[go: up one dir, main page]

HK1250741A1 - 修飾的γδ細胞及其用途 - Google Patents

修飾的γδ細胞及其用途

Info

Publication number
HK1250741A1
HK1250741A1 HK18110017.8A HK18110017A HK1250741A1 HK 1250741 A1 HK1250741 A1 HK 1250741A1 HK 18110017 A HK18110017 A HK 18110017A HK 1250741 A1 HK1250741 A1 HK 1250741A1
Authority
HK
Hong Kong
Prior art keywords
modified
cell
Prior art date
Application number
HK18110017.8A
Other languages
English (en)
Inventor
David Leek Michael
Hannigan Adele
Patakas Agapitos
Paruzina Daria
Original Assignee
Tc Biopharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/GB2015/051985 external-priority patent/WO2016005752A1/en
Application filed by Tc Biopharm Ltd filed Critical Tc Biopharm Ltd
Publication of HK1250741A1 publication Critical patent/HK1250741A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32—T-cell receptors [TCR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/421—Immunoglobulin superfamily
    • A61K40/4211—CD19 or B4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2302—Interleukin-2 (IL-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
HK18110017.8A 2015-04-15 2018-08-03 修飾的γδ細胞及其用途 HK1250741A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1506423.1A GB201506423D0 (en) 2015-04-15 2015-04-15 Gamma delta T cells and uses thereof
PCT/GB2015/051985 WO2016005752A1 (en) 2014-07-09 2015-07-08 Gamma delta t cells and uses thereof
PCT/GB2016/051050 WO2016166544A1 (en) 2015-04-15 2016-04-14 Modified gamma delta cells and uses thereof

Publications (1)

Publication Number Publication Date
HK1250741A1 true HK1250741A1 (zh) 2019-01-11

Family

ID=53333850

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18110017.8A HK1250741A1 (zh) 2015-04-15 2018-08-03 修飾的γδ細胞及其用途

Country Status (16)

