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HK40054696B - Personalized skin care system - Google Patents

Personalized skin care system Download PDF

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Publication number
HK40054696B
HK40054696B HK62021043851.6A HK62021043851A HK40054696B HK 40054696 B HK40054696 B HK 40054696B HK 62021043851 A HK62021043851 A HK 62021043851A HK 40054696 B HK40054696 B HK 40054696B
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personalized
skincare
skin care
skin
pod
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HK62021043851.6A
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HK40054696A (en
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K‧T‧瓦尔多
T‧E‧拉伯
R‧J‧帕特恩
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宝洁公司
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Publication of HK40054696B publication Critical patent/HK40054696B/en

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Description

个性化皮肤护理系统Personalized skin care system

技术领域Technical Field

本公开整体涉及在家庭环境中提供个性化皮肤护理组合物的皮肤护理系统。更具体地,本公开涉及可提供基于个人和环境因素的个性化皮肤护理组合物的家庭无菌皮肤护理系统。This disclosure relates generally to skin care systems that provide personalized skin care compositions in a home environment. More specifically, this disclosure relates to home-based sterile skin care systems that can provide personalized skin care compositions based on personal and environmental factors.

背景技术Background Technology

对在当今追求青春的社会中看起来更年轻的皮肤的期望为数十亿美元的全球皮肤护理行业提供了动力。过去,皮肤护理品牌足以提供相对少量的批量生产的皮肤护理产品,该产品旨在广泛地治疗一般类别的皮肤状况或皮肤类型(例如油性皮肤、色素沉着皮肤、或有皱纹皮肤)。然而,一些消费者可能经历多于一种类型的皮肤状况或具有落在皮肤护理行业使用的一般类别之外的皮肤状况。此外,一些消费者经历的不期望的皮肤状况可基于环境变化、激素变化、生活方式变化等而每天不同。对于这些消费者,单一皮肤护理产品可能无法令人满意地解决他们所有的皮肤护理需求,并且他们可利用购买多种产品来治疗他们经历的各种不期望的皮肤状况。然而,出于多种原因,购买多种皮肤护理产品和/或确定需要哪种皮肤产品可能是不期望的。例如,皮肤护理产品可能相对昂贵,这给消费者带来了财务障碍。此外,试图从当前市场上可获得的大量皮肤护理组合物中选择适宜的皮肤护理组合物可能是困难的。因此,提供个性化皮肤护理组合物满足了化妆品皮肤护理行业中显著的消费者需求。The desire for younger-looking skin in today's youth-obsessed society fuels the multi-billion dollar global skincare industry. In the past, skincare brands were able to offer relatively small, mass-produced skincare products designed to treat a wide range of common skin conditions or types (e.g., oily skin, pigmented skin, or skin with wrinkles). However, some consumers may experience more than one skin condition or have conditions that fall outside the common categories used in the skincare industry. Furthermore, some consumers experience undesirable skin conditions that vary daily based on environmental changes, hormonal fluctuations, lifestyle changes, and more. For these consumers, a single skincare product may not satisfactorily address all their skincare needs, and they may utilize purchasing multiple products to treat the various undesirable skin conditions they experience. However, purchasing multiple skincare products and/or determining which skincare products are needed can be undesirable for a variety of reasons. For example, skincare products can be relatively expensive, posing a financial barrier for consumers. Additionally, attempting to select the appropriate skincare composition from the vast array of skincare compositions currently available on the market can be difficult. Therefore, offering personalized skincare compositions addresses a significant consumer need within the cosmetic skincare industry.

家庭皮肤护理类别当前由各个产品主导,其中定制的最小程度能够通过用于不同皮肤类型的不同产品来获得。然而,消费者目前期望他们的皮肤护理方案使他们能够定制他们的皮肤护理产品,以不仅匹配他们通常的皮肤类型,而且足够灵活以响应他们变化的皮肤状况、环境、生活方式和活动以获得最大的效果。增加提供给消费者的皮肤护理产品的数量可为定制皮肤护理方案提供一些额外的灵活性,这也带来了与增加制剂复杂性和货架空间限制相关的挑战。The home skincare category is currently dominated by individual products, with the minimum level of customization achievable through different products for different skin types. However, consumers now expect their skincare regimens to allow them to customize their skincare products not only to match their usual skin type but also to be flexible enough to respond to their changing skin conditions, environment, lifestyle, and activities for maximum effectiveness. Increasing the number of skincare products available to consumers could provide some additional flexibility for customized skincare regimens, but it also presents challenges related to increased formulation complexity and shelf space constraints.

已作出多种尝试以在购买点向消费者提供个性化皮肤护理组合物。例如,授予Brown的美国专利第5903465号描述了提供用于递送个性化组合物的成分的定制共混物的分配机器。然而,Brown等人所述的装置仅在零售环境中提供个性化皮肤护理组合物。对于其皮肤护理需要频繁改变的消费者,经常去商店获得个性化皮肤护理产品是不便的。Various attempts have been made to provide personalized skincare compositions to consumers at the point of purchase. For example, U.S. Patent No. 5,903,465 to Brown describes a dispensing machine that provides a custom blend of ingredients for delivering personalized compositions. However, the device described by Brown et al. only provides personalized skincare compositions in a retail setting. For consumers whose skincare needs change frequently, it is inconvenient to frequently visit stores to obtain personalized skincare products.

最近,已尝试提供用于提供个性化皮肤护理组合物的家庭系统和装置。例如,授予Fuller等人的美国专利第10022741号公开了一种用于卫生环境中的精确流体分配应用、包括个性化皮肤护理应用的致动系统。为了提供个性化皮肤护理组合物,由Fuller等人描述的系统在分配之前在歧管中将成分混合在一起,或者从单独的分配喷嘴分配不同的完全混合的组合物(例如,日间和夜间组合物)。一方面,歧管必须被清洁或更换以避免后续分配的组合物的污染,这由于多种原因(例如,增加的制造成本和复杂性、用户不友好性和环境不友好性)可能是不期望的。另一方面,分配完全混合的组合物限制了用户选择定制以针对其特定皮肤状况的皮肤护理活性物质的能力。Recently, attempts have been made to provide home systems and devices for dispensing personalized skincare compositions. For example, U.S. Patent No. 10,022,741 to Fuller et al. discloses an actuation system for a precision fluid dispensing application in a hygienic environment, including a personalized skincare application. To dispense a personalized skincare composition, the system described by Fuller et al. mixes the ingredients together in a manifold before dispensing, or dispenses different fully mixed compositions (e.g., daytime and nighttime compositions) from separate dispensing nozzles. On the one hand, the manifold must be cleaned or replaced to avoid contamination of the subsequently dispensed composition, which may be undesirable for various reasons (e.g., increased manufacturing costs and complexity, user unfriendliness, and environmental unfriendliness). On the other hand, dispensing a fully mixed composition limits the user's ability to select skincare active ingredients tailored to their specific skin condition.

因此,仍然需要一种提供个性化皮肤护理组合物的家庭系统,该个性化皮肤护理组合物被定制成满足用户经常变化的皮肤护理需求。还仍然需要一种以更有成本效益、用户友好的方式提供个性化皮肤护理组合物的家庭系统。Therefore, there remains a need for a home system that provides personalized skincare compositions tailored to meet a user's frequently changing skincare needs. There also remains a need for a home system that provides personalized skincare compositions in a more cost-effective and user-friendly manner.

发明内容Summary of the Invention

本文描述了一种个性化皮肤护理系统,该系统包括:分配装置,该分配装置包括限定内部空间的至少一个壁;可移除料筒,该可移除料筒设置在该内部空间中,该可移除料筒包含皮肤护理活性物质;一次性荚包,该一次性荚包设置在该分配装置中,其中该一次性荚包与该可移除料筒流体连通并且包含基础成分;和混合元件,其中该混合元件被构造为在该一次性荚包内将该活性物质成分和该基础成分混合在一起而不接触任一成分。This document describes a personalized skin care system comprising: a dispensing device including at least one wall defining an internal space; a removable cartridge disposed in the internal space, the removable cartridge containing a skin care active ingredient; a disposable pod disposed in the dispensing device, wherein the disposable pod is in fluid communication with the removable cartridge and contains a base ingredient; and a mixing element configured to mix the active ingredient and the base ingredient together within the disposable pod without contacting either ingredient.

还描述了一种提供个性化皮肤护理组合物的方法,该方法包括:将个性化因素输入到个性化皮肤护理系统中,其中该个性化皮肤护理系统包括:分配装置,该分配装置包括限定内部空间的至少一个壁;和可移除料筒,该可移除料筒设置在该内部空间中,该可移除料筒包含皮肤护理活性物质;和混合元件;将包含基础成分的气密密封的单剂量荚包放置在该分配装置的该内部空间中,使得该一次性荚包与该可替换料筒流体连通;基于所输入的个性化因素选择个性化皮肤护理组合物;将该皮肤护理活性物质转移到该一次性荚包中;用混合元件混合该皮肤护理活性物质和该基础成分以形成个性化皮肤护理组合物;以及分配该个性化皮肤护理组合物。A method for providing a personalized skincare composition is also described, the method comprising: inputting personalization factors into a personalized skincare system, wherein the personalized skincare system includes: a dispensing device including at least one wall defining an internal space; and a removable cartridge disposed in the internal space, the removable cartridge containing a skincare active substance; and a mixing element; placing an airtight, single-dose pod containing a base ingredient in the internal space of the dispensing device such that the disposable pod is in fluid communication with the replaceable cartridge; selecting a personalized skincare composition based on the input personalization factors; transferring the skincare active substance into the disposable pod; mixing the skincare active substance and the base ingredient using the mixing element to form a personalized skincare composition; and dispensing the personalized skincare composition.

附图说明Attached Figure Description

图1A和图1B示出了用于本系统的分配装置的实施方案。Figures 1A and 1B illustrate an implementation scheme for the distribution device used in this system.

图2A和图2B示出了用于本系统的分配装置的实施方案。Figures 2A and 2B illustrate an implementation scheme for the distribution device used in this system.

图3示出了用于本系统的分配装置的实施方案。Figure 3 illustrates an implementation scheme for the distribution device used in this system.

图4示出了料筒托架的实施方案。Figure 4 shows an implementation scheme for the barrel support.

图5示出了料筒托架的另一个实施方案。Figure 5 shows another embodiment of the barrel support.

图6A、图6B和图6C示出一次性荚包的实施方案。Figures 6A, 6B, and 6C illustrate implementation schemes for disposable pods.

图7示出了接合到流体输送配件的一次性荚包的实施方案。Figure 7 illustrates an embodiment of a disposable pod attached to a fluid delivery accessory.

图8示出了一次性荚包的实施方案的剖视图。Figure 8 shows a cross-sectional view of an embodiment of the disposable pod.

图9示出了一次性荚包的实施方案的剖视图,其中可插入元件插入穿过一次性荚包的喷嘴。Figure 9 shows a cross-sectional view of an embodiment of the disposable pod, wherein an insertable element is inserted through a nozzle passing through the disposable pod.

图10示出了处于混合构型的一次性荚包的实施方案。Figure 10 illustrates an embodiment of a disposable pod in a hybrid configuration.

图11示出了处于分配构型的一次性荚包的实施方案。Figure 11 illustrates an implementation of a disposable pod in a distribution configuration.

图12示出了使用个性化皮肤护理系统的过程中的步骤。Figure 12 illustrates the steps involved in using a personalized skin care system.

