 2018-08-09 | Innate Pharma | Immunomodulatory antibody drug conjugates binding to a human mica polypeptide |
| GB201702031D0 (en) | 2017-02-08 | 2017-03-22 | Medlmmune Ltd | Pyrrolobenzodiazepine-antibody conjugates |
| HRP20210979T1 (hr) | 2017-02-08 | 2021-09-17 | Adc Therapeutics Sa | Konjugati pirolobenzodiazepin-protutijelo |
| CN110430901B (zh) | 2017-03-24 | 2024-08-16 | 西雅图基因公司 | 制备葡糖苷酸药物-接头及其中间体的方法 |
| AU2018255876B2 (en) | 2017-04-18 | 2020-04-30 | Medimmune Limited | Pyrrolobenzodiazepine conjugates |
| MX2019012464A (es) | 2017-04-20 | 2019-12-11 | Adc Therapeutics Sa | Terapia combinada con un conjugado de anticuerpo y farmaco anti-axl. |
| UA127900C2 (uk) | 2017-06-14 | 2024-02-07 | Ейдісі Терапьютікс Са | Схема дозування для введення adc до cd19 |
| HRP20220311T1 (hr) | 2017-08-18 | 2022-05-13 | Medimmune Limited | Konjugati pirolobenzodiazepina |
| EP3690038A4 (en) | 2017-09-29 | 2021-05-19 | Daiichi Sankyo Company, Limited | ANTIBODY PYRROLOBENZODIACEPINE DERIVATIVE CONJUGATE |
| WO2019092148A1 (en) | 2017-11-10 | 2019-05-16 | Innate Pharma | Antibodies with functionalized glutamine residues |
| GB201803342D0 (en) | 2018-03-01 | 2018-04-18 | Medimmune Ltd | Methods |
| GB201806022D0 (en) * | 2018-04-12 | 2018-05-30 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
| KR20210139270A (ko) | 2019-03-15 | 2021-11-22 | 메드임뮨 리미티드 | 암의 치료에 사용하기 위한 아제티도벤조디아제핀 이량체 및 이를 포함하는 컨쥬게이트 |
| EP4036149A4 (en) | 2019-09-26 | 2023-10-25 | NOF Corporation | HETEROBIFUNCTIONAL MONODISPERSED POLYETHYLENE GLYCOL HAVING A PEPTIDE LINKER |
| KR20230008723A (ko) | 2020-04-10 | 2023-01-16 | 씨젠 인크. | 전하 변이체 링커 |
| EP4251207A1 (en) | 2020-11-25 | 2023-10-04 | Innate Pharma | Treatment of cancer |
| AU2022238571A1 (en) | 2021-03-18 | 2023-09-14 | Seagen Inc. | Selective drug release from internalized conjugates of biologically active compounds |
| EP4308171A1 (en) | 2021-03-18 | 2024-01-24 | Seagen Inc. | Selective drug release from internalized conjugates of biologically active compounds |
| CN119233994A (zh) | 2022-05-25 | 2024-12-31 | 先天制药公司 | Nectin-4结合剂 |
| WO2024129756A1 (en) | 2022-12-13 | 2024-06-20 | Seagen Inc. | Site-specific engineered cysteine antibody drug conjugates |
| CN117875311B (zh) * | 2024-01-11 | 2024-06-21 | 北京领初医药科技有限公司 | 一种缩略语句匹配方法、装置及存储介质 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1516743A (fr) | 1966-04-01 | 1968-02-05 | Rhone Poulenc Sa | Nouvel antibiotique et son procédé de préparation par culture de streptomyces croceus |
| GB8307865D0 (en) * | 1983-03-22 | 1983-04-27 | Fujisawa Pharmaceutical Co | Benzimidazole derivatives |
| GB9205051D0 (en) * | 1992-03-09 | 1992-04-22 | Cancer Res Campaign Tech | Pyrrolobenzodiazepine derivatives,their preparation,and compositions containing them |
| KR19990029749A (ko) * | 1997-09-17 | 1999-04-26 | 미우라 아끼라 | 2가 반응성 수용성 고분자 유도체 및 이들을 함유하는 복합체 |
| GB9818731D0 (en) | 1998-08-27 | 1998-10-21 | Univ Portsmouth | Compounds |
| PT1109812E (pt) * | 1998-08-27 | 2005-09-30 | Spirogen Ltd | Pirrolobenzodiazepinas |
| ATE424414T1 (de) * | 2001-06-08 | 2009-03-15 | Sod Conseils Rech Applic | Chimere somatostatin-dopamin-analoga |
| US6716821B2 (en) | 2001-12-21 | 2004-04-06 | Immunogen Inc. | Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same |
| US7230101B1 (en) | 2002-08-28 | 2007-06-12 | Gpc Biotech, Inc. | Synthesis of methotrexate-containing heterodimeric molecules |
| EA010570B1 (ru) | 2002-11-07 | 2008-10-30 | Иммьюноджен, Инк. | Антитело к cd33 и способы его применения |
| HRP20160046T1 (hr) | 2003-05-20 | 2016-02-12 | Immunogen, Inc. | Poboljšana citotoksiäśna sredstva koja sadrže nove majtanzinoide |
