HN1998000187A - Proceso para la sintesis de 1,3-dioles - Google Patents
Proceso para la sintesis de 1,3-diolesInfo
- Publication number
- HN1998000187A HN1998000187A HN1998000187A HN1998000187A HN1998000187A HN 1998000187 A HN1998000187 A HN 1998000187A HN 1998000187 A HN1998000187 A HN 1998000187A HN 1998000187 A HN1998000187 A HN 1998000187A HN 1998000187 A HN1998000187 A HN 1998000187A
- Authority
- HN
- Honduras
- Prior art keywords
- dialkylalkoxyborane
- trialkylborane
- cis
- combination
- dioles
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 abstract 2
- 150000000185 1,3-diols Chemical class 0.000 abstract 1
- 238000011084 recovery Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
- C07D207/416—2,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B41/00—Formation or introduction of functional groups containing oxygen
- C07B41/02—Formation or introduction of functional groups containing oxygen of hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
- C07C255/20—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
- C07C255/21—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton the carbon skeleton being further substituted by doubly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
UN PROCESO DE MEJORA DE LA PREPARACIÓN DEL CIS 1,3-dioles DONDE SE DESCRIBE A BETA hidroxicetona se trata con un trialquilborano O dialquilalcoxiborano O LA COMBINACIÓN DE UN TRIALKYBORANE O LA COMBINACIÓN DE UN trialquilborano Y UN dialquilalcoxiborano seguida de la recuperación y la reutilización de alquilborano ESPECIES PARA CONVERTIR BETA ADICIONAL hidroxi cetona al CIS-1 ,3-diol.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6819397P | 1997-12-19 | 1997-12-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
HN1998000187A true HN1998000187A (es) | 1999-10-22 |
Family
ID=22081016
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HN1998000187A HN1998000187A (es) | 1997-12-19 | 1998-12-09 | Proceso para la sintesis de 1,3-dioles |
Country Status (31)
Country | Link |
---|---|
US (4) | US6433213B1 (es) |
EP (1) | EP1054860B1 (es) |
JP (1) | JP2001526256A (es) |
KR (2) | KR100668575B1 (es) |
AR (1) | AR014943A1 (es) |
AT (1) | ATE360608T1 (es) |
AU (1) | AU755543B2 (es) |
BR (1) | BR9813760A (es) |
CA (1) | CA2305618C (es) |
CO (1) | CO4990941A1 (es) |
CU (1) | CU22939A3 (es) |
CY (1) | CY1106612T1 (es) |
DE (1) | DE69837681T2 (es) |
DK (1) | DK1054860T3 (es) |
ES (1) | ES2284219T3 (es) |
GT (2) | GT199800197AA (es) |
HN (1) | HN1998000187A (es) |
HU (1) | HUP0100252A3 (es) |
IL (1) | IL135562A (es) |
IS (1) | IS5447A (es) |
MY (1) | MY118726A (es) |
NO (1) | NO20003139D0 (es) |
NZ (1) | NZ504346A (es) |
PA (1) | PA8464901A1 (es) |
PE (1) | PE20000136A1 (es) |
PL (1) | PL193678B1 (es) |
PT (1) | PT1054860E (es) |
SV (1) | SV1998000153A (es) |
TW (1) | TW444000B (es) |
WO (1) | WO1999032434A1 (es) |
ZA (1) | ZA9811586B (es) |
Families Citing this family (48)
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CA2391357C (en) | 1999-12-17 | 2009-01-06 | Warner Lambert Research And Development Ireland Limited | A process for producing crystalline atorvastatin calcium |
MXPA02004078A (es) | 1999-12-17 | 2002-10-11 | Warner Lambert Res & Dev | Un proceso a escala industrial para producir sal de hemi calcio de trihidrato de atorvastatin cristalino. |