具体实施方式Detailed Implementation

本皮肤护理系统包括用于在家庭环境中向消费者提供个性化皮肤护理组合物的便携式分配装置。该系统通过提供充分混合的单剂量皮肤护理组合物克服了现有系统的一些缺点,而无需组合物与分配装置的混合元件之间的接触,从而避免了分配装置部件和组合物的任何污染。虽然本文的个性化组合物通常被描述为局部皮肤护理组合物,但是应当理解,本系统可易于适用于普通技术人员技能内的其他用途(例如,毛发护理组合物和医疗/处方皮肤护理组合物)。说明书中对“实施方案”或类似方法的引用意指与该实施方案结合描述的具体材料、特征、结构、和/或特性包括在至少一个实施方案、任选多个实施方案中,但这并不意味所有实施方案包括所描述的材料、特征、结构、和/或特性。此外,材料、特征、结构、和/或特性可以任何合适的方式结合在不同的实施方案中,并且材料、特征、结构、和/或特性可以省略或替换所描述的。因此,除非另外说明或声明不相容性,否则尽管未在组合中明确地例示,本文所述的实施方案和方面可包括其他实施方案和/或方面的元件或组件或者可与其他实施方案和/或方面的元件或组件组合。This skin care system includes a portable dispensing device for delivering personalized skin care compositions to consumers in a home environment. This system overcomes some of the drawbacks of existing systems by providing a fully mixed, single-dose skin care composition without contact between the composition and the mixing element of the dispensing device, thus avoiding any contamination of the dispensing device components and the composition. While the personalized compositions described herein are generally referred to as topical skin care compositions, it should be understood that this system is readily adaptable to other uses within the skill of a general technician (e.g., hair care compositions and medical/prescription skin care compositions). References to “implementation” or similar methods in the specification mean that the specific materials, features, structures, and/or properties described in connection with that embodiment are included in at least one embodiment, optionally multiple embodiments, but do not imply that all embodiments include the described materials, features, structures, and/or properties. Furthermore, materials, features, structures, and/or properties may be combined in any suitable manner in different embodiments, and materials, features, structures, and/or properties may be omitted or substituted for those described. Therefore, unless otherwise stated or declared as incompatible, although not expressly illustrated in the combination, the embodiments and aspects described herein may include elements or components of other embodiments and/or aspects or may be combined with elements or components of other embodiments and/or aspects.

除非另外特别说明,否则所有成分百分比均按化妆品组合物的重量计。除非另外特别说明,否则所有成分比均为重量比。所有范围是包括端值在内的且可组合的。有效数字的数表示既不表达对所示量的限制,也不表达对测量精确性的限制。除非另外指明,否则所有测量均被理解为是在大约25℃和环境条件下进行的,其中“环境条件”是指在约1个大气压和约50%的相对湿度下的条件。所有数值范围是包括端值在内的更窄的范围;所描述的范围上限和下限是可互换的,以进一步形成没有明确描述的范围。Unless otherwise specified, all ingredient percentages are by weight of the cosmetic composition. Unless otherwise specified, all ingredient ratios are by weight. All ranges are inclusive and combinable. Significant figures indicate neither limitation on the quantities shown nor limitation on the accuracy of the measurement. Unless otherwise specified, all measurements are assumed to have been performed at approximately 25°C and ambient conditions, where “ambient conditions” means conditions at approximately 1 atmosphere and approximately 50% relative humidity. All numerical ranges are narrower ranges including the endpoints; the upper and lower limits of the described ranges are interchangeable to further form ranges not explicitly described.

本发明的组合物可包含本文所述的基本组分以及任选的成分,基本上由其组成或由其组成。如本文所用,“基本上由…组成”是指组合物或组分可包含附加成分,只要附加成分不在本质上改变受权利要求书保护的组合物或方法的基本特征和新颖特征。如说明书和所附权利要求书中所用,除非上下文另外清楚地指明,否则单数形式“一个”、“一种”和“该(所述)”旨在也包括复数形式。The compositions of the present invention may comprise, consist of, or be composed of the basic components described herein, as well as optional ingredients. As used herein, “consistently consisting of” means that a composition or component may contain additional ingredients, provided that the additional ingredients do not substantially alter the essential and novel features of the composition or method protected by the claims. As used in the specification and appended claims, unless the context clearly indicates otherwise, the singular forms “a,” “an,” and “the” are intended to include the plural forms as well.

定义definition

当在参数或范围的上下文中使用时,“约”是指在指定值的30%内的值(例如,25%、20%、15%、10%、5%、2%或甚至在1%内)。When used in the context of a parameter or range, “about” refers to a value within 30% of the specified value (e.g., 25%, 20%, 15%, 10%, 5%, 2%, or even within 1%).

“基础成分”是指皮肤护理组合物中不是皮肤护理活性物质的任何成分。基础成分的一些非限制性示例为载体、防腐剂、增稠剂、乳化剂、遮光剂、染色剂、pH调节剂、着色剂、香料、成膜剂、螯合剂和润滑剂。"Base ingredients" refers to any component in a skin care composition that is not an active ingredient in skin care products. Some non-limiting examples of base ingredients include carriers, preservatives, thickeners, emulsifiers, sunscreens, dyes, pH adjusters, colorants, fragrances, film-forming agents, chelating agents, and lubricants.

“衍生物”是指与另一分子相似但在某些官能部分方面不同的分子。衍生物可通过已知的反应途径形成。合适的官能部分包括相关分子的酯、醚、酰胺、胺、羧酸、羟基、卤素、硫醇和/或盐衍生物。肽衍生物包括与另一个部分(诸如脂肪酸链)接合的肽。A "derivative" is a molecule that is similar to another molecule but differs in certain functional parts. Derivatives can be formed via known reaction pathways. Suitable functional parts include esters, ethers, amides, amines, carboxylic acids, hydroxyl groups, halogens, thiols, and/or salt derivatives of the relevant molecule. Peptide derivatives include peptides that are attached to another part, such as a fatty acid chain.

“皮肤病学可接受”是指成分或组合物(例如载体)适于局部施用于角质组织,具有良好的美学性质,与组合物中的活性物质相容,并且不引起任何不合理的安全或毒性问题。"Dermatologically acceptable" means that the ingredients or composition (e.g., the carrier) are suitable for topical application to the stratum corneum, have good aesthetic properties, are compatible with the active substances in the composition, and do not cause any unreasonable safety or toxicity problems.

“设置”是指某个元件相对于另一个元件而定位在特定空间或位置中。"Setting up" refers to the positioning of a component in a specific space or location relative to another component.

“接合”是指其中通过将一个元件直接附连到另一个元件来使该元件直接固定到另一个元件的构型,以及其中通过将一个元件附连到一个或多个中间构件,继而附连到另一个元件来使该元件间接固定到另一个元件的构型。"Joint" refers to a configuration in which one element is directly fixed to another element by directly attaching one element to another element, and a configuration in which one element is indirectly fixed to another element by attaching one element to one or more intermediate members, and then to another element.

“调节皮肤状况”是指例如通过提供有益效果、诸如更光滑的外观和/或感觉来改善皮肤健康、外观和/或感觉。本文中,“改善皮肤状况”是指获得视觉上和/或触觉上皮肤外观和感觉方面可察觉的积极改变。有益效果可为慢性或急性有益效果,并且可包括以下中的一种或多种:减少皱纹和粗糙的深纹、细纹、裂纹、肿块、以及粗大毛孔的出现;增厚角质组织(例如构造皮肤的表皮和/或真皮和/或皮下层,以及指/趾甲和毛干的角质层(如果适用的话)以缓解皮肤、毛发或指/趾甲萎缩);增加真皮-表皮边界的褶皱(也称为网脊);防止例如由于功能性皮肤弹性蛋白的丧失、损伤和/或失活而造成皮肤或毛发弹性丧失,从而导致诸如弹性组织变性、松垂、皮肤或毛发变形回复功能的丧失这些状况;减少蜂窝炎;皮肤、毛发或指/趾甲色调的变化,例如黑眼圈、斑点(例如由于例如红斑痤疮产生的不均匀红色调)、灰黄、由色素沉着过度引起的变色等。"Regulating skin condition" refers to improving skin health, appearance, and/or feel, for example, by providing beneficial effects such as a smoother appearance and/or feel. In this article, "improving skin condition" means achieving perceptible positive changes in the visual and/or tactile aspects of skin appearance and feel. Beneficial effects can be chronic or acute and may include one or more of the following: reduction of wrinkles and the appearance of deep lines, fine lines, cracks, lumps, and enlarged pores; thickening of keratinized tissue (e.g., the epidermis and/or dermis and/or subcutaneous layer that constitute the skin, and the stratum corneum of the fingernails/toenails and hair shafts (if applicable) to alleviate skin, hair, or fingernail atrophy); increasing folds at the dermal-epidermal boundary (also known as reticular ridges); preventing loss of elasticity in the skin or hair due to loss, damage, and/or inactivation of functional elastin, resulting in conditions such as degeneration of elastic tissue, sagging, and loss of the ability to recover from skin or hair deformities; reduction of cellulitis; and changes in skin, hair, or fingernail color such as dark circles, spots (e.g., uneven redness due to acne erythematous rosacea), sallowness, discoloration caused by hyperpigmentation, etc.

“安全且有效量”是指一定量的化合物或组合物,该量足以显著地引起期望的皮肤有益效果,独立或组合地包括本文所公开的有益效果,但该量又足够低以避免严重的副作用(即,在技术人员合理判断的范围内提供合理的效险比)。"Safe and effective amount" means a amount of compound or composition that is sufficient to significantly produce the desired beneficial skin effects, either alone or in combination, including the beneficial effects disclosed herein, but is low enough to avoid serious side effects (i.e., provides a reasonable risk-benefit ratio within the reasonable judgment of a person skilled in the art).

“皮肤”是指哺乳动物最外层保护性覆盖物,其由诸如角质细胞、成纤维细胞和黑素细胞的细胞构成。皮肤包括外侧的表皮层和下面的真皮层。皮肤还可包括通常与皮肤相关联的毛发和指/趾甲以及其他类型的细胞,诸如例如肌细胞、梅克尔细胞、朗格汉斯细胞、巨噬细胞、干细胞、皮脂腺细胞、神经细胞和脂肪细胞。"Skin" refers to the outermost protective covering of mammals, composed of cells such as keratinocytes, fibroblasts, and melanocytes. Skin comprises the outer epidermis and the underlying dermis. Skin may also include hair and nails typically associated with it, as well as other cell types such as, for example, muscle cells, Merkel cells, Langerhans cells, macrophages, stem cells, sebaceous gland cells, nerve cells, and fat cells.

“皮肤护理”是指调节和/或改善皮肤状况。一些非限制性示例包括通过提供更光滑、更均匀的外观和/或感觉来改善皮肤外观和/或感觉;增加皮肤的一个或多个层的厚度;改善皮肤的弹性或回弹性;改善皮肤的紧致度;和减少皮肤的油性的、有光泽的、和/或无光泽的外观、改善皮肤的水合状态或保湿状态、改善细纹和/或皱纹的外观、改善皮肤剥落或脱屑、使皮肤丰满、改善皮肤屏障特性、改善肤色、减少发红或皮肤疹斑的外观、和/或改善皮肤的亮度、光彩、或半透明性。"Skin care" refers to conditioning and/or improving skin condition. Some non-limiting examples include improving the appearance and/or feel of the skin by providing a smoother, more even look and/or feel; increasing the thickness of one or more layers of the skin; improving the elasticity or resilience of the skin; improving the firmness of the skin; and reducing the oily, shiny, and/or dull appearance of the skin; improving the hydration or moisturization of the skin; improving the appearance of fine lines and/or wrinkles; improving skin peeling or flaking; plumping the skin; improving skin barrier properties; improving skin tone; reducing the appearance of redness or rashes; and/or improving the brightness, radiance, or translucency of the skin.