Country Link
US (2) US10881688B2 (zh)
EP (1) EP3283620B1 (zh)
JP (2) JP6995624B2 (zh)
KR (1) KR20180012754A (zh)
CN (2) CN107810267B (zh)
AU (2) AU2016250211B2 (zh)
BR (1) BR112017022249A2 (zh)
CA (1) CA2982523A1 (zh)
EA (1) EA201792041A1 (zh)
ES (1) ES2993441T3 (zh)
GB (1) GB201506423D0 (zh)
HK (1) HK1250741A1 (zh)
IL (1) IL255011B (zh)
SG (1) SG11201708401WA (zh)
WO (1) WO2016166544A1 (zh)
ZA (1) ZA201706922B (zh)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201506423D0 (en) 2015-04-15 2015-05-27 Tc Biopharm Ltd Gamma delta T cells and uses thereof
GB201507368D0 (en) * 2015-04-30 2015-06-17 Ucl Business Plc Cell
KR20180086183A (ko) 2015-09-03 2018-07-30 더 유에이비 리서치 파운데이션 유전자 조작 약물 내성 t 세포 및 이것의 사용 방법
TW201814042A (zh) * 2016-09-26 2018-04-16 新加坡商泰莎治療私人有限公司 T細胞擴展方法
US11421005B2 (en) 2016-12-09 2022-08-23 The Uab Research Foundation Chimeric chlorotoxin receptors
GB201701332D0 (en) * 2017-01-26 2017-03-15 Tc Biopharm Ltd Immune cells with modified metabolism and their use thereof
SG10202107136XA (en) * 2017-02-08 2021-07-29 Agency Science Tech & Res Gamma delta t cells and a method of augmenting the tumoricidal activity of the same
GB201707048D0 (en) 2017-05-03 2017-06-14 King S College London Expansion of gamma delta cells, compositions, and methods of use thereof
US12161669B2 (en) 2017-05-18 2024-12-10 Umc Utrecht Holding B.V. Compositions and methods for cell targeting therapies
KR20200064060A (ko) * 2017-07-29 2020-06-05 주노 쎄러퓨티크스 인코퍼레이티드 재조합 수용체를 발현하는 세포 증폭용 시약
GB201715918D0 (en) 2017-09-29 2017-11-15 Tc Biopharm Ltd Modified CAR-T
CN109777778B (zh) * 2017-11-14 2023-07-18 中国科学院广州生物医药与健康研究院 一种基因改造的γδT细胞
DE102017127984B4 (de) 2017-11-27 2019-12-05 Immatics US, Inc. Verfahren für die Vermehrung und Aktivierung von γδ-T-Zellen
CN108085341A (zh) * 2017-12-28 2018-05-29 河南省华隆生物技术有限公司 一种msgv重组载体及其制备方法和应用
GB201804701D0 (en) * 2018-03-23 2018-05-09 Gammadelta Therapeutics Ltd Lymphocytes expressing heterologous targeting constructs
CN108588023B (zh) * 2018-05-09 2020-02-14 河北森朗生物科技有限公司 一种生产嵌合抗原受体修饰的γδT细胞的方法
CN110577932A (zh) * 2018-06-07 2019-12-17 亘喜生物科技（上海）有限公司 一种脐带血来源的嵌合抗原受体t细胞
CN109234236A (zh) * 2018-09-29 2019-01-18 吉林大学第医院 一种嵌合抗原受体γδT细胞的制备方法
MX2021003745A (es) * 2018-10-01 2021-05-14 Adicet Bio Inc Composiciones y métodos relacionados con células t gamma delta modificadas y no modificadas para el tratamiento de tumores hematológicos.
CA3115059A1 (en) * 2018-10-01 2020-04-09 Adicet Bio Inc. Compositions and methods regarding engineered and non-engineered .gamma..delta.-t cells for treatment of solid tumors
CA3118498A1 (en) * 2018-11-05 2020-05-14 Xyphos Biosciences Inc. Non-natural nkg2d receptors that do not directly signal the cells to which they are attached
CN109517793B (zh) * 2018-11-30 2022-05-10 广州长峰生物技术有限公司 一种NK细胞和γδT细胞共培养的建立方法
CN109609465A (zh) * 2018-12-29 2019-04-12 武汉波睿达生物科技有限公司 一种利用脐血来源的γδT细胞制备CAR-T细胞的方法及该CAR-T细胞和应用
CN109762843A (zh) * 2018-12-29 2019-05-17 武汉波睿达生物科技有限公司 一种利用脐血来源的cd3阳性t细胞制备通用car-t细胞的方法
CN118546959A (zh) 2019-03-05 2024-08-27 恩卡尔塔公司 Cd19定向性嵌合抗原受体及其在免疫疗法中的用途
US20230144237A1 (en) * 2019-04-22 2023-05-11 Nanjing Legend Biotech Co., Ltd. Engineered cells and uses thereof
US20210048442A1 (en) 2019-08-13 2021-02-18 Immatics Biotechnologies Gmbh Method for the characterization of peptide:mhc binding polypeptides
CA3145523A1 (en) * 2019-08-16 2021-02-25 GammaDelta Therapeutics Limited Therapeutic uses of anti-tcr delta variable 1 antibodies
KR20220045980A (ko) * 2019-08-16 2022-04-13 감마델타 테라퓨틱스 리미티드 체외 감마 델타 t 세포 집단
CN110964698B (zh) * 2019-12-25 2022-05-10 杭州中赢生物医疗科技有限公司 一种人工抗原递呈细胞及其制备方法和应用
CA3165928A1 (en) * 2020-01-15 2021-07-22 The Regents Of The University Of California Compositions and methods for altering gamma delta t cell activity
CA3168729A1 (en) * 2020-02-24 2021-09-02 Melinda MATA Methods for expanding t cells for the treatment of cancer and related malignancies
CN115485369A (zh) * 2020-03-03 2022-12-16 詹森生物科技公司 γδT细胞及其用途
KR20230013022A (ko) * 2020-03-20 2023-01-26 감마델타 테라퓨틱스 엘티디 골수성 악성종양의 치료를 위한 v 델타1+ t 세포
CN113698489B (zh) 2020-05-22 2024-04-30 重庆精准生物技术有限公司 融合蛋白及其靶向psca的car及其应用
CN115996733A (zh) * 2020-06-22 2023-04-21 南京传奇生物科技有限公司 用于免疫疗法的基因工程化γδT细胞
AU2021308702A1 (en) 2020-07-17 2023-03-16 Instil Bio (Uk) Limited Receptors providing targeted costimulation for adoptive cell therapy
BR112023002741A2 (pt) * 2020-08-14 2023-10-10 Gammadelta Therapeutics Ltd Anticorpos multiespecíficos anti-tcr delta variáveis 1
CN114591907A (zh) * 2020-12-03 2022-06-07 复旦大学 一种γδT细胞的制备和扩增方法以及应用
CN112481284B (zh) * 2020-12-07 2023-07-25 深圳瑞吉生物科技有限公司 一种编码CAR基因的mRNA、组合mRNA、构建方法、CAR-T细胞和应用
CN114685684A (zh) * 2020-12-31 2022-07-01 博生吉医药科技(苏州)有限公司 MUC1-Tn嵌合抗原受体修饰的Vγ9Vδ2T细胞及其应用
JP2024506682A (ja) * 2021-02-17 2024-02-14 ガンマデルタ セラピューティクス リミテッド 抗ＴＣＲδ鎖可変部１抗体
CN117120597A (zh) * 2021-04-06 2023-11-24 北京清辉联诺生物科技有限责任公司 提高γδ T细胞病毒转导稳定性的方法及其应用
WO2022221506A1 (en) * 2021-04-16 2022-10-20 Acepodia Biotechnologies Ltd. Novel compositions enriched in gamma delta t cells, methods of preparation, and uses thereof
CN113156142B (zh) * 2021-04-16 2024-09-27 苏州才博医学科技有限公司 一种针对异体cart细胞特异性抗体的检测方法
EP4341286A4 (en) * 2021-05-19 2025-04-16 Celledit Llc BISPECIFIC CHIMERIC ANTIGEN RECEPTORS AND GENETICALLY MODIFIED IMMUNE CELLS EXPRESSING THESE RECEPTORS
US11945876B2 (en) 2021-06-16 2024-04-02 Instil Bio (Uk) Limited Receptors providing targeted costimulation for adoptive cell therapy
WO2023288278A1 (en) 2021-07-16 2023-01-19 Instil Bio (Uk) Limited Chimeric molecules providing targeted costimulation for adoptive cell therapy
CN113667640B (zh) * 2021-08-27 2022-09-02 广州百暨基因科技有限公司 CAR-γδT细胞的制备方法
CA3235971A1 (en) * 2021-10-20 2023-04-27 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Methods and materials for expanding tumor infiltrating gamma-delta t cells
WO2023156506A1 (en) 2022-02-16 2023-08-24 Priothera Sas Methods of treatment with car cells in combination with s1p receptor modulators
CN114645022B (zh) * 2022-05-13 2022-09-02 首都医科大学宣武医院 靶向CD5的CAR-γ δ T细胞及其制备方法与应用
WO2023235511A1 (en) * 2022-06-01 2023-12-07 Sens Research Foundation Targeted elimination of senescent cells by gamma-delta t cells
CN116813794B (zh) * 2023-02-27 2024-07-12 武汉波睿达生物科技有限公司 共表达spi1的嵌合抗原受体及其应用
EP4458412A1 (en) 2023-05-05 2024-11-06 University College Cardiff Consultants, Ltd. Novel phosphoantigen prodrug compound and use thereof

