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HK1250651A1 - 調控短鏈脫氫酶活性的組合物和方法 - Google Patents

調控短鏈脫氫酶活性的組合物和方法

Info

Publication number
HK1250651A1
HK1250651A1 HK18110182.7A HK18110182A HK1250651A1 HK 1250651 A1 HK1250651 A1 HK 1250651A1 HK 18110182 A HK18110182 A HK 18110182A HK 1250651 A1 HK1250651 A1 HK 1250651A1
Authority
HK
Hong Kong
Prior art keywords
compositions
methods
dehydrogenase activity
chain dehydrogenase
modulating short
Prior art date
Application number
HK18110182.7A
Other languages
English (en)
Inventor
Sanford D Markowitz
Joseph Ready
Yongyou Zhang
Monika Antczak
James K V Willson
Bruce A Posner
William Greenlee
Original Assignee
Univ Case Western Reserve
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Case Western Reserve, Univ Texas filed Critical Univ Case Western Reserve
Publication of HK1250651A1 publication Critical patent/HK1250651A1/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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HK18110182.7A 2015-04-14 2018-08-08 調控短鏈脫氫酶活性的組合物和方法 HK1250651A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562147305P 2015-04-14 2015-04-14
PCT/US2016/027549 WO2016168472A1 (en) 2015-04-14 2016-04-14 Compositions and methods of modulating short-chain dehydrogenase activity

Publications (1)

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HK1250651A1 true HK1250651A1 (zh) 2019-01-11

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Country Status (8)

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US (3) US20180118756A1 (zh)
EP (1) EP3283074A4 (zh)
JP (1) JP2018511616A (zh)
CN (1) CN108012528A (zh)
AU (1) AU2016248080A1 (zh)
CA (1) CA2982784A1 (zh)
HK (1) HK1250651A1 (zh)
WO (1) WO2016168472A1 (zh)

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* Cited by examiner, † Cited by third party
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EP2838533B1 (en) 2012-04-16 2017-10-04 Case Western Reserve University Compositions and methods of modulating 15-pgdh activity
US9801863B2 (en) 2012-04-16 2017-10-31 Case Western Reserve University Inhibitors of short-chain dehydrogenase activity for modulating hematopoietic stem cells and hematopoiesis
US9789116B2 (en) 2013-10-15 2017-10-17 Case Western Reserve University Compositions and methods of modulating short-chain dehydrogenase activity
CA2979203A1 (en) 2015-03-08 2016-09-15 Case Western Reserve University Inhibitors of short-chain dehydrogenase activity for treating fibrosis
CA3031091A1 (en) * 2016-07-18 2018-01-25 Case Western Reserve University Inhibitors of short-chain dehydrogenase activity for promoting neurogenesis and inhibiting nerve cell death
US11690847B2 (en) 2016-11-30 2023-07-04 Case Western Reserve University Combinations of 15-PGDH inhibitors with corticosteroids and/or TNF inhibitors and uses thereof
AU2018215678A1 (en) 2017-02-06 2019-08-22 Board Of Regents Of The University Of Texas System Compositions and methods of modulating short-chain dehydrogenase activity
US11426420B2 (en) 2017-04-07 2022-08-30 Case Western Reserve University Inhibitors of short-chain dehydrogenase activity for treating coronary disorders
CN112739344A (zh) * 2018-04-04 2021-04-30 卡斯西部储备大学 治疗肾损伤的组合物和方法
CN113507931A (zh) 2018-11-21 2021-10-15 卡斯西部储备大学 调节短链脱氢酶活性的组合物和方法
CA3142349A1 (en) * 2019-06-11 2020-12-17 The Board Of Trustees Of The Leland Stanford Junior University Methods of rejuvenating aged tissue by inhibiting 15-hydroxyprostaglandin dehydrogenase (15-pgdh)
MX2022010258A (es) * 2020-02-21 2023-01-24 Univ Case Western Reserve Composiciones y métodos para tratar la lesión renal.
IL298043A (en) * 2020-05-20 2023-01-01 Rodeo Therapeutics Corp Compositions and methods of modulating short-chain dehydrogenase activity
WO2022087631A1 (en) * 2020-10-23 2022-04-28 The Board Of Trustees Of The Leland Stanford Junior University Elevation of mitochondrial biogenesis and function by inhibition of prostaglandin degrading enzyme 15-pgdh
JP2023552832A (ja) * 2020-12-09 2023-12-19 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 関節の構造および機能を改善するためのプロスタグランジン分解酵素１５－ｐｇｄｈの阻害法
CN118591545A (zh) * 2022-01-28 2024-09-03 赛诺哈勃药业（成都）有限公司 一种调控15-pgdh活性的化合物及其制备方法
CN119013280A (zh) * 2022-04-13 2024-11-22 赛诺哈勃药业（成都）有限公司 一种调控15-pgdh活性的化合物及其制备方法
TW202419452A (zh) * 2022-11-11 2024-05-16 大陸商賽諾哈勃藥業（成都）有限公司 調控１５－ｐｇｄｈ活性的化合物、其藥物組合物及其用途
CN118027057A (zh) * 2022-11-14 2024-05-14 武汉人福创新药物研发中心有限公司 抑制15-pgdh的化合物及其用途
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