“皮肤护理活性物质”是指当施用于皮肤时,向皮肤或通常存在于其中的细胞类型提供即时和/或长久有益效果的化合物或化合物的组合。皮肤护理活性物质可调节和/或改善皮肤或其相关联的细胞(例如,改善皮肤弹性;改善皮肤水合;改善皮肤状况;和改善细胞代谢)。"Skin care active substances" refer to compounds or combinations of compounds that, when applied to the skin, provide immediate and/or long-lasting beneficial effects to the skin or the cell types typically present therein. Skin care active substances can modulate and/or improve the skin or its associated cells (e.g., improve skin elasticity; improve skin hydration; improve skin condition; and improve cellular metabolism).

“皮肤护理组合物”是指包含皮肤护理活性物质并且调节皮肤状况的组合物。"Skin care composition" refers to a composition that contains skin care active substances and regulates skin condition.

个性化皮肤护理系统Personalized skin care system

本文的个性化皮肤护理系统包括分配装置、一个或多个可替换的皮肤护理活性物质料筒、以及包含一种或多种基础成分的气密密封的一次性荚包。一次性荚包可为用后即丢弃的或可再填充的。皮肤护理活性物质料筒与一次性荚包流体连通以形成封闭的无菌系统。在一些情况下,可使用合适的泵(例如,螺杆驱动的活塞泵或蠕动泵)将皮肤活性物质通过一个或多个管等转移到一次性荚包。在转移到一次性荚包时,皮肤护理活性物质和基础成分原位混合在一起。然后可将所得的个性化皮肤护理组合物分配给用户。一次性荚包的尺寸可被设定成递送单剂量的皮肤护理组合物或多剂量。例如,当系统在家中使用时,用户可选择单剂量的皮肤护理组合物。然而,用户也可选择多剂量的皮肤护理组合物,该皮肤护理组合物可由系统分配到便携式容器中以供出门在外使用。通过提供不同尺寸的一次性荚包和/或通过改变皮肤护理活性物质在个性化皮肤护理组合物中的浓度,可改变由系统分配的剂量的数量和/或尺寸。在一些情况下,一次性荚包可具有5至50毫升(ml)(例如,10ml至30ml或15ml至25ml)的体积。The personalized skincare system described herein includes a dispensing device, one or more replaceable active skincare substance cartridges, and an airtight, disposable pod containing one or more base ingredients. The disposable pod may be disposable or refillable. The active skincare substance cartridge is in fluid communication with the disposable pod to form a closed, sterile system. In some cases, a suitable pump (e.g., a screw-driven piston pump or peristaltic pump) may be used to transfer the active skincare substance through one or more tubes to the disposable pod. During transfer to the disposable pod, the active skincare substance and base ingredients are mixed together in situ. The resulting personalized skincare composition can then be dispensed to the user. The size of the disposable pod can be configured to deliver a single dose or multiple doses of the skincare composition. For example, when the system is used at home, the user may choose a single-dose skincare composition. However, the user may also choose a multiple-dose skincare composition, which can be dispensed by the system into a portable container for use on the go. The number and/or size of the dose dispensed by the system can be varied by providing disposable pods of different sizes and/or by changing the concentration of the active skincare substance in the personalized skincare composition. In some cases, single-use pods may have a volume of 5 to 50 milliliters (ml) (e.g., 10 to 30 ml or 15 to 25 ml).

本系统包括一个或多个料筒,每个料筒包含一种或多种皮肤护理活性物质。当存在两个或更多个料筒时(例如,在2个和10个之间),包含在每个料筒中的皮肤护理活性物质可与包含在另一个料筒中的皮肤护理活性物质相同或不同。在某些情况下,2个或更多个料筒可包含相同的皮肤护理活性物质,但浓度不同。料筒的尺寸和形状不受特别限制。然而,可能期望的是将料筒构造为使将料筒储存在分配装置内所需的空间量最小化。料筒可由本领域已知的与美容皮肤护理产品一起使用的任何合适的材料(例如,无毒的、非反应性的、不透流体的和生物基的)制成。在某些情况下,料筒包含足够的皮肤护理活性物质以配制一剂量以上的个性化皮肤护理组合物。例如,料筒可包含足够的皮肤护理活性物质以配制在2剂量和100剂量之间的个性化皮肤护理组合物(例如,在5剂量和60剂量、10剂量和45剂量之间,或甚至在15剂量和30剂量之间)。在某些情况下,可能期望在具有皮肤护理活性物质的料筒中包括一种或多种基础成分。例如,可能期望的是稀释已知会引起敏感性问题或通常以低浓度使用的活性物质(例如类视色素)。在一些情况下,料筒可具有5至50毫升(mL)的总体积。This system includes one or more cartridges, each containing one or more skincare active ingredients. When two or more cartridges are present (e.g., between 2 and 10), the skincare active ingredient contained in each cartridge may be the same or different from the skincare active ingredient contained in another cartridge. In some cases, two or more cartridges may contain the same skincare active ingredient but at different concentrations. The size and shape of the cartridges are not particularly limited. However, it may be desirable to construct the cartridges to minimize the amount of space required to store them within the dispensing device. The cartridges may be made of any suitable material known in the art for use with cosmetic skincare products (e.g., non-toxic, non-reactive, impermeable, and bio-based). In some cases, the cartridges contain enough skincare active ingredient to formulate a personalized skincare composition with more than one dose. For example, the cartridges may contain enough skincare active ingredient to formulate a personalized skincare composition with doses between 2 and 100 (e.g., between 5 and 60, 10 and 45, or even between 15 and 30). In some cases, it may be desirable to include one or more base ingredients in a cartridge containing a skin-care active ingredient. For example, it may be desirable to dilute an active ingredient known to cause sensitivity problems or that is typically used at low concentrations (e.g., retinoid pigments). In some cases, the cartridge may have a total volume of 5 to 50 milliliters (mL).

在一些情况下,料筒和/或一次性荚包可被构造为向系统提供与包含在料筒和/或一次性荚包中的成分相关的信息。例如,料筒和/或一次性荚包可包括可由分配装置检测的标识符,诸如条形码、快速响应(QR)码、射频识别(RFID)芯片、这些的组合等。提供给系统的信息可用于促进个性化皮肤护理组合物的配制,而无需用户额外的工作。附加地或另选地,料筒和/或一次性荚包上的标识符可使用智能电话或类似装置上的相机来检测,该智能电话或类似装置随后经由合适的软件应用程序将标识符信息传送给系统或分配装置。In some cases, cartridges and/or disposable pods can be configured to provide the system with information relating to the ingredients contained in the cartridges and/or disposable pods. For example, cartridges and/or disposable pods may include identifiers detectable by a dispensing device, such as barcodes, quick-response (QR) codes, radio frequency identification (RFID) chips, combinations thereof, etc. The information provided to the system can be used to facilitate the formulation of personalized skincare compositions without additional effort from the user. Additionally or alternatively, the identifiers on the cartridges and/or disposable pods can be detected using a camera on a smartphone or similar device, which then transmits the identifier information to the system or dispensing device via a suitable software application.

本系统可被构造为基于手动或自动提供给系统的一个或多个用户个性化因素来选择用于制备个性化皮肤护理组合物的活性成分和/或基础成分的类型和量。例如,一个或多个个性化因素可由与系统电子通信的皮肤诊断工具自动提供给系统。附加地或另选地,一个或多个个性化因素可由用户或皮肤护理专业人员例如经由分配装置上的界面或用智能电话访问的移动或基于网络的应用程序手动提供给系统。用户个性化因素的非限制性示例可包括年龄、种族、皮肤类型、生活方式、表观皮肤年龄、地理位置、环境因素(天气、季节、一天中的时间等)、来自皮肤分析或诊断的结果、以及皮肤护理产品的使用历史。附加地或另选地,活性成分和/或基础成分的类型和/或量可由用户手动选择。This system can be configured to select the type and amount of active ingredients and/or base ingredients for preparing personalized skincare compositions based on one or more user-personalized factors provided to the system manually or automatically. For example, one or more personalization factors may be automatically provided to the system by a skin diagnostic tool that communicates electronically with the system. Additionally or alternatively, one or more personalization factors may be manually provided to the system by a user or skincare professional, for example, via an interface on a dispensing device or a mobile or web-based application accessed via a smartphone. Non-limiting examples of user personalization factors may include age, ethnicity, skin type, lifestyle, apparent skin age, geographic location, environmental factors (weather, season, time of day, etc.), results from skin analysis or diagnosis, and usage history of skincare products. Additionally or alternatively, the type and/or amount of active ingredients and/or base ingredients may be manually selected by the user.

该系统可包括与分配装置电子通信并且任选地例如经由网络(例如,广域网,诸如移动电话网络、公共交换电话网络、卫星网络和/或互联网;局域网,诸如无线保真性、Wi-Max、ZigBeeTM和/或BluetoothTM;和/或其他合适形式的联网能力)彼此电子通信的一个或多个计算机。在一些情况下,分配装置包括控制器(例如,固态微控制器),该控制器例如通过访问存储在非暂态存储器部件(例如,随机存取存储器、只读存储器、寄存器等)上的逻辑来控制分配装置的一个或多个部件。在一些情况下,控制器使得分配装置经由有线或无线连接通过网络向远程计算机发送和/或接收信息。远程计算机可以是服务器(或多个服务器)、个人计算机、移动计算机、智能电话和/或其他合适的计算装置。在一些情况下,系统可被构造为与存储在远程计算装置(例如,服务器、个人计算机或智能电话)上的基于软件的皮肤诊断工具(例如,本地或基于网络的软件应用程序)进行无线通信。在一些情况下,系统可被构造为与存储在远程计算装置上的用户个性化因素的数据库通信。以这种方式,系统可以使用来自诊断工具和/或数据库的信息来确定用户的个性化因素。The system may include one or more computers that communicate electronically with the distribution device and optionally with each other, for example, via a network (e.g., a wide area network, such as a mobile phone network, a public switched telephone network, a satellite network, and/or the Internet; a local area network, such as Wireless Fidelity, Wi-Max, ZigBee , and/or Bluetooth ; and/or other suitable forms of networking capabilities). In some cases, the distribution device includes a controller (e.g., a solid-state microcontroller) that controls one or more components of the distribution device, for example, by accessing logic stored on non-transitory memory components (e.g., random access memory, read-only memory, registers, etc.). In some cases, the controller causes the distribution device to send and/or receive information to a remote computer via a wired or wireless connection over a network. The remote computer may be a server (or servers), a personal computer, a mobile computer, a smartphone, and/or other suitable computing device. In some cases, the system may be configured to communicate wirelessly with a software-based skin diagnostic tool (e.g., a local or web-based software application) stored on a remote computing device (e.g., a server, personal computer, or smartphone). In some cases, the system can be configured to communicate with a database of user personalization factors stored on a remote computing device. In this way, the system can use information from diagnostic tools and/or the database to determine the user's personalization factors.

分配装置可包括使用户能够向本系统提供信息和/或从本系统接收信息的界面。例如,界面可指示所选择的皮肤护理组合物的类型和/或使用户能够选择特定的皮肤护理组合物。在一些情况下,界面可使用户能够访问和/或修改他们的个性化因素。界面可包括用于向用户传送信息的显示器(例如,液晶显示器(“LCD”))。在一些情况下,分配装置可包括多个灯(例如,发光二极管),这些灯单独地或协作地(例如,按顺序)打开或关闭,以向用户以非言语方式传送信息和/或提供期望的美学效果。在一些情况下,例如通过使用无线配对电子装置的常规方法将智能电话与分配装置配对,智能电话可用作与分配装置的界面。The distribution device may include an interface that enables a user to provide information to and/or receive information from the system. For example, the interface may indicate the type of skincare composition selected and/or enable the user to select a specific skincare composition. In some cases, the interface may allow the user to access and/or modify their personalization factors. The interface may include a display (e.g., a liquid crystal display (“LCD”)) for transmitting information to the user. In some cases, the distribution device may include multiple lights (e.g., light-emitting diodes) that turn on or off individually or collaboratively (e.g., sequentially) to nonverbally convey information to the user and/or provide a desired aesthetic effect. In some cases, such as by pairing a smartphone with the distribution device using conventional methods of wireless pairing electronics, the smartphone may be used as an interface to the distribution device.