US20040014195A1 (en) * | 1999-12-29 | 2004-01-22 | Diversa Corporation | Nitrilases, nucleic acids encoding them and methods for making and using them |
US7608445B1 (en) | 1999-12-29 | 2009-10-27 | Verenium Corporation | Nitrilases, nucleic acids encoding them and methods for making and using them |
US7300775B2 (en) * | 1999-12-29 | 2007-11-27 | Verenium Corporation | Methods for producing α-substituted carboxylic acids using nitrilases and strecker reagents |
US7521216B2 (en) * | 1999-12-29 | 2009-04-21 | Verenium Corporation | Nitrilases and methods for making and using them |
MXPA03009095A (es) * | 2001-04-05 | 2004-02-12 | Nissan Chemical Ind Ltd | Metodo para preparar 7-quinolinil-3,5-dihidroxihept-6-enoato. |
IL159719A0 (en) | 2001-07-06 | 2004-06-20 | Teva Pharma | Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives via 6-cyano syn 3,5-dihydroxy hexanoic acid derivatives |
CZ2004158A3 (cs) * | 2001-07-06 | 2005-01-12 | Teva Pharmaceutical Industries Ltd. | Syntéza a meziprodukty derivátů 3,5-dihydroxyheptanové kyseliny |
GB0211715D0 (en) * | 2002-05-22 | 2002-07-03 | Phoenix Chemicals Ltd | Process |
US7932064B2 (en) * | 2002-06-13 | 2011-04-26 | Verenium Corporation | Processes for making (R)-ethyl 4-cyano-3-hydroxybutyric acid |
JP4578240B2 (ja) * | 2002-08-09 | 2010-11-10 | コデクシス, インコーポレイテッド | 4−置換3−ヒドロキシ酪酸誘導体の生成のための酵素的プロセス |
PT1631533E (pt) * | 2003-04-22 | 2009-06-04 | Biocon Ltd | Novo processo para a redução estereosselectiva de betacetoésteres |
US7790197B2 (en) * | 2003-06-09 | 2010-09-07 | Warner-Lambert Company Llc | Pharmaceutical compositions of atorvastatin |
US20050271717A1 (en) | 2003-06-12 | 2005-12-08 | Alfred Berchielli | Pharmaceutical compositions of atorvastatin |
US7655692B2 (en) * | 2003-06-12 | 2010-02-02 | Pfizer Inc. | Process for forming amorphous atorvastatin |
US20040253305A1 (en) * | 2003-06-12 | 2004-12-16 | Luner Paul E. | Pharmaceutical compositions of atorvastatin |
US7588928B2 (en) * | 2003-08-11 | 2009-09-15 | Codexis, Inc. | Halohydrin dehalogenases and related polynucleotides |
CA2533838A1 (en) * | 2003-08-11 | 2005-02-24 | Codexis, Inc. | Improved ketoreductase polypeptides and related polynucleotides |
KR20060064620A (ko) * | 2003-08-11 | 2006-06-13 | 코덱시스, 인코포레이티드 | 개선된 글루코스 데히드로게나제 폴리펩티드 및 관련폴리뉴클레오티드 |
EP1660669A4 (en) * | 2003-08-11 | 2008-10-01 | Codexis Inc | ENZYMATIC PROCEDURES FOR THE PREPARATION OF 4-SUBSTITUTED 3-HYDROXYBUTYLIC ACID DERIVATIVES AND OF VICINAL CYANO, HYDROXY-SUBSTITUTED CARBOXYLIC ACID ESTERS |
US7541171B2 (en) * | 2003-08-11 | 2009-06-02 | Codexis, Inc. | Halohydrin dehalogenases and related polynucleotides |
US7824898B2 (en) * | 2003-08-11 | 2010-11-02 | Codexis, Inc. | Halohydrin dehalogenases and related polynucleotides |
CN101318923A (zh) * | 2003-09-17 | 2008-12-10 | 沃尼尔·朗伯有限责任公司 | [R-(R*,R*)]-2-(4-氟苯基)-β,δ-二羟基-5-(1-甲基乙基)-3-苯基-4-[(苯基氨基)羰基]-1H-吡咯-1-庚酸的结晶形式 |
US7557238B2 (en) * | 2003-09-18 | 2009-07-07 | Biocon Limited | Process for the preparation of tert-butyl 6-cyano-5-hydroxy-3-oxohexanoate |
US7851624B2 (en) * | 2003-12-24 | 2010-12-14 | Teva Pharamaceutical Industries Ltd. | Triol form of rosuvastatin and synthesis of rosuvastatin |