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL144339A0 (en) 1999-01-28 2002-05-23 Palmetto Health Alliance A cell line containing gamma delta lymphocytes and pharmaceutical compositions containing the same
CA2405050C (en) 2000-04-03 2010-06-15 Hemosol Inc. Production of tcr gamma delta t cells
JP4361727B2 (ja) 2000-09-11 2009-11-11 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド チロシンキナーゼインヒビターとしてのキノリノン誘導体
WO2006006720A1 (ja) 2004-07-13 2006-01-19 Medinet., Co.Ltd γδＴ細胞の培養方法、γδＴ細胞及び治療・予防剤
DE602005022728D1 (de) 2004-08-19 2010-09-16 Univ Cardiff Präparation antigenpräsentierender menschlicher gamma delta t-zellen und verwendung in der immuntherapie
WO2007029689A1 (ja) 2005-09-08 2007-03-15 Medinet Co., Ltd. 抗原提示細胞の活性化処理方法
WO2008152822A1 (ja) 2007-06-15 2008-12-18 Medinet Co., Ltd. 医薬
PH12013501201A1 (en) * 2010-12-09 2013-07-29 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
EP2814846B1 (en) 2012-02-13 2020-01-08 Seattle Children's Hospital d/b/a Seattle Children's Research Institute Bispecific chimeric antigen receptors and therapeutic uses thereof
US10117896B2 (en) * 2012-10-05 2018-11-06 The Trustees Of The University Of Pennsylvania Use of a trans-signaling approach in chimeric antigen receptors
NZ711807A (en) * 2013-02-06 2020-06-26 Celgene Corp Modified t lymphocytes having improved specificity
JP6463577B2 (ja) 2013-05-14 2019-02-06 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム 改変キメラ抗原受容体（ｃａｒ）ｔ細胞のヒト応用
ES2910004T3 (es) 2013-07-29 2022-05-11 2Seventy Bio Inc Proteínas de señalización de múltiples partes y sus usos
KR20160068960A (ko) 2013-10-25 2016-06-15 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 면역요법을 위한 다클론성 감마 델타 t 세포
WO2015066262A1 (en) 2013-11-04 2015-05-07 Trustees Of Dartmouth College Methods for preventing toxicity of adoptive cell therapy
BR112016011459A2 (pt) 2013-11-21 2017-09-26 Ucl Business Plc célula
MX369513B (es) 2014-02-14 2019-11-11 Univ Texas Receptores de antígenos quiméricos y métodos de realización.
EP3593812A3 (en) * 2014-03-15 2020-05-27 Novartis AG Treatment of cancer using chimeric antigen receptor
AU2015249655B2 (en) 2014-04-23 2021-01-07 Board Of Regents, The University Of Texas System Chimeric antigen receptors (CAR) for use in therapy and methods for making the same
JP2017524031A (ja) 2014-07-09 2017-08-24 ティーシー バイオファーム リミテッド ガンマデルタｔ細胞およびその使用
GB201506423D0 (en) 2015-04-15 2015-05-27 Tc Biopharm Ltd Gamma delta T cells and uses thereof
CN107249605A (zh) 2014-11-17 2017-10-13 阿迪塞特生物股份有限公司 工程化的γδT细胞
GB201507368D0 (en) 2015-04-30 2015-06-17 Ucl Business Plc Cell
CN105158466B (zh) * 2015-05-05 2017-12-22 中国科学院广州生物医药与健康研究院 一种检测抗cd19的嵌合抗原受体t细胞对白血病细胞抑制作用的方法