在一个示例中,用户可使用智能电话或其他物联网(IOT)装置来识别提供给人工智能(AI)皮肤诊断工具的皮肤特征(例如,皱纹、斑点、干燥)和/或环境数据。在此示例中,AI皮肤诊断工具将与分配装置和/或用户通信以基于皮肤特征和/或环境数据的分析来提供推荐的皮肤护理产品和/或皮肤护理方案。然后,用户可决定是接受推荐产品和/或方案还是选择另一个产品和/或方案。In one example, a user can use a smartphone or other Internet of Things (IoT) device to identify skin features (e.g., wrinkles, blemishes, dryness) and/or environmental data provided to an artificial intelligence (AI) skin diagnostic tool. In this example, the AI skin diagnostic tool will communicate with the distribution device and/or the user to provide recommended skincare products and/or skincare regimens based on the analysis of skin features and/or environmental data. The user can then decide whether to accept the recommended products and/or regimens or choose another product and/or regimen.

图1A和图1B示出了用于本系统的分配装置100的示例。分配装置100包括被布置为提供合适的便携性和/或使能够方便地放置在用户通常施用皮肤护理组合物的区域(例如,浴室水槽、卧室梳妆台或梳妆室柜台)中的外主体110、顶部部分120、基座130和分配部分140。外主体110被构造为提供美学上令人愉悦的面向外部的表面并且容纳内部部件。顶部部分120可被构造为提供到分配装置100的内部的通路,例如以替换包含皮肤护理活性物质组合物的料筒。如图1A和图1B所示,容器100的顶部部分120为凹形的。然而,顶部部分120可根据需要被构造为任何合适的形状(例如,平坦或凸形)。基座130通常设置在分配装置100的底部处,并且被构造为在使用期间稳定地支撑分配装置100。分配装置100的分配部分140设置在主体110和基座130之间,并且包括用于分配个性化皮肤护理组合物150的喷嘴或其他合适的部件。Figures 1A and 1B illustrate an example of a dispensing device 100 for use in this system. The dispensing device 100 includes an outer body 110, a top portion 120, a base 130, and a dispensing portion 140, arranged to provide suitable portability and/or allow for convenient placement in an area where a user typically applies a skincare composition (e.g., a bathroom sink, bedroom vanity, or dressing room counter). The outer body 110 is configured to provide an aesthetically pleasing exterior-facing surface and to house internal components. The top portion 120 may be configured to provide access to the interior of the dispensing device 100, for example, to replace a cartridge containing a skincare active ingredient composition. As shown in Figures 1A and 1B, the top portion 120 of the container 100 is concave. However, the top portion 120 may be configured to any suitable shape (e.g., flat or convex) as needed. The base 130 is typically located at the bottom of the dispensing device 100 and is configured to stably support the dispensing device 100 during use. The dispensing portion 140 of the dispensing device 100 is disposed between the main body 110 and the base 130, and includes a nozzle or other suitable component for dispensing the personalized skin care composition 150.

装置100的分配部分140可被提供为主体100和基座120之间的封闭或半封闭的空间。在一些情况下,分配部分140包括隔离和/或隐藏分配部分140的壁142。壁142可以包括可移动部分145和固定部分147。根据需要,壁142、可移动部分145和/或固定部分可为不透明的、半透明的或透明的。壁142的可移动部分145可被定位(即,打开)以允许触及装置100的分配部分140,然后重新定位(即,关闭)以部分地或完全地包封分配部分140。在一些情况下,可移动部分145可被构造为滑动门,该滑动门可经由联接到驱动马达的开关、按钮和/或传感器手动或自动打开。例如,可移动部分可被构造为在用户按下按钮和/或激活光学传感器时沿轨道或凹槽滑动打开。在某些情况下,当皮肤护理组合物150准备好被分配时,可移动部分145可自动打开,这也可向用户提供个性化皮肤护理组合物准备好的通知。可移动部分145可被构造为滑动经过固定部分147的内侧或外侧。在一些情况下,可移动部分145可被构造为例如经由铰链、液压/气压缸、铰接臂等沿垂直于固定部分147的方向(即,从分配部分140向外或向内)打开。固定部分147可为主体110的分立元件或一体部分。固定部分147和可移动部分145可被设计成提供互补美观(例如,如图1A所示看起来是一体元件)或如图1B所示看起来是装置100的分立部件。图1A描绘了处于关闭构型的可移动部分145,并且图1B描绘了处于打开构型的可移动部分145。该装置的分配部分可包括传感器,该传感器检测何时适于分配个性化皮肤护理组合物。例如,运动传感器可用于检测用户何时正确地定位他们的手以接收组合物。The dispensing portion 140 of the device 100 may be provided as an enclosed or semi-enclosed space between the main body 100 and the base 120. In some cases, the dispensing portion 140 includes a wall 142 that isolates and/or conceals the dispensing portion 140. The wall 142 may include a movable portion 145 and a fixed portion 147. Depending on the need, the wall 142, the movable portion 145, and/or the fixed portion may be opaque, translucent, or transparent. The movable portion 145 of the wall 142 may be positioned (i.e., opened) to allow access to the dispensing portion 140 of the device 100, and then repositioned (i.e., closed) to partially or completely enclose the dispensing portion 140. In some cases, the movable portion 145 may be configured as a sliding door that can be opened manually or automatically via a switch, button, and/or sensor coupled to a drive motor. For example, the movable portion may be configured to slide open along a track or groove when a user presses a button and/or activates an optical sensor. In some cases, the movable portion 145 may automatically open when the skincare composition 150 is ready to be dispensed, which may also notify the user that the personalized skincare composition is ready. The movable portion 145 may be configured to slide past the inside or outside of the fixed portion 147. In some cases, the movable portion 145 may be configured to open, for example via a hinge, hydraulic/pneumatic cylinder, articulated arm, etc., in a direction perpendicular to the fixed portion 147 (i.e., outward or inward from the dispensing portion 140). The fixed portion 147 may be a discrete element or an integral part of the body 110. The fixed portion 147 and the movable portion 145 may be designed to provide complementary aesthetics (e.g., appearing as an integral element as shown in FIG. 1A) or appearing as discrete components of the device 100 as shown in FIG. 1B. FIG. 1A depicts the movable portion 145 in a closed configuration, and FIG. 1B depicts the movable portion 145 in an open configuration. The dispensing portion of the device may include a sensor that detects when it is appropriate to dispense the personalized skincare composition. For example, motion sensors can be used to detect when a user correctly positions their hand to receive the composition.

图2A和图2B示出了来自图1A和图1B的装置100的顶部部分120的示例。顶部部分120包括将分配装置100的内部与外部环境分开的可打开/可关闭盖220。盖220可包括狭槽215或使用户201能够将包含基础成分的一次性荚包225插入分配装置100中的其他开口。一旦插入狭槽215中,可使用本领域的技术人员已知的常规方法将荚包225定位在装置100内。在使用之后,用过的荚包225可由用户手动或自动移除。例如,在分配个性化护理组合物之后,分配装置可通过颠倒用于将荚包225定位成与皮肤护理活性物质料筒液体连通的步骤来排出用过的荚包225。用过的一次性荚包225可被丢弃或回收。附加地或另选地,分配装置可使用户能够例如经由开口或可移动面板触及用过的荚包225,并且手动移除用过的荚包225。Figures 2A and 2B illustrate examples of the top portion 120 of the device 100 from Figures 1A and 1B. The top portion 120 includes an openable/closable cover 220 that separates the interior of the dispensing device 100 from the external environment. The cover 220 may include a slot 215 or other opening that allows a user 201 to insert a disposable pod 225 containing the base ingredient into the dispensing device 100. Once inserted into the slot 215, the pod 225 can be positioned within the device 100 using conventional methods known to those skilled in the art. After use, the used pod 225 can be removed manually or automatically by the user. For example, after dispensing a personalized care composition, the dispensing device can discharge the used pod 225 by reversing the step used to position the pod 225 in communication with the liquid in the skincare active ingredient cartridge. The used disposable pod 225 can be discarded or recycled. Additionally or alternatively, the dispensing device may allow the user to access and manually remove the used pod 225, for example, via an opening or a movable panel.

如图2A和图2B所示,分配装置100的盖220可包括将信息传送给用户和/或使用户201能够与分配装置100进行交互的界面部件。在一些情况下,界面部件可包括例如使用图标和/或灯(例如,发光二极管)将信息传送给用户201的一个或多个指示器255。此类信息的一些非限制性示例包括电源状态(开/关)、网络状态、互联网连接、皮肤护理活性物质水平、基础成分荚包状态、系统状态(例如,过程中的哪个步骤)、被配制的皮肤护理组合物的类型(例如,面霜、眼霜、精华液、保湿剂、爽肤水、日间产品或夜间产品)。例如,一个或多个指示器255可(例如,按顺序)点亮以指示配制过程中的步骤。在一些情况下,指示器255可被构造为按钮或开关,该按钮或开关使用户能够操作装置100(例如,打开/关闭装置、选择特定的皮肤护理组合物、改变组合物制剂,连接到网络,打开盖220和/或分配部分140,排出用过的基础成分荚包225,或操作分配装置100的一些其他特征)。在一些情况下,顶部部分120(例如,盖220)可包括运动传感器(例如,光学或声学),该运动传感器在检测到运动时(例如,当用户在距装置100的顶部30cm内移动他们的手时)激活装置100的一个或多个特征。在一些情况下,顶部部分120可包括环绕顶部部分120的灯256,以进一步将信息传送给用户201或提供期望的美学特征。例如,当检测到运动和/或当组合物被分配时,灯256可接通。在一些情况下,灯256可以以一种以上的颜色提供。例如,第一颜色(例如红色)可用于发信号通知装置已检测到运动或已通电,并且第二颜色可用于发信号通知组合物何时正在混合(黄色)或已准备好进行分配(绿色)。在一些情况下,界面可包括显示屏和/或扬声器以在视觉上和/或听觉上向用户传送言语信息。As shown in Figures 2A and 2B, the cover 220 of the dispensing device 100 may include interface components that transmit information to a user and/or enable the user 201 to interact with the dispensing device 100. In some cases, the interface components may include one or more indicators 255 that transmit information to the user 201, for example, using icons and/or lights (e.g., light-emitting diodes). Some non-limiting examples of such information include power status (on/off), network status, internet connection, skin care active ingredient level, base ingredient pod status, system status (e.g., which step in the process), and the type of skin care composition being formulated (e.g., face cream, eye cream, serum, moisturizer, toner, day product, or night product). For example, one or more indicators 255 may (e.g., sequentially) illuminate to indicate a step in the formulation process. In some cases, indicator 255 may be configured as a button or switch that allows a user to operate device 100 (e.g., turn the device on/off, select a specific skincare composition, change the composition formulation, connect to a network, open cap 220 and/or dispensing portion 140, dispose of used base ingredient pod 225, or operate some other feature of dispensing device 100). In some cases, top portion 120 (e.g., cap 220) may include a motion sensor (e.g., optical or acoustic) that activates one or more features of device 100 when motion is detected (e.g., when a user moves their hand within 30 cm of the top of device 100). In some cases, top portion 120 may include a light 256 surrounding top portion 120 to further convey information to user 201 or provide desired aesthetic features. For example, light 256 may be turned on when motion is detected and/or when a composition is dispensed. In some cases, light 256 may be provided in more than one color. For example, a first color (e.g., red) can be used to signal that the device has detected motion or has been powered on, and a second color can be used to signal when the composition is being mixed (yellow) or is ready for dispensing (green). In some cases, the interface may include a display screen and/or speakers to convey verbal information to the user visually and/or audibly.