WO2005063728A2 (en) * | 2003-12-24 | 2005-07-14 | Teva Pharmaceutical Industries Ltd. | Process for preparation of statins with high syn to anti ratio |
CA2562844A1 (en) * | 2004-04-16 | 2005-10-27 | Pfizer Products Inc. | Process for forming amorphous atorvastatin calcium |
CA2564030C (en) | 2004-05-05 | 2010-06-08 | Pfizer Products Inc. | Salt forms of [r-(r*, r*)]-2-(4-fluorophenyl)-.beta., .delta.-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid |
AU2005263550C1 (en) * | 2004-07-16 | 2013-01-17 | Lek Pharmaceuticals D.D. | Oxidative degradation products of atorvastatin calcium |
WO2006011041A2 (en) | 2004-07-20 | 2006-02-02 | Warner-Lambert Company Llc | Crystalline forms of (r-(r*))-2-(4-fluorophenyl)-beta, gamma-dihydroxy-5-(1-methylethyl)-3-phenyl-4-((phenylamino)carbonyl)-1h-pyrrole-1-hept anoic acid calcium salt (2:1) |
RU2007115543A (ru) * | 2004-10-28 | 2008-12-10 | Уорнер-Ламберт Компани Эл-Эл-Си (US) | Способ получения аморфного аторвастатина |
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JP2008521878A (ja) * | 2004-12-02 | 2008-06-26 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | 非晶質アトルバスタチンの医薬組成物及びその製造のための方法 |
WO2007029216A1 (en) * | 2005-09-09 | 2007-03-15 | Pfizer Science And Technology Ireland Limited | Preparation of an atorvastatin intermediate |
US20090221852A1 (en) * | 2005-09-09 | 2009-09-03 | Pfizer Inc. | Preparation of an Atorvastatin Intermediate |
CA2547216A1 (en) | 2005-09-21 | 2007-03-21 | Renuka D. Reddy | Process for annealing amorphous atorvastatin |
DE602006014193D1 (de) | 2005-11-21 | 2010-06-17 | Warner Lambert Co | Neue formen von är-(r*,r*)ü-2-(4-fluorphenyl)-b,d-dihydroxy-5-(1-methylethyl)-3-phenyl-4-ä(phenylamino)carbonylü-1h-pyrrol-1-heptansäure-magnesium |
US7879585B2 (en) | 2006-10-02 | 2011-02-01 | Codexis, Inc. | Ketoreductase enzymes and uses thereof |
WO2008106662A2 (en) | 2007-03-01 | 2008-09-04 | Verenium Corporation | Nitrilases, nucleic acids encoding them and methods for making and using them |
WO2009137691A2 (en) * | 2008-05-09 | 2009-11-12 | The Scripps Research Institute | 1,3-diol synthesis via controlled, radical-mediated c-h functionalization |
EP2379713A4 (en) | 2008-12-18 | 2013-07-10 | Codexis Inc | RECOMBINANT HALOHYDRIN DEHALOGENASE POLYPEPTIDES |
WO2010069593A1 (en) | 2008-12-19 | 2010-06-24 | Krka, D. D., Novo Mesto | Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates |
EP2327682A1 (en) | 2009-10-29 | 2011-06-01 | KRKA, D.D., Novo Mesto | Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates |
US9273158B2 (en) | 2011-05-16 | 2016-03-01 | The Regents Of The University Of California | Methods for production of hydrocarbons and oxygen-containing hyrdrocarbons |
US20140335179A1 (en) | 2011-07-01 | 2014-11-13 | Dsm Sinochem Pharmaceuticals Netherlands B.V. | Micronized crystals of atorvastatin hemicalcium |
CN108033899B (zh) * | 2017-12-06 | 2020-04-10 | 浙江科技学院 | 一种(r)-6-氰基-5-羟基-3-羰基己酸叔丁酯的制备方法 |
CN111978286A (zh) * | 2020-08-21 | 2020-11-24 | 江苏万年长药业有限公司 | 一种制备ats-8的方法 |
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FI94339C (fi) * | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
DE3929507A1 (de) * | 1989-09-06 | 1991-03-07 | Bayer Ag | Substituierte amino-pyridine |
US5039802A (en) | 1990-04-18 | 1991-08-13 | Merck & Co., Inc. | Arylation process for preparation of chiral catalysts for ketone reduction |