Also Published As

Publication number Publication date
KR20180012754A (ko) 2018-02-06
US10881688B2 (en) 2021-01-05
EP3283620A1 (en) 2018-02-21
ES2993441T3 (en) 2024-12-30
WO2016166544A1 (en) 2016-10-20
IL255011A0 (en) 2017-12-31
US20180125889A1 (en) 2018-05-10
ZA201706922B (en) 2023-06-28
CN114717194A (zh) 2022-07-08
EP3283620B1 (en) 2024-08-28
JP2022046549A (ja) 2022-03-23
US20210252055A1 (en) 2021-08-19
IL255011B (en) 2021-09-30
JP2018512161A (ja) 2018-05-17
CA2982523A1 (en) 2016-10-20
CN107810267A (zh) 2018-03-16
SG11201708401WA (en) 2017-11-29
AU2022203664A1 (en) 2022-06-16
JP6995624B2 (ja) 2022-02-21
BR112017022249A2 (pt) 2018-07-10
AU2016250211A1 (en) 2017-11-02
GB201506423D0 (en) 2015-05-27
EA201792041A1 (ru) 2018-04-30
CN107810267B (zh) 2022-03-04
AU2016250211B2 (en) 2022-03-03

Similar Documents

Publication Publication Date Title
HK1250741A1 (zh) 修飾的γδ細胞及其用途
FIC20230014I1 (fi) Foslevodopa ja foskarbidopa
HK1250481A1 (zh) 經過修飾的t細胞及其製備和使用方法
HK1256380A1 (zh) 修飾的細胞和治療方法
HK1256699A1 (zh) 噴射器和翼型構型
HK1250667A1 (zh) 細胞
HK1252162A1 (zh) 細胞
HK1256980A1 (zh) 氘化化合物和其用途
HK1243333A1 (zh) 用於修飾的t細胞的方法和組合物
IL258666A (en) Natural killer cells and ilc3 cells and uses thereof
EP3858365C0 (en) T CAR CELLS OPTIMIZED WITH GOLD
RS62164B1 (sr) Sulfoniluree i srodna jedinjenja i njihova upotreba
PL3265448T3 (pl) Proleki riluzolu i ich zastosowanie
IL249970B (en) Gamma delta t cells and uses thereof
DK3099172T3 (da) Modificeret biologisk bekæmpelsesmiddel og anvendelser deraf
MA40933A (fr) Difluorométhyl-aminopyridines et difluorométhyl-aminopyrimidines
KR20180084891A (ko) 구조 조성물 및 방법
PL3319612T3 (pl) Oksysterole i sposoby ich stosowania
DK3015526T3 (da) Hydrofluorolefinbaseret sammensætning og anvendelse deraf
PL3331063T3 (pl) Akumulator i zespół akumulatorowy
DK3161139T3 (da) Tlr-4-specifikke aptamerer og anvendelser heraf
IL259202A (en) Modified immune cells and uses thereof
SI3290441T1 (sl) RGMA-vezavni protein in njegova uporaba
HK1249447A1 (zh) Igfbp3及其應用
DK3128005T3 (da) Sirp-alfa-variantkonstruktioner og anvendelser deraf