HK1248555A1 - 基因修飾的t細胞的選擇方法 - Google Patents
基因修飾的t細胞的選擇方法Info
- Publication number
- HK1248555A1 HK1248555A1 HK18108279.5A HK18108279A HK1248555A1 HK 1248555 A1 HK1248555 A1 HK 1248555A1 HK 18108279 A HK18108279 A HK 18108279A HK 1248555 A1 HK1248555 A1 HK 1248555A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- genetically
- cells
- modified
- selection methods
- selection
- Prior art date
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- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562120329P | 2015-02-24 | 2015-02-24 | |
US201562120790P | 2015-02-25 | 2015-02-25 | |
US201562175794P | 2015-06-15 | 2015-06-15 | |
PCT/US2016/019288 WO2016138091A2 (en) | 2015-02-24 | 2016-02-24 | Selection methods for genetically-modified t cells |
Publications (1)
Publication Number | Publication Date |
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HK1248555A1 true HK1248555A1 (zh) | 2018-10-19 |
Family
ID=56464271
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK18108279.5A HK1248555A1 (zh) | 2015-02-24 | 2018-06-27 | 基因修飾的t細胞的選擇方法 |
Country Status (9)
Country | Link |
---|---|
US (2) | US10808230B2 (zh) |
EP (2) | EP3804741A3 (zh) |
JP (1) | JP6947647B2 (zh) |
KR (1) | KR20170117095A (zh) |
CN (1) | CN107667169B (zh) |
AU (2) | AU2016222850B2 (zh) |
CA (1) | CA2976126A1 (zh) |
HK (1) | HK1248555A1 (zh) |
WO (1) | WO2016138091A2 (zh) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9629877B2 (en) | 2013-05-14 | 2017-04-25 | Board Of Regents, The University Of Texas System | Human application of engineered chimeric antigen receptor (CAR) T-cells |
CA2938887C (en) | 2014-02-14 | 2023-04-11 | Laurence J. N. Cooper | Chimeric antigen receptors and methods of making |
US10570186B2 (en) | 2014-11-05 | 2020-02-25 | Board Of Regents, The University Of Texas System | Chimeric antigen receptors (CAR) to selectively target protein complexes |
HUE053368T2 (hu) | 2015-03-11 | 2021-06-28 | Univ Texas | Transzpozáz polipeptidek és azok alkalmazásai |
WO2017048902A1 (en) | 2015-09-15 | 2017-03-23 | Board Of Regents, The University Of Texas System | T-cell receptor (tcr)-binding antibodies and uses thereof |
US11059879B2 (en) | 2015-10-27 | 2021-07-13 | Board Of Regents, The University Of Texas System | Chimeric antigen receptor molecules and uses thereof |
US11629340B2 (en) | 2017-03-03 | 2023-04-18 | Obsidian Therapeutics, Inc. | DHFR tunable protein regulation |
CA3064000A1 (en) * | 2017-05-24 | 2018-11-29 | Effector Therapeutics, Inc. | Methods and compositions for cellular immunotherapy |
CN109136282A (zh) * | 2018-09-30 | 2019-01-04 | 北京鼎成肽源生物技术有限公司 | 一种hafft1细胞的构建方法 |
WO2020102726A1 (en) * | 2018-11-16 | 2020-05-22 | Rapa Therapeutics, Llc | Method for manufacturing of human hybrid regulatory t/th2 cells (hybrid treg/th2 cells) from de-differentiated t cells |
KR20210102264A (ko) | 2018-11-16 | 2021-08-19 | 라파 쎄라퓨틱스 엘엘씨 | 유도된 조절 T (iTREG) 세포를 사용한 ALS 치료 |
KR102594009B1 (ko) | 2021-02-01 | 2023-10-24 | 서울대학교산학협력단 | 형질전환 생식세포의 제조 방법 및 이를 이용한 형질전환 동물의 제조 방법 |
JP2024533772A (ja) * | 2021-09-30 | 2024-09-12 | ユニバーシティ オブ サザン カリフォルニア | ヒト肝細胞培養培地およびin vitro培養ヒト肝細胞の馴化培地ならびにその使用 |
CN114740196B (zh) * | 2022-04-08 | 2023-04-18 | 中南大学湘雅二医院 | 标志物及其在制备评价机体免疫功能的产品中的应用 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0920679A2 (pt) * | 2008-10-08 | 2022-05-17 | Intrexon Corp | Células construídas expressando múltiplos imunomoduladores e usos das mesmas |
EP3970736A1 (en) * | 2009-11-02 | 2022-03-23 | Emory University | Drug resistant immunotherapy for treatment of a cancer |
PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
