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HK1258440A1 - 3-羥基異戊酸的一價陽離子鹽的晶體及該晶體的製造方法 - Google Patents

3-羥基異戊酸的一價陽離子鹽的晶體及該晶體的製造方法

Info

Publication number
HK1258440A1
HK1258440A1 HK19100390.5A HK19100390A HK1258440A1 HK 1258440 A1 HK1258440 A1 HK 1258440A1 HK 19100390 A HK19100390 A HK 19100390A HK 1258440 A1 HK1258440 A1 HK 1258440A1
Authority
HK
Hong Kong
Prior art keywords
crystals
producing
monovalent cation
cation salt
hydroxyisovaleric acid
Prior art date
Application number
HK19100390.5A
Other languages
English (en)
Inventor
Tomoya Yokoi
Hiroshi Nagano
Takayuki Shimizu
Original Assignee
Otsuka Pharma Factory Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Factory Inc filed Critical Otsuka Pharma Factory Inc
Publication of HK1258440A1 publication Critical patent/HK1258440A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B29/00—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
    • C30B29/54—Organic compounds
    • C30B29/58—Macromolecular compounds
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
    • C30B7/10—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions by application of pressure, e.g. hydrothermal processes
    • C30B7/105—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions by application of pressure, e.g. hydrothermal processes using ammonia as solvent, i.e. ammonothermal processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Materials Engineering (AREA)
  • Metallurgy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
HK19100390.5A 2015-11-19 2019-01-10 3-羥基異戊酸的一價陽離子鹽的晶體及該晶體的製造方法 HK1258440A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2015226876 2015-11-19
JP2016108805 2016-05-31
PCT/JP2016/084288 WO2017086447A1 (ja) 2015-11-19 2016-11-18 ３－ヒドロキシイソ吉草酸の一価カチオン塩の結晶および該結晶の製造方法

Publications (1)

Publication Number Publication Date
HK1258440A1 true HK1258440A1 (zh) 2019-11-15

Family

ID=58719184

Family Applications (2)

Application Number Title Priority Date Filing Date
HK19100390.5A HK1258440A1 (zh) 2015-11-19 2019-01-10 3-羥基異戊酸的一價陽離子鹽的晶體及該晶體的製造方法
HK19100391.4A HK1258020A1 (zh) 2015-11-19 2019-01-10 3-羥基異戊酸的一價陽離子鹽的晶體及該晶體的製造方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK19100391.4A HK1258020A1 (zh) 2015-11-19 2019-01-10 3-羥基異戊酸的一價陽離子鹽的晶體及該晶體的製造方法

Country Status (10)

Country Link
US (1) US10647653B2 (zh)
EP (1) EP3385250B1 (zh)
JP (2) JP6875288B2 (zh)
KR (1) KR20180088809A (zh)
CN (1) CN108473411B (zh)
ES (1) ES2899261T3 (zh)
HK (2) HK1258440A1 (zh)
PH (1) PH12018501046B1 (zh)
TW (1) TWI716495B (zh)
WO (1) WO2017086447A1 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2017282515A1 (en) 2016-06-24 2019-01-17 Otsuka Pharmaceutical Factory, Inc. Crystal of β-hydroxy β-methylbutyric acid amino acid salt and production method therefor

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57128653A (en) 1981-02-03 1982-08-10 Mitsubishi Gas Chem Co Inc Preparation of alpha-oxyisobutyric acid
FR2521857B1 (fr) 1982-02-23 1985-10-31 Solvay Compositions pharmaceutiques contenant de l'acide 3-hydroxybutanoique ou un sel derive de cet acide et sels derives de l'acide 3-hydroxybutanoique et d'une base organique azotee
DE69327468T2 (de) * 1992-09-16 2000-05-11 Iowa State University Research Foundation, Inc. Verfahren zur reduktion der blutspiegel von gesamtcholesterin und ldl-cholesterin
US6090978A (en) 1996-07-19 2000-07-18 Met-Rx Usa, Inc. Process for manufacturing 3-hydroxy-3-methylbutanoic acid
US6031000A (en) 1998-06-23 2000-02-29 Iowa State University Research Foundation, Inc. Composition comprising β-hydroxy-β-methylbutyric acid and at least one amino acid and methods of use
MXPA03010610A (es) * 2001-05-18 2004-04-02 Lonza Ag Metodo para la preparacion de formulaciones solidas de 3-hidroxi-3-metilbutirato de sodio.
CN1216037C (zh) 2003-02-21 2005-08-24 华东师范大学 3－羟基－3－甲基丁酸（hmb）氨基酸盐制备方法
US6812249B2 (en) 2003-03-04 2004-11-02 Sal Abraham Process for preparing a 3-hydroxy-3-methylbutyrate amino acid salt and method of use
EP2675771B1 (en) * 2011-02-14 2020-04-08 Concert Pharmaceuticals Inc. 4-hydroxybutyric acid deuterated analogs
MX2014001835A (es) 2011-08-15 2014-02-27 Abbott Lab Procedimiento para fabricar beta-hidroxi-beta-metilbutirato y sales del mismo.
CN104098461B (zh) 2013-04-12 2017-06-16 江阴技源药业有限公司 一种β‑羟基‑β‑甲基丁酸的纯化方法
AU2017282515A1 (en) 2016-06-24 2019-01-17 Otsuka Pharmaceutical Factory, Inc. Crystal of β-hydroxy β-methylbutyric acid amino acid salt and production method therefor

Also Published As

Publication number Publication date
EP3385250B1 (en) 2021-10-20
CN108473411A (zh) 2018-08-31
PH12018501046A1 (en) 2019-01-28
CN108473411B (zh) 2022-08-12
WO2017086447A1 (ja) 2017-05-26
JPWO2017086447A1 (ja) 2018-09-06
JP2021080284A (ja) 2021-05-27
EP3385250A1 (en) 2018-10-10
KR20180088809A (ko) 2018-08-07
US10647653B2 (en) 2020-05-12
TWI716495B (zh) 2021-01-21
JP7116207B2 (ja) 2022-08-09
US20180327344A1 (en) 2018-11-15
HK1258020A1 (zh) 2019-11-01
TW201720788A (zh) 2017-06-16
EP3385250A4 (en) 2019-06-12
JP6875288B2 (ja) 2021-05-19
PH12018501046B1 (en) 2019-01-28
ES2899261T3 (es) 2022-03-10

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