图3示出了来自图2A和图2B的装置100的顶部部分120的示例,其中盖220打开。如图3所示,盖220可打开以提供到分配装置100和/或料筒360的内部的通路。当盖220关闭时,盖220中的狭槽215或其他开口被构造为覆盖料筒组件370中的对应狭槽315或其他匹配开口。盖220的内表面221可包括标记325和/或指示器355。标记325可包括与装置100的使用有关的指令或其他信息,诸如例如,如何和/或何时替换料筒360。指示器355可包括图标、灯、这些的组合等。在一些情况下,指示器355可向用户提供与每个料筒中皮肤护理活性物质的量和/或类型相关的信息。例如,当对应的料筒360中的皮肤护理活性物质的料位低和/或料筒360为空时,指示器355可点亮。如图3中的示例所示,指示器355的数量可与料筒360的数量(即,5个)相同。然而,应当理解,分配装置100可被构造为包括任何数量的指示器355和/或料筒360。Figure 3 shows an example of the top portion 120 of the device 100 from Figures 2A and 2B, with the cover 220 open. As shown in Figure 3, the cover 220 can be opened to provide access to the interior of the dispensing device 100 and/or the cartridge 360. When the cover 220 is closed, a slot 215 or other opening in the cover 220 is configured to cover a corresponding slot 315 or other matching opening in the cartridge assembly 370. The inner surface 221 of the cover 220 may include markings 325 and/or indicators 355. Markings 325 may include instructions or other information relating to the use of the device 100, such as, for example, how and/or when to replace the cartridge 360. Indicators 355 may include icons, lights, combinations thereof, etc. In some cases, indicators 355 may provide the user with information relating to the amount and/or type of skincare active ingredient in each cartridge. For example, indicators 355 may illuminate when the level of skincare active ingredient in the corresponding cartridge 360 is low and/or when the cartridge 360 is empty. As shown in the example in Figure 3, the number of indicators 355 can be the same as the number of cylinders 360 (i.e., 5). However, it should be understood that the dispensing device 100 can be configured to include any number of indicators 355 and/or cylinders 360.

如图3所示,料筒设置在料筒组件370中。料筒组件370可包括能够插入、保持、移除和/或替换料筒360的多种特征(例如,夹子、弹簧、卡扣、柱塞、销、螺钉、磁体、突片、狭槽、手柄、突起、压痕、料筒几何形状、这些的组合等)。在一些情况下,料筒组件370可被重新定位成使用户能够触及料筒360。例如,料筒组件370可在打开盖220之后朝向装置100的顶部部分120重新定位。类似地,料筒组件370可在关闭盖220之前向下移动回到装置100的主体110中。在一些情况下,料筒组件370可(例如,通过分配装置100的敞开顶部部分120)部分地或完全地从分配装置移除。料筒组件370可使用本领域的技术人员已知的常规方法手动地或自动地重新定位。As shown in Figure 3, a cartridge is disposed in a cartridge assembly 370. The cartridge assembly 370 may include various features (e.g., clips, springs, latches, plungers, pins, screws, magnets, tabs, slots, handles, protrusions, indentations, cartridge geometry, combinations thereof, etc.) capable of inserting, retaining, removing, and/or replacing the cartridge 360. In some cases, the cartridge assembly 370 may be repositioned to allow user access to the cartridge 360. For example, the cartridge assembly 370 may be repositioned toward the top portion 120 of the device 100 after the cap 220 is opened. Similarly, the cartridge assembly 370 may be moved downwards back into the body 110 of the device 100 before the cap 220 is closed. In some cases, the cartridge assembly 370 may be partially or completely removed from the dispensing device (e.g., via the open top portion 120 of the dispensing device 100). The cartridge assembly 370 may be repositioned manually or automatically using conventional methods known to those skilled in the art.

图4示出了在料筒组件370中使用的托架400的示例。托架400包括框架415,该框架提供了托架400和/或料筒组件370的其他部件可接合到其上的坚固骨架。托架400包括一个或多个料筒套管410,该料筒套管被构造为接收和保持包含皮肤护理活性物质的料筒360。在一些情况下,皮肤护理活性物质可经由联接到合适驱动机构(未示出)的活塞425从料筒分配。例如,驱动机构可包括联接到编码器的螺杆驱动马达。在此示例中,编码器可与可编程控制器(例如,固态微处理器)电子通信,该可编程控制器被编程为控制马达的速度和/或驱动时间。因此,可精确地控制从料筒分配的皮肤护理活性物质的量。活塞425可为料筒的整体部件、驱动机构的整体部件或分立部件。每个料筒套管410可包括一个或多个分配出口420。每个分配出口420可经由无菌流体输送系统(例如,无菌管和连接器)联接到一次性荚包(未示出)。Figure 4 illustrates an example of a holder 400 used in a cartridge assembly 370. The holder 400 includes a frame 415 that provides a robust skeleton to which the holder 400 and/or other components of the cartridge assembly 370 can be engaged. The holder 400 includes one or more cartridge sleeves 410 configured to receive and hold a cartridge 360 containing a skincare active ingredient. In some cases, the skincare active ingredient may be dispensed from the cartridge via a piston 425 coupled to a suitable drive mechanism (not shown). For example, the drive mechanism may include a screw drive motor coupled to an encoder. In this example, the encoder may communicate electronically with a programmable controller (e.g., a solid-state microprocessor) programmed to control the speed and/or drive timing of the motor. Therefore, the amount of skincare active ingredient dispensed from the cartridge can be precisely controlled. The piston 425 may be an integral part of the cartridge, an integral part of the drive mechanism, or a discrete component. Each cartridge sleeve 410 may include one or more dispensing outlets 420. Each dispensing outlet 420 can be connected to a disposable pod (not shown) via a sterile fluid delivery system (e.g., sterile tubing and connectors).

图5示出了托架500的示例,其中料筒套管510可水平地重新定位(即,从托架500向外)以提供到料筒的通路。在此示例中,托架500可被重新定位成使得料筒套管510的水平部署不受主体110或分配装置100的其他部件的阻碍。另选地,分配装置100的主体110可被构造为包括一个或多个开口,该一个或多个开口使料筒套筒510能够水平部署,使得料筒套筒510从分配装置100的主体110向外延伸。在一些情况下,托架500可包括一个或多个面板540,该一个或多个面板具有外观与分配装置的主体的外表面相同或基本上相同的面向外的侧面544。以这种方式,可水平部署的料筒套管510可实际上与分配装置的主体不可区分,以提供改善的美观性。Figure 5 illustrates an example of a bracket 500 in which the cartridge sleeve 510 can be horizontally repositioned (i.e., outward from the bracket 500) to provide passage to the cartridge. In this example, the bracket 500 can be repositioned such that the horizontal deployment of the cartridge sleeve 510 is not obstructed by the body 110 or other components of the dispensing device 100. Alternatively, the body 110 of the dispensing device 100 may be configured to include one or more openings that allow the cartridge sleeve 510 to be horizontally deployed such that the cartridge sleeve 510 extends outward from the body 110 of the dispensing device 100. In some cases, the bracket 500 may include one or more panels 540 having outward-facing sides 544 that have the same or substantially the same appearance as the outer surface of the body of the dispensing device. In this way, the horizontally deployable cartridge sleeve 510 can be virtually indistinguishable from the body of the dispensing device, providing improved aesthetics.

图6A、图6B和图6C示出了本系统用于提供个性化皮肤组合物的过程的定剂量、混合和分配部分的示例。在此示例中,使用无菌输送系统将个性化成分650(例如,皮肤护理活性物质)定剂量加入设置在一次性荚包600中的基础组合物610中。如图6A所示,无菌输送系统可包括可插入元件620(例如,刚性管、隔膜针、这些的组合等),该可插入元件插入穿过一次性荚包600的顶部处的开口630。一次性荚包600由不透液的柔性材料(例如,柔性箔材料)形成,该柔性材料提供足够的强度以承受该过程的每个步骤。在一些情况下,柔性材料可由可再生和/或可生物降解的材料(例如,非石油基)制成。一旦个性化成分650被定剂量添加到荚包600中,如图6B所示,移除可插入元件620并且通过密封件635重新密封开口630,这防止成分610和650回流到荚包600外。合适的密封件635的一些非限制性示例包括止回阀、隔膜阻挡件、膜、单向流动阀、这些的组合等。个性化成分650和基础成分610通过外部混合元件660混合在一起。混合元件660向荚包600的外表面施加混合力。混合力使得荚包600的柔性壁变形,从而向荚包600内的成分610和650提供混合动作。在一些情况下,混合元件660可包括一对可相对的辊,该一对可相对的辊沿一次性荚包600的长度移动,同时向荚包600的柔性壁施加压力。一旦成分适当混合,荚包600的底部处的易碎密封件670破裂以释放(分配)个性化护理组合物。在一些情况下,混合元件660可被构造为施加足以破坏易碎密封件670的分配压力。在图6C所示的示例中,混合元件660可在施加分配压力的同时从荚包600的顶部移动到底部,从而将个性化皮肤护理组合物680分配到开口690外。在某些情况下,该系统可包括单独的分配元件以分配个性化护理组合物680。Figures 6A, 6B, and 6C illustrate examples of the dosing, mixing, and dispensing portions of the process for delivering a personalized skin composition using this system. In this example, a personalized ingredient 650 (e.g., a skincare active substance) is dosed into a base composition 610 disposed in a disposable pod 600 using a sterile delivery system. As shown in Figure 6A, the sterile delivery system may include an insertable element 620 (e.g., a rigid tube, a diaphragm needle, a combination thereof, etc.) inserted through an opening 630 at the top of the disposable pod 600. The disposable pod 600 is formed of a liquid-impermeable flexible material (e.g., a flexible foil material) that provides sufficient strength to withstand each step of the process. In some cases, the flexible material may be made of a renewable and/or biodegradable material (e.g., a non-petroleum-based material). Once the personalized ingredient 650 has been dosed into the pod 600, as shown in Figure 6B, the insertable element 620 is removed and the opening 630 is resealed by a seal 635, preventing the ingredients 610 and 650 from flowing back into the pod 600. Non-limiting examples of suitable seals 635 include check valves, diaphragm barriers, membranes, one-way flow valves, combinations thereof, etc. Personalized ingredient 650 and base ingredient 610 are mixed together by an external mixing element 660. The mixing element 660 applies a mixing force to the outer surface of the pod 600. This mixing force deforms the flexible wall of the pod 600, thereby providing mixing action to ingredients 610 and 650 within the pod 600. In some cases, the mixing element 660 may include a pair of opposing rollers that move along the length of the disposable pod 600 while applying pressure to the flexible wall of the pod 600. Once the ingredients are properly mixed, a fragile seal 670 at the bottom of the pod 600 breaks to release (dispense) the personalized care composition. In some cases, the mixing element 660 may be configured to apply a dispensing pressure sufficient to break the fragile seal 670. In the example shown in Figure 6C, the mixing element 660 can move from the top to the bottom of the pod 600 while applying dispensing pressure, thereby dispensing the personalized skincare composition 680 outside the opening 690. In some cases, the system may include a separate dispensing element to dispense the personalized care composition 680.