JP3528186B2 (ja) | 1991-06-24 | 2004-05-17 | 日産化学工業株式会社 | 光学活性キノリンメバロン酸のジアステレオマー塩 |
US5155251A (en) | 1991-10-11 | 1992-10-13 | Warner-Lambert Company | Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate |
US5218138A (en) * | 1992-09-02 | 1993-06-08 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Stereoselective reduction of 3-hydroxyket-1-ones to 1,3-syn-dihydroxylated compounds |
US5298627A (en) * | 1993-03-03 | 1994-03-29 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
-
1998
- 1998-12-02 HU HU0100252A patent/HUP0100252A3/hu unknown
- 1998-12-02 PL PL98341294A patent/PL193678B1/pl not_active IP Right Cessation
- 1998-12-02 NZ NZ504346A patent/NZ504346A/en unknown
- 1998-12-02 AU AU17074/99A patent/AU755543B2/en not_active Ceased
- 1998-12-02 ES ES98961855T patent/ES2284219T3/es not_active Expired - Lifetime
- 1998-12-02 DE DE69837681T patent/DE69837681T2/de not_active Expired - Fee Related
- 1998-12-02 KR KR1020007006762A patent/KR100668575B1/ko not_active Expired - Fee Related
- 1998-12-02 BR BR9813760-3A patent/BR9813760A/pt not_active Application Discontinuation
- 1998-12-02 IL IL13556298A patent/IL135562A/xx not_active IP Right Cessation
- 1998-12-02 JP JP2000525371A patent/JP2001526256A/ja not_active Abandoned
- 1998-12-02 WO PCT/US1998/025493 patent/WO1999032434A1/en active IP Right Grant
- 1998-12-02 KR KR1020067012766A patent/KR100681366B1/ko not_active Expired - Fee Related
- 1998-12-02 DK DK98961855T patent/DK1054860T3/da active
- 1998-12-02 EP EP98961855A patent/EP1054860B1/en not_active Expired - Lifetime
- 1998-12-02 CA CA002305618A patent/CA2305618C/en not_active Expired - Fee Related
- 1998-12-02 US US09/581,798 patent/US6433213B1/en not_active Expired - Fee Related
- 1998-12-02 PT PT98961855T patent/PT1054860E/pt unknown
- 1998-12-02 AT AT98961855T patent/ATE360608T1/de not_active IP Right Cessation
- 1998-12-09 HN HN1998000187A patent/HN1998000187A/es unknown
- 1998-12-14 GT GT199800197AK patent/GT199800197AA/es unknown
- 1998-12-14 GT GT199800197A patent/GT199800197A/es unknown
- 1998-12-17 MY MYPI98005721A patent/MY118726A/en unknown
- 1998-12-17 ZA ZA9811586A patent/ZA9811586B/xx unknown
- 1998-12-18 AR ARP980106461A patent/AR014943A1/es active IP Right Grant
- 1998-12-18 TW TW087121215A patent/TW444000B/zh not_active IP Right Cessation
- 1998-12-18 SV SV1998000153A patent/SV1998000153A/es not_active Application Discontinuation
- 1998-12-18 PA PA19988464901A patent/PA8464901A1/es unknown
- 1998-12-18 CO CO98075429A patent/CO4990941A1/es unknown
- 1998-12-18 PE PE1998001245A patent/PE20000136A1/es not_active Application Discontinuation
-
2000
- 2000-04-14 IS IS5447A patent/IS5447A/is unknown
- 2000-06-09 CU CU20000144A patent/CU22939A3/es not_active IP Right Cessation
- 2000-06-16 NO NO20003139A patent/NO20003139D0/no not_active Application Discontinuation
-
2002
- 2002-06-11 US US10/166,990 patent/US6596879B2/en not_active Expired - Fee Related
-
2003
- 2003-04-11 US US10/411,886 patent/US6962994B2/en not_active Expired - Fee Related
-
2005
- 2005-04-29 US US11/119,151 patent/US7232915B2/en not_active Expired - Fee Related
-
2007
- 2007-05-21 CY CY20071100687T patent/CY1106612T1/el unknown
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