| EP1660513B9 (en) | 2003-07-21 | 2012-04-04 | ImmunoGen, Inc. | A ca6 antigen-specific cytotoxic conjugate and methods of using the same |
| AU2004284075A1 (en) | 2003-10-22 | 2005-05-06 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Pyrrolobenzodiazepine derivatives, compositions comprising the same and methods related thereto |
| US7528126B2 (en) * | 2004-03-09 | 2009-05-05 | Spirogen Limited | Pyrrolobenzodiazepines |
| EP1669358A1 (en) | 2004-12-07 | 2006-06-14 | Aventis Pharma S.A. | Cytotoxic agents comprising new taxanes |
| SG158186A1 (en) | 2004-12-22 | 2010-01-29 | Ambrx Inc | Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides |
| CA2625867C (en) * | 2005-11-08 | 2014-12-23 | Immunogen, Inc. | Processes for preparation of maytansinol |
| PL1813614T3 (pl) * | 2006-01-25 | 2012-03-30 | Sanofi Sa | Środki cytotoksyczne zawierające nowe pochodne tomaymycyny |
| EP1832577A1 (en) | 2006-03-07 | 2007-09-12 | Sanofi-Aventis | Improved prodrugs of CC-1065 analogs |
| WO2007127440A2 (en) | 2006-04-27 | 2007-11-08 | Intezyne Technologies, Inc. | Heterofunctional poly(ethylene glycol) containing acid-labile amino protecting groups and uses thereof |
| EP1864682A1 (en) | 2006-06-09 | 2007-12-12 | Sanofi-Aventis | Leptomycin derivatives |
| WO2008010101A2 (en) * | 2006-07-18 | 2008-01-24 | Sanofi-Aventis | Antagonist antibody against epha2 for the treatment of cancer |
| EP1914242A1 (en) * | 2006-10-19 | 2008-04-23 | Sanofi-Aventis | Novel anti-CD38 antibodies for the treatment of cancer |
| PT2019104E (pt) * | 2007-07-19 | 2013-12-03 | Sanofi Sa | Agentes citotóxicos compreendendo novos derivados de tomaimicina e sua utilização terapêutica |
| EP2185188B1 (en) | 2007-08-22 | 2014-08-06 | Medarex, L.L.C. | Site-specific attachment of drugs or other agents to engineered antibodies with c-terminal extensions |
| AU2009243009B2 (en) * | 2008-04-30 | 2014-09-11 | Immunogen, Inc | Potent conjugates and hydrophilic linkers |
| SG2014009138A (en) * | 2009-02-05 | 2014-03-28 | Immunogen Inc | Novel benzodiazepine derivatives |
| AR078471A1 (es) * | 2009-10-02 | 2011-11-09 | Sanofi Aventis | COMPUESTOS MAITANSINOIDES Y EL USO DE ESTOS PARA PREPARAR CONJUGADOS CON UN ANTICUERPO LOS CUALES SE UTILIZAN COMO AGENTES ANTICANCERIGENOS Y EL PROCEDIMIENTO DE PREPARACIoN DE ESTOS CONJUGADOS |
| FR2963007B1 (fr) * | 2010-07-26 | 2013-04-05 | Sanofi Aventis | Derives anticancereux, leur preparation et leur application therapeutique |
-
2009
- 2009-08-25 FR FR0904043A patent/FR2949469A1/fr active Pending
- 2009-09-11 FR FR0904368A patent/FR2949470B1/fr not_active Expired - Fee Related
-
2010
- 2010-08-12 WO PCT/FR2010/051709 patent/WO2011023883A1/fr active Application Filing
- 2010-08-12 NZ NZ598401A patent/NZ598401A/en not_active IP Right Cessation
- 2010-08-12 AU AU2010288382A patent/AU2010288382B2/en not_active Ceased
- 2010-08-12 ES ES10761055.2T patent/ES2484690T3/es active Active
- 2010-08-12 CN CN201080048398.6A patent/CN102753559B/zh active Active
- 2010-08-12 PE PE2012000267A patent/PE20120992A1/es not_active Application Discontinuation
- 2010-08-12 EP EP10761055.2A patent/EP2470547B1/fr active Active
- 2010-08-12 BR BR112012004146A patent/BR112012004146A2/pt not_active Application Discontinuation
- 2010-08-12 KR KR1020127007518A patent/KR20130026405A/ko not_active Abandoned
- 2010-08-12 JP JP2012526097A patent/JP5889189B2/ja active Active
- 2010-08-12 PH PH1/2012/500391A patent/PH12012500391A1/en unknown
- 2010-08-12 EA EA201270308A patent/EA026488B1/ru not_active IP Right Cessation
- 2010-08-12 CA CA2772102A patent/CA2772102C/fr not_active Expired - Fee Related