图7示出了用于本系统中的一次性荚包700的示例。在一些情况下,一次性荚包700可包括环绕或部分环绕更柔性的内部分716的刚性外部分714。刚性外部分714可被构造为为荚包700提供结构稳定性。在一些情况下,刚性外部分714可为基本上非柔性的(即,在不断裂或表现出塑性变形的情况下不挠曲),或者柔性外部分714可表现出一定量的柔性,但不像柔性内部分716那样多。当然,应当理解,荚包700可根据需要具有基本上均匀的柔性。一次性荚包700可包括在荚包700的顶部或底部处接合到开口730的配件745。配件745可以是刚性的或柔性的,并且被构造为与无菌流体输送系统协作以将个性化成分(例如,皮肤护理活性物质)从料筒运送到荚包700。在一些情况下,配件745可以接合到一个或多个无菌管(未示出),该无菌管进而接合到一个或多个料筒。配件745可被构造为与开口730形成不透液密封。在一些情况下,荚包700可包括易碎密封件770,该易碎密封件提供不透流体的屏障以覆盖分配开口(未示出)。易碎密封件770可为分立元件或其可集成到刚性外壁714中。易碎密封件770可设置在荚包700的底部处,如图7所示,或根据需要设置在任何其他位置。Figure 7 illustrates an example of a disposable pod 700 used in this system. In some cases, the disposable pod 700 may include a rigid outer portion 714 surrounding or partially surrounding a more flexible inner portion 716. The rigid outer portion 714 may be configured to provide structural stability to the pod 700. In some cases, the rigid outer portion 714 may be substantially non-flexible (i.e., not flexing without breaking or exhibiting plastic deformation), or the flexible outer portion 714 may exhibit a certain amount of flexibility, but not as much as the flexible inner portion 716. Of course, it should be understood that the pod 700 may have substantially uniform flexibility as required. The disposable pod 700 may include a fitting 745 engaging at the top or bottom of the pod 700 to an opening 730. The fitting 745 may be rigid or flexible and is configured to cooperate with a sterile fluid delivery system to deliver personalized ingredients (e.g., skincare active substances) from a cartridge to the pod 700. In some cases, fitting 745 may engage with one or more sterile tubes (not shown), which in turn engage with one or more cartridges. Fitting 745 may be configured to form a liquid-impermeable seal with opening 730. In some cases, pod 700 may include a fragile seal 770 that provides a fluid-impermeable barrier to cover the dispensing opening (not shown). Fragile seal 770 may be a discrete element or may be integrated into a rigid outer wall 714. Fragile seal 770 may be located at the bottom of pod 700, as shown in FIG. 7, or at any other location as required.

图8示出了一次性荚包800的示例,该一次性荚包包括密封件835以防止流体流出荚包800。密封件835被构造为例如通过采用不透流体膜855与喷嘴830机械地协作以形成不透流体的屏障。密封件835可由合适的弹性或塑性-弹性材料(例如,橡胶、聚丙烯、聚乙烯、苯乙烯嵌段共聚物等)形成,该弹性或塑性-弹性材料可弹性变形以适应无菌流体输送系统的可插入元件的插入,然后一旦可插入元件被移除,重新密封开口830。Figure 8 illustrates an example of a disposable pod 800, which includes a seal 835 to prevent fluid leakage from the pod 800. The seal 835 is configured, for example, to mechanically cooperate with the nozzle 830 using a fluid-impermeable membrane 855 to form a fluid-impermeable barrier. The seal 835 may be formed of a suitable elastic or plastic-elastic material (e.g., rubber, polypropylene, polyethylene, styrene block copolymer, etc.) that can elastically deform to accommodate the insertion of an insertable element of the sterile fluid delivery system, and then reseal the opening 830 once the insertable element is removed.

图9示出了一次性荚包900的示例,其中与无菌流体输送系统相关联的可插入元件920通过喷嘴930插入。Figure 9 shows an example of a disposable pod 900, in which an insertable element 920 associated with a sterile fluid delivery system is inserted through a nozzle 930.

图10示出了混合步骤的示例。在混合步骤中,混合元件1060混合一次性荚包1000中所包含的成分。如图10所示,混合元件1060包括一对相对的辊1061,该一对相对的辊向荚包1000的柔性壁的侧面施加压力,同时沿荚包1000的长度向上和/或向下移动。在一些情况下,辊1061行进荚包1000的长度至少两次(例如,3次、4次、5次、6次、7次、8次、9次、10次或更多次),但通常小于100次(例如,小于90次、80次、70次、60次、50次、40次、30次或甚至小于20次)。辊1061行进的速度和施加的压力可根据个性化组合物中使用的成分、组合物的特性(例如,粘度)和/或荚包1000的特性(例如,壁、易碎密封件和/或密封件的破裂强度)而变化。当然,应当理解,本文也设想了向柔性壁的外部施加压力以混合成分的其他合适的方法。荚包1000的顶部处的开口中的不透流体的密封件(未示出)应当被构造为防止在由混合元件施加混合压力时荚包中的成分回流到荚包1000外。在此示例中,提供夹具1085以帮助将荚包1000保持就位和/或帮助防止易碎密封件在分配步骤之前破裂。Figure 10 illustrates an example of the mixing step. In this step, mixing element 1060 mixes the ingredients contained in disposable pod 1000. As shown in Figure 10, mixing element 1060 includes a pair of opposing rollers 1061 that apply pressure to the sides of the flexible wall of pod 1000 while moving upward and/or downward along the length of pod 1000. In some cases, rollers 1061 travel the length of pod 1000 at least twice (e.g., 3, 4, 5, 6, 7, 8, 9, 10 or more times), but typically less than 100 times (e.g., less than 90, 80, 70, 60, 50, 40, 30 or even less than 20 times). The speed at which rollers 1061 travel and the pressure applied can vary depending on the ingredients used in the personalized composition, the properties of the composition (e.g., viscosity), and/or the properties of pod 1000 (e.g., wall, fragile seal, and/or burst strength of the seal). Of course, it should be understood that other suitable methods for applying pressure to the outside of the flexible wall to mix the components are also contemplated herein. The impermeable seal (not shown) in the opening at the top of the pod 1000 should be configured to prevent backflow of components from the pod to the outside of the pod 1000 when mixing pressure is applied by the mixing element. In this example, a clamp 1085 is provided to help hold the pod 1000 in place and/or to help prevent the fragile seal from breaking before the dispensing step.

图11示出了分配步骤的示例。在一次性荚包1100的内容物混合之后,夹具1185分离。在通过混合元件辊1161施加合适的分配压力时,易碎密封件破裂并且分配皮肤护理组合物1190。在一些情况下,夹具1185可被构造为破坏或弱化易碎密封件。分配压力可小于、等于或大于混合压力。相对的辊1161继续向荚包1100的柔性壁施加分配压力,同时沿荚包1100的长度向下移动以通过荚包1100的底部处的开口(未示出)从荚包1100中尽可能多地排出皮肤护理组合物。荚包1100的喷嘴中的不透流体的密封件应当被构造为在施加分配压力时防止荚包中的成分穿过喷嘴回流。Figure 11 illustrates an example of the dispensing step. After the contents of the disposable pod 1100 are mixed, the clamp 1185 separates. When a suitable dispensing pressure is applied by the mixing element roller 1161, the fragile seal breaks and the skincare composition 1190 is dispensed. In some cases, the clamp 1185 may be configured to break or weaken the fragile seal. The dispensing pressure may be less than, equal to, or greater than the mixing pressure. The opposing roller 1161 continues to apply dispensing pressure to the flexible wall of the pod 1100 while moving downwards along the length of the pod 1100 to expel as much of the skincare composition as possible from the pod 1100 through an opening (not shown) at the bottom of the pod 1100. The fluid-impermeable seal in the nozzle of the pod 1100 should be configured to prevent backflow of the contents of the pod through the nozzle when dispensing pressure is applied.

皮肤护理组合物Skin care composition

本文所述的皮肤护理系统提供有助于改善皮肤健康和/或外观的一次性皮肤护理组合物。皮肤护理组合物以两部分提供:包含在一次性荚包中的基础成分,该基础成分包括皮肤病学可接受的载体;和包含在一个或多个可替换料筒中的皮肤护理活性物质。当提供多个料筒时,它们可包含相同或不同浓度的相同或不同皮肤护理活性物质。将皮肤护理活性物质与一次性荚包中的基础成分混合以制备最终组合物,然后由系统分配最终组合物以局部施用到人类皮肤。适于局部施用的形式的一些非限制性示例包括溶液、悬浮液、洗剂、霜膏、凝胶、棒、铅笔、喷剂、气溶胶、油膏、清洁液洗液和固体棒、泡沫、粉末、摩丝、抹布、条、贴片、伤口敷料和胶布绷带、水凝胶、成膜产品和面膜。化妆品组合物形式可符合所选的特定皮肤病学可接受的载体。The skin care system described herein provides disposable skin care compositions that contribute to improved skin health and/or appearance. The skin care composition is provided in two parts: a base ingredient contained in a disposable pod, which includes a dermatologically acceptable carrier; and a skin care active substance contained in one or more replaceable cartridges. When multiple cartridges are provided, they may contain the same or different concentrations of the same or different skin care active substances. The skin care active substance is mixed with the base ingredient in the disposable pod to prepare the final composition, which is then dispensed by the system for topical application to human skin. Some non-limiting examples of suitable forms for topical application include solutions, suspensions, lotions, creams, gels, sticks, pencils, sprays, aerosols, ointments, cleansing solutions and solid sticks, foams, powders, mousses, wipes, strips, patches, wound dressings and adhesive bandages, hydrogels, film-forming products, and masks. The cosmetic composition form may conform to a selected specific dermatologically acceptable carrier.

本文的皮肤护理组合物包括一种或多种通常包括在所提供的特定化妆品组合物中的类型的皮肤护理活性物质。皮肤护理活性物质可以是油溶性或水溶性的,并且当掺入皮肤护理组合物中时,应该适用于与人类皮肤组织接触,而没有不适当的毒性、不相容性、不稳定性、变应性应答等等。皮肤护理活性物质类别的一些非限制性示例包括但不限于维生素(例如维生素A、维生素B和维生素E化合物以及它们的衍生物)、矿物质、肽和肽衍生物、糖胺、N-酰基氨基酸化合物、防晒剂、控油剂、类黄酮化合物、毛发生长调节剂、抗氧化剂和/或抗氧化剂前体、植物甾醇和其他植物衍生的皮肤护理活性物质、蛋白酶抑制剂、酪氨酸酶抑制剂、抗炎剂、润肤剂、湿润剂、保湿剂、皮肤调节剂、皮肤抗老化剂、去角质剂、防晒剂、无晒美黑剂、以及它们的混合物。皮肤护理活性物质可以按最终组合物的重量计0.0001%至50%(例如0.001%至20%或甚至0.01%至10%)的量包括在最终组合物中。可适用于本文的特定皮肤护理活性物质的一些非限制性示例描述于授予Millikin等人的US 9358263中。The skincare compositions described herein include one or more skincare active substances of the types commonly included in specific cosmetic compositions provided. Skincare active substances may be oil-soluble or water-soluble and, when incorporated into skincare compositions, should be suitable for contact with human skin tissue without undue toxicity, incompatibility, instability, allergic reactions, etc. Some non-limiting examples of the class of skincare active substances include, but are not limited to, vitamins (e.g., compounds of vitamin A, vitamin B, and vitamin E, and their derivatives), minerals, peptides and peptide derivatives, glycosamines, N-acyl amino acid compounds, sunscreens, oil-controlling agents, flavonoid compounds, hair growth regulators, antioxidants and/or antioxidant precursors, phytosterols and other plant-derived skincare active substances, protease inhibitors, tyrosinase inhibitors, anti-inflammatory agents, emollients, humectants, moisturizers, skin conditioners, anti-aging agents, exfoliants, sunscreens, non-tanning agents, and mixtures thereof. Skin care active ingredients may be included in the final composition in amounts from 0.0001% to 50% (e.g., 0.001% to 20% or even 0.01% to 10%) by weight of the final composition. Some non-limiting examples of specific skin care active ingredients applicable herein are described in US 9358263, granted to Millikin et al.