AU2012203048A1 (en) * | 2011-05-24 | 2012-12-13 | Agency For Science, Technology And Research | IRES mediated multicistronic vectors |
US10391126B2 (en) | 2011-11-18 | 2019-08-27 | Board Of Regents, The University Of Texas System | CAR+ T cells genetically modified to eliminate expression of T-cell receptor and/or HLA |
ES2774160T3 (es) * | 2012-02-13 | 2020-07-17 | Seattle Childrens Hospital D/B/A Seattle Childrens Res Institute | Receptores de antígenos quiméricos biespecíficos y usos terapéuticos de los mismos |
US9629877B2 (en) | 2013-05-14 | 2017-04-25 | Board Of Regents, The University Of Texas System | Human application of engineered chimeric antigen receptor (CAR) T-cells |
AU2014268364A1 (en) | 2013-05-24 | 2015-12-10 | Board Of Regents, The University Of Texas System | Chimeric antigen receptor-targeting monoclonal antibodies |
WO2015061694A2 (en) | 2013-10-25 | 2015-04-30 | Board Of Regents, The University Of Texas System | Polyclonal gamma delta t cells for immunotherapy |
BR112016011169A2 (pt) * | 2013-11-22 | 2017-09-19 | Cellectis | Método para a produção de células imunes ex vivo que são resistentes a um fármaco análogo de purina, célula t isolada resistente a um análogo de purina, composição farmacêutica e uso das mesmas |
CA2938887C (en) | 2014-02-14 | 2023-04-11 | Laurence J. N. Cooper | Chimeric antigen receptors and methods of making |
JP2017515464A (ja) | 2014-04-10 | 2017-06-15 | シアトル チルドレンズ ホスピタル, ディービーエー シアトル チルドレンズ リサーチ インスティテュート | 細胞免疫療法のための方法および組成物 |
CN106459924A (zh) | 2014-04-23 | 2017-02-22 | 得克萨斯州大学系统董事会 | 用于疗法中的嵌合抗原受体(car)及其制备方法 |
CA2945393C (en) | 2014-04-24 | 2021-03-23 | Board Of Regents, The University Of Texas System | Application of induced pluripotent stem cells to generate adoptive cell therapy products |
US10570186B2 (en) | 2014-11-05 | 2020-02-25 | Board Of Regents, The University Of Texas System | Chimeric antigen receptors (CAR) to selectively target protein complexes |
US20170333480A1 (en) | 2014-11-05 | 2017-11-23 | Board Of Regents, The University Of Texas System | Gene modified immune effector cells and engineered cells for expansion of immune effector cells |
HUE053368T2 (hu) | 2015-03-11 | 2021-06-28 | Univ Texas | Transzpozáz polipeptidek és azok alkalmazásai |
WO2017048902A1 (en) | 2015-09-15 | 2017-03-23 | Board Of Regents, The University Of Texas System | T-cell receptor (tcr)-binding antibodies and uses thereof |
US11059879B2 (en) | 2015-10-27 | 2021-07-13 | Board Of Regents, The University Of Texas System | Chimeric antigen receptor molecules and uses thereof |
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2016
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- 2016-02-24 EP EP20191615.2A patent/EP3804741A3/en not_active Withdrawn
- 2016-02-24 CA CA2976126A patent/CA2976126A1/en active Pending
- 2016-02-24 EP EP16741163.6A patent/EP3261656B1/en active Active
- 2016-02-24 JP JP2017562971A patent/JP6947647B2/ja active Active
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2018
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2020
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2021
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JP6947647B2 (ja) | 2021-10-13 |
EP3804741A3 (en) | 2021-07-14 |
CA2976126A1 (en) | 2016-09-01 |
EP3261656B1 (en) | 2020-08-19 |
AU2021203606A1 (en) | 2021-07-01 |
JP2018506995A (ja) | 2018-03-15 |
KR20170117095A (ko) | 2017-10-20 |
CN107667169B (zh) | 2021-10-29 |
CN107667169A (zh) | 2018-02-06 |
WO2016138091A2 (en) | 2016-09-01 |
AU2016222850B2 (en) | 2021-04-01 |
WO2016138091A3 (en) | 2016-12-29 |
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