- 2010-08-12 MX MX2012002434A patent/MX2012002434A/es active IP Right Grant
- 2010-08-12 UA UAA201203443A patent/UA106507C2/uk unknown
- 2010-08-12 SG SG2012012431A patent/SG178537A1/en unknown
- 2010-08-12 MY MYPI2012000814A patent/MY157469A/en unknown
- 2010-08-23 AR ARP100103066A patent/AR078143A1/es unknown
- 2010-08-24 UY UY0001032854A patent/UY32854A/es not_active Application Discontinuation
- 2010-08-24 TW TW099128330A patent/TWI477275B/zh not_active IP Right Cessation
-
2012
- 2012-02-03 TN TNP2012000053A patent/TN2012000053A1/fr unknown
- 2012-02-08 DO DO2012000038A patent/DOP2012000038A/es unknown
- 2012-02-16 GT GT201200046A patent/GT201200046A/es unknown
- 2012-02-17 CR CR20120085A patent/CR20120085A/es unknown
- 2012-02-21 CO CO12029986A patent/CO6612210A2/es unknown
- 2012-02-22 EC ECSP12011688 patent/ECSP12011688A/es unknown
- 2012-02-22 IL IL218262A patent/IL218262A0/en unknown
- 2012-02-24 NI NI201200031A patent/NI201200031A/es unknown
- 2012-02-24 HN HN2012000437A patent/HN2012000437A/es unknown
- 2012-02-24 US US13/404,872 patent/US8481042B2/en active Active
- 2012-02-24 ZA ZA2012/01397A patent/ZA201201397B/en unknown
- 2012-02-24 CL CL2012000489A patent/CL2012000489A1/es unknown
- 2012-03-21 MA MA34711A patent/MA33600B1/fr unknown
-
2013
- 2013-06-05 CL CL2013001609A patent/CL2013001609A1/es unknown
- 2013-06-21 US US13/923,544 patent/US20140155590A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HN2012000437A (es) | Nuevos agentes anticancer y la preparacion de dichos agentes | |
| JOP20180102A1 (ar) | مركب صيدلاني | |
| DOP2006000096A (es) | Pirrolopiridinas sustituidas, composiciones que las contienen, proceso de fabricacion y utilizacion | |
| HN2006000668A (es) | Compuestos de quinolina heteroaromaticos | |
| EA201401254A1 (ru) | Самостабилизирующиеся линкерные конъюгаты | |
| HN2008001191A (es) | Compuestos de biciclolactama sustituida | |
| PE20210949A1 (es) | Anticuerpos anti-fgfr2iiib afucosilados | |
| BR112015028674A2 (pt) | composição detergente compacta fluida para lavagem de roupas | |
| UY31560A1 (es) | Azolilmetiloxiranos, su uso y agentes que los contienen | |
| UY29361A1 (es) | Pirroles e imidazoles sustituídos, composiciones que los contienen, procedimiento de fabricación y utilización | |
| MA44550A1 (fr) | Anticorps anti-acide téichoique de la paroi cellulaire et conjugués associés | |
| BRPI0919048B8 (pt) | Composições pesticidas | |
| UA106889C2 (uk) | Похідні n1-ацил-5-фторпіримідинону | |
| UA107671C2 (en) | N1-substityted-5-fluoro-2-oxopyrimidinone-1(2h)-carboxamide derivatives | |
| HN2010001537A (es) | Nuevos derivados dihidroindolonas, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen | |
| CO6321288A2 (es) | Sales de compuestos inhibidores de vih | |
| UY31128A1 (es) | Formulacion de nevirapina de liberacion prolongada | |
| HN2009000856A (es) | Pirazoles sustituidos, composiciones que los contienen, procedimiento de fabricacion y utilizacion. | |
| CR20110701A (es) | Derivados de pirazoles, su preparacion y su aplicacion terapeutica. | |
| HN2012001262A (es) | Nuevos derivados de 8heterociclo-piperidina condensada)-( piperazinil)-1-alcanona o de (heterociclo-pirrolidina condensada)-(piperazinil)-1-alcanona y su utilizacion como inhibidores de p75 | |
| EP2485721A4 (en) | APOGOSSYPOLON DERIVATIVES AS ANTICREMENTS | |
| ATE533477T1 (de) | Pharmazeutische zusammensetzungen enthaltend irbesartan | |
| BR112013000941A2 (pt) | formulações de 14-epi-análogos de vitamina d | |
| UY32515A (es) | Nuevos derivados anticancerosos de nicotinamida, su preparación y su aplicación terapéutica | |
| MA33932B1 (fr) | Dérivés de 2-aldoximino-5-fluoropyrimidine |