一次性荚包中提供的基础成分包括皮肤病学可接受的载体(其可被称为“载体”)。载体可以按基础成分和/或最终皮肤护理组合物的重量计50%至99%(例如,60%至98%、70%至98%、或甚至80%至95%)存在。载体可包含一种或多种皮肤病学可接受的亲水性稀释剂。如本文所用,“稀释剂”包括其中皮肤护理活性物质或其他成分可分散、溶解或以其他方式掺入皮肤护理组合物中的材料。亲水性稀释剂包括水、有机亲水性稀释剂诸如低级一价醇(如C1-C4)和低分子量二醇和多元醇,包括丙二醇、聚乙二醇(如分子量200g/mol-600g/mol)、聚丙二醇(如分子量425g/mol-2025g/mol)、甘油、丁二醇、1,2,4-丁三醇、山梨醇酯、1,2,6-己三醇、乙醇、异丙醇、山梨醇酯、丁二醇、醚丙醇、乙氧基化醚、丙氧基化醚以及它们的组合。载体可为多种形式。在某些情况下,组分的溶解度或分散性可决定载体的形式和特性。非限制性示例包括简单溶液(例如水性的或无水的)、分散体、乳液和固体形式(例如凝胶、棒、可流动的固体或无定形材料)。在特别合适的示例中,皮肤病学可接受的载体为乳液的形式。乳液一般分类为两种或更多种不混溶的液体,它们混合在一起以提供连续相和分散相。本文中乳液可具有连续水相(例如水包油或水包油包水)或连续油相(例如油包水或油包水包油)。The base ingredients provided in the single-use pod include a dermatologically acceptable carrier (which may be referred to as the “carrier”). The carrier may be present in 50% to 99% (e.g., 60% to 98%, 70% to 98%, or even 80% to 95%) by weight of the base ingredients and/or the final skincare composition. The carrier may contain one or more dermatologically acceptable hydrophilic diluents. As used herein, a “diluent” includes materials in which the skincare active ingredient or other ingredients can be dispersed, dissolved, or otherwise incorporated into the skincare composition. Hydrophilic diluents include water, organic hydrophilic diluents such as lower monovalent alcohols (e.g., C1-C4) and low molecular weight diols and polyols, including propylene glycol, polyethylene glycol (e.g., molecular weight 200 g/mol-600 g/mol), polypropylene glycol (e.g., molecular weight 425 g/mol-2025 g/mol), glycerin, butylene glycol, 1,2,4-butanetriol, sorbitan esters, 1,2,6-hexanetriol, ethanol, isopropanol, sorbitan esters, butylene glycol, ether propanol, ethoxylated ethers, propoxylated ethers, and combinations thereof. The carrier can be in various forms. In some cases, the solubility or dispersibility of the component may determine the form and properties of the carrier. Non-limiting examples include simple solutions (e.g., aqueous or anhydrous), dispersions, emulsions, and solid forms (e.g., gels, rods, flowable solids, or amorphous materials). In particularly suitable examples, dermatologically acceptable carriers are in the form of emulsions. Emulsions are generally classified as two or more immiscible liquids mixed together to provide a continuous phase and a dispersed phase. In this context, emulsions may have a continuous aqueous phase (e.g., oil-in-water or water-in-oil-in-water) or a continuous oil phase (e.g., water-in-oil or oil-in-water-in-oil).

一次性荚包中的基础成分和/或可替换料筒中的皮肤护理活性物质可包括常规包括在所提供类型的皮肤护理组合物中的其他任选成分,只要它们是皮肤病学可接受的并且不会不期望地改变皮肤护理组合物的预期有益效果。任选成分可以按最终组合物的重量计0.0001%至50%、0.001%至20%或甚至0.01%至10%存在。可适用于本文的任选成分的一些非限制性示例包括防腐剂、流变改性剂(例如增稠剂)、pH调节剂、乳化剂、成膜剂、皮肤感觉剂(例如硅氧烷弹性体)、螯合剂、局部麻醉剂、抗微生物剂和抗真菌剂、抗橘皮组织剂、抗氧化剂、皮肤抚慰成分、感觉剂、着色剂、遮光剂、颗粒、芳香剂、精油、润滑剂、以及这些的组合。可适用于本皮肤护理组合物中的任选成分的其他示例描述于美国专利公布2002/0022040;2003/0049212;2004/0175347;2006/0275237;2007/0196344;2008/0181956;2010/00092408;2008/0206373;2010/0239510;2010/0189669;2011/0262025;2011/0097286;US2012/0197016;2012/0128683;2012/0148515;2012/0156146;和2013/0022557;以及美国专利5,939,082;5,872,112;6,492,326;6,696,049;6,524,598;5,972,359;6,174,533;和9,358,263中。The base ingredients in the single-use pods and/or the skincare active ingredients in the replaceable cartridges may include other optional ingredients routinely included in skincare compositions of the provided type, provided they are dermatologically acceptable and do not undesirably alter the intended beneficial effects of the skincare composition. Optional ingredients may be present in amounts from 0.0001% to 50%, 0.001% to 20%, or even 0.01% to 10% by weight of the final composition. Some non-limiting examples of optional ingredients applicable herein include preservatives, rheology modifiers (e.g., thickeners), pH adjusters, emulsifiers, film-forming agents, skin-sensing agents (e.g., silicone elastomers), chelating agents, local anesthetics, antimicrobial and antifungal agents, anti-cellulite agents, antioxidants, skin-soothing ingredients, sensory agents, colorants, opacifiers, particles, fragrances, essential oils, lubricants, and combinations thereof. Other examples of optional ingredients that may be used in this skin care composition are described in U.S. Patent Publications 2002/0022040; 2003/0049212; 2004/0175347; 2006/0275237; 2007/0196344; 2008/0181956; 2010/00092408; 2008/0206373; 2010/0239510; 2010/0189669; 2011/0262 025; 2011/0097286; US2012/0197016; 2012/0128683; 2012/0148515; 2012/0156146; and 2013/0022557; and U.S. Patents 5,939,082; 5,872,112; 6,492,326; 6,696,049; 6,524,598; 5,972,359; 6,174,533; and 9,358,263.

制备方法Preparation method

基础成分和/或皮肤护理活性物质一般可根据本领域已知的制备此类组合物的常规方法来制备。例如,基础成分可以通过在加热或不加热、冷却、施加真空等的情况下在一个或多个步骤中将成分混合至相对均匀的状态来制备。可通过首先将水相材料与油相材料分别混合,然后适当地将两相组合以产生所期望的连续相来制备乳液。在混合后,将基础成分置于合适的包装中,该包装的尺寸设定成储存期望剂量的个性化皮肤护理组合物。包装应能够承受制造、运输和原位混合期间经历的力。在一些情况下,一次性荚包可包括被构造为在施加合适的分配压力时破裂的易碎密封件。将皮肤护理活性物质放置在合适的料筒中,该料筒可以可移除地插入到本系统的装置中。皮肤护理活性物质料筒可包括一个或多个无菌管,该无菌管可被放置成与一次性荚包流体连通以在分配装置中提供闭环系统。The base ingredients and/or skincare active substances can generally be prepared according to conventional methods known in the art for preparing such compositions. For example, the base ingredients can be prepared by mixing the components to a relatively homogeneous state in one or more steps under heating or without heating, cooling, vacuum, etc. An emulsion can be prepared by first mixing the aqueous phase material and the oil phase material separately, and then appropriately combining the two phases to produce the desired continuous phase. After mixing, the base ingredients are placed in a suitable package sized to store a personalized dose of the skincare composition. The package should be able to withstand the forces experienced during manufacturing, transport, and in-situ mixing. In some cases, the disposable capsule may include a fragile seal configured to break upon application of a suitable dispensing pressure. The skincare active substance is placed in a suitable cartridge that can be removably inserted into the device of this system. The skincare active substance cartridge may include one or more sterile tubes positioned in fluid communication with the disposable capsule to provide a closed-loop system in the dispensing device.

使用方法How to use

各种治疗、施用、调节、或改善方法可利用本文的个性化皮肤护理组合物。在某些情况下,该方法可包括识别需要治疗的皮肤(例如包括可见色素沉着紊乱、细纹或皱纹或其他不期望的皮肤状况的皮肤)的目标部分(例如面部皮肤表面,诸如前额、口周、下巴、眶周、鼻部和/或面颊)和/或期望治疗的地方,并且将安全且有效量的个性化皮肤护理组合物施用到皮肤的目标部分。在一些情况下,皮肤的目标部分可能不表现出皮肤状况的可见迹象,但是如果用户(例如,相对年轻的用户)通常是在以后的生活中会发展出皮肤疾病,则可能仍希望以此皮肤区域(例如,通常未被衣服覆盖的皮肤表面,诸如面部皮肤表面、手和臂皮肤表面、脚和腿部皮肤表面、以及颈部和胸部皮肤表面)为目标。以这种方式,本方法和组合物可以用作预防措施。本文的个性化皮肤护理组合物可以在治疗期期间施用至目标皮肤部分,并且如果需要,每天至少一次、每天两次、或每天更频繁地施用至周围皮肤。当每天施用两次时,第一次施用与第二次施用可相隔至少1至12个小时。例如,皮肤护理组合物可在早上和/或晚上临睡觉前施用。Various methods of treatment, application, modulation, or improvement may utilize the personalized skincare compositions described herein. In some cases, the method may include identifying target areas (e.g., facial skin surfaces such as the forehead, perioral region, chin, periorbital region, nose, and/or cheeks) and/or areas where treatment is desired, including skin that requires treatment (e.g., skin with visible pigmentation disorders, fine lines or wrinkles, or other undesirable skin conditions), and applying a safe and effective amount of the personalized skincare composition to the target areas of the skin. In some cases, the target areas of the skin may not show visible signs of a skin condition, but if the user (e.g., a relatively young user) typically develops a skin condition later in life, they may still wish to target this skin area (e.g., skin surfaces that are not typically covered by clothing, such as facial skin surfaces, hand and arm skin surfaces, foot and leg skin surfaces, and neck and chest skin surfaces). In this way, the method and composition can be used as a preventative measure. The personalized skincare compositions described herein may be applied to the target skin areas during the treatment period and, if desired, to the surrounding skin at least once daily, twice daily, or more frequently daily. When applied twice daily, the first and second applications can be spaced at least 1 to 12 hours apart. For example, skincare compositions can be applied in the morning and/or at bedtime.

理想的是,治疗期的时间足以使个性化皮肤护理组合物改善皮肤目标部分的健康和/或外观(例如,色素沉着斑点尺寸的减小和/或细纹和皱纹外观的改善)。治疗期可持续至少1周(例如,约2周、4周、8周或甚至12周)。在一些情况下,治疗期将延长至多个月(即,3至12个月)或多年。在一些情况下,个性化皮肤护理组合物可在一周中的大多数天(例如,每周至少4天、5天或6天)施用,在至少2周、4周、8周或12周的治疗期期间至少每天一次或甚至每天两次。Ideally, the treatment period should be long enough for the personalized skincare composition to improve the health and/or appearance of the target areas of the skin (e.g., reduction in the size of pigmented spots and/or improvement in the appearance of fine lines and wrinkles). The treatment period can last at least one week (e.g., approximately two, four, eight, or even twelve weeks). In some cases, the treatment period will be extended to several months (i.e., three to twelve months) or years. In some cases, the personalized skincare composition may be applied on most days of the week (e.g., at least four, five, or six days per week), at least once daily or even twice daily during a treatment period of at least two, four, eight, or twelve weeks.

本文的个性化皮肤护理组合物可以局部施用或全面施用。关于组合物的施用,术语“局部的”、“局部”、“局部地”是指将组合物递送到目标区域(例如,色素沉着斑点)而使对不期望治疗的皮肤表面的递送最小化。组合物可施用到并且轻轻揉进皮肤区域中。组合物或皮肤病学可接受的载体的形式应被选择成有利于局部施用。虽然本文的某些实施方案设想将组合物局部施用到某一区域,但应当理解,本文的组合物可更全面地或广泛地施用到一个或多个皮肤表面。在某些实施方案中,本文的个性化皮肤护理组合物可用作多步骤美容方案的一部分,该多步骤美容方案涉及依次施用两种或更多种个性化皮肤护理组合物。The personalized skincare compositions described herein can be applied topically or over the entire skin surface. Regarding the application of the composition, the terms "topical," "local," and "partially" refer to delivering the composition to a target area (e.g., a pigmented spot) while minimizing delivery to skin surfaces not intended for treatment. The composition may be applied to and gently massaged into the skin area. The form of the composition or a dermatologically acceptable carrier should be chosen to facilitate topical application. While some embodiments herein envision topical application of the composition to a specific area, it should be understood that the compositions herein may be applied more comprehensively or extensively to one or more skin surfaces. In some embodiments, the personalized skincare compositions described herein may be used as part of a multi-step cosmetic regimen involving the sequential application of two or more personalized skincare compositions.

图12示出了使用本文所述的个性化皮肤护理系统的方法的示例。如图12所示,该过程的第一步骤是将基础成分荚包装载到分配装置中。接下来,系统访问个性化因素,该个性化因素可存储在装置上(例如,存储在非暂态存储器部件中)或从远程数据库或装置获得。个性化因素可包括环境因素(例如,地理位置、当地天气、UV指数)和皮肤状况因素(例如,干燥、油性、年龄、种族、在外面度过的时间、皮肤护理历史)。该系统使用个性化因素来确定包含在个性化皮肤护理组合物中的皮肤活性物质的类型和/或量。将适量的皮肤护理活性物质转移到一次性基础成分荚包中,其中将活性物质和基础成分混合在一起。一旦成分适当混合,将个性化皮肤护理组合物分配给用户以施用于皮肤的目标部分。Figure 12 illustrates an example of a method using the personalized skincare system described herein. As shown in Figure 12, the first step of the process is loading a base ingredient pod into a dispensing device. Next, the system accesses personalization factors, which may be stored on the device (e.g., in a non-transitory memory component) or obtained from a remote database or device. Personalization factors may include environmental factors (e.g., geographic location, local weather, UV index) and skin condition factors (e.g., dry, oily, age, ethnicity, time spent outdoors, skincare history). The system uses these personalization factors to determine the type and/or amount of skin-active substances contained in the personalized skincare composition. An appropriate amount of the skincare active substance is transferred to a disposable base ingredient pod, where the active substance and base ingredient are mixed together. Once the ingredients are properly mixed, the personalized skincare composition is dispensed to the user for application to the target area of the skin.

本文所公开的量纲和值不应理解为严格限于所引用的精确数值。相反,除非另外指明,否则每个此类量纲旨在表示所述值以及围绕该值功能上等同的范围。例如,公开为“40mm”的量纲旨在表示“约40mm”。The dimensions and values disclosed herein should not be construed as strictly limited to the precise numerical values cited. Rather, unless otherwise specified, each such dimension is intended to represent the stated value and a range around which it is functionally equivalent. For example, a dimension disclosed as “40 mm” is intended to represent “approximately 40 mm”.

除非明确排除或以其他方式限制,本文中引用的每一篇文献,包括任何交叉引用或相关专利或专利申请以及本申请对其要求优先权或其有益效果的任何专利申请或专利,均据此全文以引用方式并入本文。对任何文献的引用不是对其作为与本发明的任何所公开或本文受权利要求书保护的现有技术的认可,或不是对其自身或与任何一个或多个参考文献的组合提出、建议或公开任何此类发明的认可。此外,当本发明中术语的任何含义或定义与以引用方式并入的文献中相同术语的任何含义或定义矛盾时,应当服从在本发明中赋予该术语的含义或定义。Unless expressly excluded or otherwise limited, every reference cited herein, including any cross-references or related patents or patent applications, and any patent application or patent claiming priority to or benefiting from it, is incorporated herein by reference in its entirety. Reference to any reference is not an endorsement of it as prior art to any disclosed or protected art herein, nor is it an endorsement of any such invention, either on its own or in combination with any one or more references. Furthermore, where any meaning or definition of a term in this invention conflicts with any meaning or definition of the same term in referenced documents, the meaning or definition given to that term in this invention shall prevail.

虽然已举例说明和描述了本发明的具体实施方案,但是对于本领域技术人员来说显而易见的是,在不脱离本发明的实质和范围的情况下可作出各种其他变化和修改。因此,本文旨在于所附权利要求中涵盖属于本发明范围内的所有此类变化和修改。While specific embodiments of the invention have been illustrated and described by way of example, it will be apparent to those skilled in the art that various other changes and modifications can be made without departing from the spirit and scope of the invention. Therefore, it is intended that all such changes and modifications falling within the scope of the invention be covered by the appended claims.

Claims (18)

1.一种提供个性化皮肤护理组合物的方法,所述方法包括:1. A method for providing a personalized skin care composition, the method comprising: a) 将个性化因素输入到个性化皮肤护理系统中,其中所述个性化皮肤护理系统包括:a) Incorporating personalization factors into a personalized skincare system, wherein the personalized skincare system includes: (i) 分配装置,所述分配装置包括限定内部空间的至少一个壁;(i) A dispensing device, the dispensing device comprising at least one wall defining an internal space; (ii) 可更换料筒,所述可更换料筒设置在所述内部空间中,所述可更换料筒包含皮肤护理活性物质;以及(ii) a replaceable cartridge disposed within the internal space, the replaceable cartridge containing a skin-care active substance; and (iii) 混合元件;(iii) Hybrid elements; b) 将包含基础成分的一次性荚包放置在所述分配装置的所述内部空间中,使得所述一次性荚包与所述可更换料筒流体连通;c)基于所输入的个性化因素选择个性化皮肤护理组合物配方;b) Place a disposable pod containing the base ingredients into the internal space of the dispensing device, such that the disposable pod is in fluid communication with the replaceable cartridge; c) Select a personalized skin care composition formulation based on the input personalization factors; d) 将皮肤护理活性物质转移到所述一次性荚包中;d) Transfer the skin care active ingredient into the disposable pod; e)用混合元件混合所述皮肤护理活性物质和所述基础成分以形成所述个性化皮肤护理组合物,其中所述混合元件在混合期间不接触所述成分;以及e) Using a mixing element to mix the skincare active substance and the base ingredient to form the personalized skincare composition, wherein the mixing element does not come into contact with the ingredients during mixing; and f)分配所述个性化皮肤护理组合物。f) Dispense the personalized skin care composition. 2.根据权利要求1所述的方法,其特征在于,所述个性化因素从皮肤诊断工具输入。2. The method according to claim 1, wherein the personalization factor is input from a skin diagnostic tool. 3.根据权利要求1所述的方法,其特征在于,所述一次性荚包包括柔性壁部分。3. The method according to claim 1, wherein the disposable pod includes a flexible wall portion. 4.根据权利要求3所述的方法,其特征在于,所述一次性荚包包括刚性壁部分。4. The method according to claim 3, wherein the disposable pod includes a rigid wall portion. 5.根据权利要求3所述的方法,其特征在于,所述混合元件通过向所述柔性壁部分施加压力来将所述成分混合在一起。5. The method according to claim 3, wherein the mixing element mixes the components together by applying pressure to the flexible wall portion. 6.根据权利要求5所述的方法,其特征在于,所述混合元件包括一对相对的辊。6. The method according to claim 5, wherein the mixing element comprises a pair of opposing rollers. 7.根据权利要求6所述的方法,其特征在于,所述混合元件沿所述一次性荚包的长度移动,同时向所述柔性壁部分施加压力。7. The method according to claim 6, wherein the mixing element moves along the length of the disposable pod while applying pressure to the flexible wall portion. 8.根据权利要求1所述的方法,其特征在于,所述一次性荚包包括覆盖所述一次性荚包中的分配开口的易碎密封件。8. The method according to claim 1, wherein the disposable pod includes a fragile seal covering the dispensing opening in the disposable pod. 9.根据权利要求8所述的方法,其特征在于,所述混合元件被构造为施加分配压力,所述分配压力足以破坏所述易碎密封件并分配所述个性化皮肤护理组合物。9. The method of claim 8, wherein the mixing element is configured to apply a dispensing pressure sufficient to break the fragile seal and dispense the personalized skincare composition. 10.根据权利要求1所述的方法,其特征在于,所述个性化皮肤护理系统进一步包括帮助将所述一次性荚包保持就位的夹具。10. The method of claim 1, wherein the personalized skin care system further comprises a clamp to help hold the disposable pod in place. 11.根据权利要求1所述的方法,其特征在于,所述个性化皮肤护理系统进一步包括向用户提供所述个性化皮肤护理系统的状态指示的指示器。11. The method according to claim 1, wherein the personalized skin care system further includes an indicator that provides the user with a status indication of the personalized skin care system. 12.根据权利要求1所述的方法,其特征在于,所述个性化皮肤护理系统进一步包括所述分配装置被构造为与远程计算装置通信。12. The method of claim 1, wherein the personalized skin care system further comprises the dispensing device being configured to communicate with a remote computing device. 13.根据权利要求1所述的方法,其特征在于,所述一次性荚包包括标识符,所述标识符能够由所述分配装置检测并且致使所述分配装置向所述个性化皮肤护理系统提供信息。13. The method of claim 1, wherein the disposable pod includes an identifier that can be detected by the dispensing device and cause the dispensing device to provide information to the personalized skin care system. 14.根据权利要求1所述的方法,其特征在于,所述可更换料筒包含足够的皮肤护理活性物质,以配制在5剂量和60剂量之间的个性化皮肤护理组合物。14. The method according to claim 1, wherein the replaceable cartridge contains sufficient skin care active ingredients to formulate personalized skin care compositions between 5 and 60 doses. 15.根据权利要求1所述的方法,其特征在于,所述个性化皮肤护理系统进一步包括从所述分配装置的外表面延伸到所述内部空间中的开口,其中所述开口被构造为接收来自用户的所述一次性荚包。15. The method of claim 1, wherein the personalized skin care system further includes an opening extending from the outer surface of the dispensing device into the interior space, wherein the opening is configured to receive the disposable pod from the user. 16.根据权利要求1所述的方法,其特征在于,所述分配装置包含2个和10个之间的可更换料筒,并且其中所述可更换料筒中的至少两个包含不同的皮肤护理活性物质。16. The method of claim 1, wherein the dispensing device comprises between two and ten replaceable cartridges, and wherein at least two of the replaceable cartridges contain different skin care active substances. 17.根据权利要求1所述的方法,其特征在于,所述分配装置进一步包括隐藏所述分配装置的分配部分的可移动壁部分,并且其中当所述个性化皮肤护理组合物准备好被分配时,所述可移动壁部分自动打开以露出所述分配部分。17. The method of claim 1, wherein the dispensing device further comprises a movable wall portion that conceals a dispensing portion of the dispensing device, and wherein the movable wall portion automatically opens to expose the dispensing portion when the personalized skincare composition is ready to be dispensed. 18.根据权利要求1所述的方法,其特征在于,所述一次性荚包在使用前是气密密封的。18. The method according to claim 1, wherein the disposable pod is airtight before use.
HK62021043851.6A 2019-01-03 2019-12-18 Personalized skin care system HK40054696B (en)

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Application Number Priority Date Filing Date Title
US62/788,103 2019-01-03

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HK40054696A HK40054696A (en) 2022-02-25
HK40054696B true HK40054696B (en) 2024-11-29

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